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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Spib

Z-value: 2.50

Motif logo

Transcription factors associated with Spib

Gene Symbol Gene ID Gene Info
ENSRNOG00000019660 Spi-B transcription factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Spibrn6_v1_chr1_-_100537377_1005373770.922.0e-131Click!

Activity profile of Spib motif

Sorted Z-values of Spib motif

Promoter Log-likelihood Transcript Gene Gene Info
chrX_+_78196300 114.72 ENSRNOT00000048695
purinergic receptor P2Y10
chr7_-_107616038 105.69 ENSRNOT00000088752
src-like adaptor
chr9_-_9675110 92.12 ENSRNOT00000073294
vav guanine nucleotide exchange factor 1
chr7_+_145068286 91.25 ENSRNOT00000088956
ENSRNOT00000065753
NCK associated protein 1 like
chr3_+_28627084 90.54 ENSRNOT00000049884
Rho GTPase activating protein 15
chr14_-_23604834 89.49 ENSRNOT00000002760
signal transducing adaptor family member 1
chr5_+_149047681 89.02 ENSRNOT00000015198
lysosomal protein transmembrane 5
chr1_-_101236065 88.44 ENSRNOT00000066834
CD37 molecule
chr8_+_133029625 86.08 ENSRNOT00000008809
C-C motif chemokine receptor 3
chr10_-_5260608 86.04 ENSRNOT00000003572
class II, major histocompatibility complex, transactivator
chr2_+_186776644 84.13 ENSRNOT00000046778
Fc receptor-like 3
chr12_-_2826378 79.26 ENSRNOT00000061749
C-type lectin domain family 4 member M
chr14_-_100184192 78.80 ENSRNOT00000007044
pleckstrin
chr1_+_242959488 71.89 ENSRNOT00000015668
dedicator of cytokinesis 8
chr7_-_11330278 71.78 ENSRNOT00000027730
megakaryocyte-associated tyrosine kinase
chr11_-_66759402 70.67 ENSRNOT00000003326
hematopoietic cell specific Lyn substrate 1
chr4_-_155923079 69.85 ENSRNOT00000013308
C-type lectin domain family 4, member A3
chr10_+_47930633 68.58 ENSRNOT00000003515
GRB2-related adaptor protein
chr14_+_73674753 67.94 ENSRNOT00000040676
similar to High mobility group protein 2 (HMG-2)
chr17_-_46115004 66.11 ENSRNOT00000087838
acyloxyacyl hydrolase
chr11_+_67082193 65.37 ENSRNOT00000003129
CD86 molecule
chr8_+_60760078 65.16 ENSRNOT00000063930
proline-serine-threonine phosphatase-interacting protein 1
chr9_+_40972089 64.13 ENSRNOT00000067928
protein tyrosine phosphatase, non-receptor type 18
chrX_+_54390733 63.81 ENSRNOT00000004977
similar to chromosome X open reading frame 21
chr14_-_82347679 63.30 ENSRNOT00000032972
transforming, acidic coiled-coil containing protein 3
chr16_-_19349080 61.40 ENSRNOT00000038494
hematopoietic SH2 domain containing
chr2_-_203413124 60.70 ENSRNOT00000077898
ENSRNOT00000056140
CD101 molecule
chr5_+_157222636 60.20 ENSRNOT00000022579
phospholipase A2, group IID
chr13_-_89306219 60.10 ENSRNOT00000004183
ENSRNOT00000079247
Fc receptor-like A
chr1_-_47502952 59.90 ENSRNOT00000025580
T-cell activation RhoGTPase activating protein
chr10_+_55013703 59.64 ENSRNOT00000032785
phosphoinositide-3-kinase, regulatory subunit 5
chr1_-_227506822 58.66 ENSRNOT00000091506
membrane spanning 4-domains A7
chr13_-_89343868 56.49 ENSRNOT00000058497
ENSRNOT00000035400
Fc fragment of IgG receptor IIb
chr3_-_153001309 55.87 ENSRNOT00000027581
Src-like-adaptor 2
chr7_-_75422268 55.12 ENSRNOT00000080218
poly(A) binding protein, cytoplasmic 1
chr4_+_66670618 55.04 ENSRNOT00000010796
thromboxane A synthase 1
chr10_-_57436368 54.74 ENSRNOT00000056608
SLP adaptor and CSK interacting membrane protein
chr1_+_226634009 53.38 ENSRNOT00000028094
cytochrome b561 family, member A3
chr1_-_221015929 53.30 ENSRNOT00000028137
signal-induced proliferation-associated 1
chr2_+_55835151 52.84 ENSRNOT00000018634
FYN binding protein
chr20_-_5163247 52.76 ENSRNOT00000001135
allograft inflammatory factor 1
chr2_-_198439454 52.67 ENSRNOT00000028780
Fc fragment of IgG receptor Ia
chr1_-_20417637 51.96 ENSRNOT00000036049
similar to High mobility group protein 2 (HMG-2)
chr19_+_19395655 51.51 ENSRNOT00000019130
sorting nexin 20
chr7_-_75421874 49.88 ENSRNOT00000012775
poly(A) binding protein, cytoplasmic 1
chr8_+_102304095 49.62 ENSRNOT00000011358
solute carrier family 9 member A9
chr5_-_155258392 48.57 ENSRNOT00000017065
complement C1q C chain
chr9_+_94745217 48.34 ENSRNOT00000051338
inositol polyphosphate-5-phosphatase D
chr3_+_79918969 47.97 ENSRNOT00000016306
Spi-1 proto-oncogene
chr5_-_155252003 47.59 ENSRNOT00000017060
complement C1q B chain
chr4_-_157252565 47.54 ENSRNOT00000079947
protein tyrosine phosphatase, non-receptor type 6
chr1_-_260254600 47.47 ENSRNOT00000019014
B-cell linker
chr9_+_47134034 45.69 ENSRNOT00000020108
interleukin 1 receptor-like 1
chr4_-_157252104 45.31 ENSRNOT00000082739
protein tyrosine phosphatase, non-receptor type 6
chr1_-_43638161 44.90 ENSRNOT00000024460
interaction protein for cytohesin exchange factors 1
chr8_+_49378644 43.32 ENSRNOT00000007588
junction adhesion molecule like
chr10_+_83655460 42.87 ENSRNOT00000008011
G protein subunit gamma transducin 2
chrX_+_15155230 42.52 ENSRNOT00000073289
ENSRNOT00000051439
Wiskott-Aldrich syndrome
chr17_-_34905117 42.18 ENSRNOT00000088931
interferon regulatory factor 4
chr10_+_104932616 41.98 ENSRNOT00000075706
similar to leukocyte mono-Ig-like receptor2
chr7_+_70614617 40.94 ENSRNOT00000035382
Rho GTPase activating protein 9
chr13_-_91198036 39.31 ENSRNOT00000004204
low affinity immunoglobulin gamma Fc region receptor III
chr4_+_163112301 38.29 ENSRNOT00000087113
C-type lectin domain family 12, member A
chr9_-_61528882 37.83 ENSRNOT00000015432
ankyrin repeat domain 44
chr10_-_103685844 37.47 ENSRNOT00000064284
Cd300 molecule-like family member F
chr3_+_11756384 36.89 ENSRNOT00000087762
SH2 domain containing 3C
chr12_-_6879154 36.85 ENSRNOT00000001207
arachidonate 5-lipoxygenase activating protein
chr4_+_22898527 36.06 ENSRNOT00000072455
ENSRNOT00000076123
DBF4 zinc finger
chr3_+_2642531 34.98 ENSRNOT00000081798
fucosyltransferase 7
chr10_-_70506963 31.19 ENSRNOT00000076883
ENSRNOT00000012874
schlafen family member 14
chr6_-_102196138 30.86 ENSRNOT00000014132
transmembrane protein 229B
chr8_-_48634797 30.44 ENSRNOT00000012868
histone H4 transcription factor
chr13_-_91228901 30.35 ENSRNOT00000071728
ENSRNOT00000073643
ENSRNOT00000071897
low affinity immunoglobulin gamma Fc region receptor III-like
chr4_+_115024927 29.83 ENSRNOT00000090987
MOB kinase activator 1A
chr13_-_91197744 27.59 ENSRNOT00000047349
low affinity immunoglobulin gamma Fc region receptor III
chr5_-_160423811 27.27 ENSRNOT00000018864
EF-hand domain family, member D2
chr4_-_57625147 27.15 ENSRNOT00000074649
ENSRNOT00000078961
ubiquitin-conjugating enzyme E2H
chr10_-_56289882 27.03 ENSRNOT00000090762
ENSRNOT00000056903
tumor necrosis factor superfamily member 13
chr14_+_76657311 26.83 ENSRNOT00000076730
cytokine-dependent hematopoietic cell linker
chr1_+_221420271 25.79 ENSRNOT00000028481
similar to Finkel-Biskis-Reilly murine sarcoma virusubiquitously expressed
chr10_+_56187679 25.60 ENSRNOT00000085115
tumor protein p53
chr3_-_11102515 25.15 ENSRNOT00000035580
family with sequence similarity 78, member A
chrX_-_77700269 24.77 ENSRNOT00000092418
cysteinyl leukotriene receptor 1
chr3_+_103753238 24.53 ENSRNOT00000007144
solute carrier family 12, member 6
chr13_+_48287873 24.47 ENSRNOT00000068223
family with sequence similarity 72, member A
chr1_-_53520788 24.41 ENSRNOT00000060121
G protein-coupled receptor 31
chr6_-_103313074 24.12 ENSRNOT00000083677
zinc finger protein 36, C3H type-like 1
chr20_-_13706205 23.70 ENSRNOT00000038623
derlin 3
chr19_+_25815207 22.86 ENSRNOT00000003980
LYL1, basic helix-loop-helix family member
chr1_-_242440885 22.77 ENSRNOT00000076537
phosphatidylinositol-4-phosphate 5-kinase type 1 beta
chr16_-_85306366 22.25 ENSRNOT00000089650
tumor necrosis factor superfamily member 13b
chr5_+_25168295 22.08 ENSRNOT00000020245
fibrinogen silencer binding protein
chr6_+_137323713 21.72 ENSRNOT00000029017
phospholipase D family, member 4
chr1_-_64446818 21.51 ENSRNOT00000081980
myeloid-associated differentiation marker
chr3_-_23297774 21.24 ENSRNOT00000019162
ribosomal protein L35
chr3_+_103773459 21.15 ENSRNOT00000079727
solute carrier family 12, member 6
chr1_-_142183884 21.13 ENSRNOT00000016032
FES proto-oncogene, tyrosine kinase
chr2_+_34312766 20.80 ENSRNOT00000060962
centromere protein K
chr10_+_74959285 20.72 ENSRNOT00000010296
ring finger protein 43
chr1_-_242441247 20.63 ENSRNOT00000068645
phosphatidylinositol-4-phosphate 5-kinase type 1 beta
chrX_+_113948654 20.56 ENSRNOT00000068431
transmembrane protein 164
chr9_+_10471742 20.38 ENSRNOT00000072276
scaffold attachment factor B2
chr5_-_141430659 19.37 ENSRNOT00000034944
akirin 1
chr2_+_38230757 18.75 ENSRNOT00000048598
similar to 60S ribosomal protein L23a
chr6_-_47904163 18.58 ENSRNOT00000011333
ribosomal protein S7
chr9_-_46951847 18.09 ENSRNOT00000051231
similar to Zgc:56193
chr6_+_134804141 17.81 ENSRNOT00000086143
protein phosphatase 2, regulatory subunit B', gamma
chr14_+_58877806 17.64 ENSRNOT00000051559
similar to 60S ribosomal protein L23a
chr17_+_81352700 17.58 ENSRNOT00000024736
mannose receptor, C type 1
chr10_+_23661013 17.38 ENSRNOT00000076664
early B-cell factor 1
chr3_+_160467552 17.32 ENSRNOT00000066657
serine/threonine kinase 4
chr13_-_95250235 17.27 ENSRNOT00000085648
AKT serine/threonine kinase 3
chr17_-_46794845 17.01 ENSRNOT00000077910
ENSRNOT00000090663
ENSRNOT00000078331
engulfment and cell motility 1
chr11_-_33003021 17.01 ENSRNOT00000084134
runt-related transcription factor 1
chr12_+_1889331 16.94 ENSRNOT00000066281
Rho/Rac guanine nucleotide exchange factor 18
chrX_+_128493614 16.69 ENSRNOT00000044240
stromal antigen 2
chr4_+_90990088 16.52 ENSRNOT00000030320
multimerin 1
chr13_-_89433815 16.18 ENSRNOT00000091541
Fc fragment of IgG receptor IIb
chr8_-_45375435 16.16 ENSRNOT00000010873
ubiquitin associated and SH3 domain containing, B
chr1_+_197999037 16.10 ENSRNOT00000091065
apolipoprotein B receptor
chr3_+_118317761 15.37 ENSRNOT00000012700
fibroblast growth factor 7
chr1_-_224974203 14.92 ENSRNOT00000065694
transmembrane protein 179B
chr15_-_3650819 14.84 ENSRNOT00000014273
plasminogen activator, urokinase
chr5_+_61425746 14.22 ENSRNOT00000064113
hypothetical LOC298077
chr4_-_15505362 13.99 ENSRNOT00000009763
hepatocyte growth factor
chr4_+_95884743 13.84 ENSRNOT00000008585
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1`
chr10_+_31880918 13.60 ENSRNOT00000059448
T-cell immunoglobulin and mucin domain containing 4
chr5_-_137238354 13.10 ENSRNOT00000039235
seizure threshold 2 homolog (mouse)
chr2_+_157854667 12.92 ENSRNOT00000039294

chr2_-_34313094 12.84 ENSRNOT00000016863
peptidylprolyl isomerase domain and WD repeat containing 1
chr13_+_49250301 12.82 ENSRNOT00000036110
RB binding protein 5, histone lysine methyltransferase complex subunit
chr6_-_47904437 12.23 ENSRNOT00000092867
ribosomal protein S7
chr1_+_199217016 12.23 ENSRNOT00000025732
ORAI calcium release-activated calcium modulator 3
chr7_+_109411475 12.22 ENSRNOT00000051728
similar to H3 histone, family 3B
chr12_+_25497104 12.08 ENSRNOT00000002028
neutrophil cytosolic factor 1
chr8_-_76940094 11.93 ENSRNOT00000082709
ENSRNOT00000084313
ring finger protein 111
chrX_-_63204530 11.72 ENSRNOT00000076175
zinc finger protein X-linked
chr13_-_69172643 11.54 ENSRNOT00000049703

chr3_-_130114770 11.39 ENSRNOT00000010638
jagged 1
chr15_+_44441856 11.29 ENSRNOT00000018006
gonadotropin releasing hormone 1
chr4_-_120041238 11.20 ENSRNOT00000073799
40S ribosomal protein S25-like
chr1_-_164441167 11.16 ENSRNOT00000023935
ribosomal protein S3
chr3_-_140141679 10.94 ENSRNOT00000014632
crooked neck pre-mRNA splicing factor 1
chr1_+_197999336 10.84 ENSRNOT00000023555
apolipoprotein B receptor
chr8_+_114916122 10.35 ENSRNOT00000074194
toll-like receptor 9
chr2_+_189454340 9.68 ENSRNOT00000087063
nucleoporin 210-like
chr1_+_221710670 9.61 ENSRNOT00000064798
mitogen activated protein kinase kinase kinase kinase 2
chr4_+_145330457 9.35 ENSRNOT00000011937
actin related protein 2/3 complex, subunit 4
chr3_-_80875817 9.34 ENSRNOT00000091265
diacylglycerol kinase zeta
chr1_-_143169657 9.13 ENSRNOT00000025888
ribosomal protein S17
chr2_-_118882562 9.09 ENSRNOT00000058860
potassium calcium-activated channel subfamily M regulatory beta subunit 3
chr2_+_187740531 8.89 ENSRNOT00000092653
progestin and adipoQ receptor family member 6
chr17_+_90670872 8.39 ENSRNOT00000081530
G protein-coupled receptor 137B
chr5_+_64892802 8.33 ENSRNOT00000059869
ring finger protein 20
chr3_+_47439076 8.00 ENSRNOT00000011794
TRAF family member-associated NFKB activator
chr2_-_189765415 7.98 ENSRNOT00000020815
solute carrier family 27 member 3
chr19_+_19672856 7.72 ENSRNOT00000064275
ENSRNOT00000086560
bromodomain containing 7
chr13_-_67206688 7.55 ENSRNOT00000003630
ENSRNOT00000090693
phospholipase A2 group IVA
chr20_-_5466265 7.53 ENSRNOT00000000554
ral guanine nucleotide dissociation stimulator-like 2
chr8_-_108261021 7.48 ENSRNOT00000040710
40S ribosomal protein S25-like
chr3_+_28416954 7.28 ENSRNOT00000043533
kynureninase
chr7_+_122818975 7.15 ENSRNOT00000000206
E1A binding protein p300
chrX_+_156655960 7.03 ENSRNOT00000085723
methyl CpG binding protein 2
chr16_+_40050734 6.74 ENSRNOT00000067375
signal peptidase complex subunit 3
chr4_-_120414118 6.72 ENSRNOT00000072795
40S ribosomal protein S25-like
chr7_+_122160171 6.66 ENSRNOT00000074499
CG3918-like
chr13_-_90977734 6.63 ENSRNOT00000011869
SLAM family member 8
chr1_-_280233755 6.46 ENSRNOT00000064463
shootin 1
chr3_-_103203299 6.30 ENSRNOT00000047208
olfactory receptor 783
chr15_+_34270648 5.87 ENSRNOT00000026333
ring finger protein 31
chr1_+_234749568 5.74 ENSRNOT00000016871
osteoclast stimulating factor 1
chr8_+_114897011 5.73 ENSRNOT00000074683
twinfilin actin-binding protein 2
chr7_-_70407177 5.23 ENSRNOT00000049895
OS9, endoplasmic reticulum lectin
chr13_-_79744939 4.99 ENSRNOT00000076706
SUN domain containing ossification factor
chr17_-_76281660 4.78 ENSRNOT00000058070
UPF2 regulator of nonsense transcripts homolog (yeast)
chr4_-_100099517 4.71 ENSRNOT00000014277
atonal bHLH transcription factor 8
chr16_-_85305782 4.69 ENSRNOT00000067511
ENSRNOT00000076737
tumor necrosis factor superfamily member 13b
chr10_-_64642292 4.52 ENSRNOT00000084670
active BCR-related
chr3_-_59688692 4.28 ENSRNOT00000078752
Sp3 transcription factor
chr3_-_151224123 4.15 ENSRNOT00000026091
transient receptor potential cation channel, subfamily C, member 4 associated protein
chr19_-_41029206 4.15 ENSRNOT00000023383
Vac14, PIKFYVE complex component
chr7_-_116936674 4.02 ENSRNOT00000029456
eukaryotic translation elongation factor 1 delta
chr16_+_83358116 3.94 ENSRNOT00000031109
RAB20, member RAS oncogene family
chr1_-_254671778 3.93 ENSRNOT00000025493
5-hydroxytryptamine receptor 7
chr11_+_81972219 3.89 ENSRNOT00000002452
diacylglycerol kinase, gamma
chr8_-_39243882 3.80 ENSRNOT00000082086
STT3A, catalytic subunit of the oligosaccharyltransferase complex
chr15_-_52317219 3.65 ENSRNOT00000016555
dematin actin binding protein
chr9_-_42805673 3.35 ENSRNOT00000020558
UDP-glucose glycoprotein glucosyltransferase 1
chr6_+_108831108 3.28 ENSRNOT00000038594
U6 snRNA-associated Sm-like protein LSm5 pseudogene
chr3_-_125470413 3.01 ENSRNOT00000028893
tRNA methyltransferase 6
chr6_+_129609375 3.00 ENSRNOT00000083732
poly (A) polymerase alpha
chr17_-_1648973 2.61 ENSRNOT00000036212
solute carrier family 35 member D2
chr4_-_63039422 2.47 ENSRNOT00000015808
myotrophin
chr2_-_196270826 2.38 ENSRNOT00000028609
phosphatidylinositol-4-phosphate 5-kinase, type 1, alpha
chr1_-_103128743 2.00 ENSRNOT00000075006
SPT2 chromatin protein domain containing 1
chr12_-_19582185 1.94 ENSRNOT00000060020
ENSRNOT00000085853
similar to hypothetical protein FLJ10925
chr2_-_120316357 1.86 ENSRNOT00000065469
coiled-coil domain containing 39
chr1_-_84812486 1.72 ENSRNOT00000078369

chr4_+_72656125 1.39 ENSRNOT00000047359
olfactory receptor 820
chr1_-_198008893 1.37 ENSRNOT00000025950
interleukin 27

Network of associatons between targets according to the STRING database.

First level regulatory network of Spib

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
30.4 91.2 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
29.8 89.5 GO:1903972 regulation of macrophage colony-stimulating factor signaling pathway(GO:1902226) regulation of response to macrophage colony-stimulating factor(GO:1903969) regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903972) microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
23.2 92.8 GO:0033277 abortive mitotic cell cycle(GO:0033277)
22.1 88.4 GO:0030886 negative regulation of myeloid dendritic cell activation(GO:0030886)
21.8 65.4 GO:0002644 negative regulation of tolerance induction(GO:0002644)
20.6 82.5 GO:0070560 protein secretion by platelet(GO:0070560)
18.7 37.5 GO:1902214 regulation of interleukin-4-mediated signaling pathway(GO:1902214)
18.2 72.7 GO:0002434 immune complex clearance(GO:0002434) negative regulation of hypersensitivity(GO:0002884)
17.8 53.3 GO:0042631 cellular response to water deprivation(GO:0042631)
17.7 70.7 GO:0042531 regulation of tyrosine phosphorylation of STAT protein(GO:0042509) positive regulation of tyrosine phosphorylation of STAT protein(GO:0042531)
17.6 52.8 GO:0014739 positive regulation of muscle hyperplasia(GO:0014739)
17.6 52.7 GO:0001788 antibody-dependent cellular cytotoxicity(GO:0001788)
17.5 105.0 GO:2000622 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
16.8 84.1 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
15.2 45.7 GO:0038172 interleukin-33-mediated signaling pathway(GO:0038172)
15.2 45.7 GO:0071477 hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
14.4 43.3 GO:0035696 monocyte extravasation(GO:0035696)
14.3 86.0 GO:0045341 MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343) positive regulation of MHC class I biosynthetic process(GO:0045345)
14.1 42.2 GO:0045082 positive regulation of interleukin-10 biosynthetic process(GO:0045082)
12.3 61.4 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902)
12.1 48.3 GO:0045658 regulation of neutrophil differentiation(GO:0045658)
12.0 48.0 GO:0045347 negative regulation of MHC class II biosynthetic process(GO:0045347)
10.8 54.0 GO:0002636 positive regulation of germinal center formation(GO:0002636)
9.2 36.9 GO:0002540 leukotriene production involved in inflammatory response(GO:0002540)
8.8 97.3 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
8.8 79.3 GO:0042535 positive regulation of tumor necrosis factor biosynthetic process(GO:0042535)
7.4 14.8 GO:2000097 regulation of smooth muscle cell-matrix adhesion(GO:2000097)
7.2 21.5 GO:0090038 negative regulation of protein kinase C signaling(GO:0090038)
7.1 42.5 GO:0002457 T cell antigen processing and presentation(GO:0002457)
6.8 95.2 GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361)
6.7 46.9 GO:0045650 negative regulation of macrophage differentiation(GO:0045650)
6.4 25.6 GO:1901003 negative regulation of fermentation(GO:1901003) negative regulation of NAD metabolic process(GO:1902689) negative regulation of glucose catabolic process to lactate via pyruvate(GO:1904024)
6.1 86.1 GO:0048245 eosinophil chemotaxis(GO:0048245)
6.1 55.0 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
6.0 24.1 GO:0003342 proepicardium development(GO:0003342) septum transversum development(GO:0003343) mesendoderm development(GO:0048382) regulation of intracellular mRNA localization(GO:1904580)
5.7 17.0 GO:2000872 positive regulation of progesterone secretion(GO:2000872)
5.2 10.3 GO:0032741 positive regulation of interleukin-18 production(GO:0032741)
4.9 29.4 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
4.9 63.3 GO:0030953 astral microtubule organization(GO:0030953)
4.8 71.9 GO:0001771 immunological synapse formation(GO:0001771)
4.7 14.2 GO:0046865 isoprenoid transport(GO:0046864) terpenoid transport(GO:0046865)
4.5 323.0 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
4.3 17.3 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
4.3 52.0 GO:0006265 DNA topological change(GO:0006265)
4.1 24.8 GO:0061737 leukotriene signaling pathway(GO:0061737)
4.0 12.1 GO:0070946 neutrophil mediated killing of gram-positive bacterium(GO:0070946)
3.8 49.6 GO:0098719 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
3.8 11.4 GO:0061443 endocardial cushion cell differentiation(GO:0061443)
3.7 11.2 GO:1902544 regulation of DNA N-glycosylase activity(GO:1902544)
3.5 24.5 GO:0031547 brain-derived neurotrophic factor receptor signaling pathway(GO:0031547)
3.2 92.1 GO:0045954 positive regulation of natural killer cell mediated cytotoxicity(GO:0045954)
2.8 30.8 GO:1902255 positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator(GO:1902255)
2.7 10.9 GO:1990823 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
2.7 8.0 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
2.6 28.9 GO:1904153 negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
2.6 13.1 GO:1901668 regulation of superoxide dismutase activity(GO:1901668)
2.4 7.2 GO:0018076 positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990) N-terminal peptidyl-lysine acetylation(GO:0018076)
2.3 7.0 GO:1900114 positive regulation of histone H3-K9 trimethylation(GO:1900114) negative regulation of dendrite extension(GO:1903860) negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000820)
2.3 22.9 GO:0001955 blood vessel maturation(GO:0001955)
2.2 6.6 GO:0002232 leukocyte chemotaxis involved in inflammatory response(GO:0002232)
2.1 21.2 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
2.1 8.3 GO:2001166 regulation of histone H2B ubiquitination(GO:2001166) positive regulation of histone H2B ubiquitination(GO:2001168)
2.1 31.2 GO:0016075 rRNA catabolic process(GO:0016075)
2.0 30.4 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
1.9 7.5 GO:0032485 regulation of Ral protein signal transduction(GO:0032485)
1.9 11.3 GO:2000354 regulation of ovarian follicle development(GO:2000354)
1.9 16.7 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
1.8 16.2 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
1.7 11.9 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
1.6 6.5 GO:0070650 actin filament bundle distribution(GO:0070650)
1.5 47.6 GO:0006958 complement activation, classical pathway(GO:0006958)
1.5 4.5 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314) negative regulation of neutrophil activation(GO:1902564)
1.5 16.5 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977)
1.5 7.3 GO:0097052 L-kynurenine metabolic process(GO:0097052)
1.3 3.9 GO:0042322 negative regulation of circadian sleep/wake cycle, REM sleep(GO:0042322)
1.3 7.5 GO:2001280 positive regulation of prostaglandin biosynthetic process(GO:0031394) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
1.1 45.8 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
1.1 48.5 GO:0043551 regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
1.0 60.7 GO:0002763 positive regulation of myeloid leukocyte differentiation(GO:0002763)
1.0 20.7 GO:0032801 receptor catabolic process(GO:0032801)
1.0 27.1 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
1.0 13.8 GO:0070933 histone H4 deacetylation(GO:0070933)
1.0 5.9 GO:0097039 protein linear polyubiquitination(GO:0097039)
0.9 13.2 GO:0046834 lipid phosphorylation(GO:0046834)
0.8 3.3 GO:0006011 UDP-glucose metabolic process(GO:0006011)
0.8 30.1 GO:0060008 Sertoli cell differentiation(GO:0060008)
0.8 18.7 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.8 52.8 GO:0045576 mast cell activation(GO:0045576)
0.8 3.9 GO:0090383 phagosome acidification(GO:0090383)
0.8 17.3 GO:0045793 positive regulation of cell size(GO:0045793)
0.7 9.6 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.7 5.7 GO:0042989 sequestering of actin monomers(GO:0042989)
0.7 4.3 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
0.7 6.7 GO:0006465 signal peptide processing(GO:0006465)
0.7 2.0 GO:0010847 regulation of chromatin assembly(GO:0010847)
0.7 17.6 GO:0071353 cellular response to interleukin-4(GO:0071353)
0.6 66.1 GO:0044264 cellular polysaccharide metabolic process(GO:0044264)
0.6 9.1 GO:0005513 detection of calcium ion(GO:0005513)
0.6 12.2 GO:0002115 store-operated calcium entry(GO:0002115)
0.6 64.1 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.6 3.9 GO:0043686 co-translational protein modification(GO:0043686)
0.6 11.7 GO:0060746 parental behavior(GO:0060746)
0.5 17.0 GO:0006911 phagocytosis, engulfment(GO:0006911)
0.5 4.1 GO:0043550 regulation of lipid kinase activity(GO:0043550)
0.4 54.7 GO:0007127 meiosis I(GO:0007127)
0.4 55.6 GO:0008360 regulation of cell shape(GO:0008360)
0.4 61.3 GO:0051607 defense response to virus(GO:0051607)
0.3 9.1 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.3 4.7 GO:0051450 myoblast proliferation(GO:0051450)
0.3 7.7 GO:0035066 positive regulation of histone acetylation(GO:0035066)
0.3 2.5 GO:2000812 regulation of barbed-end actin filament capping(GO:2000812)
0.3 47.5 GO:0042113 B cell activation(GO:0042113)
0.3 12.8 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.3 12.8 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.2 21.7 GO:0006909 phagocytosis(GO:0006909)
0.2 34.7 GO:0007254 JNK cascade(GO:0007254)
0.2 5.0 GO:0010714 positive regulation of collagen metabolic process(GO:0010714) positive regulation of collagen biosynthetic process(GO:0032967)
0.2 4.0 GO:0009299 mRNA transcription(GO:0009299)
0.1 4.8 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.1 2.9 GO:0031440 regulation of mRNA 3'-end processing(GO:0031440)
0.1 3.0 GO:0030488 tRNA methylation(GO:0030488)
0.1 16.5 GO:0007596 blood coagulation(GO:0007596)
0.1 24.5 GO:0006898 receptor-mediated endocytosis(GO:0006898)
0.1 1.7 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.1 8.9 GO:0043401 steroid hormone mediated signaling pathway(GO:0043401)
0.0 1.3 GO:0048016 inositol phosphate-mediated signaling(GO:0048016)
0.0 12.7 GO:0006955 immune response(GO:0006955)
0.0 0.2 GO:0006670 sphingosine metabolic process(GO:0006670)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
19.9 59.6 GO:0005944 phosphatidylinositol 3-kinase complex, class IB(GO:0005944)
11.6 92.8 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
10.1 91.2 GO:0031209 SCAR complex(GO:0031209)
7.2 65.2 GO:0005826 actomyosin contractile ring(GO:0005826)
7.0 98.1 GO:0001931 uropod(GO:0001931) cell trailing edge(GO:0031254)
4.8 105.0 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
3.9 23.7 GO:0005785 signal recognition particle receptor complex(GO:0005785)
2.8 11.3 GO:1990005 granular vesicle(GO:1990005)
2.5 365.9 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
2.5 88.4 GO:0001772 immunological synapse(GO:0001772)
2.3 52.8 GO:0001891 phagocytic cup(GO:0001891)
2.1 8.3 GO:0033503 HULC complex(GO:0033503)
1.5 42.2 GO:0000788 nuclear nucleosome(GO:0000788)
1.3 4.0 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
1.3 9.4 GO:0005885 Arp2/3 protein complex(GO:0005885)
1.3 96.2 GO:0005581 collagen trimer(GO:0005581)
1.2 3.7 GO:0031095 platelet dense tubular network membrane(GO:0031095)
1.2 12.1 GO:0043020 NADPH oxidase complex(GO:0043020)
1.2 5.9 GO:0071797 LUBAC complex(GO:0071797)
1.1 10.3 GO:0032009 early phagosome(GO:0032009)
1.1 92.3 GO:0032587 ruffle membrane(GO:0032587)
1.1 6.7 GO:0005787 signal peptidase complex(GO:0005787)
1.1 17.0 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
1.0 5.2 GO:0000835 ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836)
1.0 111.6 GO:0016605 PML body(GO:0016605)
1.0 3.0 GO:0031515 tRNA (m1A) methyltransferase complex(GO:0031515)
1.0 12.8 GO:0044666 MLL3/4 complex(GO:0044666)
0.9 21.7 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.8 51.5 GO:0031901 early endosome membrane(GO:0031901)
0.8 75.2 GO:0005884 actin filament(GO:0005884)
0.7 233.1 GO:0009897 external side of plasma membrane(GO:0009897)
0.6 4.1 GO:0035032 phosphatidylinositol 3-kinase complex, class III(GO:0035032)
0.6 30.4 GO:0015030 Cajal body(GO:0015030)
0.6 35.9 GO:0031902 late endosome membrane(GO:0031902)
0.6 39.9 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.5 31.2 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.5 13.8 GO:0035861 site of double-strand break(GO:0035861)
0.5 30.3 GO:0000786 nucleosome(GO:0000786)
0.4 40.0 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.4 4.1 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.4 7.0 GO:0000930 gamma-tubulin complex(GO:0000930)
0.3 7.7 GO:0090544 BAF-type complex(GO:0090544)
0.3 13.8 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.3 99.5 GO:0000790 nuclear chromatin(GO:0000790)
0.3 2.5 GO:0008290 F-actin capping protein complex(GO:0008290)
0.3 5.0 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.3 7.5 GO:0042588 zymogen granule(GO:0042588)
0.3 55.4 GO:0005765 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.3 28.9 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.2 23.8 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.2 28.2 GO:0055037 recycling endosome(GO:0055037)
0.2 3.9 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.2 62.8 GO:0043235 receptor complex(GO:0043235)
0.2 6.5 GO:0044295 axonal growth cone(GO:0044295)
0.2 186.7 GO:0005887 integral component of plasma membrane(GO:0005887)
0.2 17.0 GO:0005604 basement membrane(GO:0005604)
0.2 39.9 GO:0031252 cell leading edge(GO:0031252)
0.2 23.8 GO:0000785 chromatin(GO:0000785)
0.2 3.9 GO:0045335 phagocytic vesicle(GO:0045335)
0.2 41.4 GO:0031965 nuclear membrane(GO:0031965)
0.1 36.0 GO:0005911 cell-cell junction(GO:0005911)
0.1 49.9 GO:0005813 centrosome(GO:0005813)
0.1 16.3 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.1 28.1 GO:0005768 endosome(GO:0005768)
0.1 14.8 GO:0005925 focal adhesion(GO:0005925)
0.1 4.3 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 3.3 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.1 16.5 GO:0031012 extracellular matrix(GO:0031012)
0.0 1.9 GO:0005815 microtubule organizing center(GO:0005815)
0.0 27.7 GO:0005654 nucleoplasm(GO:0005654)
0.0 3.9 GO:0045177 apical part of cell(GO:0045177)
0.0 1.5 GO:0043679 axon terminus(GO:0043679)
0.0 33.6 GO:0005829 cytosol(GO:0005829)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
29.8 89.5 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
18.5 222.6 GO:0019864 IgG binding(GO:0019864)
15.2 45.7 GO:0002114 interleukin-33 receptor activity(GO:0002114)
13.0 52.0 GO:0044378 non-sequence-specific DNA binding, bending(GO:0044378)
12.3 36.9 GO:0004051 arachidonate 5-lipoxygenase activity(GO:0004051) leukotriene-C4 synthase activity(GO:0004464)
12.1 48.3 GO:0016312 inositol bisphosphate phosphatase activity(GO:0016312) PTB domain binding(GO:0051425)
11.4 45.7 GO:0035827 rubidium ion transmembrane transporter activity(GO:0035827)
10.7 64.1 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
10.3 92.8 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
9.9 59.6 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
9.4 37.5 GO:0005136 interleukin-4 receptor binding(GO:0005136)
8.6 86.1 GO:0019957 C-C chemokine binding(GO:0019957)
8.1 97.3 GO:0001608 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
8.1 201.6 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
7.0 105.0 GO:0008143 poly(A) binding(GO:0008143)
6.0 48.0 GO:0051525 NFAT protein binding(GO:0051525)
5.8 35.0 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
5.7 45.8 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
5.4 26.9 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)
5.0 49.6 GO:0015386 potassium:proton antiporter activity(GO:0015386)
5.0 24.8 GO:0004974 leukotriene receptor activity(GO:0004974)
4.8 96.8 GO:0005537 mannose binding(GO:0005537)
4.5 267.2 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
4.2 92.1 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
3.6 90.9 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
3.5 17.4 GO:0045322 unmethylated CpG binding(GO:0045322)
3.4 30.8 GO:1990948 ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948)
3.2 25.6 GO:0035033 histone deacetylase regulator activity(GO:0035033)
3.1 15.4 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
2.7 21.7 GO:0004630 phospholipase D activity(GO:0004630)
2.7 8.0 GO:0035800 deubiquitinase activator activity(GO:0035800)
2.6 60.2 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
2.4 7.3 GO:0016823 hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
2.2 11.2 GO:0000702 oxidized base lesion DNA N-glycosylase activity(GO:0000702)
2.0 24.1 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
1.9 42.5 GO:0043274 phospholipase binding(GO:0043274)
1.6 9.6 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
1.6 40.3 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
1.5 11.9 GO:0032184 SUMO polymer binding(GO:0032184)
1.3 42.3 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
1.3 54.0 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
1.2 101.9 GO:0033613 activating transcription factor binding(GO:0033613)
1.1 88.1 GO:0030295 protein kinase activator activity(GO:0030295)
1.0 55.0 GO:0016860 intramolecular oxidoreductase activity(GO:0016860)
1.0 13.2 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.9 55.0 GO:0016278 lysine N-methyltransferase activity(GO:0016278) protein-lysine N-methyltransferase activity(GO:0016279)
0.9 17.4 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.9 8.0 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
0.8 7.5 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.7 70.7 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.7 22.9 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.7 12.2 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.7 17.0 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.6 14.0 GO:0042056 chemoattractant activity(GO:0042056)
0.6 31.2 GO:0004521 endoribonuclease activity(GO:0004521)
0.5 20.7 GO:0005109 frizzled binding(GO:0005109)
0.5 3.3 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.5 11.4 GO:0005112 Notch binding(GO:0005112)
0.4 23.0 GO:0005080 protein kinase C binding(GO:0005080)
0.4 101.4 GO:0005096 GTPase activator activity(GO:0005096)
0.4 65.2 GO:0019903 protein phosphatase binding(GO:0019903)
0.4 2.9 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.4 43.3 GO:0005178 integrin binding(GO:0005178)
0.4 87.4 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.4 60.9 GO:0051015 actin filament binding(GO:0051015)
0.3 9.1 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.3 7.7 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.3 13.6 GO:0001786 phosphatidylserine binding(GO:0001786)
0.3 50.9 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)
0.3 3.9 GO:0051378 serotonin binding(GO:0051378)
0.3 12.8 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.3 3.9 GO:0004579 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.3 75.1 GO:0030246 carbohydrate binding(GO:0030246)
0.3 40.8 GO:0042393 histone binding(GO:0042393)
0.2 48.7 GO:0003735 structural constituent of ribosome(GO:0003735)
0.2 4.8 GO:0042162 telomeric DNA binding(GO:0042162)
0.2 16.2 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 17.3 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.1 8.9 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.1 4.1 GO:0019902 phosphatase binding(GO:0019902)
0.1 0.2 GO:0042392 sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.1 20.4 GO:0003924 GTPase activity(GO:0003924)
0.1 76.0 GO:0005102 receptor binding(GO:0005102)
0.0 21.2 GO:0005509 calcium ion binding(GO:0005509)
0.0 14.7 GO:0003682 chromatin binding(GO:0003682)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
5.6 449.9 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
4.8 62.2 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
4.0 150.9 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
3.2 161.3 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
2.8 47.5 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
2.5 59.6 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
2.2 81.9 PID AURORA A PATHWAY Aurora A signaling
2.0 43.4 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
1.8 111.3 PID IL4 2PATHWAY IL4-mediated signaling events
1.5 42.9 PID CONE PATHWAY Visual signal transduction: Cones
1.3 17.2 PID AVB3 OPN PATHWAY Osteopontin-mediated events
1.3 132.5 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
1.3 47.8 PID RAC1 REG PATHWAY Regulation of RAC1 activity
1.0 157.9 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.7 14.0 PID TCPTP PATHWAY Signaling events mediated by TCPTP
0.7 24.8 PID ENDOTHELIN PATHWAY Endothelins
0.7 11.3 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling
0.6 12.1 PID RAC1 PATHWAY RAC1 signaling pathway
0.4 7.2 PID IFNG PATHWAY IFN-gamma pathway
0.4 16.9 PID RHOA REG PATHWAY Regulation of RhoA activity
0.4 16.7 PID PLK1 PATHWAY PLK1 signaling events
0.3 5.2 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.3 16.2 PID P73PATHWAY p73 transcription factor network
0.3 21.3 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.3 11.9 PID TGFBR PATHWAY TGF-beta receptor signaling
0.3 11.4 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.2 9.6 PID TNF PATHWAY TNF receptor signaling pathway
0.2 56.0 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.2 1.4 PID IL27 PATHWAY IL27-mediated signaling events
0.1 1.3 PID PI3KCI PATHWAY Class I PI3K signaling events
0.1 16.5 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.2 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
9.1 145.7 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
8.7 96.2 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
8.1 97.3 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
7.9 157.5 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
5.9 17.6 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
5.4 65.2 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
4.4 105.0 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
4.2 67.7 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
4.1 119.8 REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA Genes involved in G beta:gamma signalling through PI3Kgamma
3.2 180.9 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
3.1 53.3 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
3.0 47.5 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
2.1 21.1 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
2.0 42.5 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
1.9 24.8 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
1.9 72.7 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
1.7 86.1 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
1.7 55.0 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
1.6 43.4 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
1.4 14.0 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
1.3 24.1 REACTOME DESTABILIZATION OF MRNA BY BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
1.3 10.3 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
1.3 11.4 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
1.3 71.8 REACTOME SIGNALING BY ERBB2 Genes involved in Signaling by ERBB2
1.2 25.6 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
1.2 68.6 REACTOME SIGNALING BY SCF KIT Genes involved in Signaling by SCF-KIT
1.1 16.9 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
1.0 11.3 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.9 15.2 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.9 83.9 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.9 15.4 REACTOME ACTIVATED POINT MUTANTS OF FGFR2 Genes involved in Activated point mutants of FGFR2
0.8 95.3 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.8 14.6 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.8 42.2 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.8 71.9 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.7 101.4 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.7 24.1 REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX Genes involved in Activation of the pre-replicative complex
0.5 4.1 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.5 20.8 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.5 6.7 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.4 16.7 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.4 27.0 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.4 9.1 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.3 21.2 REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION Genes involved in 3' -UTR-mediated translational regulation
0.3 3.3 REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle
0.3 3.9 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.3 4.8 REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.2 17.4 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.2 3.9 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.1 2.9 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.1 22.9 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 3.9 REACTOME ASPARAGINE N LINKED GLYCOSYLATION Genes involved in Asparagine N-linked glycosylation
0.0 1.0 REACTOME TRANSLATION Genes involved in Translation