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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Rorc_Nr1d1

Z-value: 0.98

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Transcription factors associated with Rorc_Nr1d1

Gene Symbol Gene ID Gene Info
Rorc
ENSRNOG00000020836 RAR-related orphan receptor C
Nr1d1
ENSRNOG00000009329 nuclear receptor subfamily 1, group D, member 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nr1d1rn6_v1_chr10_-_86688730_866887300.545.8e-26Click!
Rorcrn6_v1_chr2_+_195617021_195617044-0.483.7e-20Click!

Activity profile of Rorc_Nr1d1 motif

Sorted Z-values of Rorc_Nr1d1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_+_79713567 107.57 ENSRNOT00000012110
C1qtnf4
C1q and tumor necrosis factor related protein 4
chr10_+_86303727 74.74 ENSRNOT00000037752
Ppp1r1b
protein phosphatase 1, regulatory (inhibitor) subunit 1B
chr3_+_98297554 57.06 ENSRNOT00000006524
Kcna4
potassium voltage-gated channel subfamily A member 4
chr11_+_66316606 49.38 ENSRNOT00000041715
Stxbp5l
syntaxin binding protein 5-like
chr11_+_87366621 42.71 ENSRNOT00000040978
Aifm3
apoptosis inducing factor, mitochondria associated 3
chr2_-_189096785 41.60 ENSRNOT00000028200
Chrnb2
cholinergic receptor nicotinic beta 2 subunit
chr8_+_33239139 38.13 ENSRNOT00000011589
Arhgap32
Rho GTPase activating protein 32
chr7_+_64672722 32.74 ENSRNOT00000064448
ENSRNOT00000005539
Grip1
glutamate receptor interacting protein 1
chr8_-_82641536 32.15 ENSRNOT00000014491
Scg3
secretogranin III
chr7_-_136853154 29.13 ENSRNOT00000087376
Nell2
neural EGFL like 2
chrX_+_6791136 27.78 ENSRNOT00000003984
LOC100909913
norrin-like
chr4_-_155275161 26.84 ENSRNOT00000032690
Rimklb
ribosomal modification protein rimK-like family member B
chr10_-_86688730 25.99 ENSRNOT00000055333
Nr1d1
nuclear receptor subfamily 1, group D, member 1
chr4_+_136512201 23.62 ENSRNOT00000051645
Cntn6
contactin 6
chrX_+_33895769 22.80 ENSRNOT00000085993
ENSRNOT00000079365
Reps2
RALBP1 associated Eps domain containing protein 2
chr1_+_101687855 21.57 ENSRNOT00000028546
ENSRNOT00000091597
Dbp
D-box binding PAR bZIP transcription factor
chr3_+_101899068 20.79 ENSRNOT00000079600
ENSRNOT00000006256
Muc15
mucin 15, cell surface associated
chr18_+_30527705 19.70 ENSRNOT00000027168
Pcdhb14
protocadherin beta 14
chr1_-_170404056 19.58 ENSRNOT00000024402
Apbb1
amyloid beta precursor protein binding family B member 1
chr4_-_124338176 18.51 ENSRNOT00000016628
Prickle2
prickle planar cell polarity protein 2
chr12_-_2174131 15.62 ENSRNOT00000001313
Pcp2
Purkinje cell protein 2
chr15_-_8183682 15.26 ENSRNOT00000011438
Nkiras1
NFKB inhibitor interacting Ras-like 1
chr9_-_40008680 14.39 ENSRNOT00000016578
Khdrbs2
KH RNA binding domain containing, signal transduction associated 2
chr5_+_172825072 13.96 ENSRNOT00000068525
Cfap74
cilia and flagella associated protein 74
chr5_+_43603043 13.64 ENSRNOT00000009899
Epha7
Eph receptor A7
chr1_-_67065797 13.23 ENSRNOT00000048152
Vom1r46
vomeronasal 1 receptor 46
chrX_+_14019961 12.45 ENSRNOT00000004785
Sytl5
synaptotagmin-like 5
chr1_-_90520012 12.30 ENSRNOT00000028698
Kctd15
potassium channel tetramerization domain containing 15
chr18_+_70548607 12.27 ENSRNOT00000085318
Myo5b
myosin Vb
chr1_+_16478127 12.08 ENSRNOT00000019076
Ahi1
Abelson helper integration site 1
chr3_-_104502471 11.96 ENSRNOT00000040306
Ryr3
ryanodine receptor 3
chr17_-_2278613 11.91 ENSRNOT00000046525
Cntnap3b
contactin associated protein-like 3B
chr19_-_25062934 11.86 ENSRNOT00000060117
Gm10644
predicted gene 10644
chr4_+_199916 11.68 ENSRNOT00000009317
Htr5a
5-hydroxytryptamine receptor 5A
chr3_+_56056925 11.32 ENSRNOT00000088351
ENSRNOT00000010508
Klhl23
kelch-like family member 23
chr1_-_88066101 11.21 ENSRNOT00000079473
ENSRNOT00000027893
Ryr1
ryanodine receptor 1
chr14_+_100311173 10.75 ENSRNOT00000031275
Ppp3r1
protein phosphatase 3, regulatory subunit B, alpha
chr1_+_219199158 10.28 ENSRNOT00000024034
LOC688778
similar to fatty aldehyde dehydrogenase-like
chr1_-_214414763 9.75 ENSRNOT00000025240
ENSRNOT00000077776
LOC100911440
mitochondrial glutamate carrier 1-like
chr13_-_49169918 9.69 ENSRNOT00000000036
Tmcc2
transmembrane and coiled-coil domain family 2
chr8_-_71055969 9.69 ENSRNOT00000075734
Ankdd1a
ankyrin repeat and death domain containing 1A
chr20_-_14573519 9.60 ENSRNOT00000001772
Rab36
RAB36, member RAS oncogene family
chr14_-_16452890 9.00 ENSRNOT00000067222
ENSRNOT00000091577
Sept11
septin 11
chr8_+_48443767 8.80 ENSRNOT00000010127
C1qtnf5
C1q and tumor necrosis factor related protein 5
chr1_+_170205591 8.57 ENSRNOT00000071063
LOC686660
similar to olfactory receptor 692
chr8_+_107882219 8.47 ENSRNOT00000019902
Dzip1l
DAZ interacting zinc finger protein 1-like
chr7_-_139223116 8.31 ENSRNOT00000086559
Endou
endonuclease, poly(U)-specific
chrX_+_106791333 8.18 ENSRNOT00000050302
Tceal9
transcription elongation factor A like 9
chr1_-_90520344 8.06 ENSRNOT00000078598
Kctd15
potassium channel tetramerization domain containing 15
chr1_+_177093387 7.93 ENSRNOT00000021858
Mical2
microtubule associated monooxygenase, calponin and LIM domain containing 2
chr1_+_221756286 7.92 ENSRNOT00000028636
Pygm
glycogen phosphorylase, muscle associated
chr2_-_166255302 7.74 ENSRNOT00000016012
B3galnt1
beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)
chr4_+_49369296 7.31 ENSRNOT00000007822
Wnt16
wingless-type MMTV integration site family, member 16
chr3_+_139894331 6.99 ENSRNOT00000064695
Rin2
Ras and Rab interactor 2
chrX_-_64908682 6.24 ENSRNOT00000084107
Zc4h2
zinc finger C4H2-type containing
chr5_-_88612626 5.94 ENSRNOT00000089560
Tle1
transducin like enhancer of split 1
chr8_+_48569328 5.48 ENSRNOT00000084030
Ccdc153
coiled-coil domain containing 153
chr3_-_112789282 5.26 ENSRNOT00000090680
ENSRNOT00000066181
Ttbk2
tau tubulin kinase 2
chr6_-_146470456 5.22 ENSRNOT00000018479
RGD1560883
similar to KIAA0825 protein
chr19_+_42983869 4.88 ENSRNOT00000025570
Glg1
golgi glycoprotein 1
chr7_+_37018459 4.80 ENSRNOT00000087297
Eea1
early endosome antigen 1
chr7_-_114573900 4.76 ENSRNOT00000011219
Ptk2
protein tyrosine kinase 2
chr1_-_22281788 4.56 ENSRNOT00000021318
Stx7
syntaxin 7
chr10_+_14248399 4.55 ENSRNOT00000077689
Spsb3
splA/ryanodine receptor domain and SOCS box containing 3
chr14_+_80403001 4.29 ENSRNOT00000012109
Cpz
carboxypeptidase Z
chr13_-_51955735 4.04 ENSRNOT00000007597
Ptprv
protein tyrosine phosphatase, receptor type, V
chr20_+_1647441 3.93 ENSRNOT00000000986
Olr1730
olfactory receptor 1730
chr6_-_76552559 3.93 ENSRNOT00000065230
Ralgapa1
Ral GTPase activating protein catalytic alpha subunit 1
chrX_+_136488691 3.91 ENSRNOT00000093432
Arhgap36
Rho GTPase activating protein 36
chr1_-_169598835 3.81 ENSRNOT00000072996
Olr156
olfactory receptor 156
chr9_-_71651512 3.75 ENSRNOT00000032782
Plekhm3
pleckstrin homology domain containing M3
chr3_+_172155496 3.61 ENSRNOT00000066279
Stx16
syntaxin 16
chr13_+_103171047 3.48 ENSRNOT00000003216
Rab3gap2
RAB3 GTPase activating non-catalytic protein subunit 2
chr15_-_32925673 3.41 ENSRNOT00000081045
Olr1646
olfactory receptor 1646
chr14_-_84334066 3.38 ENSRNOT00000006160
Mtfp1
mitochondrial fission process 1
chr10_-_72417070 3.24 ENSRNOT00000036814
Usp32
ubiquitin specific peptidase 32
chr7_-_12405022 3.20 ENSRNOT00000021648
Cirbp
cold inducible RNA binding protein
chr11_-_82664554 3.08 ENSRNOT00000002425
ENSRNOT00000087105
Senp2
Sumo1/sentrin/SMT3 specific peptidase 2
chr8_+_82380757 2.94 ENSRNOT00000013512
Leo1
LEO1 homolog, Paf1/RNA polymerase II complex component
chr11_-_39767802 2.92 ENSRNOT00000072806
RGD1565472
similar to RIKEN cDNA 2310003P10
chr17_+_68477446 2.85 ENSRNOT00000086236
ENSRNOT00000068174
Pitrm1
pitrilysin metallopeptidase 1
chr14_-_72970329 2.76 ENSRNOT00000006325
Pp2d1
protein phosphatase 2C-like domain containing 1
chr2_-_60461458 2.60 ENSRNOT00000024285
Brix1
BRX1, biogenesis of ribosomes
chrX_+_40286592 2.56 ENSRNOT00000087898
Mbtps2
membrane-bound transcription factor peptidase, site 2
chr19_-_37725623 2.16 ENSRNOT00000024197
Gfod2
glucose-fructose oxidoreductase domain containing 2
chr1_+_66663965 2.09 ENSRNOT00000040738
LOC108348135
vomeronasal type-1 receptor 2-like
chr14_+_69800156 2.07 ENSRNOT00000072746
Lcorl
ligand dependent nuclear receptor corepressor-like
chr8_-_43443531 2.06 ENSRNOT00000007901
LOC103693060
olfactory receptor 148-like
chr17_+_45801528 2.05 ENSRNOT00000089221
Olr1664
olfactory receptor 1664
chr1_-_72339395 2.00 ENSRNOT00000021772
Zfp580
zinc finger protein 580
chr18_-_74059533 1.97 ENSRNOT00000038767
RGD1308601
similar to hypothetical protein
chr3_+_44025300 1.97 ENSRNOT00000006319
Galnt5
polypeptide N-acetylgalactosaminyltransferase 5
chr14_-_115352562 1.93 ENSRNOT00000050321
Erlec1
endoplasmic reticulum lectin 1
chr1_-_172465446 1.87 ENSRNOT00000088386
LOC103690410
olfactory receptor 484-like
chr1_-_20962526 1.86 ENSRNOT00000061332
ENSRNOT00000017322
ENSRNOT00000017412
ENSRNOT00000079688
ENSRNOT00000017417
Epb41l2
erythrocyte membrane protein band 4.1-like 2
chr19_-_26194198 1.85 ENSRNOT00000005917
Wdr83
WD repeat domain 83
chr18_-_79258570 1.81 ENSRNOT00000022401
Galr1
galanin receptor 1
chr8_+_69484174 1.69 ENSRNOT00000077290
ENSRNOT00000056518
RGD1562747
similar to RIKEN cDNA 1110012L19
chr1_+_102017263 1.61 ENSRNOT00000028680
Nomo1
nodal modulator 1
chr8_-_42793484 1.54 ENSRNOT00000072871
AABR07069942.1

chr13_+_34498749 1.45 ENSRNOT00000093127
Clasp1
cytoplasmic linker associated protein 1
chr10_-_12818137 1.43 ENSRNOT00000060972
Olr1382
olfactory receptor 1382
chr12_+_25430464 1.43 ENSRNOT00000002020
Gtf2i
general transcription factor II I
chr13_-_52834134 1.33 ENSRNOT00000038874
Igfn1
immunoglobulin-like and fibronectin type III domain containing 1
chr16_+_81153489 1.29 ENSRNOT00000024999
Grk1
G protein-coupled receptor kinase 1
chr20_+_55594676 1.29 ENSRNOT00000057010
Sim1
single-minded family bHLH transcription factor 1
chr3_-_76708430 1.25 ENSRNOT00000007890
Olr630
olfactory receptor 630
chr4_+_87516218 1.22 ENSRNOT00000090182
Vom1r66
vomeronasal 1 receptor 66
chr1_-_171162912 1.16 ENSRNOT00000074866
Olr229
olfactory receptor 229
chr10_-_15610826 1.11 ENSRNOT00000027851
Hbz
hemoglobin subunit zeta
chr5_-_50684409 0.98 ENSRNOT00000013181
RGD1359108
similar to RIKEN cDNA 3110043O21
chr10_-_18131562 0.92 ENSRNOT00000006676
Tlx3
T-cell leukemia, homeobox 3
chr2_-_35192515 0.92 ENSRNOT00000086631
LOC100909937
olfactory receptor 149-like
chr1_-_63457134 0.86 ENSRNOT00000083436
AABR07071874.1

chr7_-_101140308 0.80 ENSRNOT00000006279
Fam84b
family with sequence similarity 84, member B
chr9_-_88534710 0.80 ENSRNOT00000020880
Tm4sf20
transmembrane 4 L six family member 20
chr15_-_26780965 0.75 ENSRNOT00000041733
Olr1624
olfactory receptor 1624
chr4_-_125929002 0.74 ENSRNOT00000083271
Magi1
membrane associated guanylate kinase, WW and PDZ domain containing 1
chr4_-_123510217 0.65 ENSRNOT00000080734
Slc41a3
solute carrier family 41, member 3
chr5_+_113725717 0.55 ENSRNOT00000032248
Tek
TEK receptor tyrosine kinase
chr9_+_66952720 0.54 ENSRNOT00000023678
Nbeal1
neurobeachin-like 1
chr3_-_33075685 0.50 ENSRNOT00000006937
Orc4
origin recognition complex, subunit 4
chr3_+_59408546 0.49 ENSRNOT00000031418
AABR07052523.1

chr18_+_35136132 0.49 ENSRNOT00000078731
Spink5
serine peptidase inhibitor, Kazal type 5
chr3_+_77018186 0.40 ENSRNOT00000074443
Olr646
olfactory receptor 646
chr8_+_42833019 0.39 ENSRNOT00000071050
LOC100910227
olfactory receptor 149-like
chrX_+_13989401 0.38 ENSRNOT00000004790
Hypm
huntingtin interacting protein M
chr8_-_43470377 0.34 ENSRNOT00000050312
LOC103690273
olfactory receptor 149
chr8_+_19548488 0.32 ENSRNOT00000008605
Olr1148
olfactory receptor 1148
chrX_-_72133692 0.29 ENSRNOT00000004263
Cited1
Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1
chr11_-_45616429 0.28 ENSRNOT00000046587
Olr1533
olfactory receptor 1533
chrX_-_14756047 0.26 ENSRNOT00000060737
LOC102552474
protein FAM47E-like
chr2_-_264293010 0.20 ENSRNOT00000082532
ENSRNOT00000067843
LOC103691744
cystathionine gamma-lyase
chr10_-_94365049 0.17 ENSRNOT00000011894
Strada
STE20-related kinase adaptor alpha
chr4_-_117751329 0.13 ENSRNOT00000080096
LOC100910829
probable N-acetyltransferase CML2-like

Network of associatons between targets according to the STRING database.

First level regulatory network of Rorc_Nr1d1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
13.9 41.6 GO:0060084 synaptic transmission involved in micturition(GO:0060084)
10.7 74.7 GO:0007621 negative regulation of female receptivity(GO:0007621)
8.7 26.0 GO:0060086 circadian temperature homeostasis(GO:0060086)
3.1 18.4 GO:0051964 negative regulation of synapse assembly(GO:0051964)
3.0 12.1 GO:0039020 pronephric nephron tubule development(GO:0039020)
2.6 29.1 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
2.6 7.9 GO:0019417 sulfur oxidation(GO:0019417)
2.1 16.9 GO:0016056 rhodopsin mediated signaling pathway(GO:0016056)
2.0 12.3 GO:0032439 endosome localization(GO:0032439)
1.9 11.7 GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198)
1.6 11.2 GO:0071313 cellular response to caffeine(GO:0071313)
1.2 3.5 GO:1903373 positive regulation of endoplasmic reticulum tubular network organization(GO:1903373)
1.1 4.6 GO:1902683 regulation of receptor localization to synapse(GO:1902683)
0.9 10.7 GO:0051533 positive regulation of NFAT protein import into nucleus(GO:0051533)
0.9 2.6 GO:0036500 ATF6-mediated unfolded protein response(GO:0036500)
0.8 49.4 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.7 18.5 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.6 7.3 GO:0090399 replicative senescence(GO:0090399)
0.6 13.4 GO:0051481 negative regulation of cytosolic calcium ion concentration(GO:0051481)
0.6 1.8 GO:0043400 cortisol secretion(GO:0043400) regulation of cortisol secretion(GO:0051462) positive regulation of cortisol secretion(GO:0051464)
0.6 23.6 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.6 9.7 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.6 7.7 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.5 42.7 GO:0097194 execution phase of apoptosis(GO:0097194)
0.5 5.9 GO:2000811 negative regulation of anoikis(GO:2000811)
0.5 3.2 GO:0070417 cellular response to cold(GO:0070417)
0.4 5.3 GO:1990403 embryonic brain development(GO:1990403)
0.4 2.9 GO:0033523 histone H2B ubiquitination(GO:0033523)
0.4 19.3 GO:0045739 positive regulation of DNA repair(GO:0045739)
0.4 7.9 GO:0005980 glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
0.3 3.1 GO:0016926 protein desumoylation(GO:0016926)
0.2 12.5 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.2 57.1 GO:0071805 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.2 4.8 GO:0039703 viral RNA genome replication(GO:0039694) RNA replication(GO:0039703)
0.2 3.6 GO:0090161 Golgi ribbon formation(GO:0090161)
0.2 0.5 GO:0048014 Tie signaling pathway(GO:0048014)
0.2 1.9 GO:0070862 negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.2 1.5 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.2 13.7 GO:0048024 regulation of mRNA splicing, via spliceosome(GO:0048024)
0.1 19.7 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 8.8 GO:0070206 protein trimerization(GO:0070206)
0.1 0.5 GO:1900425 negative regulation of defense response to bacterium(GO:1900425)
0.1 4.9 GO:1903318 negative regulation of protein processing(GO:0010955) negative regulation of protein maturation(GO:1903318)
0.1 1.1 GO:0043249 erythrocyte maturation(GO:0043249)
0.1 2.6 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.1 20.2 GO:0001889 liver development(GO:0001889)
0.1 0.9 GO:0002087 regulation of respiratory gaseous exchange by neurological system process(GO:0002087)
0.1 5.3 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
0.1 20.4 GO:0051260 protein homooligomerization(GO:0051260)
0.1 9.2 GO:0051291 protein heterooligomerization(GO:0051291)
0.1 24.7 GO:0016358 dendrite development(GO:0016358)
0.1 0.3 GO:0003340 negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis(GO:0003340)
0.1 28.7 GO:0007264 small GTPase mediated signal transduction(GO:0007264)
0.1 1.9 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.0 2.0 GO:0032757 positive regulation of interleukin-8 production(GO:0032757)
0.0 1.6 GO:0031648 protein destabilization(GO:0031648)
0.0 4.0 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 8.5 GO:0060271 cilium morphogenesis(GO:0060271)
0.0 1.0 GO:0016239 positive regulation of macroautophagy(GO:0016239)
0.0 11.3 GO:0016567 protein ubiquitination(GO:0016567)
0.0 27.3 GO:0007606 sensory perception of chemical stimulus(GO:0007606)
0.0 0.5 GO:0006270 DNA replication initiation(GO:0006270)
0.0 2.8 GO:0006470 protein dephosphorylation(GO:0006470)
0.0 2.2 GO:0030198 extracellular matrix organization(GO:0030198)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
4.9 19.6 GO:1990761 growth cone lamellipodium(GO:1990761) growth cone filopodium(GO:1990812)
2.6 23.2 GO:0030314 junctional membrane complex(GO:0030314)
2.1 41.6 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
1.8 10.7 GO:0005955 calcineurin complex(GO:0005955)
1.2 12.3 GO:0045179 apical cortex(GO:0045179)
0.8 4.8 GO:0044308 axonal spine(GO:0044308)
0.8 18.5 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.7 12.1 GO:0036038 MKS complex(GO:0036038)
0.6 4.6 GO:0070820 tertiary granule(GO:0070820)
0.5 57.1 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.5 23.6 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.4 4.9 GO:0005797 Golgi medial cisterna(GO:0005797)
0.4 2.9 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.4 1.5 GO:0031592 centrosomal corona(GO:0031592)
0.2 196.7 GO:0043025 neuronal cell body(GO:0043025)
0.2 32.1 GO:0030658 transport vesicle membrane(GO:0030658)
0.2 5.3 GO:0035869 ciliary transition zone(GO:0035869)
0.2 28.9 GO:0001650 fibrillar center(GO:0001650)
0.2 11.3 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.2 8.8 GO:0016328 lateral plasma membrane(GO:0016328)
0.2 3.6 GO:0031201 SNARE complex(GO:0031201)
0.2 7.9 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.1 11.5 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 12.5 GO:0070382 exocytic vesicle(GO:0070382)
0.1 55.7 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.1 0.5 GO:0097209 epidermal lamellar body(GO:0097209)
0.1 1.1 GO:0005833 hemoglobin complex(GO:0005833)
0.1 1.0 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.1 3.2 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 0.5 GO:0000808 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.1 1.9 GO:0008180 COP9 signalosome(GO:0008180)
0.0 6.2 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 3.1 GO:0005643 nuclear pore(GO:0005643)
0.0 1.3 GO:0030018 Z disc(GO:0030018)
0.0 11.5 GO:0005887 integral component of plasma membrane(GO:0005887)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
24.9 74.7 GO:0031752 D5 dopamine receptor binding(GO:0031752)
8.9 26.8 GO:0072590 N-acetyl-L-aspartate-L-glutamate ligase activity(GO:0072590)
5.8 23.2 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219)
3.0 57.1 GO:0030955 potassium ion binding(GO:0030955)
2.6 7.9 GO:0008184 glycogen phosphorylase activity(GO:0008184)
2.4 41.6 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
1.9 9.7 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
1.7 42.7 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
1.6 32.7 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
1.5 7.7 GO:0008499 UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499)
1.5 10.7 GO:0016018 cyclosporin A binding(GO:0016018)
1.4 13.6 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
1.3 26.0 GO:0001222 transcription corepressor binding(GO:0001222)
1.0 23.6 GO:0005112 Notch binding(GO:0005112)
0.9 19.6 GO:0048156 tau protein binding(GO:0048156)
0.9 14.4 GO:0008143 poly(A) binding(GO:0008143)
0.8 11.7 GO:0051378 serotonin binding(GO:0051378)
0.7 2.9 GO:1990269 RNA polymerase II C-terminal domain phosphoserine binding(GO:1990269)
0.6 3.1 GO:0070137 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.5 68.5 GO:0019905 syntaxin binding(GO:0019905)
0.5 29.1 GO:0005080 protein kinase C binding(GO:0005080)
0.5 4.8 GO:0008432 JUN kinase binding(GO:0008432)
0.5 1.9 GO:0042731 PH domain binding(GO:0042731)
0.5 3.2 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.3 8.3 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.3 7.9 GO:0071949 FAD binding(GO:0071949)
0.3 12.3 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.2 8.2 GO:0050699 WW domain binding(GO:0050699)
0.2 1.8 GO:0004966 galanin receptor activity(GO:0004966)
0.2 2.0 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.2 4.8 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.2 5.9 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.2 7.3 GO:0005109 frizzled binding(GO:0005109)
0.2 38.1 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.2 16.5 GO:0016503 pheromone receptor activity(GO:0016503)
0.2 4.9 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.2 1.3 GO:0004703 G-protein coupled receptor kinase activity(GO:0004703)
0.2 1.5 GO:0043515 kinetochore binding(GO:0043515)
0.2 4.3 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 4.5 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 17.5 GO:0005125 cytokine activity(GO:0005125)
0.1 15.6 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.1 1.1 GO:0005344 oxygen transporter activity(GO:0005344)
0.1 24.0 GO:0005525 GTP binding(GO:0005525)
0.0 2.8 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 5.4 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 1.4 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.0 3.2 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 4.0 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 0.5 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.3 GO:0050693 LBD domain binding(GO:0050693)
0.0 11.3 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 1.9 GO:0051082 unfolded protein binding(GO:0051082)
0.0 0.7 GO:0051393 alpha-actinin binding(GO:0051393)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 137.2 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.8 8.3 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.5 4.8 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.4 36.7 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.4 11.2 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.3 13.6 PID EPHA FWDPATHWAY EPHA forward signaling
0.3 23.6 PID NOTCH PATHWAY Notch signaling pathway
0.3 10.7 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.2 19.6 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.2 5.9 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling
0.1 10.4 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.1 29.1 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 1.3 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.0 0.5 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
3.5 41.6 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
2.8 85.5 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
1.4 20.8 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
1.1 57.1 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.8 11.7 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.5 20.6 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.5 7.9 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.4 8.2 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.3 4.8 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.3 28.9 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.3 12.3 REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS Genes involved in Regulation of Water Balance by Renal Aquaporins
0.2 23.6 REACTOME L1CAM INTERACTIONS Genes involved in L1CAM interactions
0.2 2.6 REACTOME ACTIVATION OF CHAPERONES BY ATF6 ALPHA Genes involved in Activation of Chaperones by ATF6-alpha
0.1 5.9 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 7.3 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 2.0 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.5 REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.0 4.8 REACTOME TOLL RECEPTOR CASCADES Genes involved in Toll Receptor Cascades
0.0 0.5 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 1.5 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 0.2 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1