ISMARA results: Sp2

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Sp2

Z-value: 0.81

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Transcription factors associated with Sp2

Gene Symbol	Gene ID	Gene Info
Sp2 NCBI RGD Ensembl	ENSRNOG00000010492	Sp2 transcription factor

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Sp2	rn6_v1_chr10_-_84920886_84920886	-0.61	2.4e-34	Click!

Activity profile of Sp2 motif

Sorted Z-values of Sp2 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr1_+_80195532 Show fit	53.95	ENSRNOT00000022528	Rtn2 NCBI RGD Ensembl Show fit	reticulon 2
chr6_+_137184820 Show fit	31.03	ENSRNOT00000073796	Adssl1 NCBI RGD Ensembl Show fit	adenylosuccinate synthase like 1
chr13_-_90602365 Show fit	30.65	ENSRNOT00000009344	Casq1 NCBI RGD Ensembl Show fit	calsequestrin 1
chr10_-_8498422 Show fit	27.83	ENSRNOT00000082332	Rbfox1 NCBI RGD Ensembl Show fit	RNA binding protein, fox-1 homolog 1
chr1_-_80609836 Show fit	20.58	ENSRNOT00000091647 ENSRNOT00000046169	Apoc1 NCBI RGD Ensembl Show fit	apolipoprotein C1
chr13_+_104284660 Show fit	20.39	ENSRNOT00000005400	Dusp10 NCBI RGD Ensembl Show fit	dual specificity phosphatase 10
chr12_+_45905371 Show fit	20.10	ENSRNOT00000039275	Hspb8 NCBI RGD Ensembl Show fit	heat shock protein family B (small) member 8
chr15_+_34251606 Show fit	19.87	ENSRNOT00000025725	Fitm1 NCBI RGD Ensembl Show fit	fat storage-inducing transmembrane protein 1
chr2_-_53413638 Show fit	18.81	ENSRNOT00000021081	Ghr NCBI RGD Ensembl Show fit	growth hormone receptor
chr1_-_198232344 Show fit	17.52	ENSRNOT00000080988	Aldoa NCBI RGD Ensembl Show fit	aldolase, fructose-bisphosphate A

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Sp2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	56.6	GO:0065002	intracellular protein transmembrane transport(GO:0065002)
10.3	31.0	GO:0044208	'de novo' AMP biosynthetic process(GO:0044208)
7.7	30.6	GO:0014809	regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
1.2	27.8	GO:2001014	regulation of skeletal muscle cell differentiation(GO:2001014)
5.1	20.6	GO:0010916	regulation of phosphatidylcholine catabolic process(GO:0010899) regulation of very-low-density lipoprotein particle clearance(GO:0010915) negative regulation of very-low-density lipoprotein particle clearance(GO:0010916)
5.1	20.4	GO:0060266	negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
6.7	20.2	GO:0060577	pulmonary vein morphogenesis(GO:0060577)
2.8	19.9	GO:0010890	positive regulation of sequestering of triglyceride(GO:0010890)
2.1	18.8	GO:0006600	allantoin metabolic process(GO:0000255) isoleucine metabolic process(GO:0006549) creatine metabolic process(GO:0006600) creatinine metabolic process(GO:0046449)
1.3	17.5	GO:0030388	fructose 1,6-bisphosphate metabolic process(GO:0030388)

Showing 1 to 10 of 132 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	45.6	GO:0005615	extracellular space(GO:0005615)
1.6	45.2	GO:0098827	endoplasmic reticulum subcompartment(GO:0098827)
0.2	39.5	GO:0005802	trans-Golgi network(GO:0005802)
7.7	30.6	GO:0033018	sarcoplasmic reticulum lumen(GO:0033018)
0.1	21.9	GO:0016607	nuclear speck(GO:0016607)
1.1	20.6	GO:0034385	very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.4	19.7	GO:0009295	nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.2	19.4	GO:0016605	PML body(GO:0016605)
3.8	18.8	GO:0070195	growth hormone receptor complex(GO:0070195)
1.0	17.5	GO:0035686	sperm fibrous sheath(GO:0035686)

Showing 1 to 10 of 68 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	31.0	GO:0016879	ligase activity, forming carbon-nitrogen bonds(GO:0016879)
0.0	22.9	GO:0005509	calcium ion binding(GO:0005509)
0.1	22.5	GO:0008022	protein C-terminus binding(GO:0008022)
0.5	21.5	GO:0001102	RNA polymerase II activating transcription factor binding(GO:0001102)
1.0	21.3	GO:0005159	insulin-like growth factor receptor binding(GO:0005159)
2.3	20.6	GO:0004859	phospholipase inhibitor activity(GO:0004859)
1.3	20.4	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
4.7	18.8	GO:0004903	growth hormone receptor activity(GO:0004903)
2.5	17.5	GO:0004332	fructose-bisphosphate aldolase activity(GO:0004332)
1.2	16.6	GO:0001206	transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)

Showing 1 to 10 of 98 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	21.4	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.5	20.4	PID P38 ALPHA BETA PATHWAY	Regulation of p38-alpha and p38-beta
0.3	19.9	PID HES HEY PATHWAY	Notch-mediated HES/HEY network
0.7	18.0	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.3	12.6	PID BMP PATHWAY	BMP receptor signaling
0.2	10.8	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.2	7.6	PID CERAMIDE PATHWAY	Ceramide signaling pathway
0.0	6.7	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.1	6.6	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
0.1	6.0	PID SHP2 PATHWAY	SHP2 signaling

Showing 1 to 10 of 26 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.6	31.0	REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	Genes involved in Purine ribonucleoside monophosphate biosynthesis
1.0	21.9	REACTOME PROLACTIN RECEPTOR SIGNALING	Genes involved in Prolactin receptor signaling
0.6	20.9	REACTOME GLUCONEOGENESIS	Genes involved in Gluconeogenesis
0.1	17.9	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives
0.3	16.5	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.8	16.2	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.8	14.5	REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION	Genes involved in Amino acid synthesis and interconversion (transamination)
0.1	14.0	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.2	10.6	REACTOME REGULATION OF INSULIN SECRETION BY GLUCAGON LIKE PEPTIDE1	Genes involved in Regulation of Insulin Secretion by Glucagon-like Peptide-1
0.6	10.5	REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM	Genes involved in Branched-chain amino acid catabolism

Showing 1 to 10 of 42 entries

Results for Sp2

Z-value: 0.81

Motif logo

Transcription factors associated with Sp2

Activity-expression correlation:

Activity profile of Sp2 motif

Sorted Z-values of Sp2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Sp2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: