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Results for BAS1

Z-value: 0.83

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Transcription factors associated with BAS1

Gene Symbol Gene ID Gene Info
BAS1
S000001807 Myb-related transcription factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
BAS1YKR099W-0.106.4e-01Click!

Activity profile of BAS1 motif

Sorted Z-values of BAS1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YMR096W 6.93
SNZ1
Protein involved in vitamin B6 biosynthesis; member of a stationary phase-induced gene family; coregulated with SNO1; interacts with Sno1p and with Yhr198p, perhaps as a multiprotein complex containing other Snz and Sno proteins
YKL217W 6.20
JEN1
Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose
YIL057C 5.01 Putative protein of unknown function; expression induced under carbon limitation and repressed under high glucose
YMR095C 4.39
SNO1
Protein of unconfirmed function, involved in pyridoxine metabolism; expression is induced during stationary phase; forms a putative glutamine amidotransferase complex with Snz1p, with Sno1p serving as the glutaminase
YBR296C 3.65
PHO89
Na+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p
YJR078W 3.60
BNA2
Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p and Aft2p
YLR356W 3.25 Putative protein of unknown function with similarity to SCM4; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR356W is not an essential gene
YLR174W 2.95
IDP2
Cytosolic NADP-specific isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose
YMR206W 2.92 Putative protein of unknown function; YMR206W is not an essential gene
YDL222C 2.80
FMP45
Integral membrane protein localized to mitochondria (untagged protein) and eisosomes, immobile patches at the cortex associated with endocytosis; sporulation and sphingolipid content are altered in mutants; has homologs SUR7 and YNL194C
YAR035W 2.77
YAT1
Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated
YMR189W 2.15
GCV2
P subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of 5,10-methylene-THF in the cytoplasm
YGR065C 2.06
VHT1
High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin
YMR081C 2.02
ISF1
Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant
YGR067C 1.94 Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p
YNR073C 1.91 Putative mannitol dehydrogenase
YHL036W 1.85
MUP3
Low affinity methionine permease, similar to Mup1p
YJR077C 1.75
MIR1
Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Pic2p but more abundant than Pic2p under normal conditions; phosphorylated
YHR096C 1.75
HXT5
Hexose transporter with moderate affinity for glucose, induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs
YER091C-A 1.71 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YIL099W 1.70
SGA1
Intracellular sporulation-specific glucoamylase involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation
YER069W 1.69
ARG5,6
Protein that is processed in the mitochondrion to yield acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase, which catalyze the 2nd and 3rd steps in arginine biosynthesis; enzymes form a complex with Arg2p
YDR019C 1.68
GCV1
T subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm
YER068C-A 1.61 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YKL163W 1.61
PIR3
O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway
YFR053C 1.60
HXK1
Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p
YCL030C 1.58
HIS4
Multifunctional enzyme containing phosphoribosyl-ATP pyrophosphatase, phosphoribosyl-AMP cyclohydrolase, and histidinol dehydrogenase activities; catalyzes the second, third, ninth and tenth steps in histidine biosynthesis
YGL062W 1.52
PYC1
Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc2p but differentially regulated; mutations in the human homolog are associated with lactic acidosis
YPL262W 1.47
FUM1
Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial localization determined by the N-terminal mitochondrial targeting sequence and protein conformation; phosphorylated in mitochondria
YOR152C 1.42 Putative protein of unknown function; has no similarity to any known protein; YOR152C is not an essential gene
YMR120C 1.39
ADE17
Enzyme of 'de novo' purine biosynthesis containing both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities, isozyme of Ade16p; ade16 ade17 mutants require adenine and histidine
YHR053C 1.37
CUP1-1
Metallothionein, binds copper and mediates resistance to high concentrations of copper and cadmium; locus is variably amplified in different strains, with two copies, CUP1-1 and CUP1-2, in the genomic sequence reference strain S288C
YER084W 1.37 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YFL030W 1.32
AGX1
Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases
YOL084W 1.32
PHM7
Protein of unknown function, expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole
YGL184C 1.28
STR3
Cystathionine beta-lyase, converts cystathionine into homocysteine
YIL101C 1.22
XBP1
Transcriptional repressor that binds to promoter sequences of the cyclin genes, CYS3, and SMF2; expression is induced by stress or starvation during mitosis, and late in meiosis; member of the Swi4p/Mbp1p family; potential Cdc28p substrate
YER162C 1.18
RAD4
Protein that recognizes and binds damaged DNA (with Rad23p) during nucleotide excision repair; subunit of Nuclear Excision Repair Factor 2 (NEF2); homolog of human XPC protein
YBR230C 1.14
OM14
Integral mitochondrial outer membrane protein; abundance is decreased in cells grown in glucose relative to other carbon sources; appears to contain 3 alpha-helical transmembrane segments; ORF encodes a 97-basepair intron
YLR164W 1.12 Mitochondrial inner membrane of unknown function; similar to Tim18p and Sdh4p; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YMR056C 1.12
AAC1
Mitochondrial inner membrane ADP/ATP translocator, exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; Aac1p is a minor isoform while Pet9p is the major ADP/ATP translocator
YGR144W 1.10
THI4
Thiazole synthase, catalyzes formation of the thiazole moiety of thiamin pyrophosphate; required for thiamine biosynthesis and for mitochondrial genome stability
YJL130C 1.09
URA2
Bifunctional carbamoylphosphate synthetase (CPSase)-aspartate transcarbamylase (ATCase), catalyzes the first two enzymatic steps in the de novo biosynthesis of pyrimidines; both activities are subject to feedback inhibition by UTP
YPL278C 1.09 Putative protein of unknown function; gene expression regulated by copper levels
YJR150C 1.08
DAN1
Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YER039C-A 1.05 Putative protein of unknown function; YER039C-A is not an essential gene
YER076C 1.05 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; analysis of HA-tagged protein suggests a membrane localization
YJR046W 1.03
TAH11
DNA replication licensing factor, required for pre-replication complex assembly
YLL019C 1.02
KNS1
Nonessential putative protein kinase of unknown cellular role; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues
YMR118C 1.02 Protein of unknown function with similarity to succinate dehydrogenase cytochrome b subunit; YMR118C is not an essential gene
YKL016C 1.02
ATP7
Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YMR107W 1.01
SPG4
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YMR188C 0.98
MRPS17
Mitochondrial ribosomal protein of the small subunit
YLR058C 0.97
SHM2
Cytosolic serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; major isoform involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis
YOR128C 0.97
ADE2
Phosphoribosylaminoimidazole carboxylase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway; red pigment accumulates in mutant cells deprived of adenine
YNR050C 0.95
LYS9
Saccharopine dehydrogenase (NADP+, L-glutamate-forming); catalyzes the formation of saccharopine from alpha-aminoadipate 6-semialdehyde, which is the seventh step in lysine biosynthesis pathway
YPL250C 0.94
ICY2
Protein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate
YLR122C 0.93 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C
YGR043C 0.93
NQM1
Protein of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift; null mutant non-quiescent cells exhibit reduced reproductive capacity
YDL170W 0.93
UGA3
Transcriptional activator necessary for gamma-aminobutyrate (GABA)-dependent induction of GABA genes (such as UGA1, UGA2, UGA4); zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type; localized to the nucleus
YPR026W 0.92
ATH1
Acid trehalase required for utilization of extracellular trehalose
YBR056W-A 0.92 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YBR056C-B
YER076W-A 0.89 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER076C
YDR263C 0.88
DIN7
Mitochondrial nuclease functioning in DNA repair and replication, modulates the stability of the mitochondrial genome, induced by exposure to mutagens, also induced during meiosis at a time nearly coincident with commitment to recombination
YPL135W 0.84
ISU1
Conserved protein of the mitochondrial matrix, performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p); isu1 isu2 double mutant is inviable
YER061C 0.83
CEM1
Mitochondrial beta-keto-acyl synthase with possible role in fatty acid synthesis; required for mitochondrial respiration
YLR123C 0.82 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR122C; contains characteristic aminoacyl-tRNA motif
YDR186C 0.81 Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YGR087C 0.79
PDC6
Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation
YPR027C 0.78 Putative protein of unknown function
YER101C 0.77
AST2
Protein that may have a role in targeting of plasma membrane [H+]ATPase (Pma1p) to the plasma membrane, as suggested by analysis of genetic interactions
YOR343C 0.74 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YJR038C 0.74 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJR154W 0.73 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YHR092C 0.72
HXT4
High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YOR227W 0.72 Protein of unknown function that may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YNL144C 0.72 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YNL144C is not an essential gene
YOR381W 0.71
FRE3
Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels
YJR146W 0.71 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HMS2
YOL085W-A 0.71 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YOL085C
YOR221C 0.70
MCT1
Predicted malonyl-CoA:ACP transferase, putative component of a type-II mitochondrial fatty acid synthase that produces intermediates for phospholipid remodeling
YJR045C 0.70
SSC1
Mitochondrial matrix ATPase, subunit of the presequence translocase-associated protein import motor (PAM) and of SceI endonuclease; involved in protein folding and translocation into the matrix; phosphorylated; member of HSP70 family
YDL130W-A 0.69
STF1
Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p may act as stabilizing factors that enhance inhibitory action of the Inh1p protein
YMR135C 0.68
GID8
Protein of unknown function, involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; contains LisH and CTLH domains, like Vid30p; dosage-dependent regulator of START
YDR453C 0.65
TSA2
Stress inducible cytoplasmic thioredoxin peroxidase; cooperates with Tsa1p in the removal of reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; deletion enhances the mutator phenotype of tsa1 mutants
YDR463W 0.65
STP1
Transcription factor, activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes and may have a role in tRNA processing
YDL234C 0.65
GYP7
GTPase-activating protein for yeast Rab family members including: Ypt7p (most effective), Ypt1p, Ypt31p, and Ypt32p (in vitro); involved in vesicle mediated protein trafficking
YKR080W 0.64
MTD1
NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase, plays a catalytic role in oxidation of cytoplasmic one-carbon units; expression is regulated by Bas1p and Bas2p, repressed by adenine, and may be induced by inositol and choline
YHR139C 0.64
SPS100
Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall
YMR182C 0.63
RGM1
Putative transcriptional repressor with proline-rich zinc fingers; overproduction impairs cell growth
YGL236C 0.63
MTO1
Mitochondrial protein, forms a heterodimer complex with Mss1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in paromomycin-resistant 15S rRNA mutants
YMR194C-B 0.63 Putative protein of unknown function
YOR011W-A 0.62 Putative protein of unknown function
YOR072W 0.62 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive
YHR150W 0.59
PEX28
Peroxisomal integral membrane peroxin, involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p
YDR298C 0.59
ATP5
Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated
YJR160C 0.59
MPH3
Alpha-glucoside permease, transports maltose, maltotriose, alpha-methylglucoside, and turanose; identical to Mph2p; encoded in a subtelomeric position in a region likely to have undergone duplication
YJR095W 0.58
SFC1
Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization
YLR125W 0.58 Putative protein of unknown function; mutant has decreased Ty3 transposition; YLR125W is not an essential gene
YOL154W 0.58
ZPS1
Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH
YDL244W 0.57
THI13
Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13
YNL333W 0.57
SNZ2
Member of a stationary phase-induced gene family; transcription of SNZ2 is induced prior to diauxic shift, and also in the absence of thiamin in a Thi2p-dependent manner; forms a coregulated gene pair with SNO2; interacts with Thi11p
YKR009C 0.57
FOX2
Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities
YHR145C 0.56 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJR152W 0.55
DAL5
Allantoin permease; ureidosuccinate permease; expression is constitutive but sensitive to nitrogen catabolite repression
YPR013C 0.55 Putative zinc finger protein; YPR013C is not an essential gene
YIL112W 0.55
HOS4
Subunit of the Set3 complex, which is a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; potential Cdc28p substrate
YIL125W 0.55
KGD1
Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA
YOL078W 0.54
AVO1
Component of a membrane-bound complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth
YFL052W 0.53 Putative zinc cluster protein that contains a DNA binding domain; null mutant sensitive to calcofluor white, low osmolarity and heat, suggesting a role for YFL052Wp in cell wall integrity
YMR306W 0.53
FKS3
Protein involved in spore wall assembly, has similarity to 1,3-beta-D-glucan synthase catalytic subunits Fks1p and Gsc2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDR490C 0.53
PKH1
Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh2p
YJL127C-B 0.52 Putative protein of unknown function; identified based on homology to the filamentous fungus, Ashbya gossypii
YFL059W 0.52
SNZ3
Member of a stationary phase-induced gene family; transcription of SNZ2 is induced prior to diauxic shift, and also in the absence of thiamin in a Thi2p-dependent manner; forms a coregulated gene pair with SNO3
YNL142W 0.52
MEP2
Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation
YDL221W 0.51 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the 3' end of essential gene CDC13
YOL058W 0.51
ARG1
Arginosuccinate synthetase, catalyzes the formation of L-argininosuccinate from citrulline and L-aspartate in the arginine biosynthesis pathway; potential Cdc28p substrate
YBR145W 0.50
ADH5
Alcohol dehydrogenase isoenzyme V; involved in ethanol production
YBL088C 0.50
TEL1
Protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; functionally redundant with Mec1p; homolog of human ataxia telangiectasia (ATM) gene
YFR047C 0.50
BNA6
Quinolinate phosphoribosyl transferase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p
YOR071C 0.50
NRT1
High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity
YAR015W 0.50
ADE1
N-succinyl-5-aminoimidazole-4-carboxamide ribotide (SAICAR) synthetase, required for 'de novo' purine nucleotide biosynthesis; red pigment accumulates in mutant cells deprived of adenine
YBR230W-A 0.50 Putative protein of unknown function
YJL037W 0.48
IRC18
Putative protein of unknown function; expression induced in respiratory-deficient cells and in carbon-limited chemostat cultures; similar to adjacent ORF, YJL038C; null mutant displays increased levels of spontaneous Rad52p foci
YGR191W 0.48
HIP1
High-affinity histidine permease, also involved in the transport of manganese ions
YNL025C 0.47
SSN8
Cyclin-like component of the RNA polymerase II holoenzyme, involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression and telomere maintenance
YIL100W 0.47 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the dubious ORF YIL100C-A
YIR017C 0.46
MET28
Transcriptional activator in the Cbf1p-Met4p-Met28p complex, participates in the regulation of sulfur metabolism
YNL220W 0.46
ADE12
Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence
YLR228C 0.45
ECM22
Sterol regulatory element binding protein, regulates transcription of the sterol biosynthetic genes ERG2 and ERG3; member of the fungus-specific Zn[2]-Cys[6] binuclear cluster family of transcription factors; homologous to Upc2p
YJR039W 0.45 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDL233W 0.45 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YDL233W is not an essential gene
YLR431C 0.44
ATG23
Peripheral membrane protein required for the cytoplasm-to-vacuole targeting (Cvt) pathway; cycles between the pre-autophagosome (PAS) and non-PAS locations; forms a complex with Atg9p and Atg27p
YDR441C 0.44
APT2
Apparent pseudogene, not transcribed or translated under normal conditions; encodes a protein with similarity to adenine phosphoribosyltransferase, but artificially expressed protein exhibits no enzymatic activity
YDL210W 0.43
UGA4
Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
YBR182C 0.42
SMP1
Putative transcription factor involved in regulating the response to osmotic stress; member of the MADS-box family of transcription factors
YBL102W 0.42
SFT2
Non-essential tetra-spanning membrane protein found mostly in the late Golgi, can suppress some sed5 alleles; may be part of the transport machinery, but precise function is unknown; similar to mammalian syntaxin 5
YLR053C 0.42 Putative protein of unknown function
YNL334C 0.42
SNO2
Protein of unknown function, nearly identical to Sno3p; expression is induced before the diauxic shift and also in the absence of thiamin
YBL101C 0.41
ECM21
Non-essential protein of unknown function; promoter contains several Gcn4p binding elements
YFR034C 0.41
PHO4
Basic helix-loop-helix (bHLH) transcription factor of the myc-family; binds cooperatively with Pho2p to the PHO5 promoter; function is regulated by phosphorylation at multiple sites and by phosphate availability
YJR037W 0.41 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene HUL4/YJR036C; YJR037W is not an essential gene.
YDL194W 0.41
SNF3
Plasma membrane glucose sensor that regulates glucose transport; has 12 predicted transmembrane segments; long cytoplasmic C-terminal tail is required for low glucose induction of hexose transporter genes HXT2 and HXT4
YBR250W 0.41
SPO23
Protein of unknown function; associates with meiosis-specific protein Spo1p
YIL100C-A 0.40 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGL186C 0.40
TPN1
Plasma membrane pyridoxine (vitamin B6) transporter; member of the purine-cytosine permease subfamily within the major facilitator superfamily; proton symporter with similarity to Fcy21p, Fcy2p, and Fcy22p
YGL219C 0.40
MDM34
Mitochondrial outer membrane protein, required for normal mitochondrial morphology and inheritance; localizes to dots on the mitochondrial surface near mtDNA nucleoids; interacts genetically with MDM31 and MDM32
YGL056C 0.39
SDS23
One of two S. cerevisiae homologs (Sds23p and Sds24p) of the Schizosaccharomyces pombe Sds23 protein, which genetic studies have implicated in APC/cyclosome regulation
YLR311C 0.39 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YAR050W 0.39
FLO1
Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p
YHR078W 0.38 High osmolarity-regulated gene of unknown function
YPR009W 0.38
SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; highly similar to Sut1p
YKR058W 0.38
GLG1
Self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin
YNL311C 0.38 Protein of unknown function that may interact with ribosomes, based on co-purification experiments; putative F-box protein; analysis of integrated high-throughput datasets predicts involvement in ubiquitin-dependent protein catabolism
YOL147C 0.38
PEX11
Peroxisomal membrane protein required for peroxisome proliferation and medium-chain fatty acid oxidation, most abundant protein in the peroxisomal membrane, regulated by Adr1p and Pip2p-Oaf1p, promoter contains ORE and UAS1-like elements
YHL016C 0.38
DUR3
Plasma membrane transporter for both urea and polyamines, expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway
YNR059W 0.37
MNT4
Putative alpha-1,3-mannosyltransferase, not required for protein O-glycosylation
YFL060C 0.37
SNO3
Protein of unknown function, nearly identical to Sno2p; expression is induced before the diauxic shift and also in the absence of thiamin
YLR124W 0.37 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YNR001C 0.36
CIT1
Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein
YMR169C 0.35
ALD3
Cytoplasmic aldehyde dehydrogenase, involved in beta-alanine synthesis; uses NAD+ as the preferred coenzyme; very similar to Ald2p; expression is induced by stress and repressed by glucose
YNR063W 0.34 Putative zinc-cluster protein of unknown function
YGR190C 0.33 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HIP1/YGR191W
YGR204W 0.33
ADE3
Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase, involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine
YDR273W 0.33
DON1
Meiosis-specific component of the spindle pole body, part of the leading edge protein (LEP) coat, forms a ring-like structure at the leading edge of the prospore membrane during meiosis II
YGL197W 0.32
MDS3
Protein with an N-terminal kelch-like domain, putative negative regulator of early meiotic gene expression; required, with Pmd1p, for growth under alkaline conditions
YMR280C 0.32
CAT8
Zinc cluster transcriptional activator necessary for derepression of a variety of genes under non-fermentative growth conditions, active after diauxic shift, binds carbon source responsive elements
YPL107W 0.32 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YPL107W is not an essential gene
YMR195W 0.31
ICY1
Protein of unknown function, required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation
YDL054C 0.31
MCH1
Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
YDR216W 0.31
ADR1
Carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization
YPR184W 0.31
GDB1
Glycogen debranching enzyme containing glucanotranferase and alpha-1,6-amyloglucosidase activities, required for glycogen degradation; phosphorylated in mitochondria
YMR058W 0.30
FET3
Ferro-O2-oxidoreductase required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases
YHL037C 0.30 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YNL104C 0.30
LEU4
Alpha-isopropylmalate synthase (2-isopropylmalate synthase); the main isozyme responsible for the first step in the leucine biosynthesis pathway
YJR036C 0.29
HUL4
Protein with similarity to hect domain E3 ubiquitin-protein ligases, not essential for viability
YDR525W-A 0.29
SNA2
Protein of unknown function, has similarity to Pmp3p, which is involved in cation transport; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YIL023C 0.29
YKE4
Zinc transporter; localizes to the ER; null mutant is sensitive to calcofluor white, leads to zinc accumulation in cytosol; ortholog of the mouse KE4 and member of the ZIP (ZRT, IRT-like Protein) family
YLR092W 0.29
SUL2
High affinity sulfate permease; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates
YDR171W 0.29
HSP42
Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock
YOR178C 0.29
GAC1
Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock
YMR179W 0.28
SPT21
Protein required for normal transcription at several loci including HTA2-HTB2 and HHF2-HHT2, but not required at the other histone loci; functionally related to Spt10p; involved in telomere maintenance
YDR409W 0.28
SIZ1
SUMO/Smt3 ligase that promotes the attachment of sumo (Smt3p; small ubiquitin-related modifier) to proteins; binds Ubc9p and may bind septins; specifically required for sumoylation of septins in vivo; localized to the septin ring
YEL021W 0.28
URA3
Orotidine-5'-phosphate (OMP) decarboxylase, catalyzes the sixth enzymatic step in the de novo biosynthesis of pyrimidines, converting OMP into uridine monophosphate (UMP); converts 5-FOA into 5-fluorouracil, a toxic compound
YNL143C 0.28 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YER084W-A 0.28 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDL079C 0.27
MRK1
Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation
YDR258C 0.27
HSP78
Oligomeric mitochondrial matrix chaperone that cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; prevents the aggregation of misfolded matrix proteins; component of the mitochondrial proteolysis system
YAR047C 0.27 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPR028W 0.27
YOP1
Membrane protein that interacts with Yip1p to mediate membrane traffic; overexpression results in cell death and accumulation of internal cell membranes; regulates vesicular traffic in stressed cells
YPL027W 0.27
SMA1
Protein of unknown function involved in the assembly of the prospore membrane during sporulation
YNL250W 0.27
RAD50
Subunit of MRX complex, with Mre11p and Xrs2p, involved in processing double-strand DNA breaks in vegetative cells, initiation of meiotic DSBs, telomere maintenance, and nonhomologous end joining
YKL171W 0.27 Putative protein of unknown function; predicted protein kinase; implicated in proteasome function; epitope-tagged protein localizes to the cytoplasm
YGR088W 0.27
CTT1
Cytosolic catalase T, has a role in protection from oxidative damage by hydrogen peroxide
YJR153W 0.26
PGU1
Endo-polygalacturonase, pectolytic enzyme that hydrolyzes the alpha-1,4-glycosidic bonds in the rhamnogalacturonan chains in pectins
YDR533C 0.26
HSP31
Possible chaperone and cysteine protease with similarity to E. coli Hsp31; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer and contains a putative metal-binding site
YOL081W 0.26
IRA2
GTPase-activating protein that negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, has similarity to Ira1p and human neurofibromin
YML116W-A 0.26 Putative protein of unknown function
YMR271C 0.26
URA10
Minor orotate phosphoribosyltransferase (OPRTase) isozyme that catalyzes the fifth enzymatic step in the de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; major OPRTase encoded by URA5
YIL117C 0.26
PRM5
Pheromone-regulated protein, predicted to have 1 transmembrane segment; induced during cell integrity signaling

Network of associatons between targets according to the STRING database.

First level regulatory network of BAS1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 12.9 GO:0042816 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
1.6 6.3 GO:0006848 pyruvate transport(GO:0006848)
0.9 3.7 GO:0006546 glycine catabolic process(GO:0006546)
0.9 2.8 GO:0006577 amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437)
0.8 4.2 GO:0034354 'de novo' NAD biosynthetic process from tryptophan(GO:0034354) 'de novo' NAD biosynthetic process(GO:0034627)
0.7 2.0 GO:0015755 fructose transport(GO:0015755)
0.6 3.1 GO:0006102 isocitrate metabolic process(GO:0006102)
0.6 1.7 GO:0006592 ornithine biosynthetic process(GO:0006592)
0.5 2.3 GO:0006544 glycine metabolic process(GO:0006544)
0.4 1.7 GO:0046688 response to copper ion(GO:0046688)
0.4 2.0 GO:0005980 glycogen catabolic process(GO:0005980)
0.4 4.3 GO:0006817 phosphate ion transport(GO:0006817)
0.4 3.0 GO:0051180 vitamin transport(GO:0051180)
0.3 1.4 GO:0015886 heme transport(GO:0015886)
0.3 1.0 GO:0043335 protein unfolding(GO:0043335)
0.3 0.9 GO:0005993 trehalose catabolic process(GO:0005993)
0.2 0.7 GO:0006103 2-oxoglutarate metabolic process(GO:0006103)
0.2 1.0 GO:0019346 transsulfuration(GO:0019346)
0.2 1.0 GO:0045980 negative regulation of nucleotide metabolic process(GO:0045980)
0.2 0.9 GO:0009450 gamma-aminobutyric acid metabolic process(GO:0009448) gamma-aminobutyric acid catabolic process(GO:0009450)
0.2 0.9 GO:0046033 AMP biosynthetic process(GO:0006167) AMP metabolic process(GO:0046033)
0.2 0.4 GO:0043419 urea catabolic process(GO:0043419)
0.2 1.7 GO:0015758 glucose transport(GO:0015758)
0.2 0.8 GO:0034764 positive regulation of lipid transport(GO:0032370) regulation of sterol transport(GO:0032371) positive regulation of sterol transport(GO:0032373) positive regulation of transmembrane transport(GO:0034764) regulation of sterol import by regulation of transcription from RNA polymerase II promoter(GO:0035968) positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter(GO:0035969) regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367) regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369) regulation of sterol import(GO:2000909) positive regulation of sterol import(GO:2000911)
0.2 0.8 GO:0000949 aromatic amino acid family catabolic process to alcohol via Ehrlich pathway(GO:0000949)
0.2 0.6 GO:0015740 C4-dicarboxylate transport(GO:0015740)
0.2 1.6 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.2 0.5 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.2 1.9 GO:0009228 thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724)
0.2 0.5 GO:0090399 replicative senescence(GO:0090399)
0.2 1.0 GO:0009113 purine nucleobase biosynthetic process(GO:0009113)
0.2 0.5 GO:0035947 regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter(GO:0035947) positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061413) positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061414)
0.2 0.5 GO:0045117 azole transport(GO:0045117)
0.2 0.5 GO:0043388 regulation of sulfur amino acid metabolic process(GO:0031335) positive regulation of DNA binding(GO:0043388) regulation of DNA binding(GO:0051101)
0.1 0.3 GO:0008272 sulfate transport(GO:0008272)
0.1 0.7 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
0.1 0.5 GO:0006075 (1->3)-beta-D-glucan biosynthetic process(GO:0006075)
0.1 1.8 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.1 1.0 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.1 0.6 GO:1900864 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
0.1 0.1 GO:0006108 malate metabolic process(GO:0006108)
0.1 0.3 GO:1904951 positive regulation of protein transport(GO:0051222) positive regulation of establishment of protein localization(GO:1904951)
0.1 1.1 GO:0019878 lysine biosynthetic process via aminoadipic acid(GO:0019878)
0.1 0.4 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.1 0.3 GO:0045596 negative regulation of cell differentiation(GO:0045596)
0.1 0.5 GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211)
0.1 1.3 GO:0034440 fatty acid oxidation(GO:0019395) lipid oxidation(GO:0034440)
0.1 2.1 GO:0072350 tricarboxylic acid metabolic process(GO:0072350)
0.1 0.9 GO:0015688 iron chelate transport(GO:0015688)
0.1 0.1 GO:0034225 cellular response to zinc ion starvation(GO:0034224) regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation(GO:0034225)
0.1 0.7 GO:0000023 maltose metabolic process(GO:0000023)
0.1 0.1 GO:0051038 negative regulation of transcription involved in meiotic cell cycle(GO:0051038)
0.1 0.5 GO:0010672 regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle(GO:0010672)
0.1 1.2 GO:0015749 hexose transport(GO:0008645) monosaccharide transport(GO:0015749)
0.1 0.3 GO:0042744 hydrogen peroxide metabolic process(GO:0042743) hydrogen peroxide catabolic process(GO:0042744)
0.1 0.3 GO:0072530 cytosine transport(GO:0015856) purine-containing compound transmembrane transport(GO:0072530)
0.1 0.3 GO:0016036 cellular response to phosphate starvation(GO:0016036)
0.1 0.5 GO:0051058 negative regulation of Ras protein signal transduction(GO:0046580) negative regulation of small GTPase mediated signal transduction(GO:0051058)
0.1 0.2 GO:0043966 histone H3 acetylation(GO:0043966) histone H3-K9 acetylation(GO:0043970) histone H3-K14 acetylation(GO:0044154) histone H3-K9 modification(GO:0061647)
0.1 0.4 GO:0044205 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) 'de novo' UMP biosynthetic process(GO:0044205)
0.1 0.2 GO:0018209 peptidyl-serine phosphorylation(GO:0018105) peptidyl-serine modification(GO:0018209)
0.1 0.3 GO:0032071 regulation of deoxyribonuclease activity(GO:0032070) regulation of endodeoxyribonuclease activity(GO:0032071)
0.1 0.9 GO:0006098 pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682)
0.1 0.4 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.1 0.6 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.1 0.4 GO:0000501 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
0.1 0.2 GO:0010039 response to iron ion(GO:0010039) regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395) cellular response to iron ion(GO:0071281)
0.1 2.7 GO:0009060 aerobic respiration(GO:0009060)
0.1 1.0 GO:0030174 regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.1 0.4 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.1 1.0 GO:0015918 sterol transport(GO:0015918)
0.1 0.6 GO:0032889 regulation of vacuole fusion, non-autophagic(GO:0032889) regulation of vacuole organization(GO:0044088)
0.1 0.2 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.1 1.2 GO:0000422 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.1 1.4 GO:0006094 gluconeogenesis(GO:0006094)
0.1 0.4 GO:0051274 (1->6)-beta-D-glucan biosynthetic process(GO:0006078) beta-glucan biosynthetic process(GO:0051274)
0.1 0.2 GO:0009107 lipoate metabolic process(GO:0009106) lipoate biosynthetic process(GO:0009107)
0.0 0.1 GO:0048015 phosphatidylinositol-mediated signaling(GO:0048015)
0.0 1.3 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 0.4 GO:0006829 zinc II ion transport(GO:0006829)
0.0 0.1 GO:0034091 regulation of maintenance of sister chromatid cohesion(GO:0034091) positive regulation of mitotic nuclear division(GO:0045840) positive regulation of mitotic metaphase/anaphase transition(GO:0045842) positive regulation of sister chromatid cohesion(GO:0045876) positive regulation of mitotic sister chromatid separation(GO:1901970) positive regulation of metaphase/anaphase transition of cell cycle(GO:1902101)
0.0 0.6 GO:0009250 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.0 3.8 GO:0048468 ascospore formation(GO:0030437) cell development(GO:0048468)
0.0 0.1 GO:0042126 nitrate metabolic process(GO:0042126) nitrate assimilation(GO:0042128)
0.0 0.2 GO:0051601 exocyst assembly(GO:0001927) exocyst localization(GO:0051601)
0.0 0.1 GO:0019748 secondary metabolic process(GO:0019748)
0.0 0.2 GO:0060237 regulation of fungal-type cell wall organization(GO:0060237)
0.0 0.2 GO:0051292 pore complex assembly(GO:0046931) nuclear pore complex assembly(GO:0051292)
0.0 0.2 GO:0033683 nucleotide-excision repair, DNA incision(GO:0033683)
0.0 0.1 GO:0000435 regulation of transcription from RNA polymerase II promoter by galactose(GO:0000431) positive regulation of transcription from RNA polymerase II promoter by galactose(GO:0000435)
0.0 0.6 GO:0016575 histone deacetylation(GO:0016575)
0.0 0.1 GO:0001113 transcriptional open complex formation at RNA polymerase II promoter(GO:0001113)
0.0 0.1 GO:0035999 tetrahydrofolate interconversion(GO:0035999)
0.0 0.1 GO:0006598 polyamine catabolic process(GO:0006598)
0.0 0.1 GO:0031138 negative regulation of conjugation(GO:0031135) negative regulation of conjugation with cellular fusion(GO:0031138) negative regulation of multi-organism process(GO:0043901)
0.0 0.2 GO:0051260 protein homooligomerization(GO:0051260)
0.0 0.2 GO:0006452 translational frameshifting(GO:0006452)
0.0 0.5 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 0.2 GO:0045033 peroxisome inheritance(GO:0045033)
0.0 0.2 GO:0015698 inorganic anion transport(GO:0015698)
0.0 0.3 GO:0007118 budding cell apical bud growth(GO:0007118)
0.0 0.1 GO:0032211 negative regulation of telomere maintenance via telomerase(GO:0032211) negative regulation of telomere maintenance via telomere lengthening(GO:1904357)
0.0 0.2 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.1 GO:0055078 cellular sodium ion homeostasis(GO:0006883) sodium ion homeostasis(GO:0055078)
0.0 0.2 GO:0061393 positive regulation of transcription from RNA polymerase II promoter in response to osmotic stress(GO:0061393)
0.0 1.3 GO:0006289 nucleotide-excision repair(GO:0006289)
0.0 0.0 GO:0008216 spermidine metabolic process(GO:0008216)
0.0 0.1 GO:0051228 mitotic spindle disassembly(GO:0051228) spindle disassembly(GO:0051230)
0.0 0.3 GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress(GO:0036003)
0.0 0.1 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.0 0.1 GO:0006655 phosphatidylglycerol biosynthetic process(GO:0006655)
0.0 0.1 GO:0016577 protein demethylation(GO:0006482) protein dealkylation(GO:0008214) histone demethylation(GO:0016577) demethylation(GO:0070988)
0.0 1.0 GO:0030435 sporulation resulting in formation of a cellular spore(GO:0030435)
0.0 0.1 GO:0046686 response to arsenic-containing substance(GO:0046685) response to cadmium ion(GO:0046686)
0.0 0.2 GO:0045332 phospholipid translocation(GO:0045332)
0.0 0.1 GO:0015680 intracellular copper ion transport(GO:0015680)
0.0 0.1 GO:0048209 regulation of COPII vesicle coating(GO:0003400) regulation of vesicle targeting, to, from or within Golgi(GO:0048209) regulation of ER to Golgi vesicle-mediated transport by GTP hydrolysis(GO:0090113)
0.0 0.2 GO:0031145 anaphase-promoting complex-dependent catabolic process(GO:0031145)
0.0 0.2 GO:0010324 membrane invagination(GO:0010324) lysosomal microautophagy(GO:0016237) single-organism membrane invagination(GO:1902534)
0.0 0.1 GO:0051181 cofactor transport(GO:0051181)
0.0 0.3 GO:0000183 chromatin silencing at rDNA(GO:0000183)
0.0 0.1 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)
0.0 0.7 GO:0007031 peroxisome organization(GO:0007031)
0.0 0.1 GO:0001101 response to acid chemical(GO:0001101)
0.0 0.1 GO:0071168 protein localization to chromatin(GO:0071168)
0.0 0.1 GO:0043207 immune effector process(GO:0002252) immune system process(GO:0002376) response to virus(GO:0009615) response to external biotic stimulus(GO:0043207) defense response to virus(GO:0051607) response to other organism(GO:0051707) defense response to other organism(GO:0098542)
0.0 0.0 GO:0031440 regulation of mRNA 3'-end processing(GO:0031440)
0.0 0.1 GO:0042766 nucleosome mobilization(GO:0042766)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 3.7 GO:0005960 glycine cleavage complex(GO:0005960)
0.5 1.6 GO:0045265 mitochondrial proton-transporting ATP synthase, stator stalk(GO:0000274) proton-transporting ATP synthase, stator stalk(GO:0045265)
0.5 2.4 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
0.4 1.2 GO:0000111 nucleotide-excision repair factor 2 complex(GO:0000111)
0.3 0.5 GO:0032126 eisosome(GO:0032126)
0.2 0.9 GO:0030287 cell wall-bounded periplasmic space(GO:0030287)
0.1 0.7 GO:0072380 ER membrane insertion complex(GO:0072379) TRC complex(GO:0072380)
0.1 0.5 GO:0000148 1,3-beta-D-glucan synthase complex(GO:0000148)
0.1 0.7 GO:0034657 GID complex(GO:0034657)
0.1 1.7 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.1 0.5 GO:0031932 TORC2 complex(GO:0031932)
0.1 0.6 GO:0034967 Set3 complex(GO:0034967)
0.1 0.3 GO:0030870 Mre11 complex(GO:0030870)
0.1 0.4 GO:0044233 ERMES complex(GO:0032865) ER-mitochondrion membrane contact site(GO:0044233)
0.1 0.2 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 0.4 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.1 0.9 GO:0005753 mitochondrial proton-transporting ATP synthase complex(GO:0005753) proton-transporting ATP synthase complex(GO:0045259)
0.1 0.3 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1 1.1 GO:0031307 intrinsic component of mitochondrial outer membrane(GO:0031306) integral component of mitochondrial outer membrane(GO:0031307)
0.1 0.2 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
0.1 0.2 GO:0030874 nucleolar chromatin(GO:0030874)
0.0 0.1 GO:0044232 organelle membrane contact site(GO:0044232)
0.0 0.3 GO:0031499 TRAMP complex(GO:0031499)
0.0 0.2 GO:0034448 EGO complex(GO:0034448)
0.0 0.1 GO:0001400 mating projection base(GO:0001400)
0.0 0.7 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.0 0.5 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0 0.6 GO:0031903 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 0.3 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 13.2 GO:0005886 plasma membrane(GO:0005886)
0.0 0.2 GO:0000145 exocyst(GO:0000145)
0.0 1.1 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 2.0 GO:0009277 fungal-type cell wall(GO:0009277)
0.0 0.1 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.0 0.3 GO:0071782 endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.0 0.4 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 0.2 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.0 0.2 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751) respiratory chain complex IV(GO:0045277)
0.0 0.4 GO:0005628 prospore membrane(GO:0005628) intracellular immature spore(GO:0042763) ascospore-type prospore(GO:0042764)
0.0 0.2 GO:0005769 early endosome(GO:0005769)
0.0 0.4 GO:0016592 mediator complex(GO:0016592)
0.0 0.1 GO:0000444 MIS12/MIND type complex(GO:0000444) nuclear MIS12/MIND complex(GO:0000818)
0.0 0.2 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.1 GO:0098552 side of membrane(GO:0098552) cytoplasmic side of membrane(GO:0098562)
0.0 2.1 GO:0000323 storage vacuole(GO:0000322) lytic vacuole(GO:0000323) fungal-type vacuole(GO:0000324)
0.0 0.1 GO:0005871 kinesin complex(GO:0005871)
0.0 0.3 GO:0070469 respiratory chain(GO:0070469)
0.0 0.1 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.0 0.1 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.2 GO:0070210 Rpd3L-Expanded complex(GO:0070210)
0.0 0.1 GO:0000783 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783)
0.0 1.5 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 0.1 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.1 GO:0000799 transcription factor TFIIIC complex(GO:0000127) condensin complex(GO:0000796) nuclear condensin complex(GO:0000799)
0.0 0.2 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.2 GO:0005680 anaphase-promoting complex(GO:0005680)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 6.6 GO:0015295 solute:proton symporter activity(GO:0015295)
1.1 5.5 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
1.0 3.0 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.9 3.7 GO:0004375 glycine dehydrogenase (decarboxylating) activity(GO:0004375) oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor(GO:0016642)
0.9 2.8 GO:0004092 carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406)
0.6 0.6 GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.5 0.5 GO:1901474 azole transmembrane transporter activity(GO:1901474)
0.5 3.2 GO:0019238 cyclohydrolase activity(GO:0019238)
0.5 3.6 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.4 1.7 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.4 2.5 GO:0051183 vitamin transporter activity(GO:0051183)
0.4 1.6 GO:0004396 hexokinase activity(GO:0004396)
0.4 2.0 GO:0008198 ferrous iron binding(GO:0008198)
0.4 1.9 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.4 1.1 GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.3 11.2 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.3 1.4 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ATP:ADP antiporter activity(GO:0005471) ADP transmembrane transporter activity(GO:0015217)
0.3 0.9 GO:0015927 alpha,alpha-trehalase activity(GO:0004555) trehalase activity(GO:0015927)
0.3 0.6 GO:0042947 alpha-glucoside transmembrane transporter activity(GO:0015151) glucoside transmembrane transporter activity(GO:0042947)
0.3 0.5 GO:0015489 putrescine transmembrane transporter activity(GO:0015489)
0.2 0.9 GO:0016417 S-acyltransferase activity(GO:0016417)
0.2 2.9 GO:0015578 fructose transmembrane transporter activity(GO:0005353) mannose transmembrane transporter activity(GO:0015578)
0.2 0.8 GO:0004737 pyruvate decarboxylase activity(GO:0004737)
0.2 0.9 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
0.2 0.5 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.2 0.5 GO:0003843 1,3-beta-D-glucan synthase activity(GO:0003843)
0.2 1.7 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.2 0.3 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1 0.6 GO:0015556 C4-dicarboxylate transmembrane transporter activity(GO:0015556)
0.1 0.6 GO:0016885 biotin carboxylase activity(GO:0004075) ligase activity, forming carbon-carbon bonds(GO:0016885)
0.1 0.3 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271) sulfate transmembrane transporter activity(GO:0015116)
0.1 0.8 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.1 0.4 GO:0005355 glucose transmembrane transporter activity(GO:0005355)
0.1 1.0 GO:0004713 protein tyrosine kinase activity(GO:0004713)
0.1 0.4 GO:0004108 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
0.1 0.8 GO:0004312 fatty acid synthase activity(GO:0004312)
0.1 0.6 GO:0016742 hydroxymethyl-, formyl- and related transferase activity(GO:0016742)
0.1 0.6 GO:0042887 amide transmembrane transporter activity(GO:0042887)
0.1 0.4 GO:0005537 mannose binding(GO:0005537)
0.1 1.1 GO:0005199 structural constituent of cell wall(GO:0005199)
0.1 0.8 GO:0015205 nucleobase transmembrane transporter activity(GO:0015205)
0.1 0.3 GO:0003691 double-stranded telomeric DNA binding(GO:0003691)
0.1 0.4 GO:0019789 SUMO transferase activity(GO:0019789)
0.1 0.2 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.1 0.2 GO:0004448 isocitrate dehydrogenase activity(GO:0004448)
0.1 0.2 GO:0072349 modified amino acid transmembrane transporter activity(GO:0072349)
0.1 0.3 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.1 0.5 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.1 1.1 GO:0016831 carboxy-lyase activity(GO:0016831)
0.1 0.6 GO:0000293 ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions(GO:0016722) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.1 3.2 GO:0001228 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.1 1.1 GO:0016769 transaminase activity(GO:0008483) transferase activity, transferring nitrogenous groups(GO:0016769)
0.1 0.6 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.1 0.3 GO:0004030 aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.1 0.5 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.1 0.2 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.1 0.2 GO:0016405 CoA-ligase activity(GO:0016405) acid-thiol ligase activity(GO:0016878)
0.1 0.4 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 0.3 GO:0090599 alpha-glucosidase activity(GO:0090599)
0.1 0.2 GO:0015603 siderophore transmembrane transporter activity(GO:0015343) iron chelate transmembrane transporter activity(GO:0015603) siderophore transporter activity(GO:0042927)
0.0 0.2 GO:0001128 RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly(GO:0001128)
0.0 0.8 GO:0015926 glucosidase activity(GO:0015926)
0.0 0.1 GO:0016882 cyclo-ligase activity(GO:0016882)
0.0 0.3 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0 0.6 GO:0044389 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
0.0 0.2 GO:0008169 C-methyltransferase activity(GO:0008169)
0.0 0.1 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.0 0.2 GO:0015293 symporter activity(GO:0015293)
0.0 0.6 GO:0042162 telomeric DNA binding(GO:0042162)
0.0 0.1 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.2 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
0.0 0.1 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.2 GO:0017022 myosin binding(GO:0017022)
0.0 0.1 GO:0052742 phosphatidylinositol kinase activity(GO:0052742)
0.0 0.3 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.0 0.1 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.0 0.7 GO:0003684 damaged DNA binding(GO:0003684)
0.0 0.3 GO:0004601 peroxidase activity(GO:0004601) oxidoreductase activity, acting on peroxide as acceptor(GO:0016684)
0.0 0.1 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.0 0.6 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.2 GO:0031072 heat shock protein binding(GO:0031072)
0.0 0.1 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.0 0.2 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.2 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.2 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.0 0.9 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.4 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.0 0.1 GO:0008310 single-stranded DNA exodeoxyribonuclease activity(GO:0008297) single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.0 0.1 GO:0051184 cofactor transporter activity(GO:0051184)
0.0 0.2 GO:0000182 rDNA binding(GO:0000182)
0.0 0.1 GO:0015088 copper uptake transmembrane transporter activity(GO:0015088)
0.0 1.3 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.0 0.1 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 0.2 GO:0022838 substrate-specific channel activity(GO:0022838)
0.0 0.2 GO:0045182 translation regulator activity(GO:0045182)
0.0 0.0 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.5 GO:0008237 metallopeptidase activity(GO:0008237)
0.0 0.0 GO:0050136 NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.4 GO:0008234 cysteine-type peptidase activity(GO:0008234)
0.0 0.3 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 0.2 GO:0030276 clathrin binding(GO:0030276)
0.0 0.0 GO:0000772 mating pheromone activity(GO:0000772) pheromone activity(GO:0005186)
0.0 0.0 GO:0003916 DNA topoisomerase activity(GO:0003916)
0.0 0.2 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 0.1 GO:0043140 ATP-dependent 3'-5' DNA helicase activity(GO:0043140)
0.0 0.0 GO:0030332 cyclin binding(GO:0030332)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 0.5 PID AR PATHWAY Coregulation of Androgen receptor activity
0.2 1.2 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.2 0.5 PID IL4 2PATHWAY IL4-mediated signaling events
0.1 0.3 PID ATM PATHWAY ATM pathway
0.1 0.2 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.0 0.1 PID FANCONI PATHWAY Fanconi anemia pathway
0.0 16.1 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 0.0 PID CMYB PATHWAY C-MYB transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 0.3 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.1 0.2 REACTOME APOPTOTIC EXECUTION PHASE Genes involved in Apoptotic execution phase
0.1 0.5 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.2 REACTOME PHOSPHORYLATION OF THE APC C Genes involved in Phosphorylation of the APC/C
0.0 16.0 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis