ISMARA results: Sox14

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Sox14

Z-value: 0.96

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Transcription factors associated with Sox14

Gene Symbol	Gene ID	Gene Info
Sox14 NCBI RGD Ensembl	ENSRNOG00000022084	SRY box 14

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Sox14	rn6_v1_chr8_-_108109801_108109801	0.17	2.7e-03	Click!

Activity profile of Sox14 motif

Sorted Z-values of Sox14 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr18_+_30562178 Show fit	28.25	ENSRNOT00000040998	LOC108348771 NCBI RGD Ensembl Show fit	protocadherin beta-16-like
chr20_+_3422461 Show fit	23.77	ENSRNOT00000084917 ENSRNOT00000079854	Tubb5 NCBI RGD Ensembl Show fit	tubulin, beta 5 class I
chrX_+_39711201 Show fit	22.76	ENSRNOT00000080512 ENSRNOT00000009802	Cnksr2 NCBI RGD Ensembl Show fit	connector enhancer of kinase suppressor of Ras 2
chr10_-_85974644 Show fit	20.31	ENSRNOT00000006098 ENSRNOT00000082974	Cacnb1 NCBI RGD Ensembl Show fit	calcium voltage-gated channel auxiliary subunit beta 1
chr10_-_90393317 Show fit	18.78	ENSRNOT00000028563	Fam171a2 NCBI RGD Ensembl Show fit	family with sequence similarity 171, member A2
chr2_-_96668222 Show fit	18.13	ENSRNOT00000016567	Pkia NCBI RGD Ensembl Show fit	cAMP-dependent protein kinase inhibitor alpha
chr1_-_170404056 Show fit	17.74	ENSRNOT00000024402	Apbb1 NCBI RGD Ensembl Show fit	amyloid beta precursor protein binding family B member 1
chr4_+_70572942 Show fit	17.68	ENSRNOT00000051964	AC142181.1 NCBI RGD Ensembl Show fit
chr20_+_5049496 Show fit	17.41	ENSRNOT00000088251 ENSRNOT00000001118	Ddah2 NCBI RGD Ensembl Show fit	dimethylarginine dimethylaminohydrolase 2
chr1_-_236900904 Show fit	16.93	ENSRNOT00000066846	AABR07006480.1 NCBI RGD Ensembl Show fit

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Sox14

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	109.4	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
2.3	38.6	GO:0048242	epinephrine secretion(GO:0048242)
0.3	28.9	GO:0051225	spindle assembly(GO:0051225)
0.8	27.7	GO:0035458	cellular response to interferon-beta(GO:0035458)
1.8	22.1	GO:0046543	development of secondary female sexual characteristics(GO:0046543)
5.5	21.8	GO:0043988	histone H3-S28 phosphorylation(GO:0043988)
2.1	21.4	GO:0002430	complement receptor mediated signaling pathway(GO:0002430)
0.5	20.3	GO:1901385	regulation of voltage-gated calcium channel activity(GO:1901385)
1.1	18.2	GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
1.5	18.1	GO:2000480	negative regulation of cAMP-dependent protein kinase activity(GO:2000480)

Showing 1 to 10 of 201 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	80.2	GO:0005887	integral component of plasma membrane(GO:0005887)
0.2	29.0	GO:0030427	site of polarized growth(GO:0030427)
0.1	26.6	GO:0098857	membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.1	24.9	GO:0005925	focal adhesion(GO:0005925)
2.6	23.8	GO:0005641	nuclear envelope lumen(GO:0005641)
0.1	22.0	GO:0043204	perikaryon(GO:0043204)
3.6	21.8	GO:0032133	chromosome passenger complex(GO:0032133)
0.3	20.5	GO:0032580	Golgi cisterna membrane(GO:0032580)
0.3	20.3	GO:0016529	sarcoplasmic reticulum(GO:0016529)
0.0	20.3	GO:0005815	microtubule organizing center(GO:0005815)

Showing 1 to 10 of 106 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	84.2	GO:0005509	calcium ion binding(GO:0005509)
2.8	38.6	GO:0030550	acetylcholine receptor inhibitor activity(GO:0030550)
0.9	31.4	GO:0001540	beta-amyloid binding(GO:0001540)
0.5	27.6	GO:0005080	protein kinase C binding(GO:0005080)
1.2	23.8	GO:0032794	GTPase activating protein binding(GO:0032794)
0.1	22.2	GO:0003924	GTPase activity(GO:0003924)
3.6	21.4	GO:0004982	N-formyl peptide receptor activity(GO:0004982)
1.1	20.3	GO:0008331	high voltage-gated calcium channel activity(GO:0008331)
1.2	19.9	GO:0035174	histone serine kinase activity(GO:0035174)
0.1	19.7	GO:0001077	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)

Showing 1 to 10 of 151 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	39.5	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.5	30.0	PID TRKR PATHWAY	Neurotrophic factor-mediated Trk receptor signaling
0.6	29.4	PID UPA UPAR PATHWAY	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.5	26.8	PID KIT PATHWAY	Signaling events mediated by Stem cell factor receptor (c-Kit)
0.5	21.8	PID AURORA A PATHWAY	Aurora A signaling
1.6	20.2	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.5	20.1	PID EPHB FWD PATHWAY	EPHB forward signaling
0.6	19.9	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.3	18.1	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.4	15.3	ST WNT BETA CATENIN PATHWAY	Wnt/beta-catenin Pathway

Showing 1 to 10 of 39 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	30.3	REACTOME SIGNALING BY NOTCH1	Genes involved in Signaling by NOTCH1
0.1	22.9	REACTOME G ALPHA I SIGNALLING EVENTS	Genes involved in G alpha (i) signalling events
0.5	20.3	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.3	19.8	REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1	Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.5	18.2	REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	Genes involved in Synthesis of PIPs at the plasma membrane
0.4	15.3	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.7	15.0	REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI	Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.2	15.0	REACTOME POTASSIUM CHANNELS	Genes involved in Potassium Channels
0.5	13.5	REACTOME SYNTHESIS OF PC	Genes involved in Synthesis of PC
0.7	13.0	REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	Genes involved in Trafficking of GluR2-containing AMPA receptors

Showing 1 to 10 of 62 entries

Results for Sox14

Z-value: 0.96

Motif logo

Transcription factors associated with Sox14

Activity-expression correlation:

Activity profile of Sox14 motif

Sorted Z-values of Sox14 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Sox14

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: