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GSE53960: rat RNA-Seq transcriptomic Bodymap
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Results for Snai1_Zeb1_Snai2
Z-value: 4.28
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Transcription factors associated with Snai1_Zeb1_Snai2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Snai2 | rn6_v1_chr11_-_90406797_90406797 | 0.49 | 8.4e-21 | Click! |
| Snai1 | rn6_v1_chr3_+_164275095_164275095 | 0.37 | 1.5e-11 | Click! |
| Zeb1 | rn6_v1_chr17_-_54678710_54678710 | 0.06 | 2.9e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr10_+_56576428 Show fit | 280.46 |
ENSRNOT00000079237
ENSRNOT00000023291 |
claudin 7 |
|
| chr8_-_22336794 Show fit | 196.70 |
ENSRNOT00000066340
|
adaptor-related protein complex 1, mu 2 subunit |
|
| chr2_-_30577218 Show fit | 190.07 |
ENSRNOT00000024674
|
occludin |
|
| chr9_-_104350308 Show fit | 173.06 |
ENSRNOT00000033958
|
solute carrier organic anion transporter family, member 4C1 |
|
| chr7_+_94130852 Show fit | 159.57 |
ENSRNOT00000011485
|
mal, T-cell differentiation protein 2 |
|
| chr11_-_67037115 Show fit | 155.62 |
ENSRNOT00000003137
|
immunoglobulin-like domain containing receptor 1 |
|
| chr9_-_9985630 Show fit | 146.22 |
ENSRNOT00000071780
|
crumbs 3, cell polarity complex component |
|
| chr3_+_164822111 Show fit | 139.16 |
ENSRNOT00000014568
|
par-6 family cell polarity regulator beta |
|
| chr1_-_87221826 Show fit | 133.98 |
ENSRNOT00000046611
ENSRNOT00000028006 |
serine peptidase inhibitor, Kunitz type, 2 |
|
| chr10_-_31359699 Show fit | 132.59 |
ENSRNOT00000081280
|
cytoplasmic FMR1 interacting protein 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Snai1_Zeb1_Snai2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 32.2 | 418.6 | GO:0016338 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338) |
| 34.7 | 312.7 | GO:0001766 | membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580) |
| 30.4 | 304.3 | GO:0070673 | response to interleukin-18(GO:0070673) |
| 57.2 | 229.0 | GO:0060671 | epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672) |
| 2.1 | 220.5 | GO:0035023 | regulation of Rho protein signal transduction(GO:0035023) |
| 16.7 | 217.3 | GO:0060670 | branching involved in labyrinthine layer morphogenesis(GO:0060670) |
| 23.7 | 189.7 | GO:0051388 | positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388) |
| 7.1 | 177.4 | GO:0060445 | branching involved in salivary gland morphogenesis(GO:0060445) |
| 21.2 | 169.3 | GO:0030321 | transepithelial chloride transport(GO:0030321) |
| 11.2 | 145.4 | GO:0071377 | cellular response to glucagon stimulus(GO:0071377) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 2624.4 | GO:0070062 | extracellular exosome(GO:0070062) |
| 40.0 | 960.0 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 5.1 | 633.0 | GO:0070160 | bicellular tight junction(GO:0005923) occluding junction(GO:0070160) |
| 2.2 | 571.9 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 6.5 | 516.3 | GO:0031526 | brush border membrane(GO:0031526) |
| 1.3 | 443.1 | GO:0005764 | lytic vacuole(GO:0000323) lysosome(GO:0005764) |
| 1.8 | 439.9 | GO:0045177 | apical part of cell(GO:0045177) |
| 2.1 | 430.6 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.7 | 329.1 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 3.5 | 297.1 | GO:0032587 | ruffle membrane(GO:0032587) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 570.4 | GO:0050839 | cell adhesion molecule binding(GO:0050839) |
| 4.2 | 492.3 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 27.0 | 324.6 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 1.9 | 235.6 | GO:0008201 | heparin binding(GO:0008201) |
| 1.1 | 220.3 | GO:0008236 | serine-type peptidase activity(GO:0008236) |
| 12.3 | 209.3 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 23.2 | 208.4 | GO:0015280 | ligand-gated sodium channel activity(GO:0015280) |
| 1.8 | 185.8 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 2.6 | 185.0 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 15.4 | 184.4 | GO:0015245 | fatty acid transporter activity(GO:0015245) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.9 | 411.3 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 5.1 | 361.4 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 2.1 | 314.7 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 4.5 | 244.9 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 4.1 | 244.0 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 7.7 | 207.7 | PID INTEGRIN CS PATHWAY | Integrin family cell surface interactions |
| 2.9 | 192.5 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 5.3 | 184.4 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
| 4.0 | 176.7 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 10.4 | 176.6 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 29.0 | 956.5 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 4.5 | 514.2 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 34.0 | 475.6 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 4.4 | 247.7 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 2.5 | 236.1 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 3.7 | 233.0 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 5.7 | 211.8 | REACTOME GPVI MEDIATED ACTIVATION CASCADE | Genes involved in GPVI-mediated activation cascade |
| 19.4 | 194.4 | REACTOME TRANSPORT OF ORGANIC ANIONS | Genes involved in Transport of organic anions |
| 24.1 | 192.7 | REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 3.8 | 180.3 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |