ISMARA results: Spi1

Project

GSE53960: rat RNA-Seq transcriptomic Bodymap

Navigation

Downloads

Results for Spi1

Z-value: 3.16

Motif logo

Transcription factors associated with Spi1

Gene Symbol	Gene ID	Gene Info
Spi1 NCBI RGD Ensembl	ENSRNOG00000012172	Spi-1 proto-oncogene

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Spi1	rn6_v1_chr3_+_79918969_79918969	0.81	9.8e-77	Click!

Activity profile of Spi1 motif

Sorted Z-values of Spi1 motif

Top targets:

Search:

Show entries

Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr13_-_55173692 Show fit	158.39	ENSRNOT00000064785 ENSRNOT00000029878 ENSRNOT00000029865 ENSRNOT00000060292 ENSRNOT00000000814	Ptprc NCBI RGD Ensembl Show fit	protein tyrosine phosphatase, receptor type, C
chr1_-_198662610 Show fit	121.84	ENSRNOT00000055012	Sept1 NCBI RGD Ensembl Show fit	septin 1
chr13_+_47602692 Show fit	110.09	ENSRNOT00000038822	Fcmr NCBI RGD Ensembl Show fit	Fc fragment of IgM receptor
chr7_+_119482272 Show fit	95.59	ENSRNOT00000009544	Ncf4 NCBI RGD Ensembl Show fit	neutrophil cytosolic factor 4
chr1_-_198577226 Show fit	90.23	ENSRNOT00000055013	Spn NCBI RGD Ensembl Show fit	sialophorin
chr10_-_70802782 Show fit	88.45	ENSRNOT00000045867	Ccl6 NCBI RGD Ensembl Show fit	chemokine (C-C motif) ligand 6
chr15_+_57221292 Show fit	86.39	ENSRNOT00000014502	Lcp1 NCBI RGD Ensembl Show fit	lymphocyte cytosolic protein 1
chr4_-_170932618 Show fit	84.93	ENSRNOT00000007779	Arhgdib NCBI RGD Ensembl Show fit	Rho GDP dissociation inhibitor beta
chr1_+_198744050 Show fit	82.62	ENSRNOT00000024404	Itgal NCBI RGD Ensembl Show fit	integrin subunit alpha L
chr1_-_226791773 Show fit	77.74	ENSRNOT00000082482 ENSRNOT00000065376 ENSRNOT00000054812 ENSRNOT00000086669	LOC100911215 NCBI RGD Ensembl Show fit	T-cell surface glycoprotein CD5-like

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Spi1

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
1.2	366.8	GO:0043547	positive regulation of GTPase activity(GO:0043547)
1.5	181.7	GO:0007265	Ras protein signal transduction(GO:0007265)
12.3	172.1	GO:0001771	immunological synapse formation(GO:0001771)
1.5	171.6	GO:0035023	regulation of Rho protein signal transduction(GO:0035023)
52.8	158.4	GO:0001915	negative regulation of T cell mediated cytotoxicity(GO:0001915)
14.0	153.6	GO:1990001	inhibition of cysteine-type endopeptidase activity involved in apoptotic process(GO:1990001)
13.8	151.3	GO:0050862	positive regulation of T cell receptor signaling pathway(GO:0050862)
6.4	147.2	GO:0071285	cellular response to lithium ion(GO:0071285)
14.4	144.5	GO:0090500	endocardial cushion to mesenchymal transition(GO:0090500)
11.9	131.1	GO:0002291	T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:0002291)

Showing 1 to 10 of 669 entries

Gene overrepresentation in cellular component category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
3.5	945.3	GO:0009897	external side of plasma membrane(GO:0009897)
0.5	484.3	GO:0005615	extracellular space(GO:0005615)
9.3	288.0	GO:0008305	integrin complex(GO:0008305)
2.4	270.5	GO:0005884	actin filament(GO:0005884)
0.9	226.7	GO:0005925	focal adhesion(GO:0005925)
27.5	220.1	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
2.1	197.3	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
12.3	184.0	GO:0001931	uropod(GO:0001931) cell trailing edge(GO:0031254)
2.0	175.2	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.5	173.4	GO:0005667	transcription factor complex(GO:0005667)

Showing 1 to 10 of 247 entries

Gene overrepresentation in molecular function category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
2.2	617.4	GO:0030695	GTPase regulator activity(GO:0030695)
1.0	356.7	GO:0005525	GTP binding(GO:0005525)
11.5	287.6	GO:0042288	MHC class I protein binding(GO:0042288)
0.8	231.6	GO:0050839	cell adhesion molecule binding(GO:0050839)
0.9	226.3	GO:0030246	carbohydrate binding(GO:0030246)
0.8	219.9	GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
23.7	213.3	GO:0019198	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.9	206.8	GO:0003735	structural constituent of ribosome(GO:0003735)
1.2	161.5	GO:0051015	actin filament binding(GO:0051015)
15.5	154.7	GO:0019957	C-C chemokine binding(GO:0019957)

Showing 1 to 10 of 379 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
9.4	618.0	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
8.1	484.9	PID BCR 5PATHWAY	BCR signaling pathway
2.3	453.9	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
9.4	271.7	PID INTEGRIN CS PATHWAY	Integrin family cell surface interactions
4.2	253.6	PID RHOA REG PATHWAY	Regulation of RhoA activity
4.0	210.1	PID ILK PATHWAY	Integrin-linked kinase signaling
1.3	199.8	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
2.4	191.9	PID CMYB PATHWAY	C-MYB transcription factor network
1.5	182.9	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
7.7	161.4	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling

Showing 1 to 10 of 107 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
3.0	407.3	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
7.8	387.8	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
33.9	373.1	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
8.3	366.1	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
8.1	317.7	REACTOME GPVI MEDIATED ACTIVATION CASCADE	Genes involved in GPVI-mediated activation cascade
2.6	264.0	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
1.6	200.8	REACTOME G ALPHA I SIGNALLING EVENTS	Genes involved in G alpha (i) signalling events
7.1	192.3	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
11.9	190.7	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
2.1	144.1	REACTOME ANTIGEN PROCESSING CROSS PRESENTATION	Genes involved in Antigen processing-Cross presentation

Showing 1 to 10 of 144 entries

Results for Spi1

Z-value: 3.16

Motif logo

Transcription factors associated with Spi1

Activity-expression correlation:

Activity profile of Spi1 motif

Sorted Z-values of Spi1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Spi1

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: