ISMARA results: Tlx2

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Tlx2

Z-value: 1.36

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Transcription factors associated with Tlx2

Gene Symbol	Gene ID	Gene Info
Tlx2 NCBI RGD Ensembl	ENSRNOG00000055188	T-cell leukemia homeobox 2
Tlx2 NCBI RGD Ensembl	ENSRNOG00000061571	T-cell leukemia homeobox 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Tlx2	rn6_v1_chr4_-_113902399_113902399	0.17	2.0e-03	Click!

Activity profile of Tlx2 motif

Sorted Z-values of Tlx2 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr11_+_84972132 Show fit	45.73	ENSRNOT00000034498	Lamp3 NCBI RGD Ensembl Show fit	lysosomal-associated membrane protein 3
chr20_+_4363508 Show fit	39.57	ENSRNOT00000077205	Ager NCBI RGD Ensembl Show fit	advanced glycosylation end product-specific receptor
chr20_+_4363152 Show fit	35.47	ENSRNOT00000000508 ENSRNOT00000084841 ENSRNOT00000072848 ENSRNOT00000077561	Ager NCBI RGD Ensembl Show fit	advanced glycosylation end product-specific receptor
chr2_+_190073815 Show fit	33.87	ENSRNOT00000015473	S100a8 NCBI RGD Ensembl Show fit	S100 calcium binding protein A8
chr17_-_69862110 Show fit	27.46	ENSRNOT00000058312	Akr1cl NCBI RGD Ensembl Show fit	aldo-keto reductase family 1, member C-like
chr1_-_225283326 Show fit	27.41	ENSRNOT00000027342	Scgb1a1 NCBI RGD Ensembl Show fit	secretoglobin family 1A member 1
chr10_+_47765432 Show fit	26.08	ENSRNOT00000078231	LOC102553715 NCBI RGD Ensembl Show fit	microfibril-associated glycoprotein 4-like
chr2_+_248219428 Show fit	25.05	ENSRNOT00000037181	LOC685067 NCBI RGD Ensembl Show fit	similar to guanylate binding protein family, member 6
chr14_-_86146744 Show fit	24.69	ENSRNOT00000019335	Myl7 NCBI RGD Ensembl Show fit	myosin light chain 7
chr2_-_191294374 Show fit	24.58	ENSRNOT00000067469	RGD1562234 NCBI RGD Ensembl Show fit	similar to S100 calcium-binding protein, ventral prostate

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Tlx2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
25.0	75.0	GO:0072714	response to selenite ion(GO:0072714) negative regulation of connective tissue replacement(GO:1905204)
1.5	45.7	GO:0035455	response to interferon-alpha(GO:0035455)
0.4	45.1	GO:0042157	lipoprotein metabolic process(GO:0042157)
2.8	41.3	GO:0002523	leukocyte migration involved in inflammatory response(GO:0002523)
4.0	40.2	GO:0001955	blood vessel maturation(GO:0001955)
0.2	38.2	GO:0002244	hematopoietic progenitor cell differentiation(GO:0002244)
0.1	28.6	GO:0043547	positive regulation of GTPase activity(GO:0043547)
0.1	28.0	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway(GO:0007169)
6.9	27.4	GO:0032696	negative regulation of interleukin-13 production(GO:0032696)
3.9	27.2	GO:0033634	positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)

Showing 1 to 10 of 283 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.2	66.5	GO:0009925	basal plasma membrane(GO:0009925)
15.2	45.7	GO:0097232	lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233)
0.4	44.0	GO:0005913	cell-cell adherens junction(GO:0005913)
0.4	41.2	GO:0005791	rough endoplasmic reticulum(GO:0005791)
0.1	40.5	GO:0005925	focal adhesion(GO:0005925)
0.4	34.8	GO:0005604	basement membrane(GO:0005604)
0.5	33.8	GO:0005581	collagen trimer(GO:0005581)
0.1	31.6	GO:0005789	endoplasmic reticulum membrane(GO:0005789)
0.4	28.9	GO:0005811	lipid particle(GO:0005811)
0.1	27.6	GO:0000790	nuclear chromatin(GO:0000790)

Showing 1 to 10 of 128 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
15.0	75.0	GO:0050785	advanced glycation end-product receptor activity(GO:0050785)
2.9	72.2	GO:0042288	MHC class I protein binding(GO:0042288)
10.0	60.2	GO:0035662	Toll-like receptor 4 binding(GO:0035662)
0.2	56.7	GO:0003924	GTPase activity(GO:0003924)
1.9	45.6	GO:0043395	heparan sulfate proteoglycan binding(GO:0043395)
0.1	44.0	GO:0050839	cell adhesion molecule binding(GO:0050839)
0.1	37.3	GO:0030246	carbohydrate binding(GO:0030246)
0.5	31.3	GO:0030971	receptor tyrosine kinase binding(GO:0030971)
0.1	31.3	GO:0005096	GTPase activator activity(GO:0005096)
0.2	29.2	GO:0019903	protein phosphatase binding(GO:0019903)

Showing 1 to 10 of 187 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.3	112.6	PID AMB2 NEUTROPHILS PATHWAY	amb2 Integrin signaling
0.4	65.3	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
2.5	60.6	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.5	39.7	PID AR PATHWAY	Coregulation of Androgen receptor activity
0.4	38.3	PID PDGFRB PATHWAY	PDGFR-beta signaling pathway
0.9	25.5	PID S1P S1P2 PATHWAY	S1P2 pathway
0.7	25.5	PID TXA2PATHWAY	Thromboxane A2 receptor signaling
0.1	24.6	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.5	23.3	PID SYNDECAN 1 PATHWAY	Syndecan-1-mediated signaling events
0.5	23.2	PID HNF3A PATHWAY	FOXA1 transcription factor network

Showing 1 to 10 of 60 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
5.3	74.9	REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	Genes involved in Advanced glycosylation endproduct receptor signaling
0.4	29.5	REACTOME DOWNSTREAM SIGNAL TRANSDUCTION	Genes involved in Downstream signal transduction
2.0	28.0	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.7	27.9	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.5	25.0	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
1.2	23.7	REACTOME HS GAG DEGRADATION	Genes involved in HS-GAG degradation
0.9	22.8	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
1.4	21.9	REACTOME ACYL CHAIN REMODELLING OF PS	Genes involved in Acyl chain remodelling of PS
0.7	19.8	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.9	19.2	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Showing 1 to 10 of 86 entries

Results for Tlx2

Z-value: 1.36

Motif logo

Transcription factors associated with Tlx2

Activity-expression correlation:

Activity profile of Tlx2 motif

Sorted Z-values of Tlx2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Tlx2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: