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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Rfx3_Rfx1_Rfx4

Z-value: 5.86

Motif logo

Transcription factors associated with Rfx3_Rfx1_Rfx4

Gene Symbol Gene ID Gene Info
ENSRNOG00000014486 regulatory factor X3
ENSRNOG00000006049 regulatory factor X1
ENSRNOG00000051536 regulatory factor X4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Rfx4rn6_v1_chr7_+_25832521_258325210.751.9e-58Click!
Rfx3rn6_v1_chr1_-_246010594_2460105940.677.4e-43Click!
Rfx1rn6_v1_chr19_+_25181564_251815640.258.1e-06Click!

Activity profile of Rfx3_Rfx1_Rfx4 motif

Sorted Z-values of Rfx3_Rfx1_Rfx4 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr5_-_138462864 333.08 ENSRNOT00000011325
coiled-coil domain containing 30
chr8_-_65587427 281.31 ENSRNOT00000016491
leucine rich repeat containing 49
chr7_+_139762614 276.46 ENSRNOT00000031157
coiled-coil domain containing 184
chr8_-_65587658 250.71 ENSRNOT00000091982
leucine rich repeat containing 49
chr3_+_113251778 242.69 ENSRNOT00000083005
microtubule-associated protein 1A
chr20_-_44220702 236.11 ENSRNOT00000036853
family with sequence similarity 229, member B
chr20_-_14573519 226.60 ENSRNOT00000001772
RAB36, member RAS oncogene family
chr16_+_2379480 218.40 ENSRNOT00000079215
dynein, axonemal, heavy chain 12
chr19_+_56010085 213.81 ENSRNOT00000058216
spermatogenesis associated 33
chr5_+_140870140 212.21 ENSRNOT00000074347
hippocalcin-like 4
chr2_-_89310946 206.96 ENSRNOT00000015195
RALY RNA binding protein-like
chr2_-_195712461 204.28 ENSRNOT00000056449
regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1
chrX_-_15428518 202.29 ENSRNOT00000075774
proSAAS
chr13_-_90710148 196.36 ENSRNOT00000010113
ENSRNOT00000080638
potassium voltage-gated channel subfamily J member 9
chr2_-_144467912 195.41 ENSRNOT00000040002
cyclin A1
chr15_-_104168564 195.31 ENSRNOT00000093385
ENSRNOT00000038596
DAZ interacting zinc finger protein 1
chr5_+_169519212 194.62 ENSRNOT00000024732
chromodomain helicase DNA binding protein 5
chr11_+_88424414 194.14 ENSRNOT00000022328
sperm associated antigen 6-like
chr1_-_266074181 190.23 ENSRNOT00000026378
pleckstrin and Sec7 domain containing
chr1_+_212230259 187.61 ENSRNOT00000034426
kinase non-catalytic C-lobe domain containing 1
chr10_-_47725172 187.36 ENSRNOT00000003228
ring finger protein 112
chr10_-_58924137 187.10 ENSRNOT00000066740
tektin 1
chr13_+_70157522 181.07 ENSRNOT00000036906
apolipoprotein B mRNA editing enzyme catalytic polypeptide like 4
chr1_+_78876205 180.08 ENSRNOT00000022610
paraneoplastic Ma antigen family-like 2
chr15_+_40665041 179.56 ENSRNOT00000018300
APC membrane recruitment protein 2
chr10_+_64174931 174.69 ENSRNOT00000035948
RGD1565611
chr1_-_226501920 173.51 ENSRNOT00000050716
leucine rich repeat containing 10B
chrX_-_15327684 172.40 ENSRNOT00000009794
proprotein convertase subtilisin/kexin type 1 inhibitor
chr20_+_41100071 171.94 ENSRNOT00000000658
TSPY-like 4
chr5_-_147148291 168.53 ENSRNOT00000085151
antizyme inhibitor 2
chr18_+_56193978 167.52 ENSRNOT00000041533
ENSRNOT00000080177
calcium/calmodulin-dependent protein kinase II alpha
chr10_-_47724499 163.07 ENSRNOT00000085011
ring finger protein 112
chr1_+_220335254 162.89 ENSRNOT00000072261
Ras and Rab interactor 1
chr3_-_71295575 162.34 ENSRNOT00000040303
ENSRNOT00000083015
zinc finger, SWIM-type containing 2
chr2_-_211322719 160.73 ENSRNOT00000027493
similar to KIAA1324 protein
chr1_-_145931583 156.42 ENSRNOT00000016433
cilia and flagella associated protein 161
chr17_-_42226377 155.62 ENSRNOT00000024536
similar to mKIAA0319 protein
chr12_+_24803686 154.75 ENSRNOT00000033499
Williams-Beuren syndrome chromosome region 28
chr1_-_212549477 154.71 ENSRNOT00000024765
calcyon neuron-specific vesicular protein
chr16_-_21338771 152.61 ENSRNOT00000014265
PBX homeobox 4
chr1_+_265298868 148.07 ENSRNOT00000023278
deleted in primary ciliary dyskinesia
chr1_+_188571953 147.45 ENSRNOT00000055096
IQ motif containing K
chr1_+_220428481 144.62 ENSRNOT00000027335
ras and Rab interactor 1
chr11_+_64975594 144.48 ENSRNOT00000040773
MYCBP associated and testis expressed 1
chr8_-_13290773 144.46 ENSRNOT00000012217
similar to RIKEN cDNA 1700012B09
chr14_+_17531398 143.83 ENSRNOT00000050038
cyclin dependent kinase like 2
chr5_+_156026911 142.85 ENSRNOT00000046802
Rap1 GTPase-activating protein
chr7_+_142397371 142.23 ENSRNOT00000040890
ENSRNOT00000065379
solute carrier family 4 member 8
chr13_-_105684374 141.66 ENSRNOT00000073142
spermatogenesis associated 17
chr1_-_212548730 141.30 ENSRNOT00000089729
calcyon neuron-specific vesicular protein
chr8_-_130475320 141.11 ENSRNOT00000075439
coiled-coil domain containing 13
chr12_-_22811058 140.10 ENSRNOT00000046412
intraflagellar transport 22
chr12_+_2534212 138.91 ENSRNOT00000001399
cortexin 1
chr8_-_25829569 138.87 ENSRNOT00000071884
dpy-19 like 2
chr1_+_201337416 138.75 ENSRNOT00000067742
BTB domain containing 16
chr12_+_17614632 138.49 ENSRNOT00000031896
protein kinase cAMP-dependent type 1 regulatory subunit beta
chr6_+_2969333 138.29 ENSRNOT00000047356
MORN repeat containing 2
chr17_-_88095729 136.96 ENSRNOT00000025140
enkurin, TRPC channel interacting protein
chr3_-_102151489 136.12 ENSRNOT00000006349
anoctamin 3
chr5_-_143062226 136.09 ENSRNOT00000029388
dynein, axonemal, light intermediate chain 1
chr1_+_78893271 135.80 ENSRNOT00000029825
paraneoplastic Ma antigen family-like 1
chr9_+_88964525 134.61 ENSRNOT00000068236
dynein assembly factor with WD repeats 1
chr10_+_38919167 133.50 ENSRNOT00000077569
kinesin family member 3a
chr7_-_120744602 133.41 ENSRNOT00000018564
potassium voltage-gated channel subfamily J member 4
chr10_-_54512169 133.16 ENSRNOT00000005066
cilia and flagella associated protein 52
chr10_-_103340922 132.75 ENSRNOT00000004191
BTB domain containing 17
chr10_+_38918748 131.25 ENSRNOT00000009999
kinesin family member 3a
chr4_-_157304653 129.72 ENSRNOT00000051613
leucine rich repeat containing 23
chr5_-_160555083 128.08 ENSRNOT00000018953
forkhead associated phosphopeptide binding domain 1
chr16_-_39970532 127.36 ENSRNOT00000071331
spermatogenesis associated 4
chr14_-_43584343 124.80 ENSRNOT00000039835
NOP2/Sun RNA methyltransferase family member 7
chr8_-_55491152 124.71 ENSRNOT00000014965
rCG58364-like
chr18_-_38088457 122.93 ENSRNOT00000077814
janus kinase and microtubule interacting protein 2
chr5_-_59165160 122.61 ENSRNOT00000029035
family with sequence similarity 221, member B
chr9_-_65693822 122.51 ENSRNOT00000038431
amyotrophic lateral sclerosis 2 chromosome region, candidate 12
chrX_+_122808605 120.80 ENSRNOT00000017567
zinc finger CCHC-type containing 12
chr11_-_90234286 120.73 ENSRNOT00000071986
EF hand calcium binding domain 1
chr9_-_17114177 119.44 ENSRNOT00000061185
leucine rich repeat containing 73
chr1_+_196737627 119.38 ENSRNOT00000066652
hypothetical protein LOC100271845
chr6_-_108076186 118.85 ENSRNOT00000014814
family with sequence similarity 161, member B
chr8_+_116302513 118.42 ENSRNOT00000039258
zinc finger, MYND-type containing 10
chr19_-_10380809 117.54 ENSRNOT00000031064
dynein regulatory complex subunit 7
chr4_+_2053712 117.19 ENSRNOT00000045086
ring finger protein 32
chr3_+_7279340 116.51 ENSRNOT00000017029
adenylate kinase 8
chr14_+_8080275 115.16 ENSRNOT00000065965
ENSRNOT00000092542
mitogen activated protein kinase 10
chr9_+_27068443 114.54 ENSRNOT00000017393
EF-hand domain containing 1
chr9_+_20241062 112.47 ENSRNOT00000071593
leucine-rich repeat-containing protein 23-like
chr7_-_129970550 110.88 ENSRNOT00000055879
megalencephalic leukoencephalopathy with subcortical cysts 1
chr5_+_131719922 109.78 ENSRNOT00000010524
spermatogenesis associated 6
chr5_+_144067416 109.52 ENSRNOT00000037246
organic solute carrier partner 1
chr9_-_13311924 108.83 ENSRNOT00000015584
kinesin family member 6
chr13_+_90909486 108.63 ENSRNOT00000011450
cilia and flagella associated protein 45
chr3_+_15379109 107.05 ENSRNOT00000036495
MORN repeat containing 5
chr4_+_114854458 105.91 ENSRNOT00000013312
hypothetical gene supported by BC079424
chr2_-_231521052 105.44 ENSRNOT00000089534
ENSRNOT00000080470
ENSRNOT00000084756
ankyrin 2
chr6_+_7900972 104.41 ENSRNOT00000006953
ENSRNOT00000068030
dynein cytoplasmic 2 light intermediate chain 1
chr13_+_82574966 104.40 ENSRNOT00000003844
coiled-coil domain containing 181
chr7_-_54855557 104.38 ENSRNOT00000039475
GLI pathogenesis-related 1 like 1
chr5_-_59149625 104.36 ENSRNOT00000040641
ENSRNOT00000084216
sperm associated antigen 8
chr1_-_220165678 104.06 ENSRNOT00000026915
Bardet-Biedl syndrome 1
chr7_+_94375020 102.68 ENSRNOT00000011904
nephroblastoma overexpressed
chr12_+_14092541 101.03 ENSRNOT00000033998
Rap associating with DIL domain
chr10_+_54126486 100.67 ENSRNOT00000078820
growth arrest specific 7
chr6_+_2886764 100.56 ENSRNOT00000023114
tetratricopeptide repeat domain 39D
chr8_+_90343154 100.14 ENSRNOT00000068482
interleukin-1 receptor-associated kinase 1 binding protein 1
chr10_-_56154548 99.66 ENSRNOT00000090809
dynein, axonemal, heavy chain 2
chr11_-_64421248 98.38 ENSRNOT00000066997
immunoglobulin superfamily, member 11
chr1_-_52354175 98.35 ENSRNOT00000015010
hypothetical protein LOC681210
chr7_-_74901997 97.86 ENSRNOT00000039378
regulator of G-protein signaling 22
chr8_-_6235967 97.73 ENSRNOT00000068290
hypothetical protein LOC654482
chr17_+_6701315 97.71 ENSRNOT00000026054
ENSRNOT00000080683
kinesin family member 27
chr4_+_138269142 97.57 ENSRNOT00000007788
contactin 4
chr7_-_144837583 96.83 ENSRNOT00000055289
chromobox 5
chr5_-_136706936 96.74 ENSRNOT00000081925
ENSRNOT00000068130
coiled-coil domain containing 24
chr3_+_129501105 96.67 ENSRNOT00000007893
ankyrin repeat and EF-hand domain containing 1
chr1_-_199037267 95.76 ENSRNOT00000078779
coiled-coil domain containing 189
chr4_+_66090681 95.72 ENSRNOT00000078066
tetratricopeptide repeat domain 26
chr5_-_157165767 94.36 ENSRNOT00000000167
UBX domain protein 10
chr12_+_7454884 93.04 ENSRNOT00000077328
katanin p60 ATPase-containing subunit A-like 1-like
chr18_-_73360373 92.77 ENSRNOT00000048702
katanin catalytic subunit A1 like 2
chr1_+_84070983 91.47 ENSRNOT00000090478
NUMB-like, endocytic adaptor protein
chr9_+_76913639 91.04 ENSRNOT00000089203

chr8_+_55050284 91.03 ENSRNOT00000013242
PIH1 domain containing 2
chr10_+_37458452 90.47 ENSRNOT00000079411
cyclin-dependent kinase-like 3
chr14_+_8080565 90.46 ENSRNOT00000092395
mitogen activated protein kinase 10
chr14_-_82055290 89.83 ENSRNOT00000058062
RGD1560394
chr20_+_4369178 89.50 ENSRNOT00000088079
1-acylglycerol-3-phosphate O-acyltransferase 1
chr1_+_211543751 89.43 ENSRNOT00000049631
leucine rich repeat containing 27
chr10_+_55653946 88.22 ENSRNOT00000008787
transmembrane protein 107
chr4_+_62299044 86.65 ENSRNOT00000032077
ATP/GTP binding protein-like 3
chr4_-_135069970 84.96 ENSRNOT00000008221
contactin 3
chr1_-_247088012 84.56 ENSRNOT00000020464
spermatogenesis associated 6-like
chr14_-_113644779 82.73 ENSRNOT00000005306
cilia and flagella associated protein 36
chrX_+_105134498 82.66 ENSRNOT00000002058
transmembrane protein 35
chr6_-_107633012 82.63 ENSRNOT00000014018
paraneoplastic Ma antigen 1
chr8_-_5429581 82.58 ENSRNOT00000044174
dynein cytoplasmic 2 heavy chain 1
chr20_-_14620019 82.36 ENSRNOT00000001779
G protein subunit alpha z
chr3_-_62803373 81.99 ENSRNOT00000013565
tetratricopeptide repeat domain 30A1
chr2_-_208623314 81.69 ENSRNOT00000022731
primary cilia formation
chr12_+_16030788 81.45 ENSRNOT00000051565
IQ motif containing E
chr7_+_12433933 80.93 ENSRNOT00000060690
CACN beta subunit associated regulatory protein
chrX_-_16306078 80.93 ENSRNOT00000003939
A-kinase anchoring protein 4
chr19_-_10653800 79.11 ENSRNOT00000022128
C-X3-C motif chemokine ligand 1
chr1_+_203971152 78.93 ENSRNOT00000075540
G protein-coupled receptor 26
chr8_-_14156656 78.84 ENSRNOT00000089364
deuterosome assembly protein 1
chr5_+_61474000 78.49 ENSRNOT00000013930
coiled-coil domain containing 180
chr4_+_147756553 77.94 ENSRNOT00000086549
ENSRNOT00000014733
intraflagellar transport 122
chr12_+_47551935 77.92 ENSRNOT00000056932
RGD1560398
chr7_-_120380200 77.85 ENSRNOT00000014878
similar to RIKEN cDNA 1700088E04
chr11_-_71601662 77.08 ENSRNOT00000002397
Tctex1 domain containing 2
chr8_-_61519507 76.63 ENSRNOT00000038347
outer dense fiber of sperm tails 3-like 1
chr19_+_52225582 76.38 ENSRNOT00000020917
dynein, axonemal, assembly factor 1
chr3_+_176721827 75.93 ENSRNOT00000066617
fibronectin type III domain containing 11
chr1_+_205842489 75.72 ENSRNOT00000081610
fibronectin type 3 and ankyrin repeat domains 1
chr8_-_14157141 74.22 ENSRNOT00000079034
deuterosome assembly protein 1
chr4_+_86275717 73.81 ENSRNOT00000016414
protein phosphatase 1, regulatory subunit 17
chr5_-_122642202 73.77 ENSRNOT00000046691
WD repeat domain 78
chr8_+_127789048 73.52 ENSRNOT00000052275
deleted in lung and esophageal cancer 1
chr8_-_59077690 73.16 ENSRNOT00000066197
Dmx-like 2
chr4_+_159403501 73.08 ENSRNOT00000086525
A-kinase anchoring protein 3
chr5_-_110706656 72.98 ENSRNOT00000033781
IZUMO family member 3
chr8_-_68525911 72.76 ENSRNOT00000080588
ENSRNOT00000011109
IQ motif containing H
chr11_-_31238026 72.70 ENSRNOT00000032366
similar to Putative protein C21orf62 homolog
chr2_+_228544418 72.00 ENSRNOT00000013030
translocation associated membrane protein 1-like 1
chr8_-_23014499 71.78 ENSRNOT00000017820
coiled-coil domain containing 151
chr1_-_48825364 70.69 ENSRNOT00000024213
1-acylglycerol-3-phosphate O-acyltransferase 4
chr10_-_74679858 70.18 ENSRNOT00000003859
protein phosphatase, Mg2+/Mn2+ dependent, 1E
chr7_+_119647375 69.58 ENSRNOT00000046563
potassium channel tetramerization domain containing 17
chr3_+_151335292 69.31 ENSRNOT00000073642
matrix metallopeptidase 24
chr11_+_42858478 69.09 ENSRNOT00000002293
ADP-ribosylation factor like GTPase 6
chr12_-_6703979 69.01 ENSRNOT00000061246
testis expressed 26
chr3_-_45210474 68.81 ENSRNOT00000091777
coiled-coil domain containing 148
chr9_+_81644355 68.58 ENSRNOT00000071700
ciliogenesis associated TTC17 interacting protein
chr19_-_44158621 68.32 ENSRNOT00000031243
ENSRNOT00000088297
transmembrane protein 231
chr14_-_84393421 67.94 ENSRNOT00000006911
coiled-coil domain containing 157
chr7_+_13013541 67.09 ENSRNOT00000042792
ENSRNOT00000010549
theg spermatid protein
chr20_+_4369394 66.67 ENSRNOT00000088734
ENSRNOT00000091491
1-acylglycerol-3-phosphate O-acyltransferase 1
chr16_-_55132191 66.66 ENSRNOT00000017025
mitochondrial calcium uptake family, member 3
chr2_-_60538088 66.41 ENSRNOT00000086809
tetratricopeptide repeat domain 23-like
chr10_-_57671080 65.58 ENSRNOT00000082511
hypothetical protein LOC691995
chr1_-_220786615 65.28 ENSRNOT00000038198
testis specific 10 interacting protein
chr5_+_157165341 65.18 ENSRNOT00000087072
phospholipase A2, group IIC
chr15_+_18399515 64.19 ENSRNOT00000071273
family with sequence similarity 107, member A
chr5_-_12563429 64.05 ENSRNOT00000059625
suppression of tumorigenicity 18
chr2_+_211381036 63.87 ENSRNOT00000055862
WD repeat domain 47
chr7_-_144837395 63.83 ENSRNOT00000089024
chromobox 5
chr6_-_135259603 63.77 ENSRNOT00000010529
MOK protein kinase
chr19_-_9931930 63.77 ENSRNOT00000085144
coiled-coil domain containing 113
chr4_-_113988246 63.73 ENSRNOT00000013128
WD repeat-containing protein 54
chr1_+_266952561 63.33 ENSRNOT00000076452
neuralized E3 ubiquitin protein ligase 1
chr16_+_80729400 63.04 ENSRNOT00000036383
testis development related protein
chr3_-_7632345 62.69 ENSRNOT00000049889
cilia and flagella associated protein 77
chr4_+_172709724 62.69 ENSRNOT00000010707
immunoglobulin (CD79A) binding protein 1b
chr3_+_148438939 61.57 ENSRNOT00000064196
tubulin tyrosine ligase like 9
chr18_-_14016713 61.36 ENSRNOT00000041125
nucleolar protein 4
chr6_-_27024129 60.76 ENSRNOT00000012273
dihydropyrimidinase-like 5
chr5_+_153845094 60.55 ENSRNOT00000041600
sperm-tail PG-rich repeat containing 1
chr17_+_24242642 60.49 ENSRNOT00000024323
ring finger protein 182
chr6_-_27460038 60.48 ENSRNOT00000036815
dynein regulatory complex subunit 1
chr6_-_8346197 60.35 ENSRNOT00000061826
prolyl endopeptidase-like

Network of associatons between targets according to the STRING database.

First level regulatory network of Rfx3_Rfx1_Rfx4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
88.3 264.8 GO:2000771 epidermal stem cell homeostasis(GO:0036334) regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000769) positive regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000771)
58.2 174.7 GO:0016598 protein arginylation(GO:0016598)
56.2 168.5 GO:1902269 positive regulation of polyamine transmembrane transport(GO:1902269)
49.4 148.1 GO:0021678 third ventricle development(GO:0021678)
47.6 142.9 GO:1990792 response to glial cell derived neurotrophic factor(GO:1990790) cellular response to glial cell derived neurotrophic factor(GO:1990792)
41.5 207.4 GO:1903251 multi-ciliated epithelial cell differentiation(GO:1903251)
34.7 104.1 GO:0008594 photoreceptor cell morphogenesis(GO:0008594)
34.2 102.7 GO:0060392 negative regulation of SMAD protein import into nucleus(GO:0060392) negative regulation of sensory perception of pain(GO:1904057)
33.5 167.5 GO:0099628 receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) NMDA selective glutamate receptor signaling pathway(GO:0098989) neurotransmitter receptor diffusion trapping(GO:0099628)
32.4 194.6 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
31.7 190.2 GO:0006863 purine nucleobase transport(GO:0006863) nucleobase transport(GO:0015851)
30.5 91.5 GO:0021849 neuroblast division in subventricular zone(GO:0021849)
28.1 112.5 GO:0018406 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
26.4 105.4 GO:0036309 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
25.6 358.9 GO:0060294 cilium movement involved in cell motility(GO:0060294)
25.0 124.8 GO:0030382 sperm mitochondrion organization(GO:0030382)
24.2 120.8 GO:2000327 positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
23.5 328.4 GO:0007288 sperm axoneme assembly(GO:0007288)
23.3 581.4 GO:0044458 motile cilium assembly(GO:0044458)
22.7 136.1 GO:0061591 calcium activated phospholipid scrambling(GO:0061588) calcium activated phosphatidylcholine scrambling(GO:0061590) calcium activated galactosylceramide scrambling(GO:0061591)
19.5 77.9 GO:0035720 intraciliary anterograde transport(GO:0035720) ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830)
19.3 57.8 GO:0032423 regulation of mismatch repair(GO:0032423)
18.9 113.5 GO:1904491 protein localization to ciliary transition zone(GO:1904491)
18.7 205.6 GO:0007258 JUN phosphorylation(GO:0007258)
18.3 54.8 GO:1904457 positive regulation of neuronal action potential(GO:1904457)
16.7 333.6 GO:0048268 clathrin coat assembly(GO:0048268)
16.5 82.6 GO:0035721 intraciliary retrograde transport(GO:0035721)
16.3 390.4 GO:0042073 intraciliary transport(GO:0042073)
16.1 32.1 GO:0060300 regulation of cytokine activity(GO:0060300)
16.0 176.0 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
15.7 47.0 GO:0006532 aspartate biosynthetic process(GO:0006532)
15.1 45.4 GO:0070649 formin-nucleated actin cable assembly(GO:0070649)
15.1 45.3 GO:0000821 regulation of arginine metabolic process(GO:0000821) negative regulation of cellular amino acid metabolic process(GO:0045763)
14.3 185.8 GO:0051013 microtubule severing(GO:0051013)
14.1 42.3 GO:0042357 thiamine diphosphate metabolic process(GO:0042357)
13.9 55.6 GO:0036353 histone H2A-K119 monoubiquitination(GO:0036353)
13.4 187.6 GO:0021707 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
13.4 160.7 GO:2000786 positive regulation of autophagosome assembly(GO:2000786)
13.2 39.7 GO:1903445 protein transport from ciliary membrane to plasma membrane(GO:1903445)
13.2 79.1 GO:0032914 positive regulation of transforming growth factor beta1 production(GO:0032914)
13.0 156.2 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654)
12.9 154.3 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
12.6 50.5 GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316)
12.4 86.6 GO:0035610 protein side chain deglutamylation(GO:0035610)
12.3 24.6 GO:0003356 regulation of cilium movement(GO:0003352) regulation of cilium beat frequency(GO:0003356)
12.2 24.5 GO:1900126 negative regulation of hyaluronan biosynthetic process(GO:1900126)
12.1 60.5 GO:0060285 cilium or flagellum-dependent cell motility(GO:0001539) cilium-dependent cell motility(GO:0060285)
10.9 97.7 GO:0003351 epithelial cilium movement(GO:0003351)
10.0 30.0 GO:0021508 floor plate formation(GO:0021508)
10.0 329.8 GO:0010107 potassium ion import(GO:0010107)
9.8 117.8 GO:0047484 regulation of response to osmotic stress(GO:0047484)
9.1 81.8 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)
8.3 58.3 GO:0061002 negative regulation of dendritic spine morphogenesis(GO:0061002)
8.2 40.8 GO:0035082 axoneme assembly(GO:0035082)
8.1 24.3 GO:1903348 positive regulation of bicellular tight junction assembly(GO:1903348)
8.0 55.7 GO:0000459 exonucleolytic trimming involved in rRNA processing(GO:0000459) exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000467)
7.9 23.6 GO:0048003 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
7.9 70.7 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024)
7.8 47.0 GO:1900425 negative regulation of defense response to bacterium(GO:1900425)
7.6 68.6 GO:0044782 cilium organization(GO:0044782)
7.5 113.0 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
7.5 59.7 GO:0007220 Notch receptor processing(GO:0007220)
7.4 163.3 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
7.2 71.8 GO:0036158 outer dynein arm assembly(GO:0036158)
7.2 50.1 GO:0010968 regulation of microtubule nucleation(GO:0010968)
7.1 57.0 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
7.1 148.9 GO:0021591 ventricular system development(GO:0021591)
6.6 26.5 GO:0019918 peptidyl-arginine methylation, to symmetrical-dimethyl arginine(GO:0019918)
6.6 19.9 GO:0034499 late endosome to Golgi transport(GO:0034499)
6.6 26.3 GO:0061641 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
6.3 37.9 GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
6.1 18.2 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
6.0 29.9 GO:0048549 positive regulation of pinocytosis(GO:0048549)
5.9 254.0 GO:0045494 photoreceptor cell maintenance(GO:0045494)
5.9 17.6 GO:0046340 diacylglycerol catabolic process(GO:0046340) retrograde trans-synaptic signaling(GO:0098917)
5.7 40.2 GO:0003341 cilium movement(GO:0003341)
5.7 51.4 GO:0098915 membrane repolarization during ventricular cardiac muscle cell action potential(GO:0098915)
5.4 265.2 GO:0071158 positive regulation of cell cycle arrest(GO:0071158)
5.4 21.5 GO:1903818 positive regulation of voltage-gated potassium channel activity(GO:1903818)
5.4 53.6 GO:0010248 establishment or maintenance of transmembrane electrochemical gradient(GO:0010248)
5.3 69.3 GO:0044331 cell-cell adhesion mediated by cadherin(GO:0044331)
5.3 37.1 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
5.3 21.2 GO:0097167 circadian regulation of translation(GO:0097167)
5.2 20.6 GO:0030581 intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
5.2 31.0 GO:0021937 cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation(GO:0021937)
5.1 41.1 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
5.0 94.3 GO:0007035 vacuolar acidification(GO:0007035)
4.8 38.8 GO:0097211 response to gonadotropin-releasing hormone(GO:0097210) cellular response to gonadotropin-releasing hormone(GO:0097211)
4.8 80.9 GO:1901386 negative regulation of voltage-gated calcium channel activity(GO:1901386)
4.7 28.5 GO:0090154 positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304)
4.7 884.2 GO:0060271 cilium morphogenesis(GO:0060271)
4.7 155.6 GO:2000171 negative regulation of dendrite development(GO:2000171)
4.7 14.0 GO:1903070 negative regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903070)
4.5 117.0 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
4.4 22.1 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
4.4 13.1 GO:0046103 inosine biosynthetic process(GO:0046103)
4.4 30.5 GO:0035740 CD8-positive, alpha-beta T cell proliferation(GO:0035740)
4.2 142.2 GO:0015701 bicarbonate transport(GO:0015701)
4.1 41.3 GO:0002934 desmosome organization(GO:0002934)
3.8 119.2 GO:0050482 arachidonic acid secretion(GO:0050482) arachidonate transport(GO:1903963)
3.8 133.1 GO:0007339 binding of sperm to zona pellucida(GO:0007339)
3.4 13.7 GO:0009212 dTTP biosynthetic process(GO:0006235) pyrimidine deoxyribonucleoside triphosphate biosynthetic process(GO:0009212)
3.4 27.4 GO:0034551 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) pyrimidine-containing compound transmembrane transport(GO:0072531)
3.4 332.3 GO:1903955 positive regulation of establishment of protein localization to mitochondrion(GO:1903749) positive regulation of protein targeting to mitochondrion(GO:1903955)
3.4 13.5 GO:0006420 arginyl-tRNA aminoacylation(GO:0006420)
3.2 9.7 GO:0052572 response to immune response of other organism involved in symbiotic interaction(GO:0052564) response to host immune response(GO:0052572)
3.2 6.4 GO:1902953 positive regulation of ER to Golgi vesicle-mediated transport(GO:1902953)
3.1 37.7 GO:0001302 replicative cell aging(GO:0001302)
3.1 18.7 GO:0030913 paranodal junction assembly(GO:0030913)
3.1 9.3 GO:0034983 peptidyl-lysine deacetylation(GO:0034983)
3.1 27.5 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
3.0 124.7 GO:0048741 skeletal muscle fiber development(GO:0048741)
3.0 33.1 GO:1904322 response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322)
2.8 90.5 GO:0030517 negative regulation of axon extension(GO:0030517)
2.8 22.1 GO:0003406 retinal pigment epithelium development(GO:0003406)
2.7 10.8 GO:0060279 positive regulation of ovulation(GO:0060279)
2.7 8.1 GO:0045575 basophil activation(GO:0045575)
2.7 13.4 GO:0060903 positive regulation of meiosis I(GO:0060903)
2.6 7.8 GO:0006478 peptidyl-tyrosine sulfation(GO:0006478)
2.6 82.9 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
2.5 5.0 GO:0033092 positive regulation of immature T cell proliferation in thymus(GO:0033092)
2.5 27.1 GO:0097120 receptor localization to synapse(GO:0097120)
2.5 22.2 GO:0021942 radial glia guided migration of Purkinje cell(GO:0021942)
2.4 24.4 GO:0046085 adenosine metabolic process(GO:0046085)
2.4 107.3 GO:0031122 cytoplasmic microtubule organization(GO:0031122)
2.4 17.0 GO:0006868 glutamine transport(GO:0006868)
2.4 12.0 GO:1904781 positive regulation of protein localization to centrosome(GO:1904781)
2.4 62.2 GO:0071625 vocalization behavior(GO:0071625)
2.3 69.6 GO:0001578 microtubule bundle formation(GO:0001578)
2.3 36.9 GO:1901663 ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
2.3 11.3 GO:0051036 regulation of endosome size(GO:0051036)
2.2 26.7 GO:1900017 positive regulation of cytokine production involved in inflammatory response(GO:1900017)
2.1 12.9 GO:0072675 osteoclast fusion(GO:0072675)
2.1 6.4 GO:0090071 negative regulation of ribosome biogenesis(GO:0090071)
2.1 99.9 GO:0021795 cerebral cortex cell migration(GO:0021795)
2.1 6.4 GO:1901856 negative regulation of cellular respiration(GO:1901856)
2.1 179.6 GO:0090090 negative regulation of canonical Wnt signaling pathway(GO:0090090)
2.1 14.8 GO:0046599 regulation of centriole replication(GO:0046599)
2.1 312.4 GO:0007018 microtubule-based movement(GO:0007018)
2.1 10.6 GO:0060689 cell differentiation involved in salivary gland development(GO:0060689)
2.1 6.3 GO:0070212 protein poly-ADP-ribosylation(GO:0070212) regulation of telomeric DNA binding(GO:1904742)
2.1 27.3 GO:0006707 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
2.0 17.6 GO:1900364 negative regulation of mRNA polyadenylation(GO:1900364)
1.9 5.8 GO:0048669 collateral sprouting in absence of injury(GO:0048669)
1.9 17.3 GO:0070995 NADPH oxidation(GO:0070995)
1.9 134.6 GO:0007368 determination of left/right symmetry(GO:0007368)
1.8 12.8 GO:0071318 cellular response to ATP(GO:0071318)
1.8 172.4 GO:0007218 neuropeptide signaling pathway(GO:0007218)
1.8 19.9 GO:0071578 zinc II ion transmembrane import(GO:0071578)
1.8 48.0 GO:0090307 mitotic spindle assembly(GO:0090307) microtubule cytoskeleton organization involved in mitosis(GO:1902850)
1.8 7.1 GO:0071494 cellular response to UV-C(GO:0071494)
1.8 10.5 GO:0034427 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'(GO:0034427)
1.8 17.5 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
1.8 82.4 GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway(GO:0007193)
1.7 173.1 GO:0006334 nucleosome assembly(GO:0006334)
1.7 16.6 GO:0070862 negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
1.6 23.1 GO:0071481 cellular response to X-ray(GO:0071481)
1.6 17.1 GO:1903543 positive regulation of exosomal secretion(GO:1903543)
1.5 24.7 GO:1904355 positive regulation of telomere capping(GO:1904355)
1.4 4.3 GO:0070343 RNA repair(GO:0042245) white fat cell proliferation(GO:0070343) regulation of white fat cell proliferation(GO:0070350)
1.4 22.3 GO:0050884 neuromuscular process controlling posture(GO:0050884)
1.4 76.5 GO:0002437 inflammatory response to antigenic stimulus(GO:0002437)
1.4 30.5 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
1.4 11.0 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260) negative regulation of voltage-gated potassium channel activity(GO:1903817)
1.3 22.9 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
1.3 2.7 GO:0099545 trans-synaptic signaling by trans-synaptic complex(GO:0099545)
1.3 11.9 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
1.3 5.3 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
1.3 48.5 GO:0046839 phospholipid dephosphorylation(GO:0046839)
1.3 3.9 GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
1.3 10.4 GO:0051533 positive regulation of NFAT protein import into nucleus(GO:0051533)
1.3 27.3 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095) G2 DNA damage checkpoint(GO:0031572)
1.3 40.9 GO:0009395 phospholipid catabolic process(GO:0009395)
1.3 8.8 GO:0032927 positive regulation of activin receptor signaling pathway(GO:0032927)
1.3 15.0 GO:0045648 positive regulation of erythrocyte differentiation(GO:0045648)
1.2 56.1 GO:0007131 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
1.2 55.4 GO:2000649 regulation of sodium ion transmembrane transporter activity(GO:2000649)
1.2 6.0 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719)
1.2 4.8 GO:0070317 negative regulation of G0 to G1 transition(GO:0070317)
1.2 8.2 GO:0045048 protein insertion into ER membrane(GO:0045048)
1.1 3.4 GO:0045041 protein import into mitochondrial intermembrane space(GO:0045041)
1.0 14.3 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
1.0 67.4 GO:0032092 positive regulation of protein binding(GO:0032092)
1.0 4.9 GO:0002318 myeloid progenitor cell differentiation(GO:0002318)
1.0 13.7 GO:0050771 negative regulation of axonogenesis(GO:0050771)
1.0 21.4 GO:0097503 sialylation(GO:0097503)
1.0 2.9 GO:0043633 mitochondrial mRNA catabolic process(GO:0000958) positive regulation of mitochondrial RNA catabolic process(GO:0000962) RNA 5'-end processing(GO:0000966) rRNA import into mitochondrion(GO:0035928) polyadenylation-dependent RNA catabolic process(GO:0043633)
0.9 34.5 GO:0034766 negative regulation of ion transmembrane transport(GO:0034766)
0.9 23.4 GO:1903959 regulation of anion transmembrane transport(GO:1903959)
0.9 136.4 GO:0007411 axon guidance(GO:0007411)
0.9 2.7 GO:0044375 regulation of peroxisome size(GO:0044375)
0.8 6.7 GO:0008616 queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116)
0.8 16.8 GO:0014002 astrocyte development(GO:0014002)
0.8 8.3 GO:0090331 negative regulation of platelet aggregation(GO:0090331)
0.7 4.5 GO:0007290 spermatid nucleus elongation(GO:0007290) formaldehyde metabolic process(GO:0046292)
0.7 27.4 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.7 168.6 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.7 29.9 GO:2001244 positive regulation of intrinsic apoptotic signaling pathway(GO:2001244)
0.6 7.6 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617)
0.6 24.0 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.6 12.2 GO:0045646 regulation of erythrocyte differentiation(GO:0045646)
0.6 4.1 GO:0000722 telomere maintenance via recombination(GO:0000722)
0.6 19.3 GO:1902475 L-alpha-amino acid transmembrane transport(GO:1902475)
0.5 11.0 GO:0097178 ruffle assembly(GO:0097178)
0.5 60.8 GO:0051017 actin filament bundle assembly(GO:0051017)
0.5 8.8 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.5 0.9 GO:1900368 regulation of RNA interference(GO:1900368)
0.5 12.4 GO:0042417 dopamine metabolic process(GO:0042417)
0.4 8.7 GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968)
0.4 11.8 GO:0006779 porphyrin-containing compound biosynthetic process(GO:0006779)
0.4 28.7 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.4 10.7 GO:1904377 positive regulation of protein localization to plasma membrane(GO:1903078) positive regulation of protein localization to cell periphery(GO:1904377)
0.4 0.8 GO:0098759 response to interleukin-8(GO:0098758) cellular response to interleukin-8(GO:0098759)
0.3 1.0 GO:0036500 ATF6-mediated unfolded protein response(GO:0036500)
0.3 28.3 GO:0010921 regulation of phosphatase activity(GO:0010921)
0.3 6.1 GO:0048566 embryonic digestive tract development(GO:0048566)
0.3 7.0 GO:0030252 growth hormone secretion(GO:0030252)
0.3 2.2 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.3 2.6 GO:0031145 anaphase-promoting complex-dependent catabolic process(GO:0031145)
0.3 28.6 GO:0007416 synapse assembly(GO:0007416)
0.3 2.5 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
0.3 22.2 GO:0008585 female gonad development(GO:0008585)
0.2 4.7 GO:0006817 phosphate ion transport(GO:0006817)
0.2 10.5 GO:0045454 cell redox homeostasis(GO:0045454)
0.2 18.8 GO:0044070 regulation of anion transport(GO:0044070)
0.2 1.4 GO:0072502 cellular phosphate ion homeostasis(GO:0030643) cellular divalent inorganic anion homeostasis(GO:0072501) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.2 11.1 GO:0050905 neuromuscular process(GO:0050905)
0.2 9.7 GO:0000186 activation of MAPKK activity(GO:0000186)
0.2 83.8 GO:0007283 spermatogenesis(GO:0007283)
0.2 8.3 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
0.2 13.3 GO:0007613 memory(GO:0007613)
0.2 1.0 GO:0032264 IMP salvage(GO:0032264)
0.2 26.0 GO:0071805 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.1 8.3 GO:0006406 mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.1 2.4 GO:0006415 translational termination(GO:0006415)
0.1 7.0 GO:0030148 sphingolipid biosynthetic process(GO:0030148)
0.1 1.4 GO:0042753 positive regulation of circadian rhythm(GO:0042753)
0.1 3.1 GO:1901998 toxin transport(GO:1901998)
0.1 6.1 GO:0006400 tRNA modification(GO:0006400)
0.1 3.5 GO:0007631 feeding behavior(GO:0007631)
0.1 1.3 GO:0045063 T-helper 1 cell differentiation(GO:0045063) semaphorin-plexin signaling pathway(GO:0071526)
0.1 1.9 GO:0032781 positive regulation of ATPase activity(GO:0032781)
0.1 2.5 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.1 2.9 GO:0001764 neuron migration(GO:0001764)
0.0 0.7 GO:0035428 hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.0 1.1 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.0 0.1 GO:0046477 glycosylceramide catabolic process(GO:0046477)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
53.0 264.8 GO:0016939 kinesin II complex(GO:0016939)
42.1 168.5 GO:1990005 granular vesicle(GO:1990005)
41.9 167.5 GO:0099522 region of cytosol(GO:0099522) postsynaptic cytosol(GO:0099524)
38.8 194.1 GO:1990716 axonemal central apparatus(GO:1990716)
30.6 153.1 GO:0098536 deuterosome(GO:0098536)
22.6 293.5 GO:0097539 ciliary transition fiber(GO:0097539)
21.0 734.1 GO:0030990 intraciliary transport particle(GO:0030990)
19.3 77.1 GO:0031021 interphase microtubule organizing center(GO:0031021)
17.3 294.7 GO:0035686 sperm fibrous sheath(GO:0035686)
16.9 169.5 GO:0034464 BBSome(GO:0034464)
15.6 78.0 GO:0044316 cone cell pedicle(GO:0044316)
14.7 249.6 GO:0036038 MKS complex(GO:0036038)
14.6 248.4 GO:0035869 ciliary transition zone(GO:0035869)
14.0 335.3 GO:0034451 centriolar satellite(GO:0034451)
13.7 672.6 GO:0030286 dynein complex(GO:0030286)
13.5 229.6 GO:0097228 sperm principal piece(GO:0097228)
13.0 116.9 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
11.9 95.3 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
11.7 187.6 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
11.2 111.8 GO:0002177 manchette(GO:0002177)
9.6 623.2 GO:0036126 sperm flagellum(GO:0036126)
9.4 141.5 GO:0097546 ciliary base(GO:0097546)
8.0 160.7 GO:0010369 chromocenter(GO:0010369)
8.0 152.6 GO:0001741 XY body(GO:0001741)
7.9 23.6 GO:0098830 presynaptic endosome(GO:0098830)
7.2 157.5 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
6.5 45.2 GO:0000235 astral microtubule(GO:0000235) aster(GO:0005818)
6.1 357.0 GO:0005930 axoneme(GO:0005930) ciliary plasm(GO:0097014)
5.1 35.4 GO:0032584 growth cone membrane(GO:0032584)
5.0 229.0 GO:0016235 aggresome(GO:0016235)
4.9 108.8 GO:0001673 male germ cell nucleus(GO:0001673)
4.9 19.5 GO:0032021 NELF complex(GO:0032021)
4.5 53.6 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
4.1 28.5 GO:0000137 Golgi cis cisterna(GO:0000137)
4.0 169.1 GO:0032809 neuronal cell body membrane(GO:0032809)
3.6 271.1 GO:0001750 photoreceptor outer segment(GO:0001750)
3.6 10.8 GO:0043511 inhibin complex(GO:0043511)
3.5 10.5 GO:0055087 Ski complex(GO:0055087)
3.5 251.1 GO:0036064 ciliary basal body(GO:0036064)
3.4 13.5 GO:0005869 dynactin complex(GO:0005869)
3.3 9.8 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
3.2 102.7 GO:0005921 gap junction(GO:0005921)
3.2 38.5 GO:0097431 mitotic spindle pole(GO:0097431)
3.1 42.8 GO:0030122 AP-2 adaptor complex(GO:0030122)
3.0 29.9 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
2.9 52.7 GO:0030131 clathrin adaptor complex(GO:0030131)
2.7 79.2 GO:0031430 M band(GO:0031430)
2.7 8.1 GO:0035838 growing cell tip(GO:0035838)
2.7 408.8 GO:0005929 cilium(GO:0005929)
2.7 82.4 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
2.6 28.7 GO:0002199 zona pellucida receptor complex(GO:0002199)
2.6 66.8 GO:0032588 trans-Golgi network membrane(GO:0032588)
2.6 58.7 GO:0098563 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
2.5 15.1 GO:0090568 nuclear transcriptional repressor complex(GO:0090568)
2.5 152.2 GO:0031901 early endosome membrane(GO:0031901)
2.5 124.5 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
2.4 65.3 GO:0097440 apical dendrite(GO:0097440)
2.4 28.3 GO:0044224 juxtaparanode region of axon(GO:0044224)
2.3 13.7 GO:0005672 transcription factor TFIIA complex(GO:0005672)
2.2 28.9 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
2.2 43.5 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
2.0 9.8 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221)
1.8 70.2 GO:0005801 cis-Golgi network(GO:0005801)
1.8 49.4 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
1.7 10.4 GO:0005955 calcineurin complex(GO:0005955)
1.6 68.7 GO:0005637 nuclear inner membrane(GO:0005637)
1.6 33.1 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
1.5 6.1 GO:0000938 GARP complex(GO:0000938) EARP complex(GO:1990745)
1.5 22.3 GO:0034709 methylosome(GO:0034709)
1.5 22.1 GO:0032279 asymmetric synapse(GO:0032279)
1.5 445.3 GO:0030659 cytoplasmic vesicle membrane(GO:0030659)
1.4 8.6 GO:0030681 nucleolar ribonuclease P complex(GO:0005655) ribonuclease P complex(GO:0030677) multimeric ribonuclease P complex(GO:0030681)
1.4 393.2 GO:0014069 postsynaptic density(GO:0014069)
1.4 164.1 GO:0005802 trans-Golgi network(GO:0005802)
1.3 127.7 GO:0031225 anchored component of membrane(GO:0031225)
1.3 3.9 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
1.2 17.6 GO:0043196 varicosity(GO:0043196)
1.2 7.0 GO:0005785 signal recognition particle receptor complex(GO:0005785)
1.1 11.4 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
1.1 13.7 GO:0071437 invadopodium(GO:0071437)
1.1 20.6 GO:0060077 inhibitory synapse(GO:0060077)
1.1 171.9 GO:0005769 early endosome(GO:0005769)
1.0 5.8 GO:1990357 terminal web(GO:1990357)
1.0 2.9 GO:0045025 mitochondrial degradosome(GO:0045025)
0.9 37.8 GO:0005765 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.8 4.1 GO:0035061 interchromatin granule(GO:0035061)
0.8 36.5 GO:0009925 basal plasma membrane(GO:0009925)
0.7 5.8 GO:0030008 TRAPP complex(GO:0030008)
0.7 50.3 GO:0008021 synaptic vesicle(GO:0008021)
0.7 14.1 GO:0005849 mRNA cleavage factor complex(GO:0005849)
0.6 6.4 GO:0032797 SMN complex(GO:0032797)
0.5 4.3 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.5 4.8 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.5 12.8 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.5 26.3 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.5 174.4 GO:0043025 neuronal cell body(GO:0043025)
0.5 11.0 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.4 11.8 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.4 6.4 GO:0031201 SNARE complex(GO:0031201)
0.4 23.5 GO:0030496 midbody(GO:0030496)
0.4 26.3 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.4 4.8 GO:0000812 Swr1 complex(GO:0000812)
0.4 344.3 GO:0005887 integral component of plasma membrane(GO:0005887)
0.3 13.7 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.3 31.9 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.3 13.3 GO:1990391 DNA repair complex(GO:1990391)
0.3 22.0 GO:0034702 ion channel complex(GO:0034702)
0.3 29.4 GO:0005761 organellar ribosome(GO:0000313) mitochondrial ribosome(GO:0005761)
0.3 0.9 GO:0031074 nucleocytoplasmic shuttling complex(GO:0031074)
0.3 12.1 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.3 1.8 GO:0000808 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.2 8.9 GO:0043596 nuclear replication fork(GO:0043596)
0.2 28.9 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.2 14.5 GO:0005884 actin filament(GO:0005884)
0.2 7.9 GO:0098793 presynapse(GO:0098793)
0.2 8.3 GO:0005814 centriole(GO:0005814)
0.2 31.8 GO:0030141 secretory granule(GO:0030141)
0.2 51.6 GO:0005794 Golgi apparatus(GO:0005794)
0.2 20.1 GO:0005882 intermediate filament(GO:0005882)
0.2 2.6 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 4.2 GO:0048770 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 51.3 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.1 4.7 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.1 7.5 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 5.5 GO:0055037 recycling endosome(GO:0055037)
0.1 18.4 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 31.9 GO:0005813 centrosome(GO:0005813)
0.1 0.8 GO:0042629 mast cell granule(GO:0042629)
0.1 1.4 GO:0031226 intrinsic component of plasma membrane(GO:0031226)
0.0 10.9 GO:0015630 microtubule cytoskeleton(GO:0015630)
0.0 171.7 GO:0016021 integral component of membrane(GO:0016021)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
64.9 194.6 GO:0061628 H3K27me3 modified histone binding(GO:0061628)
56.2 168.5 GO:0015203 polyamine transmembrane transporter activity(GO:0015203) putrescine transmembrane transporter activity(GO:0015489) ornithine decarboxylase activator activity(GO:0042978)
51.1 102.2 GO:0008158 hedgehog receptor activity(GO:0008158)
49.3 296.0 GO:0032051 clathrin light chain binding(GO:0032051)
46.7 187.0 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
39.3 196.4 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
34.7 104.1 GO:0005119 smoothened binding(GO:0005119)
29.1 116.5 GO:0004127 cytidylate kinase activity(GO:0004127)
22.7 136.1 GO:0045504 dynein heavy chain binding(GO:0045504)
20.6 205.6 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
19.3 57.8 GO:0004698 calcium-dependent protein kinase C activity(GO:0004698)
18.9 226.9 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
18.6 167.5 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
18.3 109.8 GO:0032027 myosin light chain binding(GO:0032027)
16.7 116.9 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
15.9 190.2 GO:0015216 purine nucleotide transmembrane transporter activity(GO:0015216)
15.7 47.0 GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069)
13.2 119.2 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
12.1 96.7 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
11.8 82.4 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
11.6 185.8 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
10.3 51.4 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
10.1 795.5 GO:0003777 microtubule motor activity(GO:0003777)
9.4 94.1 GO:0045505 dynein intermediate chain binding(GO:0045505)
9.1 54.4 GO:0097506 uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506)
7.8 225.0 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
7.5 37.4 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
7.4 133.4 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
7.1 21.4 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
6.8 136.1 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
6.8 162.4 GO:0005112 Notch binding(GO:0005112)
6.6 26.5 GO:0035243 protein-arginine omega-N symmetric methyltransferase activity(GO:0035243)
5.8 120.8 GO:0032183 SUMO binding(GO:0032183)
5.5 182.0 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
5.3 58.0 GO:0030346 protein phosphatase 2B binding(GO:0030346)
5.1 142.2 GO:0005452 inorganic anion exchanger activity(GO:0005452)
5.1 91.0 GO:0017160 Ral GTPase binding(GO:0017160)
5.0 60.4 GO:0070008 serine-type exopeptidase activity(GO:0070008)
4.7 112.5 GO:0000030 mannosyltransferase activity(GO:0000030)
4.6 23.2 GO:0005280 hydrogen:amino acid symporter activity(GO:0005280)
4.4 204.6 GO:0005246 calcium channel regulator activity(GO:0005246)
4.4 22.1 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
4.4 48.5 GO:0042577 lipid phosphatase activity(GO:0042577)
4.4 17.5 GO:0002046 opsin binding(GO:0002046)
4.4 61.0 GO:0016500 protein-hormone receptor activity(GO:0016500)
4.3 17.0 GO:0015186 L-glutamine transmembrane transporter activity(GO:0015186)
4.1 69.6 GO:0097602 cullin family protein binding(GO:0097602)
4.0 60.7 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)
4.0 221.0 GO:0051018 protein kinase A binding(GO:0051018)
3.9 50.5 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
3.9 11.6 GO:0008281 sulfonylurea receptor activity(GO:0008281)
3.8 53.6 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
3.8 76.4 GO:0070840 dynein complex binding(GO:0070840)
3.5 14.0 GO:1904288 BAT3 complex binding(GO:1904288)
3.5 31.4 GO:0015215 nucleotide transmembrane transporter activity(GO:0015215)
3.4 13.5 GO:0004814 arginine-tRNA ligase activity(GO:0004814)
3.3 59.1 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
3.2 86.6 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
3.2 15.8 GO:0004140 dephospho-CoA kinase activity(GO:0004140)
3.1 15.3 GO:0001729 ceramide kinase activity(GO:0001729)
3.0 106.1 GO:0043015 gamma-tubulin binding(GO:0043015)
3.0 578.1 GO:0008017 microtubule binding(GO:0008017)
3.0 53.4 GO:0004707 MAP kinase activity(GO:0004707)
2.9 8.7 GO:0097363 protein O-GlcNAc transferase activity(GO:0097363)
2.9 20.1 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
2.9 194.4 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
2.9 171.2 GO:0035064 methylated histone binding(GO:0035064)
2.8 11.1 GO:1990955 G-rich single-stranded DNA binding(GO:1990955)
2.8 33.1 GO:0008179 adenylate cyclase binding(GO:0008179)
2.7 32.8 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
2.7 105.8 GO:0030507 spectrin binding(GO:0030507)
2.7 8.1 GO:0035651 AP-3 adaptor complex binding(GO:0035651)
2.7 18.7 GO:0016413 O-acetyltransferase activity(GO:0016413)
2.6 7.8 GO:0008476 protein-tyrosine sulfotransferase activity(GO:0008476)
2.4 14.7 GO:0019211 phosphatase activator activity(GO:0019211)
2.4 33.9 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
2.3 33.9 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
2.1 79.1 GO:0048020 chemokine activity(GO:0008009) CCR chemokine receptor binding(GO:0048020)
2.1 37.9 GO:0008327 methyl-CpG binding(GO:0008327)
2.1 12.4 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
1.9 13.1 GO:0004017 adenylate kinase activity(GO:0004017)
1.8 493.1 GO:0003924 GTPase activity(GO:0003924)
1.8 386.0 GO:0004866 endopeptidase inhibitor activity(GO:0004866)
1.8 54.8 GO:0030552 cAMP binding(GO:0030552)
1.8 68.3 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
1.7 36.1 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
1.7 18.8 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
1.7 11.9 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
1.7 60.8 GO:0017080 sodium channel regulator activity(GO:0017080)
1.6 4.7 GO:0052723 inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724)
1.5 10.8 GO:0034711 inhibin binding(GO:0034711)
1.5 55.6 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
1.5 35.5 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
1.5 37.1 GO:0004623 phospholipase A2 activity(GO:0004623)
1.5 6.1 GO:0070568 guanylyltransferase activity(GO:0070568)
1.5 10.4 GO:0016018 cyclosporin A binding(GO:0016018)
1.5 63.3 GO:0045182 translation regulator activity(GO:0045182)
1.4 183.6 GO:0005516 calmodulin binding(GO:0005516)
1.4 24.4 GO:0008253 5'-nucleotidase activity(GO:0008253)
1.4 175.0 GO:0004222 metalloendopeptidase activity(GO:0004222)
1.4 12.8 GO:0046790 virion binding(GO:0046790)
1.4 28.3 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)
1.4 220.5 GO:0017137 Rab GTPase binding(GO:0017137)
1.4 176.5 GO:0017016 Ras GTPase binding(GO:0017016)
1.4 66.3 GO:0030276 clathrin binding(GO:0030276)
1.4 167.2 GO:0005525 GTP binding(GO:0005525)
1.3 13.2 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
1.2 5.0 GO:0071535 RING-like zinc finger domain binding(GO:0071535)
1.2 19.6 GO:0016854 racemase and epimerase activity(GO:0016854)
1.1 4.3 GO:0035515 DNA demethylase activity(GO:0035514) oxidative RNA demethylase activity(GO:0035515)
1.0 9.3 GO:0032041 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
1.0 18.2 GO:0031005 filamin binding(GO:0031005)
1.0 13.0 GO:0098879 structural constituent of postsynaptic specialization(GO:0098879) structural constituent of postsynaptic density(GO:0098919)
1.0 28.6 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.9 51.2 GO:0044325 ion channel binding(GO:0044325)
0.9 11.0 GO:0004791 thioredoxin-disulfide reductase activity(GO:0004791)
0.8 13.5 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.8 6.7 GO:0008479 queuine tRNA-ribosyltransferase activity(GO:0008479)
0.8 58.3 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.8 50.1 GO:0043621 protein self-association(GO:0043621)
0.8 27.6 GO:0019894 kinesin binding(GO:0019894)
0.7 24.0 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.7 26.7 GO:0051059 NF-kappaB binding(GO:0051059)
0.6 17.3 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.6 37.7 GO:0030145 manganese ion binding(GO:0030145)
0.6 2.4 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.6 17.5 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.6 313.9 GO:0005509 calcium ion binding(GO:0005509)
0.5 18.7 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.5 46.4 GO:0008565 protein transporter activity(GO:0008565)
0.5 11.6 GO:0008198 ferrous iron binding(GO:0008198)
0.5 9.8 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.5 22.5 GO:0070888 E-box binding(GO:0070888)
0.5 2.9 GO:0034046 poly(G) binding(GO:0034046)
0.4 2.7 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.4 9.7 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.4 37.0 GO:0043130 ubiquitin-like protein binding(GO:0032182) ubiquitin binding(GO:0043130)
0.4 68.6 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.3 17.3 GO:0015179 L-amino acid transmembrane transporter activity(GO:0015179)
0.3 3.7 GO:0016595 glutamate binding(GO:0016595)
0.3 14.0 GO:0043022 ribosome binding(GO:0043022)
0.3 13.7 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.3 4.5 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.3 5.8 GO:0003785 actin monomer binding(GO:0003785)
0.3 6.3 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.3 25.3 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.3 7.8 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650)
0.3 0.8 GO:0019959 interleukin-8 receptor activity(GO:0004918) interleukin-8 binding(GO:0019959)
0.2 6.0 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.2 8.3 GO:0005088 Ras guanyl-nucleotide exchange factor activity(GO:0005088)
0.2 2.2 GO:0019966 interleukin-1 binding(GO:0019966)
0.2 4.4 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.2 13.7 GO:0051082 unfolded protein binding(GO:0051082)
0.2 17.8 GO:0019955 cytokine binding(GO:0019955)
0.1 2.7 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.1 3.8 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.1 2.5 GO:0051393 alpha-actinin binding(GO:0051393)
0.1 6.4 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 8.3 GO:0031625 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
0.0 2.0 GO:0008013 beta-catenin binding(GO:0008013)
0.0 1.7 GO:0030674 protein binding, bridging(GO:0030674)
0.0 0.7 GO:0005355 glucose transmembrane transporter activity(GO:0005355)
0.0 0.1 GO:0016936 galactoside binding(GO:0016936)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
11.5 195.4 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
10.5 167.5 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
9.2 375.6 ST ADRENERGIC Adrenergic Pathway
6.3 82.4 PID S1P S1P4 PATHWAY S1P4 pathway
5.0 277.9 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
3.0 106.1 PID RAS PATHWAY Regulation of Ras family activation
2.9 58.5 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
2.4 71.9 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
2.0 142.8 PID E2F PATHWAY E2F transcription factor network
2.0 98.1 PID PLK1 PATHWAY PLK1 signaling events
2.0 135.1 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
1.9 33.1 PID LPA4 PATHWAY LPA4-mediated signaling events
1.9 82.8 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
1.9 58.3 PID EPHA FWDPATHWAY EPHA forward signaling
1.6 22.2 PID ALK2 PATHWAY ALK2 signaling events
1.2 21.2 PID CIRCADIAN PATHWAY Circadian rhythm pathway
1.2 28.5 PID CERAMIDE PATHWAY Ceramide signaling pathway
1.1 24.5 PID ARF 3PATHWAY Arf1 pathway
1.0 8.1 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.8 15.6 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.7 20.6 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.7 32.1 PID BMP PATHWAY BMP receptor signaling
0.7 39.2 PID NOTCH PATHWAY Notch signaling pathway
0.7 140.7 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.6 9.3 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.5 4.0 ST G ALPHA S PATHWAY G alpha s Pathway
0.5 12.0 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.5 13.2 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.5 16.1 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.5 9.7 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.5 25.4 PID AR PATHWAY Coregulation of Androgen receptor activity
0.5 15.4 PID ATM PATHWAY ATM pathway
0.5 6.8 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.4 5.5 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.4 22.1 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway
0.4 6.0 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.3 11.2 PID IL6 7 PATHWAY IL6-mediated signaling events
0.3 72.1 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.3 3.9 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.2 27.1 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.2 6.3 PID TELOMERASE PATHWAY Regulation of Telomerase
0.1 2.7 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.1 2.0 PID P73PATHWAY p73 transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
12.2 195.4 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
11.0 329.8 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
11.0 373.5 REACTOME TRAFFICKING OF AMPA RECEPTORS Genes involved in Trafficking of AMPA receptors
10.3 165.0 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
10.0 170.3 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
7.7 245.5 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
7.5 150.0 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
5.5 82.4 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
4.2 54.4 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
3.8 26.3 REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS Genes involved in NRIF signals cell death from the nucleus
3.4 60.8 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
2.9 46.7 REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS Genes involved in Regulation of Water Balance by Renal Aquaporins
2.9 87.2 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
2.7 138.9 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
2.5 69.3 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
2.5 37.1 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
2.3 27.3 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
2.3 260.4 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
2.0 28.7 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
2.0 47.0 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
2.0 33.3 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
1.8 85.0 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
1.7 11.6 REACTOME INWARDLY RECTIFYING K CHANNELS Genes involved in Inwardly rectifying K+ channels
1.6 14.7 REACTOME ER PHAGOSOME PATHWAY Genes involved in ER-Phagosome pathway
1.6 79.9 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
1.2 12.8 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
1.2 25.3 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
1.1 32.1 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
1.1 65.2 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
1.1 10.8 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
1.1 28.9 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
1.0 78.4 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.9 12.0 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.8 178.1 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.7 42.3 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.7 13.1 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.6 24.1 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.6 17.6 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.6 8.1 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.6 22.5 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.5 10.4 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.5 6.0 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.4 22.3 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA
0.4 9.8 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.3 11.8 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.3 2.5 REACTOME FORMATION OF TRANSCRIPTION COUPLED NER TC NER REPAIR COMPLEX Genes involved in Formation of transcription-coupled NER (TC-NER) repair complex
0.3 5.5 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.3 5.3 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.3 1.0 REACTOME ACTIVATION OF CHAPERONES BY ATF6 ALPHA Genes involved in Activation of Chaperones by ATF6-alpha
0.2 19.2 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.1 4.1 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1 1.3 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 3.9 REACTOME L1CAM INTERACTIONS Genes involved in L1CAM interactions