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GSE53960: rat RNA-Seq transcriptomic Bodymap
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Results for Zbtb18
Z-value: 1.47
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Transcription factors associated with Zbtb18
| Gene Symbol | Gene ID | Gene Info |
|---|
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Zfp238 | rn6_v1_chr13_+_95589668_95589668 | -0.52 | 6.2e-24 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_+_128046780 Show fit | 130.12 |
ENSRNOT00000078064
|
Ab1-233 |
|
| chr16_+_6970342 Show fit | 92.96 |
ENSRNOT00000061294
ENSRNOT00000048344 |
inter-alpha-trypsin inhibitor heavy chain family, member 4 |
|
| chr2_+_252452269 Show fit | 79.62 |
ENSRNOT00000021970
|
urate oxidase |
|
| chr16_+_18690246 Show fit | 71.25 |
ENSRNOT00000081484
|
methionine adenosyltransferase 1A |
|
| chr13_+_78805347 Show fit | 68.61 |
ENSRNOT00000003748
|
serpin family C member 1 |
|
| chr1_-_170431073 Show fit | 66.43 |
ENSRNOT00000024710
|
hemopexin |
|
| chr3_+_28416954 Show fit | 65.45 |
ENSRNOT00000043533
|
kynureninase |
|
| chr16_+_18690649 Show fit | 63.27 |
ENSRNOT00000015190
|
methionine adenosyltransferase 1A |
|
| chr4_+_65110746 Show fit | 60.11 |
ENSRNOT00000017675
|
aldo-keto reductase family 1, member D1 |
|
| chr1_+_83714347 Show fit | 55.88 |
ENSRNOT00000085245
|
cytochrome P450, family 2, subfamily a, polypeptide 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Zbtb18
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 413.3 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 5.8 | 189.8 | GO:0030212 | hyaluronan metabolic process(GO:0030212) |
| 9.8 | 137.2 | GO:0016127 | cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127) |
| 26.9 | 134.5 | GO:0006556 | S-adenosylmethionine biosynthetic process(GO:0006556) |
| 1.5 | 100.6 | GO:0032094 | response to food(GO:0032094) |
| 8.1 | 81.1 | GO:0006145 | purine nucleobase catabolic process(GO:0006145) |
| 1.8 | 80.0 | GO:0030199 | collagen fibril organization(GO:0030199) |
| 14.9 | 74.6 | GO:0006548 | histidine catabolic process(GO:0006548) |
| 17.2 | 68.6 | GO:0007597 | blood coagulation, intrinsic pathway(GO:0007597) |
| 16.6 | 66.4 | GO:0060335 | positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.9 | 389.5 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.2 | 257.1 | GO:0005615 | extracellular space(GO:0005615) |
| 0.3 | 211.9 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.0 | 142.0 | GO:0016021 | integral component of membrane(GO:0016021) |
| 1.0 | 114.5 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.2 | 107.7 | GO:0000323 | lytic vacuole(GO:0000323) lysosome(GO:0005764) |
| 0.1 | 95.1 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.1 | 87.0 | GO:0070062 | extracellular exosome(GO:0070062) |
| 4.0 | 79.6 | GO:0031907 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 2.2 | 58.0 | GO:0005640 | nuclear outer membrane(GO:0005640) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 381.8 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 2.0 | 231.9 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.6 | 142.4 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 44.8 | 134.5 | GO:0004478 | methionine adenosyltransferase activity(GO:0004478) |
| 4.1 | 109.7 | GO:0008392 | arachidonic acid epoxygenase activity(GO:0008392) |
| 3.3 | 93.0 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 30.7 | 92.0 | GO:0047787 | delta4-3-oxosteroid 5beta-reductase activity(GO:0047787) |
| 11.7 | 81.8 | GO:0016661 | oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661) |
| 7.4 | 66.4 | GO:0015232 | heme transporter activity(GO:0015232) |
| 21.8 | 65.4 | GO:0016823 | hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 377.8 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.4 | 89.7 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 1.5 | 82.7 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.5 | 76.9 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.7 | 61.3 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.6 | 49.3 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.7 | 35.9 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.9 | 21.1 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.2 | 15.5 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.3 | 15.0 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.8 | 139.3 | REACTOME LIPID DIGESTION MOBILIZATION AND TRANSPORT | Genes involved in Lipid digestion, mobilization, and transport |
| 4.8 | 138.7 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.9 | 138.6 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 8.9 | 133.9 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol |
| 5.0 | 85.7 | REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 1.9 | 75.4 | REACTOME PHASE II CONJUGATION | Genes involved in Phase II conjugation |
| 7.3 | 65.4 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |
| 5.3 | 63.4 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 4.8 | 62.3 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 1.4 | 53.5 | REACTOME REGULATION OF BETA CELL DEVELOPMENT | Genes involved in Regulation of beta-cell development |