ISMARA results: Spic

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Spic

Z-value: 2.54

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Transcription factors associated with Spic

Gene Symbol	Gene ID	Gene Info
Spic NCBI RGD Ensembl	ENSRNOG00000005720	Spi-C transcription factor

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Spic	rn6_v1_chr7_-_29233392_29233392	0.86	1.2e-94	Click!

Activity profile of Spic motif

Sorted Z-values of Spic motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr1_-_98521551 Show fit	103.34	ENSRNOT00000081922	Siglec10 NCBI RGD Ensembl Show fit	sialic acid binding Ig-like lectin 10
chrX_+_78196300 Show fit	101.44	ENSRNOT00000048695	P2ry10 NCBI RGD Ensembl Show fit	purinergic receptor P2Y10
chr5_-_155258392 Show fit	100.17	ENSRNOT00000017065	C1qc NCBI RGD Ensembl Show fit	complement C1q C chain
chr3_+_16610086 Show fit	98.34	ENSRNOT00000046231	LOC100361009 NCBI RGD Ensembl Show fit	rCG64257-like
chr5_+_149047681 Show fit	85.94	ENSRNOT00000015198	Laptm5 NCBI RGD Ensembl Show fit	lysosomal protein transmembrane 5
chr3_+_19045214 Show fit	82.01	ENSRNOT00000070878	AABR07051670.1 NCBI RGD Ensembl Show fit
chr2_+_186776644 Show fit	80.21	ENSRNOT00000046778	Fcrl3 NCBI RGD Ensembl Show fit	Fc receptor-like 3
chr1_-_98521706 Show fit	78.65	ENSRNOT00000015941	Siglec10 NCBI RGD Ensembl Show fit	sialic acid binding Ig-like lectin 10
chr9_-_9675110 Show fit	77.77	ENSRNOT00000073294	Vav1 NCBI RGD Ensembl Show fit	vav guanine nucleotide exchange factor 1
chr6_-_143590448 Show fit	77.14	ENSRNOT00000056771	Ighv8-4 NCBI RGD Ensembl Show fit	immunoglobulin heavy variable V8-4

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Spic

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	164.2	GO:0002244	hematopoietic progenitor cell differentiation(GO:0002244)
12.4	161.7	GO:0038095	Fc-gamma receptor signaling pathway(GO:0038094) Fc-epsilon receptor signaling pathway(GO:0038095)
27.9	111.5	GO:0002434	immune complex clearance(GO:0002434)
9.8	107.8	GO:0035589	G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
14.3	100.2	GO:0045650	negative regulation of macrophage differentiation(GO:0045650)
23.6	94.5	GO:0033277	abortive mitotic cell cycle(GO:0033277)
2.9	90.2	GO:0045954	positive regulation of natural killer cell mediated cytotoxicity(GO:0045954)
4.3	85.8	GO:0001833	inner cell mass cell proliferation(GO:0001833)
16.0	80.2	GO:0050859	negative regulation of B cell receptor signaling pathway(GO:0050859)
4.8	76.6	GO:0000185	activation of MAPKKK activity(GO:0000185)

Showing 1 to 10 of 189 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	614.2	GO:0016021	integral component of membrane(GO:0016021)
1.3	420.4	GO:0009897	external side of plasma membrane(GO:0009897)
0.2	165.4	GO:0005887	integral component of plasma membrane(GO:0005887)
2.3	165.0	GO:0005581	collagen trimer(GO:0005581)
3.7	135.1	GO:0001772	immunological synapse(GO:0001772)
3.1	95.5	GO:0042588	zymogen granule(GO:0042588)
11.8	94.5	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.2	87.1	GO:0031012	extracellular matrix(GO:0031012)
3.0	80.4	GO:0001891	phagocytic cup(GO:0001891)
0.2	78.3	GO:0009986	cell surface(GO:0009986)

Showing 1 to 10 of 95 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.3	753.3	GO:0030246	carbohydrate binding(GO:0030246)
32.2	193.0	GO:0019767	IgE receptor activity(GO:0019767)
0.4	137.6	GO:0005525	GTP binding(GO:0005525)
0.5	134.1	GO:0005096	GTPase activator activity(GO:0005096)
9.0	107.8	GO:0001608	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
5.3	100.2	GO:0005149	interleukin-1 receptor binding(GO:0005149)
1.3	95.6	GO:0005089	Rho guanyl-nucleotide exchange factor activity(GO:0005089)
10.5	94.5	GO:0019198	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
8.5	93.3	GO:0019864	IgG binding(GO:0019864)
0.5	86.6	GO:0051015	actin filament binding(GO:0051015)

Showing 1 to 10 of 118 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
5.1	347.3	PID FCER1 PATHWAY	Fc-epsilon receptor I signaling in mast cells
1.5	241.1	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
11.8	213.1	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
3.7	168.7	PID KIT PATHWAY	Signaling events mediated by Stem cell factor receptor (c-Kit)
2.3	128.1	PID RAC1 PATHWAY	RAC1 signaling pathway
6.2	86.5	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
2.2	71.7	PID CXCR3 PATHWAY	CXCR3-mediated signaling events
0.3	67.0	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
2.3	66.6	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
2.3	65.5	PID CONE PATHWAY	Visual signal transduction: Cones

Showing 1 to 10 of 55 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.0	298.1	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
4.9	238.8	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
14.4	157.9	REACTOME CREATION OF C4 AND C2 ACTIVATORS	Genes involved in Creation of C4 and C2 activators
3.1	153.5	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
7.2	144.4	REACTOME CD28 DEPENDENT VAV1 PATHWAY	Genes involved in CD28 dependent Vav1 pathway
8.1	130.3	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.8	115.9	REACTOME G ALPHA I SIGNALLING EVENTS	Genes involved in G alpha (i) signalling events
3.8	109.8	REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA	Genes involved in G beta:gamma signalling through PI3Kgamma
9.0	107.8	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors
2.4	94.7	REACTOME IL1 SIGNALING	Genes involved in Interleukin-1 signaling

Showing 1 to 10 of 68 entries

Results for Spic

Z-value: 2.54

Motif logo

Transcription factors associated with Spic

Activity-expression correlation:

Activity profile of Spic motif

Sorted Z-values of Spic motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Spic

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: