ISMARA results: Scrt1

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Scrt1

Z-value: 1.35

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Transcription factors associated with Scrt1

Gene Symbol	Gene ID	Gene Info
Scrt1 NCBI RGD Ensembl	ENSRNOG00000025594	scratch family transcriptional repressor 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Scrt1	rn6_v1_chr7_-_117587103_117587103	-0.50	1.8e-21	Click!

Activity profile of Scrt1 motif

Sorted Z-values of Scrt1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr4_-_123557501 Show fit	63.51	ENSRNOT00000075042 ENSRNOT00000085966	Aldh1l1 NCBI RGD Ensembl Show fit	aldehyde dehydrogenase 1 family, member L1
chr2_+_60337667 Show fit	60.76	ENSRNOT00000024035	Agxt2 NCBI RGD Ensembl Show fit	alanine-glyoxylate aminotransferase 2
chr1_+_213511874 Show fit	57.88	ENSRNOT00000078080 ENSRNOT00000016883	Cyp2e1 NCBI RGD Ensembl Show fit	cytochrome P450, family 2, subfamily e, polypeptide 1
chr6_-_127630734 Show fit	57.51	ENSRNOT00000089931	Serpina1 NCBI RGD Ensembl Show fit	serpin family A member 1
chr19_+_52077501 Show fit	54.48	ENSRNOT00000079240	Osgin1 NCBI RGD Ensembl Show fit	oxidative stress induced growth inhibitor 1
chr19_+_37052556 Show fit	50.88	ENSRNOT00000019072	Ces2h NCBI RGD Ensembl Show fit	carboxylesterase 2H
chr3_-_14112851 Show fit	50.40	ENSRNOT00000092736	C5 NCBI RGD Ensembl Show fit	complement C5
chr10_+_71159869 Show fit	43.61	ENSRNOT00000075977 ENSRNOT00000047427	Hnf1b NCBI RGD Ensembl Show fit	HNF1 homeobox B
chr1_-_189199376 Show fit	40.53	ENSRNOT00000021027	Umod NCBI RGD Ensembl Show fit	uromodulin
chr13_-_99287887 Show fit	38.79	ENSRNOT00000004780	Ephx1 NCBI RGD Ensembl Show fit	epoxide hydrolase 1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Scrt1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
21.2	63.5	GO:0009397	folic acid-containing compound catabolic process(GO:0009397) pteridine-containing compound catabolic process(GO:0042560)
20.3	60.8	GO:0019265	glycine biosynthetic process, by transamination of glyoxylate(GO:0019265)
11.6	57.9	GO:0016098	monoterpenoid metabolic process(GO:0016098)
19.2	57.5	GO:0033986	response to methanol(GO:0033986)
17.7	53.0	GO:0010133	proline catabolic process to glutamate(GO:0010133)
5.9	52.8	GO:0001766	membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
8.4	50.4	GO:0010760	negative regulation of macrophage chemotaxis(GO:0010760)
14.5	43.6	GO:0061215	mesonephros morphogenesis(GO:0061206) mesonephric nephron development(GO:0061215) mesonephric nephron morphogenesis(GO:0061228) mesenchymal stem cell maintenance involved in mesonephric nephron morphogenesis(GO:0061235) regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:0061295) negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:0061296) mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:1901146)
10.1	40.5	GO:0072021	ascending thin limb development(GO:0072021) metanephric ascending thin limb development(GO:0072218)
1.7	39.8	GO:0006855	drug transmembrane transport(GO:0006855)

Showing 1 to 10 of 188 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	183.2	GO:0005783	endoplasmic reticulum(GO:0005783)
0.3	93.6	GO:0005759	mitochondrial matrix(GO:0005759)
0.2	84.3	GO:0005667	transcription factor complex(GO:0005667)
0.0	72.3	GO:0070062	extracellular exosome(GO:0070062)
12.6	62.9	GO:0061689	tricellular tight junction(GO:0061689)
0.4	61.8	GO:0031227	intrinsic component of endoplasmic reticulum membrane(GO:0031227)
0.4	51.8	GO:0072562	blood microparticle(GO:0072562)
0.1	50.8	GO:0005743	mitochondrial inner membrane(GO:0005743)
0.9	50.6	GO:0060170	ciliary membrane(GO:0060170)
7.2	50.4	GO:0005579	membrane attack complex(GO:0005579)

Showing 1 to 10 of 76 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	105.5	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
7.9	63.5	GO:0016742	hydroxymethyl-, formyl- and related transferase activity(GO:0016742)
12.2	60.8	GO:0008453	alanine-glyoxylate transaminase activity(GO:0008453)
0.4	60.8	GO:0008083	growth factor activity(GO:0008083)
2.9	57.9	GO:0010181	FMN binding(GO:0010181)
17.7	53.0	GO:0004657	proline dehydrogenase activity(GO:0004657)
16.8	50.4	GO:0031714	C5a anaphylatoxin chemotactic receptor binding(GO:0031714)
0.3	50.1	GO:0052689	carboxylic ester hydrolase activity(GO:0052689)
3.9	47.3	GO:0019864	IgG binding(GO:0019864)
0.3	40.3	GO:0004222	metalloendopeptidase activity(GO:0004222)

Showing 1 to 10 of 130 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	109.4	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
1.3	74.1	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
1.4	73.7	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
1.2	57.5	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.3	44.3	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.5	30.7	PID ARF6 TRAFFICKING PATHWAY	Arf6 trafficking events
1.0	26.4	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
0.3	22.1	PID TGFBR PATHWAY	TGF-beta receptor signaling
0.2	20.7	PID PDGFRB PATHWAY	PDGFR-beta signaling pathway
0.5	17.7	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway

Showing 1 to 10 of 31 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.1	81.9	REACTOME REGULATION OF BETA CELL DEVELOPMENT	Genes involved in Regulation of beta-cell development
4.7	60.8	REACTOME PYRIMIDINE CATABOLISM	Genes involved in Pyrimidine catabolism
19.3	57.9	REACTOME XENOBIOTICS	Genes involved in Xenobiotics
1.4	50.4	REACTOME COMPLEMENT CASCADE	Genes involved in Complement cascade
2.5	47.2	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
2.3	41.5	REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS	Genes involved in p130Cas linkage to MAPK signaling for integrins
0.3	41.3	REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production
0.2	37.2	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives
0.5	32.3	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
2.5	29.9	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol

Showing 1 to 10 of 52 entries

Results for Scrt1

Z-value: 1.35

Motif logo

Transcription factors associated with Scrt1

Activity-expression correlation:

Activity profile of Scrt1 motif

Sorted Z-values of Scrt1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Scrt1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: