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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Tbp

Z-value: 2.98

Motif logo

Transcription factors associated with Tbp

Gene Symbol Gene ID Gene Info
ENSRNOG00000001489 TATA box binding protein

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Tbprn6_v1_chr1_+_57491643_57491643-0.346.7e-10Click!

Activity profile of Tbp motif

Sorted Z-values of Tbp motif

Promoter Log-likelihood Transcript Gene Gene Info
chr10_-_109729019 111.44 ENSRNOT00000054959
protein phosphatase 1, regulatory subunit 27
chr10_+_53818818 98.00 ENSRNOT00000057260
myosin heavy chain 8
chr2_-_105089659 96.03 ENSRNOT00000043381
carboxypeptidase B1
chr1_+_80321585 86.77 ENSRNOT00000022895
creatine kinase, M-type
chr17_+_44794130 83.31 ENSRNOT00000077571
histone cluster 1, H2ac
chr10_+_53621375 82.54 ENSRNOT00000004147
myosin heavy chain 3
chr4_+_70776046 79.32 ENSRNOT00000040403
protease, serine 1
chr2_-_190100276 77.74 ENSRNOT00000015351
S100 calcium binding protein A9
chr3_-_105512939 76.52 ENSRNOT00000011773
actin, alpha, cardiac muscle 1
chr1_-_213650247 76.36 ENSRNOT00000019679
cytochrome c oxidase, subunit VIIIb
chr12_-_2438817 72.92 ENSRNOT00000037059
C-C motif chemokine ligand 25
chr4_-_69268336 71.37 ENSRNOT00000018042
protease, serine, 3B
chr17_+_44766313 71.17 ENSRNOT00000091688
histone cluster 1 H1 family member b
chr3_+_72385666 70.02 ENSRNOT00000011168
proteoglycan 2
chr15_-_34612432 68.19 ENSRNOT00000090206
mast cell protease 1-like 1
chr5_-_58198782 67.55 ENSRNOT00000023951
C-C motif chemokine ligand 21
chr17_-_44793927 65.49 ENSRNOT00000086309
histone cluster 1 H2B family member o
chr7_-_118108864 64.36 ENSRNOT00000006184
myoglobin
chr4_+_70755795 64.27 ENSRNOT00000043527
similar to Anionic trypsin II precursor (Pretrypsinogen II)
chr2_+_198390166 64.11 ENSRNOT00000081042
histone cluster 2, H3c2
chr9_-_73948583 63.33 ENSRNOT00000018097
myosin, light chain 1
chr17_-_43798383 63.09 ENSRNOT00000075069
similar to Histone H1.2 (H1 VAR.1) (H1c)
chr8_+_119030875 62.87 ENSRNOT00000028458
myosin light chain 3
chr17_+_44758460 62.02 ENSRNOT00000089436
histone cluster 1, H2an
chr4_+_14070553 60.40 ENSRNOT00000077505
CD36 molecule
chr10_-_88163712 58.77 ENSRNOT00000005382
ENSRNOT00000084493
keratin 17
chr8_+_5606592 58.13 ENSRNOT00000011727
matrix metallopeptidase 12
chr10_+_31880918 57.98 ENSRNOT00000059448
T-cell immunoglobulin and mucin domain containing 4
chr7_-_29171783 57.38 ENSRNOT00000079235
myosin binding protein C, slow type
chr13_-_50916982 57.37 ENSRNOT00000004408
BTG anti-proliferation factor 2
chr17_-_43807540 57.33 ENSRNOT00000074763
similar to CG31613-PA
chr4_+_14151343 56.98 ENSRNOT00000061687
ENSRNOT00000076573
ENSRNOT00000077219
ENSRNOT00000008319
CD36 molecule
chr4_+_14212925 56.33 ENSRNOT00000076946
platelet glycoprotein 4-like
chr3_-_7141522 55.76 ENSRNOT00000014572
carboxyl ester lipase
chr8_+_50537009 55.10 ENSRNOT00000080658
apolipoprotein A4
chr2_-_105047984 54.36 ENSRNOT00000014970
carboxypeptidase A3
chr1_+_168945449 54.08 ENSRNOT00000087661
ENSRNOT00000019913
hemoglobin subunit beta-2-like
chr10_-_88036040 53.11 ENSRNOT00000018851
keratin 13
chr1_-_100537377 52.97 ENSRNOT00000026599
Spi-B transcription factor
chr1_-_85220237 52.66 ENSRNOT00000026907
syncollin
chr10_-_88050622 52.38 ENSRNOT00000019037
keratin 15
chr2_-_198380836 52.17 ENSRNOT00000040906
histone H4-like
chr4_+_70689737 52.16 ENSRNOT00000018852
protease, serine, 2
chr10_+_11240138 50.60 ENSRNOT00000048687
sarcalumenin
chr1_+_168957460 49.94 ENSRNOT00000090745
hemoglobin subunit beta-2
chr17_+_43627930 49.93 ENSRNOT00000081719
histone H2B type 1-N-like
chr2_+_181987217 49.71 ENSRNOT00000034521
fibrinogen gamma chain
chr4_-_70628470 49.67 ENSRNOT00000029319
trypsin 5
chr5_+_164808323 49.59 ENSRNOT00000011005
natriuretic peptide A
chr2_-_88135410 48.36 ENSRNOT00000014180
carbonic anhydrase 3
chr20_+_30791422 48.17 ENSRNOT00000047394
ENSRNOT00000000683
thymus, brain and testes associated
chr17_-_43614844 47.33 ENSRNOT00000023054
histone cluster 1 H1 family member a
chr17_-_44758170 47.04 ENSRNOT00000091176
histone cluster 1 H2B family member o
chr15_+_35032049 45.95 ENSRNOT00000091757
mast cell protease 2
chr10_-_87067456 44.77 ENSRNOT00000014163
C-C motif chemokine receptor 7
chr6_-_128003418 44.32 ENSRNOT00000013896
serine (or cysteine) proteinase inhibitor, clade A, member 3C
chr5_+_79179417 44.12 ENSRNOT00000010454
orosomucoid 1
chr10_-_38774449 44.06 ENSRNOT00000049820
liver-expressed antimicrobial peptide 2
chr1_+_83653234 43.95 ENSRNOT00000085008
ENSRNOT00000084230
ENSRNOT00000090071
cytochrome P450, family 2, subfamily a, polypeptide 1
chr17_+_43734461 43.82 ENSRNOT00000072564
histone cluster 1, H1d
chr7_+_11908107 43.67 ENSRNOT00000041106
MAP kinase-interacting serine/threonine kinase 2
chr19_-_11341863 43.64 ENSRNOT00000025694
metallothionein 4
chr9_+_9721105 43.63 ENSRNOT00000073042
ENSRNOT00000075494
complement C3
chr2_+_93792601 43.33 ENSRNOT00000014701
ENSRNOT00000077311
fatty acid binding protein 4
chr10_+_82292110 42.40 ENSRNOT00000004435
chondroadherin
chr13_+_90260783 41.18 ENSRNOT00000050547
CD84 molecule
chr1_+_168964202 40.66 ENSRNOT00000089102
hemoglobin subunit beta-2-like
chr5_-_19368431 40.65 ENSRNOT00000012819
cytochrome P450, family 7, subfamily a, polypeptide 1
chr2_-_123281856 40.48 ENSRNOT00000079745
cyclin A2
chr17_+_43673294 40.37 ENSRNOT00000074109
histone cluster 2, H4
chr6_+_33176778 39.61 ENSRNOT00000046811
ENSRNOT00000007371
apolipoprotein B
chrX_-_157013443 39.28 ENSRNOT00000082711
SRSF protein kinase 3
chr15_-_23969011 39.27 ENSRNOT00000014821
GTP cyclohydrolase 1
chr10_-_88172910 39.19 ENSRNOT00000046956
keratin 42
chr3_-_48451650 38.34 ENSRNOT00000007356
glucagon
chr2_+_189997129 38.16 ENSRNOT00000015958
S100 calcium-binding protein A4
chr1_+_91363492 37.91 ENSRNOT00000014517
CCAAT/enhancer binding protein alpha
chr1_-_25839198 37.20 ENSRNOT00000090388
ENSRNOT00000092757
ENSRNOT00000042072
triadin
chr4_-_69196430 37.03 ENSRNOT00000017673
Trypsin V-A
chr7_-_54778848 36.66 ENSRNOT00000005399
GLI pathogenesis-related 1
chr7_+_121841855 36.60 ENSRNOT00000024673
GRB2-related adaptor protein 2
chr2_+_198388809 36.23 ENSRNOT00000083087
histone cluster 2, H2aa3
chr14_-_18853315 36.14 ENSRNOT00000003794
pro-platelet basic protein
chr6_-_139142218 35.60 ENSRNOT00000006975
Immunoglobulin heavy chain (gamma polypeptide)
chr9_-_42839837 35.38 ENSRNOT00000038610
neuralized E3 ubiquitin protein ligase 3
chr7_+_37812831 35.36 ENSRNOT00000005910
BTG anti-proliferation factor 1
chr17_+_44522140 34.93 ENSRNOT00000080490
histone H4 variant H4-v.1
chr1_-_168972725 34.93 ENSRNOT00000090422
hemoglobin subunit beta
chr10_+_70262361 34.89 ENSRNOT00000064625
ENSRNOT00000076973
unc-45 myosin chaperone B
chr3_+_111422267 34.48 ENSRNOT00000052312
nucleolar and spindle associated protein 1
chr13_-_61070599 34.46 ENSRNOT00000005251
regulator of G-protein signaling 1
chr2_-_198382190 34.39 ENSRNOT00000044268
histone cluster 2, H2aa2
chr17_+_43632397 34.24 ENSRNOT00000013790
histone cluster 1, H2ah
chr2_+_198417619 33.86 ENSRNOT00000085945
histone cluster 2, H3c2
chr4_+_109467272 33.50 ENSRNOT00000008212
regenerating family member 3 beta
chr3_-_156340913 33.49 ENSRNOT00000021452
MAF bZIP transcription factor B
chr1_-_89369960 33.44 ENSRNOT00000028545
hepcidin antimicrobial peptide
chr3_-_111422203 33.39 ENSRNOT00000084290
Opa interacting protein 5
chr10_-_87541851 33.24 ENSRNOT00000089610
similar to keratin associated protein 2-4
chr17_+_43617247 32.96 ENSRNOT00000075065
histone cluster 1, H2ao
chr7_+_141249044 32.50 ENSRNOT00000084911
aquaporin 5
chr19_+_54314865 32.08 ENSRNOT00000024069
interferon regulatory factor 8
chr7_-_143141589 32.07 ENSRNOT00000068505
ENSRNOT00000077207
type II keratin 23
chr2_-_251532312 32.05 ENSRNOT00000019501
cysteine-rich, angiogenic inducer, 61
chr3_-_121882726 31.83 ENSRNOT00000006308
interleukin 1 beta
chr17_+_81352700 30.85 ENSRNOT00000024736
mannose receptor, C type 1
chr17_-_43821536 30.71 ENSRNOT00000072286
histone H4 variant H4-v.1
chr17_-_44815995 30.66 ENSRNOT00000091201
histone H4 variant H4-v.1
chr2_-_45518502 30.18 ENSRNOT00000014627
heat shock protein family B (small) member 3
chr1_+_201620642 30.12 ENSRNOT00000093674
deleted in malignant brain tumors 1
chr16_-_75637789 30.08 ENSRNOT00000058029
defensin beta 4
chr11_-_32550539 30.06 ENSRNOT00000002715
regulator of calcineurin 1
chr8_+_50559126 29.91 ENSRNOT00000024918
apolipoprotein A5
chr1_+_261281543 29.91 ENSRNOT00000018890
ankyrin repeat domain 2
chr5_+_164796185 29.86 ENSRNOT00000010779
natriuretic peptide B
chr9_+_46840992 29.83 ENSRNOT00000019415
interleukin 1 receptor type 2
chr7_-_143497108 29.62 ENSRNOT00000048613
keratin 76
chr1_+_101324652 29.49 ENSRNOT00000028116
histidine rich calcium binding protein
chr12_+_23473270 29.23 ENSRNOT00000001935
SH2B adaptor protein 2
chr1_-_81627710 28.86 ENSRNOT00000071704
CD177 antigen-like
chr8_+_22035256 28.62 ENSRNOT00000028066
intercellular adhesion molecule 1
chr6_-_128149220 28.49 ENSRNOT00000014204
goosecoid homeobox
chr1_-_80594136 28.48 ENSRNOT00000024800
apolipoprotein C2
chr10_-_87928251 28.30 ENSRNOT00000064120
keratin associated protein 17-1
chr6_+_33885495 28.10 ENSRNOT00000086633
syndecan 1
chr8_+_5768811 27.67 ENSRNOT00000013936
matrix metallopeptidase 8
chr8_+_50525091 26.95 ENSRNOT00000074357
apolipoprotein A1
chr2_-_53313884 26.89 ENSRNOT00000046951
growth hormone receptor
chr15_+_30270740 26.84 ENSRNOT00000070991

chr1_+_279798187 26.76 ENSRNOT00000024065
pancreatic lipase
chr17_-_44744902 26.61 ENSRNOT00000085381
histone H4 variant H4-v.1
chr7_+_61236037 26.49 ENSRNOT00000009776
interleukin 22
chr7_+_143122269 26.28 ENSRNOT00000082542
ENSRNOT00000045495
ENSRNOT00000081386
ENSRNOT00000067422
keratin 86
chr4_-_109532234 26.19 ENSRNOT00000008665
regenerating family member 3 gamma
chr10_+_69476775 26.15 ENSRNOT00000031626
chemokine (C-C motif) ligand 12
chr10_-_70744315 25.92 ENSRNOT00000014865
C-C motif chemokine ligand 5
chr7_-_143228060 25.84 ENSRNOT00000088923
ENSRNOT00000012640
keratin 75
chr17_-_43627629 25.75 ENSRNOT00000022965
histone cluster 1, H2af
chr10_-_87954055 25.70 ENSRNOT00000018048
keratin 34
chr5_+_149047681 25.37 ENSRNOT00000015198
lysosomal protein transmembrane 5
chr3_+_149643481 25.31 ENSRNOT00000020713
BPI fold containing family A, member 5
chr10_-_87510629 25.07 ENSRNOT00000084197
keratin associated protein 1-3
chr7_-_143112960 25.00 ENSRNOT00000012845
ENSRNOT00000068748
ENSRNOT00000093507
keratin 81
chr20_+_10438444 24.97 ENSRNOT00000071248
ENSRNOT00000075545
crystallin, alpha A
chr16_+_81616604 24.94 ENSRNOT00000026392
ENSRNOT00000057740
ADP-ribosylhydrolase like 1
growth hormone regulated TBC protein 1
chr3_-_121836086 24.90 ENSRNOT00000006113
interleukin 1 alpha
chr4_+_71675383 24.60 ENSRNOT00000051265
chloride voltage-gated channel 1
chr3_+_19045214 24.60 ENSRNOT00000070878

chr1_+_89008117 24.48 ENSRNOT00000028401
heat shock protein family B (small) member 6
chr9_-_23493081 24.28 ENSRNOT00000072144
Rh-associated glycoprotein
chr10_+_14088319 24.24 ENSRNOT00000019508
ribosomal protein S2
chr16_-_10706073 24.15 ENSRNOT00000089114
family with sequence similarity 25, member A
chr4_-_164406146 24.15 ENSRNOT00000090110
killer cell lectin-like receptor subfamily A, member 22
chr4_+_179481263 23.91 ENSRNOT00000021284
electron transfer flavoprotein regulatory factor 1
chr17_-_43770561 23.88 ENSRNOT00000088408
histone H4 variant H4-v.1
chr20_+_33077106 23.78 ENSRNOT00000000456
vestigial-like family member 2
chr10_-_87521514 23.57 ENSRNOT00000084668
ENSRNOT00000071705
keratin associated protein 2-4-like
chr2_-_198360678 23.30 ENSRNOT00000051917
histone cluster 2 H2A family member c
chr10_+_110138586 23.12 ENSRNOT00000086096
solute carrier family 16 member 3
chr4_-_163570803 23.09 ENSRNOT00000082002
ENSRNOT00000078642
killer cell lectin-like receptor family I member 2
chr1_+_272799784 22.99 ENSRNOT00000016052
insulin 1
chrX_-_23187341 22.73 ENSRNOT00000000180
5'-aminolevulinate synthase 2
chr20_+_5441876 22.68 ENSRNOT00000092476
ribosomal protein S18
chr8_-_66863476 22.55 ENSRNOT00000018820
ribosomal protein lateral stalk subunit P1
chr6_+_26602144 22.40 ENSRNOT00000008037
urocortin
chr11_+_47243342 22.34 ENSRNOT00000041116
NFKB inhibitor zeta
chr1_-_82987253 21.91 ENSRNOT00000051619
CD177 molecule
chr10_-_87195075 21.43 ENSRNOT00000014851
keratin 24
chrX_-_156440461 21.36 ENSRNOT00000083951
ribosomal protein L10
chr15_-_37325178 21.29 ENSRNOT00000011699
gap junction protein, alpha 3
chr5_+_152533349 21.12 ENSRNOT00000067524
tripartite motif containing 63
chr18_+_27424328 20.89 ENSRNOT00000033784
kinesin family member 20A
chr10_-_87517199 20.87 ENSRNOT00000080171
keratin associated protein 1-3-like
chr15_-_29532988 20.75 ENSRNOT00000074782

chr10_-_88000423 20.74 ENSRNOT00000076787
ENSRNOT00000046751
ENSRNOT00000091394
keratin 32
chr4_-_69211671 20.05 ENSRNOT00000017852
preprotrypsinogen IV
chr7_-_143392777 19.92 ENSRNOT00000086504
ENSRNOT00000038105
keratin 72
chr20_+_4855829 19.78 ENSRNOT00000001110
tumor necrosis factor-like
chr14_-_18839420 19.72 ENSRNOT00000034090
chemokine (C-X-C motif) ligand 3
chr10_-_89454681 19.59 ENSRNOT00000028109
BRCA1, DNA repair associated
chr17_-_43689311 19.50 ENSRNOT00000028779
histone cluster 1, H2bc-like 1
chr14_+_22375955 19.46 ENSRNOT00000063915
ENSRNOT00000034784
UDP-glucuronosyltransferase 2 family, member 37
chr2_+_208749996 19.31 ENSRNOT00000086321
chitinase, acidic
chr10_-_87564327 19.29 ENSRNOT00000064760
ENSRNOT00000068237
similar to keratin associated protein 4-7
chr5_-_79691258 19.11 ENSRNOT00000072920
tumor necrosis factor superfamily member 8
chr13_-_47623849 18.51 ENSRNOT00000006106
interleukin 24
chr10_-_87232723 18.32 ENSRNOT00000015150
keratin 25
chr10_-_87535438 18.06 ENSRNOT00000086873
keratin associated protein 2-4
chr10_-_87962846 18.06 ENSRNOT00000018176
keratin 31
chr12_-_23841049 17.97 ENSRNOT00000031555
heat shock protein family B (small) member 1
chr7_-_143453544 17.64 ENSRNOT00000034450
ENSRNOT00000083956
keratin 1
keratin 5
chr1_+_99749936 17.54 ENSRNOT00000025299
kallikrein-related peptidase 7
chr15_+_44441856 17.54 ENSRNOT00000018006
gonadotropin releasing hormone 1
chr3_+_61590376 17.46 ENSRNOT00000002155
homeo box D13
chr15_+_35001838 17.39 ENSRNOT00000038253
mast cell protease 1-like 4
chr1_-_169005190 17.22 ENSRNOT00000043719
hemoglobin subunit epsilon 1
chr3_+_114236718 17.12 ENSRNOT00000024201
dual oxidase maturation factor 2
chr2_+_40000313 17.08 ENSRNOT00000014270
DEP domain containing 1B
chr3_+_79918969 16.93 ENSRNOT00000016306
Spi-1 proto-oncogene
chr9_-_97151832 16.90 ENSRNOT00000040169
ankyrin repeat and SOCS box-containing 18

Network of associatons between targets according to the STRING database.

First level regulatory network of Tbp

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
28.1 140.5 GO:1903237 negative regulation of leukocyte tethering or rolling(GO:1903237)
24.8 74.5 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
23.3 70.0 GO:0002215 defense response to nematode(GO:0002215)
21.5 64.4 GO:0031444 slow-twitch skeletal muscle fiber contraction(GO:0031444)
19.6 117.4 GO:2000332 blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
19.1 76.5 GO:0030240 skeletal muscle thin filament assembly(GO:0030240)
18.4 55.1 GO:0034444 regulation of plasma lipoprotein particle oxidation(GO:0034444) negative regulation of plasma lipoprotein particle oxidation(GO:0034445) multicellular organism lipid catabolic process(GO:0044240)
18.0 71.8 GO:1903576 response to L-arginine(GO:1903576)
16.5 49.6 GO:1902304 positive regulation of potassium ion export(GO:1902304)
16.0 272.3 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
15.9 31.8 GO:0046136 positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
15.8 79.2 GO:0001794 type IIa hypersensitivity(GO:0001794) regulation of type IIa hypersensitivity(GO:0001796) positive regulation of type IIa hypersensitivity(GO:0001798) type II hypersensitivity(GO:0002445) regulation of type II hypersensitivity(GO:0002892) positive regulation of type II hypersensitivity(GO:0002894)
14.9 44.8 GO:2000523 regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
14.5 58.1 GO:0072641 type I interferon secretion(GO:0072641) interferon-alpha secretion(GO:0072642) regulation of interferon-alpha secretion(GO:1902739) positive regulation of interferon-alpha secretion(GO:1902741)
14.2 56.9 GO:0010901 regulation of very-low-density lipoprotein particle remodeling(GO:0010901)
14.1 14.1 GO:0014866 skeletal myofibril assembly(GO:0014866)
14.0 195.7 GO:0015671 oxygen transport(GO:0015671)
13.4 106.9 GO:0016584 nucleosome positioning(GO:0016584)
13.1 39.3 GO:0014916 regulation of lung blood pressure(GO:0014916)
12.4 37.2 GO:0090158 endoplasmic reticulum membrane organization(GO:0090158)
10.3 41.2 GO:0032701 negative regulation of interleukin-18 production(GO:0032701)
10.2 71.2 GO:0071169 establishment of protein localization to chromatin(GO:0071169)
9.9 29.8 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
9.8 29.5 GO:1990036 calcium ion import into sarcoplasmic reticulum(GO:1990036)
9.8 98.0 GO:0033275 actin-myosin filament sliding(GO:0033275)
9.5 28.5 GO:0010916 regulation of very-low-density lipoprotein particle clearance(GO:0010915) negative regulation of very-low-density lipoprotein particle clearance(GO:0010916) positive regulation of phospholipid catabolic process(GO:0060697)
9.1 36.5 GO:0014873 response to muscle activity involved in regulation of muscle adaptation(GO:0014873)
8.7 43.4 GO:0002439 chronic inflammatory response to antigenic stimulus(GO:0002439)
8.4 33.5 GO:0021571 rhombomere 5 development(GO:0021571)
8.4 33.4 GO:1903413 negative regulation of iron ion transmembrane transport(GO:0034760) cellular response to bile acid(GO:1903413)
8.3 24.9 GO:1904444 regulation of establishment of Sertoli cell barrier(GO:1904444)
8.3 24.8 GO:0002149 hypochlorous acid metabolic process(GO:0002148) hypochlorous acid biosynthetic process(GO:0002149)
8.1 56.8 GO:0015669 gas transport(GO:0015669) carbon dioxide transport(GO:0015670)
8.0 32.1 GO:2000304 positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304)
7.9 39.6 GO:0010886 positive regulation of cholesterol storage(GO:0010886)
7.7 69.1 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
7.5 15.1 GO:0098528 skeletal muscle fiber differentiation(GO:0098528)
7.5 22.4 GO:0035483 gastric emptying(GO:0035483)
7.2 28.6 GO:0046813 receptor-mediated virion attachment to host cell(GO:0046813)
7.0 28.1 GO:1903553 positive regulation of extracellular exosome assembly(GO:1903553)
6.9 34.7 GO:0006030 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
6.9 96.4 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
6.8 54.4 GO:0002002 regulation of angiotensin levels in blood(GO:0002002)
6.5 19.6 GO:2000620 positive regulation of histone H4-K16 acetylation(GO:2000620)
6.5 25.9 GO:0042531 CD8-positive, alpha-beta T cell extravasation(GO:0035697) regulation of tyrosine phosphorylation of STAT protein(GO:0042509) positive regulation of tyrosine phosphorylation of STAT protein(GO:0042531) diapedesis(GO:0050904) cellular response to vitamin K(GO:0071307)
6.4 76.4 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
6.3 44.0 GO:0009804 coumarin metabolic process(GO:0009804)
6.2 87.4 GO:0006335 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
6.2 24.9 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
6.0 18.0 GO:0071348 cellular response to interleukin-11(GO:0071348) response to butyrate(GO:1903544)
5.8 17.5 GO:0002803 positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antibacterial peptide production(GO:0002803)
5.7 34.5 GO:0061737 leukotriene signaling pathway(GO:0061737)
5.7 22.7 GO:1901423 response to benzene(GO:1901423)
5.6 16.9 GO:0045347 negative regulation of MHC class II biosynthetic process(GO:0045347)
5.3 21.1 GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878)
5.3 15.8 GO:2000645 negative regulation of receptor catabolic process(GO:2000645)
5.0 15.0 GO:1903860 negative regulation of dendrite extension(GO:1903860)
5.0 5.0 GO:2000229 pancreatic stellate cell proliferation(GO:0072343) regulation of pancreatic stellate cell proliferation(GO:2000229)
5.0 25.0 GO:0070309 lens fiber cell morphogenesis(GO:0070309)
5.0 29.9 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
4.9 14.7 GO:0048319 axial mesoderm morphogenesis(GO:0048319)
4.9 9.8 GO:0009644 response to high light intensity(GO:0009644)
4.8 57.4 GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213)
4.7 113.3 GO:0030574 collagen catabolic process(GO:0030574)
4.7 42.4 GO:0060346 bone trabecula formation(GO:0060346)
4.7 14.1 GO:1904383 response to sodium phosphate(GO:1904383) response to putrescine(GO:1904585) cellular response to putrescine(GO:1904586)
4.6 13.7 GO:0006407 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000448) rRNA export from nucleus(GO:0006407)
4.5 13.6 GO:1902544 regulation of DNA N-glycosylase activity(GO:1902544)
4.5 22.5 GO:1904401 cellular response to Thyroid stimulating hormone(GO:1904401)
4.5 26.8 GO:0061365 positive regulation of triglyceride lipase activity(GO:0061365)
4.4 53.1 GO:0043587 tongue morphogenesis(GO:0043587)
4.4 13.1 GO:0006738 nicotinamide riboside catabolic process(GO:0006738) urate biosynthetic process(GO:0034418) nicotinamide riboside metabolic process(GO:0046495) pyridine nucleoside metabolic process(GO:0070637) pyridine nucleoside catabolic process(GO:0070638)
4.2 8.5 GO:0038189 neuropilin signaling pathway(GO:0038189) VEGF-activated neuropilin signaling pathway(GO:0038190)
4.2 37.9 GO:0000050 urea cycle(GO:0000050)
4.2 29.2 GO:0001922 B-1 B cell homeostasis(GO:0001922)
4.1 49.7 GO:0072378 blood coagulation, fibrin clot formation(GO:0072378) negative regulation of platelet aggregation(GO:0090331)
4.1 24.8 GO:0071314 cellular response to cocaine(GO:0071314)
4.1 45.2 GO:0051798 positive regulation of hair follicle development(GO:0051798)
4.1 12.2 GO:0061470 astrocyte chemotaxis(GO:0035700) T follicular helper cell differentiation(GO:0061470) regulation of astrocyte chemotaxis(GO:2000458)
4.0 12.0 GO:1904528 positive regulation of microtubule binding(GO:1904528)
3.9 270.2 GO:0006334 nucleosome assembly(GO:0006334)
3.7 26.2 GO:0045617 negative regulation of keratinocyte differentiation(GO:0045617)
3.7 14.6 GO:1900147 Schwann cell migration(GO:0036135) regulation of Schwann cell migration(GO:1900147)
3.6 309.4 GO:0006342 chromatin silencing(GO:0006342)
3.6 14.3 GO:0034124 regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124)
3.5 35.4 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
3.5 17.5 GO:0048619 embryonic hindgut morphogenesis(GO:0048619)
3.4 16.8 GO:0097070 ductus arteriosus closure(GO:0097070)
3.4 10.1 GO:0016103 diterpenoid catabolic process(GO:0016103) retinoic acid catabolic process(GO:0034653)
3.3 23.1 GO:0035879 plasma membrane lactate transport(GO:0035879)
3.3 19.8 GO:0097527 necroptotic signaling pathway(GO:0097527)
3.3 13.2 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
3.2 9.6 GO:1902268 negative regulation of polyamine transmembrane transport(GO:1902268)
3.2 35.1 GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619)
3.1 9.3 GO:1902949 regulation of neuronal signal transduction(GO:1902847) positive regulation of tau-protein kinase activity(GO:1902949) neurofibrillary tangle assembly(GO:1902988) regulation of neurofibrillary tangle assembly(GO:1902996) positive regulation of neurofibrillary tangle assembly(GO:1902998)
3.0 39.1 GO:0007076 mitotic chromosome condensation(GO:0007076)
3.0 26.9 GO:0000255 allantoin metabolic process(GO:0000255) isoleucine metabolic process(GO:0006549) creatine metabolic process(GO:0006600) creatinine metabolic process(GO:0046449)
3.0 11.9 GO:0002930 trabecular meshwork development(GO:0002930)
2.9 17.5 GO:2000354 regulation of ovarian follicle development(GO:2000354)
2.9 17.1 GO:2000609 regulation of thyroid hormone generation(GO:2000609)
2.8 8.3 GO:0042222 interleukin-1 biosynthetic process(GO:0042222)
2.7 10.7 GO:0014043 negative regulation of neuron maturation(GO:0014043)
2.7 8.0 GO:1900111 regulation of histone H3-K9 dimethylation(GO:1900109) positive regulation of histone H3-K9 dimethylation(GO:1900111)
2.6 89.8 GO:0071353 cellular response to interleukin-4(GO:0071353)
2.6 28.5 GO:0014029 neural crest formation(GO:0014029)
2.5 30.4 GO:0044130 negative regulation of growth of symbiont in host(GO:0044130) negative regulation of growth of symbiont involved in interaction with host(GO:0044146)
2.5 10.1 GO:0035519 regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994) protein K29-linked ubiquitination(GO:0035519)
2.5 72.9 GO:0090023 positive regulation of neutrophil chemotaxis(GO:0090023)
2.5 30.1 GO:0051151 negative regulation of smooth muscle cell differentiation(GO:0051151)
2.4 7.3 GO:1900195 spindle assembly involved in female meiosis(GO:0007056) positive regulation of oocyte maturation(GO:1900195)
2.4 43.3 GO:0050872 white fat cell differentiation(GO:0050872)
2.4 16.6 GO:0060591 chondroblast differentiation(GO:0060591)
2.3 43.7 GO:0071243 cellular response to arsenic-containing substance(GO:0071243)
2.3 6.9 GO:0071469 cellular response to alkaline pH(GO:0071469)
2.3 27.3 GO:0048245 eosinophil chemotaxis(GO:0048245)
2.2 91.2 GO:0003009 skeletal muscle contraction(GO:0003009)
2.2 15.1 GO:0000103 sulfate assimilation(GO:0000103)
2.1 6.4 GO:0021524 visceral motor neuron differentiation(GO:0021524)
2.1 29.6 GO:0048733 sebaceous gland development(GO:0048733)
2.1 4.2 GO:1903116 positive regulation of actin filament-based movement(GO:1903116)
2.1 4.2 GO:0070447 positive regulation of oligodendrocyte progenitor proliferation(GO:0070447)
2.1 6.2 GO:0006579 amino-acid betaine catabolic process(GO:0006579)
2.0 56.4 GO:0002026 regulation of the force of heart contraction(GO:0002026)
2.0 53.0 GO:0030225 macrophage differentiation(GO:0030225)
1.9 3.8 GO:0032747 positive regulation of interleukin-23 production(GO:0032747)
1.9 24.6 GO:0098870 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
1.9 11.2 GO:0006729 tetrahydrobiopterin biosynthetic process(GO:0006729) pteridine-containing compound biosynthetic process(GO:0042559)
1.9 5.6 GO:0070666 negative regulation of mast cell apoptotic process(GO:0033026) mast cell proliferation(GO:0070662) regulation of mast cell proliferation(GO:0070666) positive regulation of mast cell proliferation(GO:0070668)
1.8 5.3 GO:0002397 MHC class I protein complex assembly(GO:0002397)
1.7 19.1 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
1.7 6.7 GO:0044691 tooth eruption(GO:0044691)
1.7 30.1 GO:0001833 inner cell mass cell proliferation(GO:0001833)
1.7 11.6 GO:0030223 neutrophil differentiation(GO:0030223)
1.6 83.6 GO:0042398 cellular modified amino acid biosynthetic process(GO:0042398)
1.6 67.8 GO:0018149 peptide cross-linking(GO:0018149)
1.5 15.4 GO:0018298 protein-chromophore linkage(GO:0018298)
1.5 20.9 GO:0000920 cell separation after cytokinesis(GO:0000920)
1.5 5.9 GO:1901318 negative regulation of sperm motility(GO:1901318)
1.5 11.7 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
1.4 4.3 GO:0019064 fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800)
1.4 5.5 GO:0070858 negative regulation of bile acid biosynthetic process(GO:0070858) negative regulation of bile acid metabolic process(GO:1904252)
1.3 106.6 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
1.3 14.2 GO:0014807 regulation of somitogenesis(GO:0014807)
1.3 12.7 GO:2000035 regulation of stem cell division(GO:2000035)
1.3 15.2 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
1.2 3.7 GO:0061056 deltoid tuberosity development(GO:0035993) sclerotome development(GO:0061056)
1.2 8.3 GO:0043031 negative regulation of macrophage activation(GO:0043031)
1.2 10.5 GO:0032277 negative regulation of gonadotropin secretion(GO:0032277)
1.1 12.4 GO:0046784 viral mRNA export from host cell nucleus(GO:0046784)
1.1 3.2 GO:1902047 polyamine transmembrane transport(GO:1902047) regulation of polyamine transmembrane transport(GO:1902267) positive regulation of polyamine transmembrane transport(GO:1902269)
1.0 1.0 GO:0090191 negative regulation of branching involved in ureteric bud morphogenesis(GO:0090191)
1.0 26.8 GO:0010831 positive regulation of myotube differentiation(GO:0010831)
1.0 58.9 GO:0061077 chaperone-mediated protein folding(GO:0061077)
0.9 14.7 GO:0034587 piRNA metabolic process(GO:0034587)
0.9 3.5 GO:0010992 ubiquitin homeostasis(GO:0010992)
0.9 6.0 GO:0000711 meiotic DNA repair synthesis(GO:0000711)
0.8 32.0 GO:0001937 negative regulation of endothelial cell proliferation(GO:0001937)
0.8 18.3 GO:0031069 hair follicle morphogenesis(GO:0031069)
0.8 21.4 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.8 37.6 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.7 9.7 GO:0006880 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.6 25.1 GO:0050829 defense response to Gram-negative bacterium(GO:0050829)
0.6 4.3 GO:0060136 embryonic process involved in female pregnancy(GO:0060136)
0.6 2.9 GO:0072014 proximal tubule development(GO:0072014)
0.6 4.0 GO:1904628 response to phorbol 13-acetate 12-myristate(GO:1904627) cellular response to phorbol 13-acetate 12-myristate(GO:1904628)
0.6 11.3 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
0.6 15.1 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.5 4.9 GO:0031424 keratinization(GO:0031424)
0.5 6.4 GO:0032025 response to cobalt ion(GO:0032025)
0.5 1.6 GO:0003219 cardiac right ventricle formation(GO:0003219)
0.5 10.0 GO:0072606 interleukin-8 secretion(GO:0072606)
0.5 19.0 GO:0006182 cGMP biosynthetic process(GO:0006182)
0.5 10.4 GO:0044381 glucose import in response to insulin stimulus(GO:0044381)
0.5 21.3 GO:0009268 response to pH(GO:0009268)
0.4 2.7 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.4 4.0 GO:2000344 positive regulation of acrosome reaction(GO:2000344)
0.4 16.2 GO:0033189 response to vitamin A(GO:0033189)
0.4 8.7 GO:0030851 granulocyte differentiation(GO:0030851)
0.4 42.6 GO:0060048 cardiac muscle contraction(GO:0060048)
0.4 3.8 GO:2000210 positive regulation of anoikis(GO:2000210)
0.4 7.8 GO:0006415 translational termination(GO:0006415)
0.4 40.7 GO:0007586 digestion(GO:0007586)
0.4 8.6 GO:0006450 regulation of translational fidelity(GO:0006450)
0.3 1.0 GO:1904350 regulation of protein catabolic process in the vacuole(GO:1904350)
0.3 2.4 GO:0048739 elastic fiber assembly(GO:0048251) cardiac muscle fiber development(GO:0048739)
0.3 1.3 GO:0021526 medial motor column neuron differentiation(GO:0021526)
0.3 6.5 GO:0030903 notochord development(GO:0030903)
0.3 13.7 GO:2000242 negative regulation of reproductive process(GO:2000242)
0.3 3.2 GO:2000018 regulation of male gonad development(GO:2000018)
0.3 9.1 GO:0006270 DNA replication initiation(GO:0006270)
0.3 12.3 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.3 78.5 GO:0016485 protein processing(GO:0016485)
0.3 14.5 GO:0022904 respiratory electron transport chain(GO:0022904)
0.3 3.3 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.3 14.1 GO:0030500 regulation of bone mineralization(GO:0030500)
0.2 12.1 GO:0016525 negative regulation of angiogenesis(GO:0016525) negative regulation of vasculature development(GO:1901343) negative regulation of blood vessel morphogenesis(GO:2000181)
0.2 15.0 GO:0032465 regulation of cytokinesis(GO:0032465)
0.2 7.7 GO:0006414 translational elongation(GO:0006414)
0.2 27.3 GO:0002244 hematopoietic progenitor cell differentiation(GO:0002244)
0.2 24.7 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123)
0.2 1.5 GO:0019430 removal of superoxide radicals(GO:0019430)
0.2 9.4 GO:0042303 molting cycle(GO:0042303) hair cycle(GO:0042633)
0.1 16.8 GO:0043484 regulation of RNA splicing(GO:0043484)
0.1 5.5 GO:0042733 embryonic digit morphogenesis(GO:0042733)
0.1 0.7 GO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071)
0.1 0.6 GO:1903593 regulation of histamine secretion by mast cell(GO:1903593)
0.1 22.7 GO:0042254 ribosome biogenesis(GO:0042254)
0.1 8.6 GO:0017158 regulation of calcium ion-dependent exocytosis(GO:0017158)
0.1 1.3 GO:0007339 binding of sperm to zona pellucida(GO:0007339)
0.1 0.4 GO:0006102 isocitrate metabolic process(GO:0006102)
0.1 1.4 GO:0060043 regulation of cardiac muscle cell proliferation(GO:0060043)
0.1 2.1 GO:0097502 mannosylation(GO:0097502)
0.1 6.0 GO:0007093 mitotic cell cycle checkpoint(GO:0007093)
0.1 1.6 GO:0030318 melanocyte differentiation(GO:0030318)
0.1 3.9 GO:1903955 positive regulation of establishment of protein localization to mitochondrion(GO:1903749) positive regulation of protein targeting to mitochondrion(GO:1903955)
0.0 1.1 GO:0018345 protein palmitoylation(GO:0018345)
0.0 3.9 GO:0042742 defense response to bacterium(GO:0042742)
0.0 0.6 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 2.4 GO:0007229 integrin-mediated signaling pathway(GO:0007229)
0.0 1.2 GO:0002088 lens development in camera-type eye(GO:0002088)
0.0 12.0 GO:0006412 translation(GO:0006412)
0.0 0.1 GO:0046687 response to chromate(GO:0046687)
0.0 2.2 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 0.4 GO:0050912 detection of chemical stimulus involved in sensory perception of taste(GO:0050912)
0.0 0.7 GO:0030177 positive regulation of Wnt signaling pathway(GO:0030177)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
17.8 195.7 GO:0005833 hemoglobin complex(GO:0005833)
16.8 252.1 GO:0032982 myosin filament(GO:0032982)
13.9 180.1 GO:0042627 chylomicron(GO:0042627)
13.5 40.5 GO:0097124 cyclin A2-CDK2 complex(GO:0097124)
12.6 37.9 GO:0036488 CHOP-C/EBP complex(GO:0036488)
12.4 37.2 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
11.7 327.4 GO:0000788 nuclear nucleosome(GO:0000788)
11.6 808.8 GO:0000786 nucleosome(GO:0000786)
9.1 686.0 GO:0045095 keratin filament(GO:0045095)
8.9 35.6 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
6.8 33.8 GO:0070195 growth hormone receptor complex(GO:0070195)
6.2 49.7 GO:0005577 fibrinogen complex(GO:0005577)
5.0 80.0 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
4.9 19.6 GO:0031436 BRCA1-BARD1 complex(GO:0031436)
4.4 17.5 GO:1990005 granular vesicle(GO:1990005)
3.9 11.6 GO:1990590 ATF1-ATF4 transcription factor complex(GO:1990590)
3.7 33.4 GO:0045179 apical cortex(GO:0045179)
3.5 109.7 GO:0042588 zymogen granule(GO:0042588)
2.9 17.5 GO:0097209 epidermal lamellar body(GO:0097209)
2.8 14.1 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
2.6 7.7 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
2.5 10.0 GO:0045098 type III intermediate filament(GO:0045098)
2.5 14.7 GO:0071547 piP-body(GO:0071547)
2.3 112.7 GO:0016459 myosin complex(GO:0016459)
2.2 18.0 GO:0097512 cardiac myofibril(GO:0097512)
2.1 51.4 GO:0001533 cornified envelope(GO:0001533)
2.1 15.0 GO:0005827 polar microtubule(GO:0005827)
2.0 20.2 GO:0032593 insulin-responsive compartment(GO:0032593)
2.0 13.7 GO:0001652 granular component(GO:0001652)
1.9 9.3 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
1.8 7.3 GO:0042585 germinal vesicle(GO:0042585)
1.7 22.4 GO:0043196 varicosity(GO:0043196)
1.7 12.0 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
1.6 15.8 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
1.6 113.2 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
1.5 33.4 GO:0010369 chromocenter(GO:0010369)
1.5 6.0 GO:0070876 SOSS complex(GO:0070876)
1.4 120.5 GO:0042641 actomyosin(GO:0042641)
1.3 5.3 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
1.1 28.5 GO:0042629 mast cell granule(GO:0042629)
1.1 8.5 GO:0097443 sorting endosome(GO:0097443)
1.0 21.3 GO:0005922 connexon complex(GO:0005922)
0.9 14.0 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.8 32.2 GO:0000791 euchromatin(GO:0000791)
0.8 29.7 GO:0001772 immunological synapse(GO:0001772)
0.8 13.9 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.8 7.1 GO:0036057 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.8 3.8 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.7 29.8 GO:0031672 A band(GO:0031672)
0.7 76.2 GO:0005901 caveola(GO:0005901)
0.7 37.7 GO:0009925 basal plasma membrane(GO:0009925)
0.7 12.1 GO:0031091 platelet alpha granule(GO:0031091)
0.7 2.7 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
0.7 16.4 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.6 12.4 GO:0000346 transcription export complex(GO:0000346)
0.6 15.2 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.6 53.3 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.6 40.1 GO:0005811 lipid particle(GO:0005811)
0.6 794.5 GO:0005615 extracellular space(GO:0005615)
0.5 6.0 GO:0000801 central element(GO:0000801)
0.5 54.7 GO:0016605 PML body(GO:0016605)
0.5 10.7 GO:0005680 anaphase-promoting complex(GO:0005680)
0.5 24.8 GO:0005876 spindle microtubule(GO:0005876)
0.5 10.2 GO:0005640 nuclear outer membrane(GO:0005640)
0.4 24.6 GO:0034707 chloride channel complex(GO:0034707)
0.4 20.9 GO:0005871 kinesin complex(GO:0005871)
0.3 0.7 GO:1990037 Lewy body core(GO:1990037)
0.3 4.3 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233) anchored component of external side of plasma membrane(GO:0031362)
0.2 8.6 GO:0016235 aggresome(GO:0016235)
0.2 18.1 GO:0001750 photoreceptor outer segment(GO:0001750)
0.2 2.6 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.2 44.8 GO:0009897 external side of plasma membrane(GO:0009897)
0.2 9.1 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.2 21.2 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.2 59.1 GO:0031965 nuclear membrane(GO:0031965)
0.2 4.2 GO:0034706 sodium channel complex(GO:0034706)
0.2 23.8 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.2 15.3 GO:0000922 spindle pole(GO:0000922)
0.1 7.0 GO:0031594 neuromuscular junction(GO:0031594)
0.1 26.8 GO:0010008 endosome membrane(GO:0010008)
0.1 10.3 GO:0030658 transport vesicle membrane(GO:0030658)
0.1 5.0 GO:0032592 integral component of mitochondrial membrane(GO:0032592)
0.1 30.2 GO:0016604 nuclear body(GO:0016604)
0.0 14.4 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 1.3 GO:0036126 sperm flagellum(GO:0036126)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
24.3 72.9 GO:0031735 CCR10 chemokine receptor binding(GO:0031735)
23.5 117.4 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
19.9 59.7 GO:0050253 retinyl-palmitate esterase activity(GO:0050253)
19.5 58.4 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
17.4 52.1 GO:0031721 hemoglobin alpha binding(GO:0031721)
17.3 207.9 GO:0005344 oxygen transporter activity(GO:0005344)
14.5 43.6 GO:0031714 C5a anaphylatoxin chemotactic receptor binding(GO:0031714)
13.7 82.1 GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
13.0 77.7 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
12.4 86.8 GO:0004111 creatine kinase activity(GO:0004111)
9.8 58.8 GO:0042289 MHC class II protein binding(GO:0042289)
9.6 38.4 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
9.5 47.6 GO:0032564 dATP binding(GO:0032564)
8.7 26.2 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
8.2 180.5 GO:0000146 microfilament motor activity(GO:0000146)
7.9 39.6 GO:0035473 lipase binding(GO:0035473)
7.6 22.7 GO:0016748 succinyltransferase activity(GO:0016748)
7.5 30.1 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
7.5 29.9 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
7.5 44.7 GO:0004568 chitinase activity(GO:0004568)
6.7 26.9 GO:0004903 growth hormone receptor activity(GO:0004903)
6.0 48.4 GO:0016151 nickel cation binding(GO:0016151)
5.6 39.3 GO:0019238 cyclohydrolase activity(GO:0019238)
5.6 72.9 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
5.6 22.4 GO:0051431 corticotropin-releasing hormone receptor 2 binding(GO:0051431)
5.6 150.4 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
5.5 38.2 GO:0050786 RAGE receptor binding(GO:0050786)
5.3 69.1 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
5.2 25.9 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
5.0 15.1 GO:0004779 adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781)
4.9 14.7 GO:0070698 type I activin receptor binding(GO:0070698)
4.5 44.8 GO:0019957 C-C chemokine binding(GO:0019957)
4.4 13.1 GO:0002060 purine nucleobase binding(GO:0002060) purine-nucleoside phosphorylase activity(GO:0004731)
4.3 30.1 GO:0035375 zymogen binding(GO:0035375)
4.2 12.7 GO:0008263 pyrimidine-specific mismatch base pair DNA N-glycosylase activity(GO:0008263)
4.2 37.9 GO:0001013 RNA polymerase I regulatory region DNA binding(GO:0001013)
4.1 12.2 GO:0008142 oxysterol binding(GO:0008142)
4.0 43.7 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
3.8 79.4 GO:0051428 peptide hormone receptor binding(GO:0051428)
3.7 29.8 GO:0004908 interleukin-1 receptor activity(GO:0004908)
3.7 14.7 GO:0034584 piRNA binding(GO:0034584)
3.7 29.2 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
3.4 10.1 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
3.3 16.4 GO:0030280 structural constituent of epidermis(GO:0030280)
3.3 16.3 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
3.2 9.6 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
3.2 56.7 GO:0005149 interleukin-1 receptor binding(GO:0005149)
3.2 15.8 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
3.0 66.8 GO:0005212 structural constituent of eye lens(GO:0005212)
3.0 24.3 GO:0022842 leak channel activity(GO:0022840) narrow pore channel activity(GO:0022842)
3.0 35.6 GO:0034987 immunoglobulin receptor binding(GO:0034987)
2.9 23.1 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
2.7 76.4 GO:0008395 steroid hydroxylase activity(GO:0008395)
2.7 80.0 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
2.5 74.5 GO:0003785 actin monomer binding(GO:0003785)
2.4 16.8 GO:0004957 prostaglandin E receptor activity(GO:0004957)
2.2 6.5 GO:0004655 porphobilinogen synthase activity(GO:0004655)
2.1 481.8 GO:0004252 serine-type endopeptidase activity(GO:0004252)
2.1 16.9 GO:0051525 NFAT protein binding(GO:0051525)
2.1 14.6 GO:0008061 chitin binding(GO:0008061)
2.0 408.6 GO:0042393 histone binding(GO:0042393)
2.0 14.1 GO:0003680 AT DNA binding(GO:0003680)
1.7 70.8 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
1.7 6.9 GO:0005131 growth hormone receptor binding(GO:0005131)
1.7 15.4 GO:0009881 photoreceptor activity(GO:0009881)
1.7 184.1 GO:0031490 chromatin DNA binding(GO:0031490)
1.6 21.3 GO:0005243 gap junction channel activity(GO:0005243)
1.4 4.3 GO:0033906 hyaluronoglucuronidase activity(GO:0033906)
1.4 7.1 GO:0031404 chloride ion binding(GO:0031404)
1.4 25.4 GO:0004806 triglyceride lipase activity(GO:0004806)
1.3 8.0 GO:1990226 histone methyltransferase binding(GO:1990226)
1.3 23.5 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
1.3 24.6 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
1.2 32.1 GO:0005520 insulin-like growth factor binding(GO:0005520)
1.2 14.6 GO:0008097 5S rRNA binding(GO:0008097)
1.2 5.9 GO:0004668 protein-arginine deiminase activity(GO:0004668)
1.2 10.4 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
1.1 25.9 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds(GO:0016799)
1.1 14.1 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
1.1 3.2 GO:0042979 ornithine decarboxylase activator activity(GO:0042978) ornithine decarboxylase regulator activity(GO:0042979)
1.1 8.5 GO:0038085 vascular endothelial growth factor-activated receptor activity(GO:0005021) vascular endothelial growth factor binding(GO:0038085)
1.1 28.5 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
1.0 45.0 GO:0005504 fatty acid binding(GO:0005504)
1.0 5.2 GO:1990459 transferrin receptor binding(GO:1990459)
1.0 32.2 GO:0097472 cyclin-dependent protein kinase activity(GO:0097472)
1.0 58.0 GO:0001786 phosphatidylserine binding(GO:0001786)
1.0 13.2 GO:0003796 lysozyme activity(GO:0003796)
1.0 2.9 GO:0035939 microsatellite binding(GO:0035939)
1.0 34.5 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.9 26.3 GO:0050840 extracellular matrix binding(GO:0050840)
0.9 24.2 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.9 32.5 GO:0051879 Hsp90 protein binding(GO:0051879)
0.8 113.7 GO:0008201 heparin binding(GO:0008201)
0.8 5.6 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.8 6.2 GO:0008172 S-methyltransferase activity(GO:0008172)
0.8 48.3 GO:0005518 collagen binding(GO:0005518)
0.7 49.7 GO:0017022 myosin binding(GO:0017022)
0.7 6.5 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.7 23.0 GO:0005158 insulin receptor binding(GO:0005158)
0.7 9.3 GO:0051787 misfolded protein binding(GO:0051787)
0.7 7.8 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.7 57.2 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.7 91.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.7 2.1 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.7 16.4 GO:0004383 guanylate cyclase activity(GO:0004383)
0.7 2.7 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656)
0.7 5.2 GO:0043522 leucine zipper domain binding(GO:0043522)
0.7 3.3 GO:0001968 fibronectin binding(GO:0001968)
0.6 11.3 GO:0005537 mannose binding(GO:0005537)
0.6 19.5 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.6 33.5 GO:0019838 growth factor binding(GO:0019838)
0.6 419.0 GO:0005198 structural molecule activity(GO:0005198)
0.6 281.5 GO:0046982 protein heterodimerization activity(GO:0046982)
0.6 2.3 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.6 106.8 GO:0019902 phosphatase binding(GO:0019902)
0.6 14.3 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.6 12.0 GO:0051010 microtubule plus-end binding(GO:0051010)
0.6 9.1 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.5 2.7 GO:0010853 cyclase activator activity(GO:0010853) guanylate cyclase activator activity(GO:0030250)
0.5 8.3 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.4 10.7 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.4 3.6 GO:0031432 titin binding(GO:0031432)
0.4 19.6 GO:0003684 damaged DNA binding(GO:0003684)
0.4 11.2 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.4 4.0 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.4 12.1 GO:0042605 peptide antigen binding(GO:0042605)
0.4 7.7 GO:0003746 translation elongation factor activity(GO:0003746)
0.3 10.1 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.3 29.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.3 62.6 GO:0000982 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982)
0.3 6.7 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.3 19.8 GO:0051117 ATPase binding(GO:0051117)
0.2 5.3 GO:0050681 androgen receptor binding(GO:0050681)
0.2 10.5 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.2 18.4 GO:0003697 single-stranded DNA binding(GO:0003697)
0.2 0.4 GO:0051538 3 iron, 4 sulfur cluster binding(GO:0051538)
0.2 12.7 GO:0004896 cytokine receptor activity(GO:0004896)
0.2 10.2 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors(GO:0016627)
0.1 27.7 GO:0008017 microtubule binding(GO:0008017)
0.1 4.2 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.1 6.4 GO:0005496 steroid binding(GO:0005496)
0.1 1.6 GO:0030742 GTP-dependent protein binding(GO:0030742)
0.1 23.5 GO:0005525 GTP binding(GO:0005525)
0.1 0.6 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 2.2 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 3.1 GO:0051219 phosphoprotein binding(GO:0051219)
0.0 1.1 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 13.3 GO:0005549 odorant binding(GO:0005549)
0.0 3.8 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)
0.0 11.1 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 0.4 GO:0008527 taste receptor activity(GO:0008527)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
5.0 154.0 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
3.2 77.7 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
2.9 49.6 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
2.8 50.9 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
2.8 112.4 NABA PROTEOGLYCANS Genes encoding proteoglycans
2.6 36.6 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
2.5 170.1 PID RB 1PATHWAY Regulation of retinoblastoma protein
2.1 68.0 ST P38 MAPK PATHWAY p38 MAPK Pathway
1.9 85.9 PID HNF3A PATHWAY FOXA1 transcription factor network
1.9 28.1 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
1.8 53.0 PID IL1 PATHWAY IL1-mediated signaling events
1.3 47.1 PID IL23 PATHWAY IL23-mediated signaling events
1.1 77.9 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
1.1 49.3 PID AURORA B PATHWAY Aurora B signaling
1.0 29.1 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.9 19.3 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.8 5.0 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.8 14.8 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.8 39.0 PID INSULIN PATHWAY Insulin Pathway
0.8 8.5 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.7 17.5 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling
0.6 143.9 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.6 12.5 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.6 16.2 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.6 165.4 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.5 18.4 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.5 9.6 PID AURORA A PATHWAY Aurora A signaling
0.5 13.2 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.5 57.4 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.5 12.0 PID NCADHERIN PATHWAY N-cadherin signaling events
0.5 34.5 PID CXCR4 PATHWAY CXCR4-mediated signaling events
0.5 14.3 PID ATM PATHWAY ATM pathway
0.5 13.9 PID RAS PATHWAY Regulation of Ras family activation
0.5 10.4 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.5 17.6 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.3 14.3 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.3 2.2 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.2 4.2 PID EPHB FWD PATHWAY EPHB forward signaling
0.2 4.7 PID AP1 PATHWAY AP-1 transcription factor network
0.2 5.2 PID RHOA PATHWAY RhoA signaling pathway
0.2 6.5 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.2 3.8 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.1 3.0 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.1 2.2 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 2.3 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 7.5 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
14.8 162.3 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
12.4 322.6 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
9.7 378.7 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
9.0 153.1 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
5.8 52.2 REACTOME DEFENSINS Genes involved in Defensins
4.7 223.5 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
4.0 32.1 REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
3.4 43.6 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
3.3 49.7 REACTOME COMMON PATHWAY Genes involved in Common Pathway
3.0 32.5 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
2.8 41.9 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
2.7 33.0 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
2.7 40.6 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
2.6 71.0 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
2.3 32.9 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
2.2 35.7 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
2.0 153.7 REACTOME ANTIGEN PROCESSING CROSS PRESENTATION Genes involved in Antigen processing-Cross presentation
2.0 47.0 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
1.9 26.9 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
1.9 15.4 REACTOME OPSINS Genes involved in Opsins
1.8 12.8 REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
1.8 49.6 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
1.7 29.2 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
1.7 23.5 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
1.7 23.1 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
1.6 67.8 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
1.6 14.3 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
1.5 82.3 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
1.5 34.8 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
1.5 26.8 REACTOME LIPID DIGESTION MOBILIZATION AND TRANSPORT Genes involved in Lipid digestion, mobilization, and transport
1.5 36.6 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
1.4 9.8 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
1.3 13.1 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
1.2 21.3 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
1.2 15.1 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
1.1 9.1 REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21 Genes involved in SCF(Skp2)-mediated degradation of p27/p21
1.0 14.7 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.9 58.5 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.9 14.1 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.9 19.6 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.9 12.2 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.7 14.7 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.7 29.7 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.7 20.9 REACTOME KINESINS Genes involved in Kinesins
0.6 10.4 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.5 5.2 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.5 14.8 REACTOME NUCLEAR SIGNALING BY ERBB4 Genes involved in Nuclear signaling by ERBB4
0.5 6.5 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.4 7.8 REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.4 12.7 REACTOME PLATELET AGGREGATION PLUG FORMATION Genes involved in Platelet Aggregation (Plug Formation)
0.4 10.1 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.3 7.7 REACTOME TRANSLATION Genes involved in Translation
0.2 4.3 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.2 6.4 REACTOME NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION Genes involved in Nuclear Events (kinase and transcription factor activation)
0.2 12.0 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.2 6.5 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.2 5.0 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.2 2.4 REACTOME MUSCLE CONTRACTION Genes involved in Muscle contraction
0.1 24.1 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 4.7 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 3.6 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.7 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4
0.0 0.4 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 1.3 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+