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GSE53960: rat RNA-Seq transcriptomic Bodymap
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Results for Sox17
Z-value: 0.91
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Transcription factors associated with Sox17
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Sox17 | rn6_v1_chr5_+_14890408_14890408 | -0.42 | 4.8e-15 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_-_161246351 Show fit | 37.25 |
ENSRNOT00000020348
|
troponin C2, fast skeletal type |
|
| chr16_-_75581325 Show fit | 26.22 |
ENSRNOT00000058031
|
defensin beta 33 |
|
| chr10_+_4953879 Show fit | 25.46 |
ENSRNOT00000003455
|
transition protein 2 |
|
| chr1_-_101210675 Show fit | 25.37 |
ENSRNOT00000028082
|
dickkopf like acrosomal protein 1 |
|
| chr9_+_15582564 Show fit | 23.51 |
ENSRNOT00000020640
|
uncharacterized LOC100912849 |
|
| chr1_+_215666628 Show fit | 20.53 |
ENSRNOT00000040598
ENSRNOT00000066135 ENSRNOT00000051425 ENSRNOT00000080339 ENSRNOT00000066896 ENSRNOT00000063918 |
troponin T3, fast skeletal type |
|
| chr14_+_96300596 Show fit | 19.30 |
ENSRNOT00000071967
|
similar to Spindlin-like protein 2 (SPIN-2) |
|
| chr13_-_47331187 Show fit | 19.26 |
ENSRNOT00000035577
ENSRNOT00000049915 |
zona pellucida 3 receptor |
|
| chrX_+_43745604 Show fit | 19.01 |
ENSRNOT00000040825
|
rCG36365-like |
|
| chr16_+_72086878 Show fit | 18.62 |
ENSRNOT00000023756
ENSRNOT00000078085 |
ADAM metallopeptidase domain 3A |
Network of associatons between targets according to the STRING database.
First level regulatory network of Sox17
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 57.8 | GO:0003009 | skeletal muscle contraction(GO:0003009) |
| 1.2 | 37.9 | GO:0007339 | binding of sperm to zona pellucida(GO:0007339) |
| 3.6 | 25.5 | GO:0007341 | penetration of zona pellucida(GO:0007341) |
| 0.1 | 25.5 | GO:0042742 | defense response to bacterium(GO:0042742) |
| 0.4 | 25.4 | GO:0045600 | positive regulation of fat cell differentiation(GO:0045600) |
| 3.6 | 21.7 | GO:2000741 | positive regulation of mesenchymal stem cell differentiation(GO:2000741) |
| 0.5 | 16.4 | GO:0034314 | Arp2/3 complex-mediated actin nucleation(GO:0034314) |
| 1.9 | 15.3 | GO:0090286 | cytoskeletal anchoring at nuclear membrane(GO:0090286) |
| 3.0 | 15.0 | GO:0035617 | stress granule disassembly(GO:0035617) |
| 0.5 | 12.9 | GO:0010614 | negative regulation of cardiac muscle hypertrophy(GO:0010614) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.8 | 57.8 | GO:0005861 | troponin complex(GO:0005861) |
| 0.0 | 38.0 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 34.1 | GO:0005576 | extracellular region(GO:0005576) |
| 1.1 | 25.5 | GO:0001673 | male germ cell nucleus(GO:0001673) |
| 4.8 | 19.3 | GO:0034774 | secretory granule lumen(GO:0034774) |
| 0.1 | 19.0 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.2 | 17.3 | GO:0045178 | basal part of cell(GO:0045178) |
| 1.3 | 16.4 | GO:0005885 | Arp2/3 protein complex(GO:0005885) |
| 0.0 | 16.2 | GO:0045121 | membrane raft(GO:0045121) membrane microdomain(GO:0098857) |
| 0.3 | 15.3 | GO:0005637 | nuclear inner membrane(GO:0005637) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 12.1 | 60.7 | GO:0005550 | pheromone binding(GO:0005550) |
| 0.5 | 37.3 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
| 5.1 | 20.5 | GO:0030172 | troponin C binding(GO:0030172) calcium-dependent ATPase activity(GO:0030899) |
| 0.0 | 19.7 | GO:0003677 | DNA binding(GO:0003677) |
| 0.2 | 18.6 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.2 | 15.2 | GO:0016503 | pheromone receptor activity(GO:0016503) |
| 0.1 | 14.7 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.3 | 14.6 | GO:0004712 | protein serine/threonine/tyrosine kinase activity(GO:0004712) |
| 1.8 | 12.9 | GO:0035375 | zymogen binding(GO:0035375) |
| 0.1 | 12.9 | GO:0001191 | transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 6.9 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.2 | 6.4 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 5.7 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 5.2 | PID ATR PATHWAY | ATR signaling pathway |
| 0.0 | 1.1 | PID PS1 PATHWAY | Presenilin action in Notch and Wnt signaling |
| 0.0 | 0.4 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 48.4 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.4 | 10.3 | REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS | Genes involved in Transport of Ribonucleoproteins into the Host Nucleus |
| 0.1 | 6.4 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.0 | 6.3 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.5 | 5.7 | REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES | Genes involved in Recruitment of NuMA to mitotic centrosomes |
| 0.0 | 5.4 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.1 | 4.0 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.0 | 2.9 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.2 | 2.4 | REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |
| 0.1 | 1.1 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |