ISMARA results: Tbp

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Tbp

Z-value: 2.98

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Transcription factors associated with Tbp

Gene Symbol	Gene ID	Gene Info
Tbp NCBI RGD Ensembl	ENSRNOG00000001489	TATA box binding protein

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Tbp	rn6_v1_chr1_+_57491643_57491643	-0.34	6.7e-10	Click!

Activity profile of Tbp motif

Sorted Z-values of Tbp motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr10_-_109729019 Show fit	111.44	ENSRNOT00000054959	Ppp1r27 NCBI RGD Ensembl Show fit	protein phosphatase 1, regulatory subunit 27
chr10_+_53818818 Show fit	98.00	ENSRNOT00000057260	Myh8 NCBI RGD Ensembl Show fit	myosin heavy chain 8
chr2_-_105089659 Show fit	96.03	ENSRNOT00000043381	Cpb1 NCBI RGD Ensembl Show fit	carboxypeptidase B1
chr1_+_80321585 Show fit	86.77	ENSRNOT00000022895	Ckm NCBI RGD Ensembl Show fit	creatine kinase, M-type
chr17_+_44794130 Show fit	83.31	ENSRNOT00000077571	Hist1h2ac NCBI RGD Ensembl Show fit	histone cluster 1, H2ac
chr10_+_53621375 Show fit	82.54	ENSRNOT00000004147	Myh3 NCBI RGD Ensembl Show fit	myosin heavy chain 3
chr4_+_70776046 Show fit	79.32	ENSRNOT00000040403	Prss1 NCBI RGD Ensembl Show fit	protease, serine 1
chr2_-_190100276 Show fit	77.74	ENSRNOT00000015351	S100a9 NCBI RGD Ensembl Show fit	S100 calcium binding protein A9
chr3_-_105512939 Show fit	76.52	ENSRNOT00000011773	Actc1 NCBI RGD Ensembl Show fit	actin, alpha, cardiac muscle 1
chr1_-_213650247 Show fit	76.36	ENSRNOT00000019679	Cox8b NCBI RGD Ensembl Show fit	cytochrome c oxidase, subunit VIIIb

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Tbp

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.6	309.4	GO:0006342	chromatin silencing(GO:0006342)
16.0	272.3	GO:0045653	negative regulation of megakaryocyte differentiation(GO:0045653)
3.9	270.2	GO:0006334	nucleosome assembly(GO:0006334)
14.0	195.7	GO:0015671	oxygen transport(GO:0015671)
28.1	140.5	GO:1903237	negative regulation of leukocyte tethering or rolling(GO:1903237)
19.6	117.4	GO:2000332	blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
4.7	113.3	GO:0030574	collagen catabolic process(GO:0030574)
13.4	106.9	GO:0016584	nucleosome positioning(GO:0016584)
1.3	106.6	GO:0010923	negative regulation of phosphatase activity(GO:0010923)
9.8	98.0	GO:0033275	actin-myosin filament sliding(GO:0033275)

Showing 1 to 10 of 225 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
11.6	808.8	GO:0000786	nucleosome(GO:0000786)
0.6	794.5	GO:0005615	extracellular space(GO:0005615)
9.1	686.0	GO:0045095	keratin filament(GO:0045095)
11.7	327.4	GO:0000788	nuclear nucleosome(GO:0000788)
16.8	252.1	GO:0032982	myosin filament(GO:0032982)
17.8	195.7	GO:0005833	hemoglobin complex(GO:0005833)
13.9	180.1	GO:0042627	chylomicron(GO:0042627)
1.4	120.5	GO:0042641	actomyosin(GO:0042641)
1.6	113.2	GO:0022627	cytosolic small ribosomal subunit(GO:0022627)
2.3	112.7	GO:0016459	myosin complex(GO:0016459)

Showing 1 to 10 of 85 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.1	481.8	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.6	419.0	GO:0005198	structural molecule activity(GO:0005198)
2.0	408.6	GO:0042393	histone binding(GO:0042393)
0.6	281.5	GO:0046982	protein heterodimerization activity(GO:0046982)
17.3	207.9	GO:0005344	oxygen transporter activity(GO:0005344)
1.7	184.1	GO:0031490	chromatin DNA binding(GO:0031490)
8.2	180.5	GO:0000146	microfilament motor activity(GO:0000146)
5.6	150.4	GO:0004181	metallocarboxypeptidase activity(GO:0004181)
23.5	117.4	GO:0070892	lipoteichoic acid receptor activity(GO:0070892)
0.8	113.7	GO:0008201	heparin binding(GO:0008201)

Showing 1 to 10 of 151 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.5	170.1	PID RB 1PATHWAY	Regulation of retinoblastoma protein
0.6	165.4	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
5.0	154.0	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.6	143.9	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
2.8	112.4	NABA PROTEOGLYCANS	Genes encoding proteoglycans
1.9	85.9	PID HNF3A PATHWAY	FOXA1 transcription factor network
1.1	77.9	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
3.2	77.7	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
2.1	68.0	ST P38 MAPK PATHWAY	p38 MAPK Pathway
0.5	57.4	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors

Showing 1 to 10 of 46 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
9.7	378.7	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
12.4	322.6	REACTOME PACKAGING OF TELOMERE ENDS	Genes involved in Packaging Of Telomere Ends
4.7	223.5	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
14.8	162.3	REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION	Genes involved in Apoptosis induced DNA fragmentation
2.0	153.7	REACTOME ANTIGEN PROCESSING CROSS PRESENTATION	Genes involved in Antigen processing-Cross presentation
9.0	153.1	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
1.5	82.3	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
2.6	71.0	REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	Genes involved in Degradation of the extracellular matrix
1.6	67.8	REACTOME IL1 SIGNALING	Genes involved in Interleukin-1 signaling
0.9	58.5	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation

Showing 1 to 10 of 64 entries

Results for Tbp

Z-value: 2.98

Motif logo

Transcription factors associated with Tbp

Activity-expression correlation:

Activity profile of Tbp motif

Sorted Z-values of Tbp motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Tbp

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: