ISMARA results: Rorc

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Rorc_Nr1d1

Z-value: 0.98

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Transcription factors associated with Rorc_Nr1d1

Gene Symbol	Gene ID	Gene Info
Rorc NCBI RGD Ensembl	ENSRNOG00000020836	RAR-related orphan receptor C
Nr1d1 NCBI RGD Ensembl	ENSRNOG00000009329	nuclear receptor subfamily 1, group D, member 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Nr1d1	rn6_v1_chr10_-_86688730_86688730	0.54	5.8e-26	Click!
Rorc	rn6_v1_chr2_+_195617021_195617044	-0.48	3.7e-20	Click!

Activity profile of Rorc_Nr1d1 motif

Sorted Z-values of Rorc_Nr1d1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr3_+_79713567 Show fit	107.57	ENSRNOT00000012110	C1qtnf4 NCBI RGD Ensembl Show fit	C1q and tumor necrosis factor related protein 4
chr10_+_86303727 Show fit	74.74	ENSRNOT00000037752	Ppp1r1b NCBI RGD Ensembl Show fit	protein phosphatase 1, regulatory (inhibitor) subunit 1B
chr3_+_98297554 Show fit	57.06	ENSRNOT00000006524	Kcna4 NCBI RGD Ensembl Show fit	potassium voltage-gated channel subfamily A member 4
chr11_+_66316606 Show fit	49.38	ENSRNOT00000041715	Stxbp5l NCBI RGD Ensembl Show fit	syntaxin binding protein 5-like
chr11_+_87366621 Show fit	42.71	ENSRNOT00000040978	Aifm3 NCBI RGD Ensembl Show fit	apoptosis inducing factor, mitochondria associated 3
chr2_-_189096785 Show fit	41.60	ENSRNOT00000028200	Chrnb2 NCBI RGD Ensembl Show fit	cholinergic receptor nicotinic beta 2 subunit
chr8_+_33239139 Show fit	38.13	ENSRNOT00000011589	Arhgap32 NCBI RGD Ensembl Show fit	Rho GTPase activating protein 32
chr7_+_64672722 Show fit	32.74	ENSRNOT00000064448 ENSRNOT00000005539	Grip1 NCBI RGD Ensembl Show fit	glutamate receptor interacting protein 1
chr8_-_82641536 Show fit	32.15	ENSRNOT00000014491	Scg3 NCBI RGD Ensembl Show fit	secretogranin III
chr7_-_136853154 Show fit	29.13	ENSRNOT00000087376	Nell2 NCBI RGD Ensembl Show fit	neural EGFL like 2

Showing 1 to 10 of 135 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Rorc_Nr1d1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
10.7	74.7	GO:0007621	negative regulation of female receptivity(GO:0007621)
0.2	57.1	GO:0071805	cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.8	49.4	GO:0046676	negative regulation of insulin secretion(GO:0046676)
0.5	42.7	GO:0097194	execution phase of apoptosis(GO:0097194)
13.9	41.6	GO:0060084	synaptic transmission involved in micturition(GO:0060084)
2.6	29.1	GO:0046543	development of secondary female sexual characteristics(GO:0046543)
0.1	28.7	GO:0007264	small GTPase mediated signal transduction(GO:0007264)
0.0	27.3	GO:0007606	sensory perception of chemical stimulus(GO:0007606)
8.7	26.0	GO:0060086	circadian temperature homeostasis(GO:0060086)
0.1	24.7	GO:0016358	dendrite development(GO:0016358)

Showing 1 to 10 of 64 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	196.7	GO:0043025	neuronal cell body(GO:0043025)
0.5	57.1	GO:0008076	voltage-gated potassium channel complex(GO:0008076)
0.1	55.7	GO:0005743	mitochondrial inner membrane(GO:0005743)
2.1	41.6	GO:0005892	acetylcholine-gated channel complex(GO:0005892)
0.2	32.1	GO:0030658	transport vesicle membrane(GO:0030658)
0.2	28.9	GO:0001650	fibrillar center(GO:0001650)
0.5	23.6	GO:0046658	anchored component of plasma membrane(GO:0046658)
2.6	23.2	GO:0030314	junctional membrane complex(GO:0030314)
4.9	19.6	GO:1990761	growth cone lamellipodium(GO:1990761) growth cone filopodium(GO:1990812)
0.8	18.5	GO:0016327	apicolateral plasma membrane(GO:0016327)

Showing 1 to 10 of 35 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
24.9	74.7	GO:0031752	D5 dopamine receptor binding(GO:0031752)
0.5	68.5	GO:0019905	syntaxin binding(GO:0019905)
3.0	57.1	GO:0030955	potassium ion binding(GO:0030955)
1.7	42.7	GO:0051537	2 iron, 2 sulfur cluster binding(GO:0051537)
2.4	41.6	GO:0022848	acetylcholine-gated cation channel activity(GO:0022848)
0.2	38.1	GO:0035091	phosphatidylinositol binding(GO:0035091)
1.6	32.7	GO:0030159	receptor signaling complex scaffold activity(GO:0030159)
0.5	29.1	GO:0005080	protein kinase C binding(GO:0005080)
8.9	26.8	GO:0072590	N-acetyl-L-aspartate-L-glutamate ligase activity(GO:0072590)
1.3	26.0	GO:0001222	transcription corepressor binding(GO:0001222)

Showing 1 to 10 of 54 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	137.2	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.4	36.7	PID TRKR PATHWAY	Neurotrophic factor-mediated Trk receptor signaling
0.1	29.1	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.3	23.6	PID NOTCH PATHWAY	Notch signaling pathway
0.2	19.6	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network
0.3	13.6	PID EPHA FWDPATHWAY	EPHA forward signaling
0.4	11.2	ST MYOCYTE AD PATHWAY	Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.3	10.7	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.1	10.4	WNT SIGNALING	Genes related to Wnt-mediated signal transduction
0.8	8.3	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.

Showing 1 to 10 of 14 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.8	85.5	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
1.1	57.1	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels
3.5	41.6	REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS	Genes involved in Presynaptic nicotinic acetylcholine receptors
0.3	28.9	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.2	23.6	REACTOME L1CAM INTERACTIONS	Genes involved in L1CAM interactions
1.4	20.8	REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS	Genes involved in Termination of O-glycan biosynthesis
0.5	20.6	REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION	Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.3	12.3	REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS	Genes involved in Regulation of Water Balance by Renal Aquaporins
0.8	11.7	REACTOME SEROTONIN RECEPTORS	Genes involved in Serotonin receptors
0.4	8.2	REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	Genes involved in Proteolytic cleavage of SNARE complex proteins

Showing 1 to 10 of 21 entries

Results for Rorc_Nr1d1

Z-value: 0.98

Motif logo

Transcription factors associated with Rorc_Nr1d1

Activity-expression correlation:

Activity profile of Rorc_Nr1d1 motif

Sorted Z-values of Rorc_Nr1d1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Rorc_Nr1d1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: