ISMARA results: Tead1

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Tead1

Z-value: 1.28

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Transcription factors associated with Tead1

Gene Symbol	Gene ID	Gene Info
Tead1 NCBI RGD Ensembl	ENSRNOG00000015488	TEA domain transcription factor 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Tead1	rn6_v1_chr1_+_177569618_177569618	0.68	1.3e-44	Click!

Activity profile of Tead1 motif

Sorted Z-values of Tead1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr1_-_21854763 Show fit	45.18	ENSRNOT00000089196 ENSRNOT00000020528	Ctgf NCBI RGD Ensembl Show fit	connective tissue growth factor
chr1_+_214203861 Show fit	39.80	ENSRNOT00000023219	Rassf7 NCBI RGD Ensembl Show fit	Ras association domain family member 7
chr11_+_64522130 Show fit	39.41	ENSRNOT00000004315	Upk1b NCBI RGD Ensembl Show fit	uroplakin 1B
chr18_+_57286322 Show fit	39.15	ENSRNOT00000026174	Sh3tc2 NCBI RGD Ensembl Show fit	SH3 domain and tetratricopeptide repeats 2
chr16_+_47368768 Show fit	38.24	ENSRNOT00000017966	Wwc2 NCBI RGD Ensembl Show fit	WW and C2 domain containing 2
chr13_-_108841482 Show fit	36.78	ENSRNOT00000004632 ENSRNOT00000086775	Ptpn14 NCBI RGD Ensembl Show fit	protein tyrosine phosphatase, non-receptor type 14
chr10_-_88874528 Show fit	32.42	ENSRNOT00000026783	Ptrf NCBI RGD Ensembl Show fit	polymerase I and transcript release factor
chr20_-_3605638 Show fit	32.11	ENSRNOT00000074460	Sfta2 NCBI RGD Ensembl Show fit	surfactant associated 2
chr6_+_109617596 Show fit	30.97	ENSRNOT00000085031 ENSRNOT00000089972 ENSRNOT00000082402	Flvcr2 NCBI RGD Ensembl Show fit	feline leukemia virus subgroup C cellular receptor family, member 2
chr10_+_84182118 Show fit	30.24	ENSRNOT00000011027	Hoxb3 NCBI RGD Ensembl Show fit	homeo box B3

Showing 1 to 10 of 89 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Tead1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
10.1	60.7	GO:0035331	negative regulation of hippo signaling(GO:0035331)
5.8	58.3	GO:0015886	heme transport(GO:0015886)
0.3	49.9	GO:0070507	regulation of microtubule cytoskeleton organization(GO:0070507)
9.0	45.2	GO:0070318	positive regulation of G0 to G1 transition(GO:0070318)
0.3	44.1	GO:0010811	positive regulation of cell-substrate adhesion(GO:0010811)
0.1	39.4	GO:0030855	epithelial cell differentiation(GO:0030855)
3.6	39.2	GO:0032287	peripheral nervous system myelin maintenance(GO:0032287)
1.9	36.8	GO:0001946	lymphangiogenesis(GO:0001946)
0.5	32.7	GO:0070527	platelet aggregation(GO:0070527)
7.6	30.2	GO:0021615	glossopharyngeal nerve morphogenesis(GO:0021615)

Showing 1 to 10 of 63 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	79.7	GO:0005856	cytoskeleton(GO:0005856)
0.4	48.0	GO:0005923	bicellular tight junction(GO:0005923)
0.1	46.9	GO:0005789	endoplasmic reticulum membrane(GO:0005789)
0.1	46.4	GO:0005911	cell-cell junction(GO:0005911)
0.8	45.2	GO:0005801	cis-Golgi network(GO:0005801)
0.3	39.2	GO:0055037	recycling endosome(GO:0055037)
0.1	37.3	GO:0016324	apical plasma membrane(GO:0016324)
6.0	29.9	GO:0030485	smooth muscle contractile fiber(GO:0030485)
1.5	29.6	GO:0016460	myosin II complex(GO:0016460)
0.0	28.0	GO:0005829	cytosol(GO:0005829)

Showing 1 to 10 of 41 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.4	69.7	GO:0005520	insulin-like growth factor binding(GO:0005520)
6.5	58.3	GO:0015232	heme transporter activity(GO:0015232)
0.1	49.2	GO:0005198	structural molecule activity(GO:0005198)
0.5	38.2	GO:0032947	protein complex scaffold(GO:0032947)
0.2	38.0	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.4	30.9	GO:0030971	receptor tyrosine kinase binding(GO:0030971)
0.5	26.7	GO:0001786	phosphatidylserine binding(GO:0001786)
0.9	26.2	GO:0001968	fibronectin binding(GO:0001968)
1.5	24.6	GO:0035497	cAMP response element binding(GO:0035497)
6.0	23.9	GO:0030172	troponin C binding(GO:0030172)

Showing 1 to 10 of 49 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	50.3	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.9	45.2	PID AMB2 NEUTROPHILS PATHWAY	amb2 Integrin signaling
0.3	28.7	PID PDGFRB PATHWAY	PDGFR-beta signaling pathway
1.2	20.4	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.9	20.3	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway
0.9	19.9	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.8	19.0	PID EPHA FWDPATHWAY	EPHA forward signaling
0.4	19.0	PID SYNDECAN 1 PATHWAY	Syndecan-1-mediated signaling events
0.6	18.8	PID NEPHRIN NEPH1 PATHWAY	Nephrin/Neph1 signaling in the kidney podocyte
0.3	17.7	PID FGF PATHWAY	FGF signaling pathway

Showing 1 to 10 of 17 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.7	46.7	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
1.6	45.2	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
1.2	40.5	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
2.2	33.5	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
1.5	32.4	REACTOME RNA POL I TRANSCRIPTION TERMINATION	Genes involved in RNA Polymerase I Transcription Termination
1.7	23.6	REACTOME FGFR4 LIGAND BINDING AND ACTIVATION	Genes involved in FGFR4 ligand binding and activation
0.7	20.8	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.3	20.4	REACTOME CELL JUNCTION ORGANIZATION	Genes involved in Cell junction organization
0.9	19.5	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.4	19.0	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions

Showing 1 to 10 of 20 entries

Results for Tead1

Z-value: 1.28

Motif logo

Transcription factors associated with Tead1

Activity-expression correlation:

Activity profile of Tead1 motif

Sorted Z-values of Tead1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Tead1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: