ISMARA results: Smarcc1

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Smarcc1_Fosl1

Z-value: 2.22

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Transcription factors associated with Smarcc1_Fosl1

Gene Symbol	Gene ID	Gene Info
Smarcc1 NCBI RGD Ensembl	ENSRNOG00000020804	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
Fosl1 NCBI RGD Ensembl	ENSRNOG00000020552	FOS like 1, AP-1 transcription factor subunit

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Fosl1	rn6_v1_chr1_+_220826560_220826560	-0.51	3.3e-22	Click!
Smarcc1	rn6_v1_chr8_+_118206698_118206703	-0.13	1.9e-02	Click!

Activity profile of Smarcc1_Fosl1 motif

Sorted Z-values of Smarcc1_Fosl1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr4_+_98370797 Show fit	82.40	ENSRNOT00000031991	AABR07060872.1 NCBI RGD Ensembl Show fit
chr3_+_16753703 Show fit	58.75	ENSRNOT00000077741	AABR07051548.2 NCBI RGD Ensembl Show fit
chr3_+_19274273 Show fit	54.44	ENSRNOT00000040102	AABR07051684.1 NCBI RGD Ensembl Show fit
chr1_-_197821936 Show fit	54.27	ENSRNOT00000055027	Cd19 NCBI RGD Ensembl Show fit	CD19 molecule
chr6_-_138508753 Show fit	50.85	ENSRNOT00000006888	Ighm NCBI RGD Ensembl Show fit	immunoglobulin heavy constant mu
chr1_+_215666628 Show fit	50.55	ENSRNOT00000040598 ENSRNOT00000066135 ENSRNOT00000051425 ENSRNOT00000080339 ENSRNOT00000066896 ENSRNOT00000063918	Tnnt3 NCBI RGD Ensembl Show fit	troponin T3, fast skeletal type
chr4_+_98457810 Show fit	49.42	ENSRNOT00000074175	AABR07060872.1 NCBI RGD Ensembl Show fit
chr4_+_70828894 Show fit	47.90	ENSRNOT00000064892	Trbc2 NCBI RGD Ensembl Show fit	T cell receptor beta, constant 2
chr4_-_155401480 Show fit	46.87	ENSRNOT00000020735	Apobec1 NCBI RGD Ensembl Show fit	apolipoprotein B mRNA editing enzyme catalytic subunit 1
chr20_-_4132604 Show fit	46.34	ENSRNOT00000077630 ENSRNOT00000048332	RT1-Da NCBI RGD Ensembl Show fit	RT1 class II, locus Da

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Smarcc1_Fosl1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	134.7	GO:0050911	detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.5	122.8	GO:0010466	negative regulation of peptidase activity(GO:0010466)
3.2	116.5	GO:0035458	cellular response to interferon-beta(GO:0035458)
18.5	92.6	GO:0009608	response to symbiont(GO:0009608)
1.8	91.8	GO:0030239	myofibril assembly(GO:0030239)
8.9	88.8	GO:0050862	positive regulation of T cell receptor signaling pathway(GO:0050862)
2.2	87.2	GO:0002474	antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
1.9	81.3	GO:0006956	complement activation(GO:0006956)
7.5	74.5	GO:0046642	negative regulation of alpha-beta T cell proliferation(GO:0046642)
5.8	69.1	GO:0001778	plasma membrane repair(GO:0001778)

Showing 1 to 10 of 668 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.6	443.4	GO:0009897	external side of plasma membrane(GO:0009897)
0.3	392.0	GO:0005615	extracellular space(GO:0005615)
1.7	182.2	GO:0072562	blood microparticle(GO:0072562)
2.0	148.2	GO:0045095	keratin filament(GO:0045095)
9.1	145.9	GO:0042613	MHC class II protein complex(GO:0042613)
4.0	134.5	GO:0008305	integrin complex(GO:0008305)
0.3	87.0	GO:0005667	transcription factor complex(GO:0005667)
6.1	73.1	GO:0005861	troponin complex(GO:0005861)
0.9	66.4	GO:0022627	cytosolic small ribosomal subunit(GO:0022627)
1.6	64.9	GO:0009925	basal plasma membrane(GO:0009925)

Showing 1 to 10 of 231 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.6	346.5	GO:0004252	serine-type endopeptidase activity(GO:0004252)
2.2	246.1	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.6	151.8	GO:0003735	structural constituent of ribosome(GO:0003735)
0.6	142.2	GO:0030246	carbohydrate binding(GO:0030246)
4.6	97.3	GO:0023026	MHC class II protein complex binding(GO:0023026)
0.8	96.0	GO:0031072	heat shock protein binding(GO:0031072)
2.3	92.3	GO:0070330	aromatase activity(GO:0070330)
0.1	82.4	GO:0004984	olfactory receptor activity(GO:0004984)
6.0	78.3	GO:1990405	protein antigen binding(GO:1990405)
2.0	69.0	GO:0042605	peptide antigen binding(GO:0042605)

Showing 1 to 10 of 408 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	193.7	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
4.6	134.5	PID INTEGRIN CS PATHWAY	Integrin family cell surface interactions
2.5	126.8	PID IL12 2PATHWAY	IL12-mediated signaling events
2.7	106.7	PID EPO PATHWAY	EPO signaling pathway
2.7	105.2	PID IL23 PATHWAY	IL23-mediated signaling events
2.2	93.9	PID AMB2 NEUTROPHILS PATHWAY	amb2 Integrin signaling
1.3	85.7	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
4.7	84.5	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.5	68.0	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
2.8	66.4	PID S1P META PATHWAY	Sphingosine 1-phosphate (S1P) pathway

Showing 1 to 10 of 94 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.4	170.5	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
2.9	108.8	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
5.4	69.7	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
1.6	67.5	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
1.1	59.3	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
5.1	55.9	REACTOME REGULATION OF IFNG SIGNALING	Genes involved in Regulation of IFNG signaling
1.0	53.1	REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL	Genes involved in Cell surface interactions at the vascular wall
2.2	52.3	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.7	50.7	REACTOME ANTIGEN PROCESSING CROSS PRESENTATION	Genes involved in Antigen processing-Cross presentation
0.4	50.1	REACTOME MRNA PROCESSING	Genes involved in mRNA Processing

Showing 1 to 10 of 140 entries

Results for Smarcc1_Fosl1

Z-value: 2.22

Motif logo

Transcription factors associated with Smarcc1_Fosl1

Activity-expression correlation:

Activity profile of Smarcc1_Fosl1 motif

Sorted Z-values of Smarcc1_Fosl1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Smarcc1_Fosl1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: