Results for ACE2

Z-value: 2.52

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Transcription factors associated with ACE2

Gene Symbol Gene ID Gene Info
S000004121 Transcription factor required for septum destruction after cytokinesis

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot

Activity profile of ACE2 motif

Sorted Z-values of ACE2 motif

Promoter Log-likelihood Transcript Gene Gene Info
YLR154W-B 35.30 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YLR154W-A 34.61 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YLR154C 33.29 Ribonuclease H2 subunit, required for RNase H2 activity
YER124C 32.89 Daughter cell-specific protein, may participate in pathways regulating cell wall metabolism; deletion affects cell separation after division and sensitivity to drugs targeted against the cell wall
YFR055W 32.75 Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YDL055C 30.16 GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure
YFR056C 26.89 Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W
YNL327W 25.80 Glycosylphosphatidylinositol (GPI)-anchored cell wall endoglucanase required for proper cell separation after cytokinesis, expression is activated by Swi5p and tightly regulated in a cell cycle-dependent manner
YNL066W 19.57 Cell wall protein related to glucanases, possibly involved in cell wall septation; member of the SUN family
YHR143W 19.23 Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP
YDR345C 19.02 Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions
YKR092C 18.80 Nucleolar, serine-rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140
YGL028C 17.73 Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on its regulation by Ste12p
YLR286C 17.29 Endochitinase, required for cell separation after mitosis; transcriptional activation during late G and early M cell cycle phases is mediated by transcription factor Ace2p
YJR094W-A 16.04 Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein
YLR154W-C 15.58 Mitochondrial protein of unknown function, overexpression suppresses an rpo41 mutation affecting mitochondrial RNA polymerase; encoded within the 25S rRNA gene on the opposite strand
YOL086C 14.63 Alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway
YBR158W 13.49 Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN)
YGL031C 13.44 Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Bp and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rate
YGL030W 13.40 Protein component of the large (60S) ribosomal subunit, has similarity to rat L30 ribosomal protein; involved in pre-rRNA processing in the nucleolus; autoregulates splicing of its transcript
YKL164C 12.51 O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle
YNL178W 12.33 Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; has similarity to E. coli S3 and rat S3 ribosomal proteins
YNR067C 12.17 Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother
YLR110C 12.09 Cell wall mannoprotein, mutants are defective in mating and agglutination, expression is downregulated by alpha-factor
YOR263C 12.04 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF DES3/YOR264W
YJL136C 11.46 Protein component of the small (40S) ribosomal subunit; nearly identical to Rps21Ap and has similarity to rat S21 ribosomal protein
YGR108W 10.67 B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YFL022C 10.57 Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar
YKL218C 10.55 3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required for survival in the presence of hydroxyaspartate
YDR385W 10.54 Elongation factor 2 (EF-2), also encoded by EFT1; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin
YDR133C 10.28 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C
YOR315W 10.12 Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate
YOR264W 10.03 Daughter cell-specific protein, may help establish daughter fate
YER131W 10.02 Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Ap and has similarity to rat S26 ribosomal protein
YIR021W 9.95 Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA
YKL063C 9.53 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi
YOR342C 9.36 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus
YOR176W 8.94 Ferrochelatase, a mitochondrial inner membrane protein, catalyzes the insertion of ferrous iron into protoporphyrin IX, the eighth and final step in the heme biosynthetic pathway
YCR018C 8.66 Protein involved in the processing of pre-rRNA to mature rRNA; contains a C2/C2 zinc finger motif; srd1 mutation suppresses defects caused by the rrp1-1 mutation
YIL118W 8.38 Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p
YKR093W 8.35 Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p
YDR044W 8.33 Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; localizes to the mitochondrial inner membrane; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)
YIL056W 7.98 Transcriptional activator, required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations
YGR148C 7.84 Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Ap and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rate
YML056C 7.84 Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed
YGR249W 7.74 Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants
YOL085C 7.21 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOL085W-A
YHR181W 7.17 Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment
YKL152C 7.11 Tetrameric phosphoglycerate mutase, mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis
YJR145C 7.08 Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; identical to Rps4Bp and has similarity to rat S4 ribosomal protein
YPL250W-A 6.97 Identified by fungal homology and RT-PCR
YOR175C 6.96 Lysophospholipid acyltransferase, partially redundant with Slc1p; part of MBOAT family of membrane-bound O-acyltransferases; key component of Lands cycle; may have role in fatty acid exchange at sn-2 position of mature glycerophospholipids
YDL047W 6.92 Type 2A-related serine-threonine phosphatase that functions in the G1/S transition of the mitotic cycle; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization
YBR126W-A 6.82 Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YBR126W-B; identified by gene-trapping, microarray analysis, and genome-wide homology searches
YKL110C 6.81 Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
YNR018W 6.74 Putative protein of unknown function; non-tagged protein is detected in purified mitochondria; null mutant displays decreased frequency of mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media
YLR437C 6.70 Putative protein of unknown function; epitope tagged protein localizes to the cytoplasm
YGR279C 6.66 Cell wall protein with similarity to glucanases; scw4 scw10 double mutants exhibit defects in mating
YOR063W 6.65 Protein component of the large (60S) ribosomal subunit, has similarity to E. coli L3 and rat L3 ribosomal proteins; involved in the replication and maintenance of killer double stranded RNA virus
YDR384C 6.61 Plasma membrane protein, regulation pattern suggests a possible role in export of ammonia from the cell; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family of putative transporters
YCL064C 6.47 Catabolic L-serine (L-threonine) deaminase, catalyzes the degradation of both L-serine and L-threonine; required to use serine or threonine as the sole nitrogen source, transcriptionally induced by serine and threonine
YDR508C 6.42 High-affinity glutamine permease, also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids
YDR509W 6.37 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHR203C 6.26 Protein component of the small (40S) ribosomal subunit; identical to Rps4Ap and has similarity to rat S4 ribosomal protein
YNR001W-A 6.23 Dubious open reading frame unlikely to encode a functional protein; identified by homology
YML075C 5.99 One of two isozymes of HMG-CoA reductase that catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; localizes to the nuclear envelope; overproduction induces the formation of karmellae
YKR038C 5.94 Putative glycoprotease proposed to be in transcription as a component of the EKC protein complex with Bud32p, Cgi121p, Pcc1p, and Gon7p; also identified as a component of the KEOPS protein complex
YMR183C 5.91 Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane; syntaxin homolog that is functionally redundant with Sso1p
YGL077C 5.80 Choline/ethanolamine transporter; involved in the uptake of nitrogen mustard and the uptake of glycine betaine during hypersaline stress; co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol
YMR217W 5.78 GMP synthase, an enzyme that catalyzes the second step in the biosynthesis of GMP from inosine 5'-phosphate (IMP); transcription is not subject to regulation by guanine but is negatively regulated by nutrient starvation
YKL181W 5.77 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes
YFR054C 5.71 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YNL300W 5.70 Glycosylphosphatidylinositol-dependent cell wall protein, expression is periodic and decreases in respone to ergosterol perturbation or upon entry into stationary phase; depletion increases resistance to lactic acid
YHR094C 5.69 Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting
YIL053W 5.69 Constitutively expressed isoform of DL-glycerol-3-phosphatase; involved in glycerol biosynthesis, induced in response to both anaerobic and, along with the Hor2p/Gpp2p isoform, osmotic stress
YCR031C 5.68 Ribosomal protein 59 of the small subunit, required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; nearly identical to Rps14Bp and similar to E. coli S11 and rat S14 ribosomal proteins
YDR025W 5.58 Protein component of the small (40S) ribosomal subunit; identical to Rps11Bp and has similarity to E. coli S17 and rat S11 ribosomal proteins
YNL301C 5.57 Protein component of the large (60S) ribosomal subunit, identical to Rpl18Ap and has similarity to rat L18 ribosomal protein
YDR002W 5.57 Ran GTPase binding protein; involved in nuclear protein import and RNA export, ubiquitin-mediated protein degradation during the cell cycle; shuttles between the nucleus and cytoplasm; is essential; homolog of human RanBP1
YDR098C 5.46 Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage
YGL179C 5.44 Protein kinase, related to and functionally redundant with Elm1p and Sak1p for the phosphorylation and activation of Snf1p; functionally orthologous to LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome
YGR118W 5.37 Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; nearly identical to Rps23Bp and similar to E. coli S12 and rat S23 ribosomal proteins; deletion of both RPS23A and RPS23B is lethal
YMR049C 5.29 Protein required for maturation of the 25S and 5.8S ribosomal RNAs; constituent of 66S pre-ribosomal particles; homologous to mammalian Bop1
YGL126W 5.29 Protein required for inositol prototrophy, identified as an ortholog of the FIT family of proteins involved in triglyceride droplet biosynthesis; disputed role in the synthesis of inositol phospholipids from inositol
YNL079C 5.28 Major isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; acetylated by the NatB complex and acetylated form binds actin most efficiently
YNL078W 5.27 Protein localized in the bud neck at G2/M phase; physically interacts with septins; possibly involved in a mitotic signaling network
YAL033W 5.23 Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends
YPL014W 5.20 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus
YGR052W 5.15 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; induced by treatment with 8-methoxypsoralen and UVA irradiation
YDR353W 5.13 Cytoplasmic thioredoxin reductase, key regulatory enzyme that determines the redox state of the thioredoxin system, which acts as a disulfide reductase system and protects cells against both oxidative and reductive stress
YMR106C 5.10 Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair
YCL063W 5.09 Protein involved in vacuole inheritance; acts as a vacuole-specific receptor for myosin Myo2p
YKL065C 5.08 Endoplasmic reticulum transmembrane protein; may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein
YGL209W 5.03 Protein containing zinc fingers, involved in repression, along with Mig1p, of SUC2 (invertase) expression by high levels of glucose; binds to Mig1p-binding sites in SUC2 promoter
YBL092W 5.01 Protein component of the large (60S) ribosomal subunit, has similarity to rat L32 ribosomal protein; overexpression disrupts telomeric silencing
YNR054C 4.99 Essential nucleolar protein involved in pre-18S rRNA processing; binds to RNA and stimulates ATPase activity of Dbp8; involved in assembly of the small subunit (SSU) processome
YOR050C 4.96 Hypothetical protein
YJL107C 4.96 Putative protein of unknown function; expression is induced by activation of the HOG1 mitogen-activated signaling pathway and this induction is Hog1p/Pbs2p dependent; YJL107C and adjacent ORF, YJL108C are merged in related fungi
YJL200C 4.92 Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol
YIL096C 4.86 Putative protein of unknown function; associates with precursors of the 60S ribosomal subunit
YBR126C 4.85 Synthase subunit of trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; also found in a monomeric form; expression is induced by the stress response and repressed by the Ras-cAMP pathway
YKR094C 4.85 Fusion protein, identical to Rpl40Ap, that is cleaved to yield ubiquitin and a ribosomal protein of the large (60S) ribosomal subunit with similarity to rat L40; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes
YPL245W 4.85 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm
YGR192C 4.78 Glyceraldehyde-3-phosphate dehydrogenase, isozyme 3, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell-wall
YBR118W 4.76 Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes
YLR048W 4.74 Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Ap; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal
YHR216W 4.69 Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, expression is induced by mycophenolic acid resulting in resistance to the drug, expression is repressed by nutrient limitation
YGR234W 4.65 Nitric oxide oxidoreductase, flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses
YHR193C 4.64 Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation, associated with cytoplasmic ribosomes
YGR285C 4.64 Cytosolic ribosome-associated chaperone that acts, together with Ssz1p and the Ssb proteins, as a chaperone for nascent polypeptide chains; contains a DnaJ domain and functions as a J-protein partner for Ssb1p and Ssb2p
YOL155C 4.64 Haze-protective mannoprotein that reduces the particle size of aggregated proteins in white wines
YPL037C 4.63 Subunit beta1 of the nascent polypeptide-associated complex (NAC) involved in protein targeting, associated with cytoplasmic ribosomes; enhances DNA binding of the Gal4p activator; homolog of human BTF3b
YOL012C 4.61 Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin
YIL052C 4.61 Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl34Ap and has similarity to rat L34 ribosomal protein
YBR175W 4.61 Essential subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member and ortholog of mammalian WDR5
YBR162C 4.58 Covalently-bound cell wall protein of unknown function; identified as a cell cycle regulated SBF target gene; deletion mutants are highly resistant to treatment with beta-1,3-glucanase; has sequence similarity to YJL171C
YBR174C 4.55 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YBR175W; null mutant is viable and sporulation defective
YMR307W 4.53 Beta-1,3-glucanosyltransferase, required for cell wall assembly; localizes to the cell surface via a glycosylphosphatidylinositol (GPI) anchor
YML074C 4.52 Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p
YBL032W 4.44 RNA binding protein with similarity to hnRNP-K that localizes to the cytoplasm and to subtelomeric DNA; required for the proper localization of ASH1 mRNA; involved in the regulation of telomere position effect and telomere length
YDR037W 4.44 Lysyl-tRNA synthetase; also identified as a negative regulator of general control of amino acid biosynthesis
YDR399W 4.40 Dimeric hypoxanthine-guanine phosphoribosyltransferase, catalyzes the formation of both inosine monophosphate and guanosine monophosphate; mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome
YBR210W 4.40 Protein involved in export of proteins from the endoplasmic reticulum, has similarity to Erv14p
YGR242W 4.39 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YAP1802/YGR241C
YJL198W 4.32 Low-affinity phosphate transporter; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth
YJR114W 4.31 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSM7/YJR113C
YPR119W 4.31 B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YHR020W 4.27 Protein of unknown function that may interact with ribosomes, based on co-purification experiments; has similarity to proline-tRNA ligase; YHR020W is an essential gene
YGR055W 4.25 High affinity methionine permease, integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake
YGR040W 4.20 Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains
YAL040C 4.20 G1 cyclin involved in cell cycle progression; activates Cdc28p kinase to promote the G1 to S phase transition; plays a role in regulating transcription of the other G1 cyclins, CLN1 and CLN2; regulated by phosphorylation and proteolysis
YDL241W 4.18 Putative protein of unknown function; YDL241W is not an essential gene
YIL016W 4.10 Protein of unknown function proposed to be involved in nuclear pore complex biogenesis and maintenance as well as protein folding; has similarity to the mammalian BAG-1 protein
YMR199W 4.09 G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)
YGR180C 4.08 Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits
YHR180W-A 4.06 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious ORF YHR180C-B and long terminal repeat YHRCsigma3
YDR041W 4.01 Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins
YGR189C 4.00 Putative chitin transglycosidase, cell wall protein that functions in the transfer of chitin to beta(1-6)glucan; localizes to sites of polarized growth; expression is induced under cell wall stress conditions
YMR208W 4.00 Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate
YOR096W 3.97 Protein component of the small (40S) ribosomal subunit, nearly identical to Rps7Bp; interacts with Kti11p; deletion causes hypersensitivity to zymocin; has similarity to rat S7 and Xenopus S8 ribosomal proteins
YBR066C 3.97 Transcriptional repressor that mediates glucose repression and negatively regulates filamentous growth; has similarity to Nrg1p
YGR155W 3.93 Cystathionine beta-synthase, catalyzes the synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis
YGR241C 3.89 Protein involved in clathrin cage assembly; binds Pan1p and clathrin; homologous to Yap1801p, member of the AP180 protein family
YDL191W 3.88 Protein component of the large (60S) ribosomal subunit, identical to Rpl35Bp and has similarity to rat L35 ribosomal protein
YLR028C 3.85 Enzyme of 'de novo' purine biosynthesis containing both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities, isozyme of Ade17p; ade16 ade17 mutants require adenine and histidine
YPR170W-B 3.82 Putative protein of unknown function, conserved in fungi; partially overlaps the dubious genes YPR169W-A, YPR170W-A and YRP170C
YJR113C 3.81 Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S7 ribosomal protein
YOR247W 3.80 Mannoprotein that exhibits a tight association with the cell wall, required for cell wall stability in the absence of GPI-anchored mannoproteins; has a high serine-threonine content; expression is induced in cell wall mutants
YKL096W-A 3.78 Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored
YGR050C 3.77 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YNL160W 3.76 Cell wall-related secretory glycoprotein; induced by nutrient deprivation-associated growth arrest and upon entry into stationary phase; may be involved in adaptation prior to stationary phase entry; has similarity to Sps100p
YBR189W 3.75 Protein component of the small (40S) ribosomal subunit; nearly identical to Rps9Ap and has similarity to E. coli S4 and rat S9 ribosomal proteins
YPL010W 3.72 Zeta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER
YML073C 3.71 N-terminally acetylated protein component of the large (60S) ribosomal subunit, has similarity to Rpl6Bp and to rat L6 ribosomal protein; binds to 5.8S rRNA
YOR376W-A 3.68 Putative protein of unknown function; identified by fungal homology and RT-PCR
YDR534C 3.68 Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YJR105W 3.66 Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle
YOL124C 3.64 Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain
YLR060W 3.62 Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs2p to generate active enzyme; sequence is evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase (Msf1p), but substrate binding is similar
YGR229C 3.59 Protein involved in the regulation of cell wall synthesis; proposed to be involved in coordinating cell cycle progression with cell wall integrity
YKL030W 3.59 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene MAE1
YLR249W 3.50 Translational elongation factor 3, stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing EF-1 alpha from the ribosomal complex; contains two ABC cassettes; binds and hydrolyses ATP
YER137C 3.48 Putative protein of unknown function
YLR150W 3.47 Protein that binds G4 quadruplex and purine motif triplex nucleic acid; acts with Cdc13p to maintain telomere structure; interacts with ribosomes and subtelomeric Y' DNA; multicopy suppressor of tom1 and pop2 mutations
YDR040C 3.47 P-type ATPase sodium pump, involved in Na+ and Li+ efflux to allow salt tolerance
YGR195W 3.44 3'-to-5' phosphorolytic exoribonuclease that is a subunit of the exosome; required for 3' processing of the 5.8S rRNA; involved in 3' to 5' mRNA degradation and translation inhibition of non-poly(A) mRNAs
YHR019C 3.43 Cytosolic asparaginyl-tRNA synthetase, required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA
YHR067W 3.43 Mitochondrial 3-hydroxyacyl-thioester dehydratase involved in fatty acid biosynthesis, required for respiratory growth and for normal mitochondrial morphology
YHR052W 3.43 Essential protein that interacts with proteasome components and has a potential role in proteasome substrate specificity; also copurifies with 66S pre-ribosomal particles
YDR517W 3.43 Acetylated, cis-golgi localized protein involved in ER to Golgi transport; homolog of human GRASP65; forms a complex with the coiled-coil protein Bug1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
YDR094W 3.41 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF DNF2
YIL018W 3.40 Protein component of the large (60S) ribosomal subunit, identical to Rpl2Ap and has similarity to E. coli L2 and rat L8 ribosomal proteins; expression is upregulated at low temperatures
YBL039C 3.39 Major CTP synthase isozyme (see also URA8), catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis
YMR032W 3.39 Bud neck-localized, SH3 domain-containing protein required for cytokinesis; regulates actomyosin ring dynamics and septin localization; interacts with the formins, Bni1p and Bnr1p, and with Cyk3p, Vrp1p, and Bni5p
YGR181W 3.34 Mitochondrial intermembrane space protein, forms a complex with TIm8p that mediates import and insertion of a subset of polytopic inner membrane proteins; may prevent aggregation of incoming proteins in a chaperone-like manner
YOL011W 3.33 Phospholipase B (lysophospholipase) involved in phospholipid metabolism; hydrolyzes phosphatidylinositol and phosphatidylserine and displays transacylase activity in vitro
YOR314W 3.32 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YKR013W 3.32 Protein of unknown function, has similarity to Pry1p and Pry3p and to the plant PR-1 class of pathogen related proteins
YPL238C 3.29 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified essential gene SUI3/YPL237W
YER130C 3.28 Hypothetical protein
YGR261C 3.28 Beta3-like subunit of the yeast AP-3 complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; exists in both cytosolic and peripherally associated membrane-bound pools
YGL225W 3.27 Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi
YDR033W 3.27 Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p
YJL106W 3.25 Serine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p
YNR016C 3.19 Acetyl-CoA carboxylase, biotin containing enzyme that catalyzes the carboxylation of acetyl-CoA to form malonyl-CoA; required for de novo biosynthesis of long-chain fatty acids
YOR107W 3.17 Negative regulator of glucose-induced cAMP signaling; directly activates the GTPase activity of the heterotrimeric G protein alpha subunit Gpa2p
YKL153W 3.16 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLK153W and the overlapping essential gene GPM1 is reduced in the gcr1 null mutant
YDR074W 3.10 Phosphatase subunit of the trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway
YFL015C 3.08 Dubious open reading frame unlikely to encode a protein; partially overlaps dubious ORF YFL015W-A; YFL015C is not an essential gene
YJL190C 3.08 Protein component of the small (40S) ribosomal subunit; nearly identical to Rps22Bp and has similarity to E. coli S8 and rat S15a ribosomal proteins
YOL103W 3.07 Myo-inositol transporter with strong similarity to the major myo-inositol transporter Itr1p, member of the sugar transporter superfamily; expressed constitutively
YER102W 3.06 Protein component of the small (40S) ribosomal subunit; identical to Rps8Ap and has similarity to rat S8 ribosomal protein
YDR095C 3.06 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YER031C 3.06 GTPase of the Ypt/Rab family, very similar to Ypt32p; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi
YBR106W 3.04 Probable membrane protein, involved in phosphate transport; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations
YDL048C 3.03 Protein containing a Kruppel-type zinc-finger domain; has similarity to Stp1p, Stp2p, and Stp3p
YFL015W-A 3.03 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR132C 2.98 Protein of unknown function; green fluorescent protein (GFP)-tagged protein localizes to mitochondria and nucleus; YLR132C is an essential gene
YLR300W 2.97 Major exo-1,3-beta-glucanase of the cell wall, involved in cell wall beta-glucan assembly; exists as three differentially glycosylated isoenzymes
YJL196C 2.95 Elongase I, medium-chain acyl elongase, catalyzes carboxy-terminal elongation of unsaturated C12-C16 fatty acyl-CoAs to C16-C18 fatty acids

Network of associatons between targets according to the STRING database.

First level regulatory network of ACE2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
10.9 32.8 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
10.1 30.2 GO:0019673 GDP-mannose biosynthetic process(GO:0009298) GDP-mannose metabolic process(GO:0019673)
9.1 99.8 GO:0007109 obsolete cytokinesis, completion of separation(GO:0007109)
5.1 35.7 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
4.7 14.2 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
4.5 22.7 GO:0006177 GMP biosynthetic process(GO:0006177)
4.3 12.9 GO:0043484 regulation of RNA splicing(GO:0043484) regulation of mRNA splicing, via spliceosome(GO:0048024)
4.2 16.8 GO:0000461 endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000461)
3.6 10.7 GO:0045901 positive regulation of translational elongation(GO:0045901)
3.0 12.2 GO:0009240 isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287) isopentenyl diphosphate metabolic process(GO:0046490)
2.8 11.4 GO:0000771 agglutination involved in conjugation with cellular fusion(GO:0000752) agglutination involved in conjugation(GO:0000771) heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) cell-cell adhesion(GO:0098609) adhesion between unicellular organisms(GO:0098610) multi organism cell adhesion(GO:0098740) cell-cell adhesion via plasma-membrane adhesion molecules(GO:0098742)
2.5 7.5 GO:0006567 threonine catabolic process(GO:0006567)
2.5 9.9 GO:0090337 regulation of formin-nucleated actin cable assembly(GO:0090337) positive regulation of formin-nucleated actin cable assembly(GO:0090338)
2.0 14.0 GO:0006007 glucose catabolic process(GO:0006007) glycolytic fermentation to ethanol(GO:0019655) glycolytic fermentation(GO:0019660) hexose catabolic process to ethanol(GO:1902707)
2.0 13.9 GO:0010696 positive regulation of spindle pole body separation(GO:0010696)
2.0 23.4 GO:0000917 barrier septum assembly(GO:0000917) cell septum assembly(GO:0090529)
1.9 5.8 GO:0009186 deoxyribonucleoside diphosphate metabolic process(GO:0009186)
1.9 29.8 GO:0051029 rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029)
1.9 9.3 GO:0051083 'de novo' cotranslational protein folding(GO:0051083)
1.7 5.2 GO:0038032 termination of signal transduction(GO:0023021) termination of G-protein coupled receptor signaling pathway(GO:0038032)
1.7 8.7 GO:0001676 long-chain fatty acid metabolic process(GO:0001676)
1.6 14.3 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
1.4 5.7 GO:0036170 filamentous growth of a population of unicellular organisms in response to starvation(GO:0036170) regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900434) positive regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900436)
1.4 19.1 GO:0000028 ribosomal small subunit assembly(GO:0000028)
1.4 5.4 GO:0045048 protein insertion into ER membrane(GO:0045048)
1.3 9.3 GO:0005992 trehalose biosynthetic process(GO:0005992) oligosaccharide biosynthetic process(GO:0009312) disaccharide biosynthetic process(GO:0046351)
1.3 5.1 GO:0009423 chorismate biosynthetic process(GO:0009423)
1.2 6.2 GO:0072337 modified amino acid transport(GO:0072337)
1.2 8.6 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
1.2 3.6 GO:0000101 sulfur amino acid transport(GO:0000101)
1.2 4.8 GO:0000296 spermine transport(GO:0000296)
1.2 8.4 GO:0043457 regulation of cellular respiration(GO:0043457)
1.2 4.8 GO:0019346 transsulfuration(GO:0019346)
1.2 8.4 GO:0042938 dipeptide transport(GO:0042938)
1.2 3.5 GO:0043066 negative regulation of apoptotic process(GO:0043066) negative regulation of programmed cell death(GO:0043069) negative regulation of cell death(GO:0060548)
1.2 5.8 GO:0046391 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
1.1 142.8 GO:0002181 cytoplasmic translation(GO:0002181)
1.1 5.5 GO:0007535 donor selection(GO:0007535)
1.1 8.7 GO:0000372 Group I intron splicing(GO:0000372) RNA splicing, via transesterification reactions with guanosine as nucleophile(GO:0000376)
1.1 14.1 GO:0006450 regulation of translational fidelity(GO:0006450)
1.0 2.0 GO:0033559 unsaturated fatty acid biosynthetic process(GO:0006636) unsaturated fatty acid metabolic process(GO:0033559)
1.0 1.0 GO:0014070 response to organic cyclic compound(GO:0014070) response to cycloheximide(GO:0046898)
1.0 3.9 GO:0030497 fatty acid elongation(GO:0030497)
1.0 5.7 GO:0007030 Golgi organization(GO:0007030)
0.9 2.8 GO:0006114 glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401)
0.9 8.3 GO:0006814 sodium ion transport(GO:0006814)
0.9 7.2 GO:0033014 porphyrin-containing compound biosynthetic process(GO:0006779) heme biosynthetic process(GO:0006783) tetrapyrrole biosynthetic process(GO:0033014)
0.9 13.4 GO:0001100 negative regulation of exit from mitosis(GO:0001100)
0.9 3.5 GO:0018196 peptidyl-asparagine modification(GO:0018196) protein N-linked glycosylation via asparagine(GO:0018279)
0.9 2.6 GO:0043171 peptide catabolic process(GO:0043171)
0.9 5.3 GO:0007119 budding cell isotropic bud growth(GO:0007119)
0.9 1.7 GO:0061422 positive regulation of transcription from RNA polymerase II promoter in response to alkaline pH(GO:0061422)
0.9 3.4 GO:0034473 U1 snRNA 3'-end processing(GO:0034473)
0.8 2.5 GO:0044209 AMP salvage(GO:0044209)
0.8 2.5 GO:0009211 pyrimidine deoxyribonucleoside triphosphate metabolic process(GO:0009211)
0.8 3.3 GO:1900461 positive regulation of cell growth(GO:0030307) positive regulation of pseudohyphal growth by positive regulation of transcription from RNA polymerase II promoter(GO:1900461) positive regulation of pseudohyphal growth(GO:2000222)
0.8 2.5 GO:1904667 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051439) negative regulation of ubiquitin protein ligase activity(GO:1904667)
0.8 4.9 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.8 9.7 GO:0009636 response to toxic substance(GO:0009636)
0.8 2.4 GO:0015691 cadmium ion transport(GO:0015691)
0.8 6.3 GO:0070525 tRNA threonylcarbamoyladenosine metabolic process(GO:0070525)
0.8 2.4 GO:0045338 terpenoid metabolic process(GO:0006721) terpenoid biosynthetic process(GO:0016114) farnesyl diphosphate biosynthetic process(GO:0045337) farnesyl diphosphate metabolic process(GO:0045338)
0.8 2.3 GO:0042454 NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356) ribonucleoside catabolic process(GO:0042454) cytidine metabolic process(GO:0046087)
0.7 4.4 GO:0048255 RNA stabilization(GO:0043489) mRNA stabilization(GO:0048255)
0.7 0.7 GO:0015833 peptide transport(GO:0015833)
0.7 7.8 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
0.7 3.5 GO:0000162 tryptophan biosynthetic process(GO:0000162) indole-containing compound biosynthetic process(GO:0042435) indolalkylamine biosynthetic process(GO:0046219)
0.7 3.5 GO:0015780 nucleotide-sugar transport(GO:0015780)
0.7 2.7 GO:0006898 receptor-mediated endocytosis(GO:0006898)
0.7 3.4 GO:0006116 NADH oxidation(GO:0006116)
0.7 1.3 GO:0015909 long-chain fatty acid transport(GO:0015909)
0.7 2.6 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.7 3.3 GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity(GO:0043433)
0.7 2.0 GO:0042981 regulation of cell death(GO:0010941) positive regulation of cell death(GO:0010942) regulation of apoptotic process(GO:0042981) positive regulation of apoptotic process(GO:0043065) regulation of programmed cell death(GO:0043067) positive regulation of programmed cell death(GO:0043068)
0.6 14.1 GO:0002097 tRNA wobble base modification(GO:0002097) tRNA wobble uridine modification(GO:0002098)
0.6 7.7 GO:0006037 cell wall chitin metabolic process(GO:0006037)
0.6 3.8 GO:0035999 tetrahydrofolate interconversion(GO:0035999)
0.6 2.5 GO:0031591 wybutosine metabolic process(GO:0031590) wybutosine biosynthetic process(GO:0031591)
0.6 1.8 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.6 1.8 GO:0019419 sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)(GO:0019379) sulfate reduction(GO:0019419)
0.6 1.1 GO:0070637 nicotinamide riboside metabolic process(GO:0046495) pyridine nucleoside metabolic process(GO:0070637)
0.6 0.6 GO:0009090 homoserine biosynthetic process(GO:0009090)
0.6 1.7 GO:0032108 negative regulation of macroautophagy(GO:0016242) negative regulation of response to external stimulus(GO:0032102) negative regulation of response to extracellular stimulus(GO:0032105) negative regulation of response to nutrient levels(GO:0032108)
0.6 1.7 GO:0070475 rRNA base methylation(GO:0070475)
0.6 2.8 GO:0044070 regulation of anion transport(GO:0044070)
0.6 1.7 GO:0046416 D-amino acid metabolic process(GO:0046416)
0.5 8.7 GO:0018208 protein peptidyl-prolyl isomerization(GO:0000413) peptidyl-proline modification(GO:0018208)
0.5 2.2 GO:0071406 response to methylmercury(GO:0051597) cellular response to methylmercury(GO:0071406)
0.5 2.2 GO:0010674 negative regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle(GO:0010674)
0.5 1.6 GO:0030037 actin filament reorganization involved in cell cycle(GO:0030037) actin filament reorganization(GO:0090527)
0.5 9.6 GO:0042790 transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:0042790)
0.5 5.8 GO:0000921 septin ring assembly(GO:0000921)
0.5 1.0 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.5 3.1 GO:0000743 nuclear migration involved in conjugation with cellular fusion(GO:0000743)
0.5 1.0 GO:0010695 regulation of spindle pole body separation(GO:0010695)
0.5 4.0 GO:0006549 isoleucine metabolic process(GO:0006549)
0.5 1.0 GO:0006734 NADH metabolic process(GO:0006734)
0.5 1.0 GO:0032509 endosome transport via multivesicular body sorting pathway(GO:0032509)
0.5 2.5 GO:0046459 short-chain fatty acid metabolic process(GO:0046459)
0.5 1.5 GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189)
0.5 1.0 GO:0034724 DNA replication-independent nucleosome organization(GO:0034724)
0.5 1.0 GO:0071902 positive regulation of protein serine/threonine kinase activity(GO:0071902)
0.5 4.3 GO:0031070 intronic snoRNA processing(GO:0031070) intronic box C/D snoRNA processing(GO:0034965)
0.5 3.3 GO:0009098 leucine biosynthetic process(GO:0009098)
0.5 0.9 GO:0060188 regulation of protein desumoylation(GO:0060188)
0.5 6.0 GO:0030488 tRNA methylation(GO:0030488)
0.5 5.1 GO:0072593 reactive oxygen species metabolic process(GO:0072593)
0.5 2.3 GO:0034476 U5 snRNA 3'-end processing(GO:0034476)
0.5 1.4 GO:1900101 regulation of endoplasmic reticulum unfolded protein response(GO:1900101)
0.4 1.3 GO:0006343 establishment of chromatin silencing(GO:0006343)
0.4 4.0 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.4 1.3 GO:0033241 regulation of cellular amine catabolic process(GO:0033241)
0.4 10.5 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.4 2.1 GO:0006491 N-glycan processing(GO:0006491)
0.4 3.0 GO:0034063 stress granule assembly(GO:0034063)
0.4 1.3 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654) phosphatidic acid metabolic process(GO:0046473)
0.4 3.4 GO:0019856 pyrimidine nucleobase biosynthetic process(GO:0019856)
0.4 1.7 GO:0000379 tRNA-type intron splice site recognition and cleavage(GO:0000379)
0.4 4.2 GO:0000011 vacuole inheritance(GO:0000011)
0.4 8.8 GO:0006633 fatty acid biosynthetic process(GO:0006633)
0.4 1.7 GO:0060277 obsolete negative regulation of transcription involved in G1 phase of mitotic cell cycle(GO:0060277)
0.4 1.7 GO:0015867 ATP transport(GO:0015867)
0.4 4.8 GO:0007120 axial cellular bud site selection(GO:0007120)
0.4 0.8 GO:0008612 peptidyl-lysine modification to peptidyl-hypusine(GO:0008612)
0.4 3.6 GO:0006829 zinc II ion transport(GO:0006829)
0.4 0.4 GO:0018344 protein geranylgeranylation(GO:0018344)
0.4 1.2 GO:0070827 chromatin maintenance(GO:0070827)
0.4 16.6 GO:0000910 cytokinesis(GO:0000910)
0.4 9.6 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.4 6.5 GO:0006999 nuclear pore organization(GO:0006999)
0.4 0.4 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
0.4 0.4 GO:0034067 protein localization to Golgi apparatus(GO:0034067)
0.4 4.1 GO:0006415 translational termination(GO:0006415)
0.4 0.7 GO:0006658 phosphatidylserine metabolic process(GO:0006658)
0.4 1.4 GO:0006857 oligopeptide transport(GO:0006857)
0.3 7.0 GO:0097384 ergosterol biosynthetic process(GO:0006696) phytosteroid biosynthetic process(GO:0016129) cellular alcohol biosynthetic process(GO:0044108) cellular lipid biosynthetic process(GO:0097384)
0.3 3.7 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.3 2.3 GO:0007000 nucleolus organization(GO:0007000)
0.3 1.6 GO:0007009 plasma membrane organization(GO:0007009)
0.3 1.0 GO:0035066 positive regulation of histone acetylation(GO:0035066) positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.3 4.5 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.3 1.0 GO:0042256 mature ribosome assembly(GO:0042256)
0.3 2.9 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.3 2.9 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.3 8.0 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.3 0.6 GO:0033262 regulation of nuclear cell cycle DNA replication(GO:0033262)
0.3 6.6 GO:0006334 nucleosome assembly(GO:0006334)
0.3 4.0 GO:0006409 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.3 0.3 GO:0018342 protein prenylation(GO:0018342) prenylation(GO:0097354)
0.3 6.7 GO:0045454 cell redox homeostasis(GO:0045454)
0.3 0.3 GO:0031120 snRNA pseudouridine synthesis(GO:0031120) snRNA modification(GO:0040031)
0.3 29.7 GO:0051169 nucleocytoplasmic transport(GO:0006913) nuclear transport(GO:0051169)
0.3 1.2 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.3 0.9 GO:0007234 osmosensory signaling via phosphorelay pathway(GO:0007234)
0.3 0.6 GO:0031684 heterotrimeric G-protein complex cycle(GO:0031684)
0.3 1.7 GO:0048017 inositol lipid-mediated signaling(GO:0048017)
0.3 1.1 GO:0006720 isoprenoid metabolic process(GO:0006720) isoprenoid biosynthetic process(GO:0008299)
0.3 2.2 GO:0015939 pantothenate metabolic process(GO:0015939) pantothenate biosynthetic process(GO:0015940)
0.3 0.5 GO:0009226 nucleotide-sugar biosynthetic process(GO:0009226)
0.3 7.0 GO:0006893 Golgi to plasma membrane transport(GO:0006893) vesicle-mediated transport to the plasma membrane(GO:0098876)
0.3 5.4 GO:0042255 ribosome assembly(GO:0042255)
0.3 0.5 GO:0009847 spore germination(GO:0009847)
0.3 0.8 GO:0050000 telomere localization(GO:0034397) meiotic telomere clustering(GO:0045141) chromosome localization(GO:0050000) establishment of chromosome localization(GO:0051303) chromosome localization to nuclear envelope involved in homologous chromosome segregation(GO:0090220)
0.3 1.1 GO:0007329 positive regulation of transcription from RNA polymerase II promoter by pheromones(GO:0007329) positive regulation of transcription by pheromones(GO:0009371)
0.3 2.4 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.3 8.9 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.2 0.5 GO:0034059 response to anoxia(GO:0034059) cellular response to anoxia(GO:0071454)
0.2 3.2 GO:0072507 cellular divalent inorganic cation homeostasis(GO:0072503) divalent inorganic cation homeostasis(GO:0072507)
0.2 0.5 GO:0019365 nicotinate nucleotide biosynthetic process(GO:0019357) nicotinate nucleotide salvage(GO:0019358) pyridine nucleotide salvage(GO:0019365) nicotinate nucleotide metabolic process(GO:0046497)
0.2 1.0 GO:0006021 inositol biosynthetic process(GO:0006021)
0.2 0.9 GO:0070070 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.2 1.9 GO:0071709 ascospore-type prospore membrane assembly(GO:0032120) membrane biogenesis(GO:0044091) membrane assembly(GO:0071709)
0.2 1.8 GO:1903338 regulation of cell wall organization or biogenesis(GO:1903338)
0.2 2.0 GO:0031204 posttranslational protein targeting to membrane, translocation(GO:0031204)
0.2 3.1 GO:0006614 cotranslational protein targeting to membrane(GO:0006613) SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.2 0.2 GO:0034517 ribophagy(GO:0034517)
0.2 1.1 GO:0043555 regulation of translation in response to stress(GO:0043555)
0.2 2.1 GO:0007021 tubulin complex assembly(GO:0007021)
0.2 0.8 GO:0030030 cell projection organization(GO:0030030) cell projection assembly(GO:0030031)
0.2 2.1 GO:0006356 regulation of transcription from RNA polymerase I promoter(GO:0006356)
0.2 0.8 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.2 1.1 GO:0000492 box C/D snoRNP assembly(GO:0000492)
0.2 0.7 GO:0002943 tRNA dihydrouridine synthesis(GO:0002943)
0.2 0.7 GO:0035376 sterol import(GO:0035376)
0.2 3.3 GO:0042797 tRNA transcription(GO:0009304) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.2 23.0 GO:0042254 ribosome biogenesis(GO:0042254)
0.2 1.4 GO:0006012 galactose metabolic process(GO:0006012)
0.2 0.9 GO:0060304 regulation of phosphatidylinositol dephosphorylation(GO:0060304) endoplasmic reticulum membrane organization(GO:0090158)
0.2 1.3 GO:0046020 regulation of transcription by pheromones(GO:0009373) negative regulation of transcription by pheromones(GO:0045996) regulation of transcription from RNA polymerase II promoter by pheromones(GO:0046019) negative regulation of transcription from RNA polymerase II promoter by pheromones(GO:0046020)
0.2 1.9 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.2 0.4 GO:0032261 purine nucleotide salvage(GO:0032261)
0.2 0.5 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
0.2 1.8 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.2 2.3 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.2 8.4 GO:0000747 conjugation with cellular fusion(GO:0000747)
0.2 5.8 GO:0006413 translational initiation(GO:0006413)
0.2 0.6 GO:0016036 cellular response to phosphate starvation(GO:0016036)
0.2 9.2 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.2 1.6 GO:0010970 establishment of localization by movement along microtubule(GO:0010970) nuclear migration along microtubule(GO:0030473) organelle transport along microtubule(GO:0072384)
0.2 4.2 GO:0006896 Golgi to vacuole transport(GO:0006896)
0.2 0.2 GO:0006621 protein retention in ER lumen(GO:0006621) maintenance of protein localization in endoplasmic reticulum(GO:0035437)
0.1 0.4 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.1 0.7 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.1 0.8 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.1 4.2 GO:0007088 regulation of mitotic nuclear division(GO:0007088)
0.1 0.3 GO:0097577 intracellular sequestering of iron ion(GO:0006880) sequestering of metal ion(GO:0051238) sequestering of iron ion(GO:0097577)
0.1 2.4 GO:0006885 regulation of pH(GO:0006885)
0.1 0.5 GO:0019748 secondary metabolic process(GO:0019748)
0.1 0.4 GO:0006529 asparagine biosynthetic process(GO:0006529)
0.1 0.3 GO:2000134 negative regulation of cell cycle G1/S phase transition(GO:1902807) negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.1 0.8 GO:0006672 ceramide metabolic process(GO:0006672) ceramide biosynthetic process(GO:0046513)
0.1 0.9 GO:0015677 copper ion import(GO:0015677)
0.1 1.8 GO:0030148 sphingolipid biosynthetic process(GO:0030148)
0.1 1.0 GO:0031163 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.1 2.2 GO:0045324 late endosome to vacuole transport(GO:0045324)
0.1 0.4 GO:0006086 acetyl-CoA biosynthetic process from pyruvate(GO:0006086)
0.1 1.4 GO:0032986 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.1 0.5 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
0.1 0.5 GO:0051654 establishment of mitochondrion localization(GO:0051654)
0.1 0.8 GO:0000105 histidine biosynthetic process(GO:0000105) histidine metabolic process(GO:0006547) imidazole-containing compound metabolic process(GO:0052803)
0.1 0.9 GO:0051666 actin cortical patch localization(GO:0051666)
0.1 1.0 GO:0007076 mitotic chromosome condensation(GO:0007076)
0.1 1.7 GO:0006400 tRNA modification(GO:0006400)
0.1 0.8 GO:0018410 C-terminal protein amino acid modification(GO:0018410) post-translational protein modification(GO:0043687)
0.1 0.4 GO:0009306 protein secretion(GO:0009306)
0.1 0.4 GO:0015883 FAD transport(GO:0015883)
0.1 1.0 GO:0015918 sterol transport(GO:0015918)
0.1 0.3 GO:0015908 fatty acid transport(GO:0015908)
0.1 1.2 GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.1 0.3 GO:0048309 endoplasmic reticulum inheritance(GO:0048309)
0.1 0.9 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.1 0.2 GO:0035268 protein mannosylation(GO:0035268) protein O-linked mannosylation(GO:0035269) mannosylation(GO:0097502)
0.1 0.3 GO:0043007 maintenance of rDNA(GO:0043007)
0.1 0.2 GO:0036498 mRNA splicing via endonucleolytic cleavage and ligation involved in unfolded protein response(GO:0030969) IRE1-mediated unfolded protein response(GO:0036498) mRNA splicing, via endonucleolytic cleavage and ligation(GO:0070054)
0.1 2.7 GO:0046474 glycerophospholipid biosynthetic process(GO:0046474)
0.1 0.2 GO:0030835 regulation of actin filament depolymerization(GO:0030834) negative regulation of actin filament depolymerization(GO:0030835) barbed-end actin filament capping(GO:0051016) actin filament capping(GO:0051693)
0.1 0.5 GO:0034551 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551)
0.1 0.8 GO:0006273 lagging strand elongation(GO:0006273)
0.1 0.3 GO:0070898 transcription initiation from RNA polymerase III promoter(GO:0006384) RNA polymerase III transcriptional preinitiation complex assembly(GO:0070898)
0.1 0.5 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.1 0.2 GO:0055075 cellular potassium ion homeostasis(GO:0030007) potassium ion homeostasis(GO:0055075)
0.1 4.8 GO:0032543 mitochondrial translation(GO:0032543)
0.1 0.5 GO:0009086 methionine biosynthetic process(GO:0009086)
0.1 0.9 GO:0030472 mitotic spindle organization in nucleus(GO:0030472)
0.1 0.1 GO:0051176 regulation of vitamin metabolic process(GO:0030656) positive regulation of vitamin metabolic process(GO:0046136) positive regulation of sulfur metabolic process(GO:0051176) regulation of thiamine biosynthetic process(GO:0070623) positive regulation of thiamine biosynthetic process(GO:0090180)
0.1 0.3 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.0 0.4 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 0.2 GO:0051495 positive regulation of cytoskeleton organization(GO:0051495)
0.0 0.1 GO:0006311 meiotic gene conversion(GO:0006311)
0.0 0.1 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.0 0.2 GO:0044088 regulation of vacuole fusion, non-autophagic(GO:0032889) regulation of vacuole organization(GO:0044088)
0.0 0.5 GO:0007004 RNA-dependent DNA biosynthetic process(GO:0006278) telomere maintenance via telomerase(GO:0007004)
0.0 0.5 GO:0043413 protein glycosylation(GO:0006486) macromolecule glycosylation(GO:0043413)
0.0 0.2 GO:0030847 termination of RNA polymerase II transcription, exosome-dependent(GO:0030847)
0.0 0.1 GO:0031047 gene silencing involved in chronological cell aging(GO:0010978) gene silencing by RNA(GO:0031047)
0.0 0.1 GO:0006816 calcium ion transport(GO:0006816)
0.0 0.1 GO:0007323 peptide pheromone maturation(GO:0007323)
0.0 0.0 GO:0006892 post-Golgi vesicle-mediated transport(GO:0006892)
0.0 0.1 GO:0001111 promoter clearance during DNA-templated transcription(GO:0001109) promoter clearance from RNA polymerase II promoter(GO:0001111)
0.0 0.2 GO:0016482 cytosolic transport(GO:0016482)
0.0 0.1 GO:0006089 lactate metabolic process(GO:0006089)
0.0 0.1 GO:0032786 regulation of DNA-templated transcription, elongation(GO:0032784) positive regulation of DNA-templated transcription, elongation(GO:0032786) positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968) regulation of transcription elongation from RNA polymerase II promoter(GO:0034243)
0.0 0.1 GO:0006370 7-methylguanosine mRNA capping(GO:0006370)
0.0 0.0 GO:0072530 cytosine transport(GO:0015856) purine-containing compound transmembrane transport(GO:0072530)
0.0 0.1 GO:0042138 meiotic DNA double-strand break formation(GO:0042138)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
14.2 42.5 GO:0030428 cell septum(GO:0030428)
11.9 35.7 GO:0032299 ribonuclease H2 complex(GO:0032299)
3.2 9.6 GO:0070545 PeBoW complex(GO:0070545)
3.1 9.3 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
1.9 5.6 GO:0045298 polar microtubule(GO:0005827) tubulin complex(GO:0045298)
1.8 7.3 GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)(GO:0005946)
1.8 5.4 GO:0043529 GET complex(GO:0043529)
1.7 101.3 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
1.6 1.6 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
1.5 127.3 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
1.4 7.2 GO:0000408 EKC/KEOPS complex(GO:0000408)
1.3 10.4 GO:0030126 COPI vesicle coat(GO:0030126)
1.2 86.8 GO:0005576 extracellular region(GO:0005576)
1.1 5.6 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
1.1 3.3 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
1.1 8.7 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
1.0 7.8 GO:0000144 cellular bud neck septin ring(GO:0000144)
1.0 5.8 GO:0043527 tRNA methyltransferase complex(GO:0043527)
1.0 2.9 GO:0031417 NatC complex(GO:0031417)
1.0 2.9 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.9 6.2 GO:0032432 actin filament bundle(GO:0032432)
0.9 2.6 GO:0071261 Ssh1 translocon complex(GO:0071261)
0.9 1.7 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.8 11.3 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.8 3.2 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.7 5.6 GO:0031933 nuclear heterochromatin(GO:0005720) nuclear telomeric heterochromatin(GO:0005724) telomeric heterochromatin(GO:0031933)
0.7 2.1 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.7 11.7 GO:0022626 cytosolic ribosome(GO:0022626)
0.6 8.9 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.6 5.1 GO:0035097 histone methyltransferase complex(GO:0035097) Set1C/COMPASS complex(GO:0048188)
0.6 20.7 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.5 3.0 GO:0005940 septin ring(GO:0005940)
0.5 2.9 GO:0035339 serine C-palmitoyltransferase complex(GO:0017059) SPOTS complex(GO:0035339)
0.5 4.3 GO:0030681 nucleolar ribonuclease P complex(GO:0005655) multimeric ribonuclease P complex(GO:0030681)
0.5 6.7 GO:0000786 nucleosome(GO:0000786)
0.5 6.4 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.5 2.7 GO:0034456 UTP-C complex(GO:0034456)
0.5 3.6 GO:0030008 TRAPP complex(GO:0030008)
0.4 1.8 GO:0033254 vacuolar transporter chaperone complex(GO:0033254)
0.4 3.5 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.4 6.0 GO:0034399 nuclear periphery(GO:0034399)
0.4 3.4 GO:0005688 U6 snRNP(GO:0005688)
0.4 75.3 GO:0005933 cellular bud(GO:0005933)
0.4 1.7 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.4 2.1 GO:0030689 Noc complex(GO:0030689)
0.4 1.2 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.4 15.0 GO:0005811 lipid particle(GO:0005811)
0.4 1.5 GO:0044611 nuclear pore inner ring(GO:0044611)
0.4 2.3 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.4 1.5 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.4 1.1 GO:0005845 mRNA cap binding complex(GO:0005845)
0.4 2.6 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.3 3.1 GO:0000137 Golgi cis cisterna(GO:0000137)
0.3 2.4 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.3 2.4 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.3 1.0 GO:0005880 nuclear microtubule(GO:0005880)
0.3 1.0 GO:0032301 MutSalpha complex(GO:0032301)
0.3 1.3 GO:0017053 transcriptional repressor complex(GO:0017053)
0.3 8.7 GO:0005844 polysome(GO:0005844)
0.3 2.8 GO:0030137 COPI-coated vesicle(GO:0030137)
0.3 2.1 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
0.3 4.0 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.3 2.1 GO:0000346 transcription export complex(GO:0000346)
0.3 1.2 GO:0034990 mitotic cohesin complex(GO:0030892) nuclear mitotic cohesin complex(GO:0034990)
0.3 2.1 GO:0072686 mitotic spindle(GO:0072686)
0.3 0.9 GO:0097344 Rix1 complex(GO:0097344)
0.3 1.4 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.3 2.3 GO:0005791 rough endoplasmic reticulum(GO:0005791) rough endoplasmic reticulum membrane(GO:0030867)
0.3 34.0 GO:0005840 ribosome(GO:0005840)
0.3 1.3 GO:0000500 RNA polymerase I upstream activating factor complex(GO:0000500)
0.3 0.8 GO:0000120 RNA polymerase I transcription factor complex(GO:0000120) RNA polymerase I core factor complex(GO:0070860)
0.3 0.8 GO:0043541 UDP-N-acetylglucosamine transferase complex(GO:0043541)
0.2 1.5 GO:0042555 MCM complex(GO:0042555)
0.2 0.7 GO:0033186 CAF-1 complex(GO:0033186)
0.2 0.9 GO:0031518 CBF3 complex(GO:0031518)
0.2 4.9 GO:0005887 integral component of plasma membrane(GO:0005887)
0.2 0.7 GO:0097255 R2TP complex(GO:0097255)
0.2 1.3 GO:0042597 periplasmic space(GO:0042597)
0.2 1.1 GO:0016272 prefoldin complex(GO:0016272)
0.2 0.8 GO:0031502 dolichyl-phosphate-mannose-protein mannosyltransferase complex(GO:0031502)
0.2 1.4 GO:0034455 t-UTP complex(GO:0034455)
0.2 1.0 GO:0005641 nuclear envelope lumen(GO:0005641)
0.2 30.7 GO:0005730 nucleolus(GO:0005730)
0.2 1.0 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.2 1.3 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.2 0.4 GO:0005796 Golgi lumen(GO:0005796)
0.2 0.8 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.2 0.6 GO:0034044 exomer complex(GO:0034044)
0.1 0.6 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 0.7 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.1 0.6 GO:0005797 Golgi medial cisterna(GO:0005797)
0.1 2.1 GO:0000784 nuclear chromosome, telomeric region(GO:0000784)
0.1 1.4 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.1 0.9 GO:0000439 core TFIIH complex(GO:0000439)
0.1 0.4 GO:0000814 ESCRT II complex(GO:0000814)
0.1 0.5 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220) proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.1 3.9 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.1 0.8 GO:0033180 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221) proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.1 0.4 GO:0005955 calcineurin complex(GO:0005955)
0.1 0.7 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.1 2.1 GO:0016586 RSC complex(GO:0016586)
0.1 0.4 GO:0031597 cytosolic proteasome complex(GO:0031597) proteasome storage granule(GO:0034515)
0.1 0.4 GO:0045254 mitochondrial pyruvate dehydrogenase complex(GO:0005967) pyruvate dehydrogenase complex(GO:0045254)
0.1 0.7 GO:0031227 intrinsic component of endoplasmic reticulum membrane(GO:0031227)
0.1 4.9 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 1.7 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 11.6 GO:0005759 mitochondrial matrix(GO:0005759)
0.1 0.6 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.1 0.1 GO:0033553 rDNA heterochromatin(GO:0033553)
0.1 1.1 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
0.1 0.2 GO:0070762 nuclear pore transmembrane ring(GO:0070762)
0.1 0.3 GO:0031985 Golgi cisterna(GO:0031985)
0.1 0.5 GO:0008023 transcription elongation factor complex(GO:0008023)
0.1 0.1 GO:0005640 nuclear outer membrane(GO:0005640)
0.1 0.5 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.1 0.4 GO:0031080 nuclear pore outer ring(GO:0031080)
0.1 0.1 GO:0005801 cis-Golgi network(GO:0005801)
0.1 0.7 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.1 12.5 GO:0005783 endoplasmic reticulum(GO:0005783)
0.0 0.3 GO:0031228 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.0 0.2 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.0 0.5 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 0.5 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0 0.2 GO:0000815 ESCRT III complex(GO:0000815)
0.0 3.8 GO:0005768 endosome(GO:0005768)
0.0 0.1 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 0.1 GO:0005674 transcription factor TFIIF complex(GO:0005674)
0.0 0.1 GO:0032116 SMC loading complex(GO:0032116)
0.0 0.2 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.3 GO:0000243 commitment complex(GO:0000243)
0.0 0.1 GO:0070823 HDA1 complex(GO:0070823)
0.0 0.1 GO:0097196 Shu complex(GO:0097196)
0.0 0.1 GO:0034708 methyltransferase complex(GO:0034708)
0.0 0.4 GO:0005874 microtubule(GO:0005874)
0.0 0.1 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.1 GO:0005663 DNA replication factor C complex(GO:0005663)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
10.1 30.2 GO:0070568 guanylyltransferase activity(GO:0070568)
8.9 35.7 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
7.5 29.9 GO:0042973 glucan endo-1,3-beta-D-glucosidase activity(GO:0042973)
5.6 33.3 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
4.7 14.2 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
4.3 17.0 GO:0016841 ammonia-lyase activity(GO:0016841)
4.2 12.5 GO:0003938 IMP dehydrogenase activity(GO:0003938)
3.1 3.1 GO:0004805 trehalose-phosphatase activity(GO:0004805)
2.9 52.0 GO:0015926 glucosidase activity(GO:0015926)
2.7 13.3 GO:0036002 pre-mRNA binding(GO:0036002)
2.6 7.9 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
2.6 15.6 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
2.4 7.2 GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
2.4 7.1 GO:0004619 phosphoglycerate mutase activity(GO:0004619)
2.2 38.7 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
2.1 12.8 GO:0070300 phosphatidic acid binding(GO:0070300)
2.1 8.3 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
2.0 12.1 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
1.8 7.1 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
1.6 4.8 GO:0019003 GDP binding(GO:0019003)
1.4 4.2 GO:0003825 alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity(GO:0003825)
1.4 5.5 GO:0004467 long-chain fatty acid-CoA ligase activity(GO:0004467)
1.4 9.5 GO:0015665 alcohol transmembrane transporter activity(GO:0015665)
1.3 1.3 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
1.3 3.9 GO:0009922 fatty acid elongase activity(GO:0009922)
1.2 3.7 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
1.2 4.8 GO:0000297 spermine transmembrane transporter activity(GO:0000297)
1.2 3.6 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
1.2 7.1 GO:0016408 C-acyltransferase activity(GO:0016408)
1.2 54.5 GO:0019843 rRNA binding(GO:0019843)
1.2 11.8 GO:0001133 RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding(GO:0001133)
1.2 5.8 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
1.1 6.8 GO:0015198 oligopeptide transporter activity(GO:0015198)
1.1 5.7 GO:0042124 glucanosyltransferase activity(GO:0042123) 1,3-beta-glucanosyltransferase activity(GO:0042124)
1.1 5.6 GO:0008536 Ran GTPase binding(GO:0008536)
1.1 8.7 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
1.1 15.3 GO:0015578 fructose transmembrane transporter activity(GO:0005353) mannose transmembrane transporter activity(GO:0015578)
1.1 4.2 GO:0004622 lysophospholipase activity(GO:0004622)
1.0 4.0 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
1.0 4.9 GO:0004707 MAP kinase activity(GO:0004707)
1.0 2.9 GO:0016838 carbon-oxygen lyase activity, acting on phosphates(GO:0016838)
0.9 169.7 GO:0003735 structural constituent of ribosome(GO:0003735)
0.9 6.5 GO:0016742 hydroxymethyl-, formyl- and related transferase activity(GO:0016742)
0.9 5.6 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.9 2.7 GO:0015114 phosphate ion transmembrane transporter activity(GO:0015114)
0.9 3.7 GO:0019206 nucleoside kinase activity(GO:0019206)
0.9 7.9 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.8 2.5 GO:0019203 carbohydrate phosphatase activity(GO:0019203) sugar-phosphatase activity(GO:0050308)
0.8 3.4 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.8 2.5 GO:0051219 phosphoprotein binding(GO:0051219)
0.8 2.4 GO:0031370 eukaryotic initiation factor 4G binding(GO:0031370)
0.8 11.3 GO:0001054 RNA polymerase I activity(GO:0001054)
0.8 2.4 GO:0019202 amino acid kinase activity(GO:0019202)
0.7 0.7 GO:1904680 peptide-transporting ATPase activity(GO:0015440) peptide transmembrane transporter activity(GO:1904680)
0.7 3.5 GO:0005338 nucleotide-sugar transmembrane transporter activity(GO:0005338)
0.7 3.5 GO:0005496 steroid binding(GO:0005496) sterol binding(GO:0032934)
0.7 6.6 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.6 5.1 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.6 16.3 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.6 1.8 GO:0015088 copper uptake transmembrane transporter activity(GO:0015088)
0.6 6.7 GO:0043495 protein anchor(GO:0043495)
0.6 4.8 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.6 1.8 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.6 1.8 GO:0016504 peptidase activator activity(GO:0016504)
0.6 3.4 GO:0001132 RNA polymerase II transcription factor activity, TBP-class protein binding(GO:0001132)
0.6 2.2 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.5 2.7 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.5 2.7 GO:0043141 5'-3' DNA helicase activity(GO:0043139) ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.5 3.2 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.5 3.7 GO:0003725 double-stranded RNA binding(GO:0003725)
0.5 1.5 GO:0016972 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor(GO:0016670) thiol oxidase activity(GO:0016972)
0.5 9.4 GO:0042162 telomeric DNA binding(GO:0042162)
0.5 0.5 GO:0016778 diphosphotransferase activity(GO:0016778)
0.5 2.0 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.5 3.9 GO:0031490 chromatin DNA binding(GO:0031490)
0.5 1.9 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.5 5.9 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.4 5.8 GO:0051015 actin filament binding(GO:0051015)
0.4 1.7 GO:0019901 protein kinase binding(GO:0019901)
0.4 1.3 GO:0051010 microtubule plus-end binding(GO:0051010)
0.4 4.3 GO:0000171 ribonuclease MRP activity(GO:0000171)
0.4 1.7 GO:0000213 tRNA-intron endonuclease activity(GO:0000213)
0.4 1.2 GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.4 0.8 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.4 1.2 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.4 1.9 GO:0030145 manganese ion binding(GO:0030145)
0.4 1.1 GO:0004376 glycolipid mannosyltransferase activity(GO:0004376)
0.4 10.8 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.4 2.9 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.4 1.8 GO:0016423 tRNA (guanine) methyltransferase activity(GO:0016423)
0.4 6.4 GO:0004520 endodeoxyribonuclease activity(GO:0004520)
0.4 2.5 GO:0072509 divalent inorganic cation transmembrane transporter activity(GO:0072509)
0.3 2.7 GO:0005216 ion channel activity(GO:0005216)
0.3 1.0 GO:0042910 xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.3 1.7 GO:0019201 nucleotide kinase activity(GO:0019201)
0.3 6.0 GO:0043022 ribosome binding(GO:0043022)
0.3 1.0 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.3 1.3 GO:0001168 transcription factor activity, RNA polymerase I upstream control element sequence-specific binding(GO:0001168)
0.3 0.7 GO:0003785 actin monomer binding(GO:0003785)
0.3 1.6 GO:0070403 NAD+ binding(GO:0070403)
0.3 1.6 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.3 4.5 GO:0004659 prenyltransferase activity(GO:0004659)
0.3 2.9 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.3 0.6 GO:0099516 ion antiporter activity(GO:0099516)
0.3 2.2 GO:0000009 alpha-1,6-mannosyltransferase activity(GO:0000009)
0.3 2.5 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.3 1.3 GO:0009378 four-way junction helicase activity(GO:0009378)
0.3 8.4 GO:0003743 translation initiation factor activity(GO:0003743)
0.3 3.1 GO:0004177 aminopeptidase activity(GO:0004177)
0.3 0.9 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.3 3.7 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.3 2.1 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.3 3.3 GO:0015079 potassium ion transmembrane transporter activity(GO:0015079)
0.3 18.2 GO:0003924 GTPase activity(GO:0003924)
0.3 4.1 GO:0001671 ATPase activator activity(GO:0001671)
0.3 2.0 GO:0031386 protein tag(GO:0031386)
0.3 2.3 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.3 4.7 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.3 8.6 GO:0016876 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.3 0.8 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.3 2.4 GO:0008175 tRNA methyltransferase activity(GO:0008175)
0.3 1.1 GO:0016886 ligase activity, forming phosphoric ester bonds(GO:0016886)
0.3 1.6 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.3 5.9 GO:0016836 hydro-lyase activity(GO:0016836)
0.3 0.8 GO:0004497 monooxygenase activity(GO:0004497)
0.2 0.5 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.2 6.0 GO:0003779 actin binding(GO:0003779)
0.2 1.2 GO:0017048 Rho GTPase binding(GO:0017048)
0.2 4.4 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.2 1.2 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.2 0.5 GO:0008238 exopeptidase activity(GO:0008238)
0.2 0.7 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.2 2.6 GO:0042803 protein homodimerization activity(GO:0042803)
0.2 0.9 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.2 2.8 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.2 3.1 GO:0050661 NADP binding(GO:0050661)
0.2 7.3 GO:0008092 cytoskeletal protein binding(GO:0008092)
0.2 0.9 GO:0003746 translation elongation factor activity(GO:0003746)
0.2 0.4 GO:0015606 spermidine transmembrane transporter activity(GO:0015606)
0.2 0.8 GO:0008172 S-methyltransferase activity(GO:0008172)
0.2 0.8 GO:0001055 RNA polymerase II activity(GO:0001055)
0.2 1.6 GO:0005516 calmodulin binding(GO:0005516)
0.2 1.0 GO:0003993 acid phosphatase activity(GO:0003993)
0.2 0.7 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.2 5.4 GO:0046982 protein heterodimerization activity(GO:0046982)
0.2 0.5 GO:0003968 RNA-directed RNA polymerase activity(GO:0003968)
0.2 3.2 GO:0008301 DNA binding, bending(GO:0008301)
0.2 1.4 GO:0030295 protein kinase activator activity(GO:0030295)
0.2 0.5 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds(GO:0016799)
0.2 0.3 GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671)
0.1 0.7 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
0.1 3.5 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 0.7 GO:0034318 alcohol O-acetyltransferase activity(GO:0004026) alcohol O-acyltransferase activity(GO:0034318)
0.1 0.7 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.1 1.7 GO:0016859 peptidyl-prolyl cis-trans isomerase activity(GO:0003755) cis-trans isomerase activity(GO:0016859)
0.1 2.0 GO:0015605 organophosphate ester transmembrane transporter activity(GO:0015605)
0.1 7.0 GO:0008565 protein transporter activity(GO:0008565)
0.1 1.8 GO:0003714 transcription corepressor activity(GO:0003714)
0.1 0.4 GO:0016872 intramolecular lyase activity(GO:0016872)
0.1 0.4 GO:0008251 adenosine deaminase activity(GO:0004000) tRNA-specific adenosine deaminase activity(GO:0008251)
0.1 0.4 GO:0008242 metalloexopeptidase activity(GO:0008235) omega peptidase activity(GO:0008242)
0.1 0.6 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.1 0.2 GO:0001082 transcription factor activity, RNA polymerase I transcription factor binding(GO:0001082)
0.1 0.3 GO:0000339 RNA cap binding(GO:0000339)
0.1 2.9 GO:0030674 protein binding, bridging(GO:0030674)
0.1 1.4 GO:0016866 intramolecular transferase activity(GO:0016866)
0.1 2.7 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.1 0.8 GO:0016780 phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.1 0.4 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.1 0.6 GO:0000182 rDNA binding(GO:0000182)
0.1 1.7 GO:0016831 carboxy-lyase activity(GO:0016831)
0.1 1.2 GO:0016853 isomerase activity(GO:0016853)
0.1 0.6 GO:0000991 transcription factor activity, core RNA polymerase II binding(GO:0000991)
0.1 0.8 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.1 0.3 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.1 0.7 GO:0000049 tRNA binding(GO:0000049)
0.1 0.3 GO:0016417 S-acyltransferase activity(GO:0016417)
0.1 0.9 GO:0051087 chaperone binding(GO:0051087)
0.1 1.2 GO:0000030 mannosyltransferase activity(GO:0000030)
0.1 0.7 GO:0043175 RNA polymerase core enzyme binding(GO:0043175) RNA polymerase binding(GO:0070063)
0.1 0.5 GO:0019904 protein domain specific binding(GO:0019904)
0.1 0.8 GO:0030515 snoRNA binding(GO:0030515)
0.1 1.8 GO:0043130 ubiquitin binding(GO:0043130)
0.0 0.2 GO:0080130 L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.0 0.4 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.0 0.5 GO:0003774 motor activity(GO:0003774)
0.0 0.1 GO:0060090 binding, bridging(GO:0060090)
0.0 0.2 GO:0008525 phosphatidylcholine transporter activity(GO:0008525) phosphatidylinositol transporter activity(GO:0008526)
0.0 0.6 GO:0005048 signal sequence binding(GO:0005048)
0.0 0.2 GO:0030276 clathrin binding(GO:0030276)
0.0 0.6 GO:0005525 GTP binding(GO:0005525) guanyl nucleotide binding(GO:0019001) guanyl ribonucleotide binding(GO:0032561)
0.0 0.2 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.6 GO:0008237 metallopeptidase activity(GO:0008237)
0.0 0.1 GO:0004312 fatty acid synthase activity(GO:0004312)
0.0 0.2 GO:0017069 snRNA binding(GO:0017069)
0.0 0.0 GO:0008601 protein phosphatase type 2A regulator activity(GO:0008601)
0.0 0.1 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor(GO:0016655)
0.0 0.8 GO:0016791 phosphatase activity(GO:0016791)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
3.5 10.6 PID SHP2 PATHWAY SHP2 signaling
2.5 2.5 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
1.8 5.4 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.9 0.9 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.7 2.0 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.6 1.2 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.6 1.7 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.4 0.4 PID VEGFR1 PATHWAY VEGFR1 specific signals
0.4 1.3 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.4 1.2 PID FGF PATHWAY FGF signaling pathway
0.4 1.8 PID PLK1 PATHWAY PLK1 signaling events
0.2 0.2 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.2 0.5 PID FOXO PATHWAY FoxO family signaling
0.1 0.3 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.1 0.2 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
3.5 10.6 REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR Genes involved in Downstream signaling of activated FGFR
2.0 47.3 REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION Genes involved in 3' -UTR-mediated translational regulation
1.6 4.9 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
1.4 5.4 REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS Genes involved in Class A/1 (Rhodopsin-like receptors)
0.9 0.9 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.9 0.9 REACTOME INTERFERON SIGNALING Genes involved in Interferon Signaling
0.9 3.6 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA
0.8 3.2 REACTOME GPCR DOWNSTREAM SIGNALING Genes involved in GPCR downstream signaling
0.6 1.2 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.5 0.9 REACTOME HOST INTERACTIONS OF HIV FACTORS Genes involved in Host Interactions of HIV factors
0.5 0.5 REACTOME G1 PHASE Genes involved in G1 Phase
0.4 1.7 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.4 0.7 REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE Genes involved in MyD88:Mal cascade initiated on plasma membrane
0.3 2.4 REACTOME METABOLISM OF RNA Genes involved in Metabolism of RNA
0.3 0.8 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.3 0.8 REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION Genes involved in Platelet activation, signaling and aggregation
0.2 1.7 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.2 0.6 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.2 1.3 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.2 1.8 REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM Genes involved in Fatty acid, triacylglycerol, and ketone body metabolism
0.1 0.4 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 0.4 REACTOME AXON GUIDANCE Genes involved in Axon guidance
0.1 0.2 REACTOME DEVELOPMENTAL BIOLOGY Genes involved in Developmental Biology
0.1 0.6 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
0.1 1.0 REACTOME POST TRANSLATIONAL PROTEIN MODIFICATION Genes involved in Post-translational protein modification
0.1 0.8 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 0.4 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.1 0.4 REACTOME TRANSLATION Genes involved in Translation
0.1 0.2 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 0.2 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism
0.0 0.0 REACTOME MRNA SPLICING Genes involved in mRNA Splicing