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GSE53960: rat RNA-Seq transcriptomic Bodymap
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Results for Spib
Z-value: 2.50
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Transcription factors associated with Spib
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Spib | rn6_v1_chr1_-_100537377_100537377 | 0.92 | 2.0e-131 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chrX_+_78196300 Show fit | 114.72 |
ENSRNOT00000048695
|
purinergic receptor P2Y10 |
|
| chr7_-_107616038 Show fit | 105.69 |
ENSRNOT00000088752
|
src-like adaptor |
|
| chr9_-_9675110 Show fit | 92.12 |
ENSRNOT00000073294
|
vav guanine nucleotide exchange factor 1 |
|
| chr7_+_145068286 Show fit | 91.25 |
ENSRNOT00000088956
ENSRNOT00000065753 |
NCK associated protein 1 like |
|
| chr3_+_28627084 Show fit | 90.54 |
ENSRNOT00000049884
|
Rho GTPase activating protein 15 |
|
| chr14_-_23604834 Show fit | 89.49 |
ENSRNOT00000002760
|
signal transducing adaptor family member 1 |
|
| chr5_+_149047681 Show fit | 89.02 |
ENSRNOT00000015198
|
lysosomal protein transmembrane 5 |
|
| chr1_-_101236065 Show fit | 88.44 |
ENSRNOT00000066834
|
CD37 molecule |
|
| chr8_+_133029625 Show fit | 86.08 |
ENSRNOT00000008809
|
C-C motif chemokine receptor 3 |
|
| chr10_-_5260608 Show fit | 86.04 |
ENSRNOT00000003572
|
class II, major histocompatibility complex, transactivator |
Network of associatons between targets according to the STRING database.
First level regulatory network of Spib
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.5 | 323.0 | GO:0038083 | peptidyl-tyrosine autophosphorylation(GO:0038083) |
| 17.5 | 105.0 | GO:2000622 | regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623) |
| 8.8 | 97.3 | GO:0035589 | G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589) |
| 6.8 | 95.2 | GO:0002361 | CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361) |
| 23.2 | 92.8 | GO:0033277 | abortive mitotic cell cycle(GO:0033277) |
| 3.2 | 92.1 | GO:0045954 | positive regulation of natural killer cell mediated cytotoxicity(GO:0045954) |
| 30.4 | 91.2 | GO:0070358 | actin polymerization-dependent cell motility(GO:0070358) |
| 29.8 | 89.5 | GO:1903972 | regulation of macrophage colony-stimulating factor signaling pathway(GO:1902226) regulation of response to macrophage colony-stimulating factor(GO:1903969) regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903972) microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139) |
| 22.1 | 88.4 | GO:0030886 | negative regulation of myeloid dendritic cell activation(GO:0030886) |
| 6.1 | 86.1 | GO:0048245 | eosinophil chemotaxis(GO:0048245) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.5 | 365.9 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.7 | 233.1 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.2 | 186.7 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 1.0 | 111.6 | GO:0016605 | PML body(GO:0016605) |
| 4.8 | 105.0 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.3 | 99.5 | GO:0000790 | nuclear chromatin(GO:0000790) |
| 7.0 | 98.1 | GO:0001931 | uropod(GO:0001931) cell trailing edge(GO:0031254) |
| 1.3 | 96.2 | GO:0005581 | collagen trimer(GO:0005581) |
| 11.6 | 92.8 | GO:0042105 | alpha-beta T cell receptor complex(GO:0042105) |
| 1.1 | 92.3 | GO:0032587 | ruffle membrane(GO:0032587) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.5 | 267.2 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 18.5 | 222.6 | GO:0019864 | IgG binding(GO:0019864) |
| 8.1 | 201.6 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 7.0 | 105.0 | GO:0008143 | poly(A) binding(GO:0008143) |
| 1.2 | 101.9 | GO:0033613 | activating transcription factor binding(GO:0033613) |
| 0.4 | 101.4 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 8.1 | 97.3 | GO:0001608 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 4.8 | 96.8 | GO:0005537 | mannose binding(GO:0005537) |
| 10.3 | 92.8 | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 4.2 | 92.1 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.6 | 449.9 | PID TCR PATHWAY | TCR signaling in naïve CD4+ T cells |
| 3.2 | 161.3 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 1.0 | 157.9 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 4.0 | 150.9 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 1.3 | 132.5 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 1.8 | 111.3 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 2.2 | 81.9 | PID AURORA A PATHWAY | Aurora A signaling |
| 4.8 | 62.2 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 2.5 | 59.6 | SIG PIP3 SIGNALING IN B LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 0.2 | 56.0 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.2 | 180.9 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 7.9 | 157.5 | REACTOME CD28 DEPENDENT VAV1 PATHWAY | Genes involved in CD28 dependent Vav1 pathway |
| 9.1 | 145.7 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 4.1 | 119.8 | REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA | Genes involved in G beta:gamma signalling through PI3Kgamma |
| 4.4 | 105.0 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.7 | 101.4 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 8.1 | 97.3 | REACTOME P2Y RECEPTORS | Genes involved in P2Y receptors |
| 8.7 | 96.2 | REACTOME CREATION OF C4 AND C2 ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.8 | 95.3 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 1.7 | 86.1 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |