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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Rad21_Smc3

Z-value: 1.83

Motif logo

Transcription factors associated with Rad21_Smc3

Gene Symbol Gene ID Gene Info
ENSRNOG00000004420 RAD21 cohesin complex component
ENSRNOG00000014173 structural maintenance of chromosomes 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Rad21rn6_v1_chr7_-_91538673_915386730.297.7e-08Click!
Smc3rn6_v1_chr1_+_274309758_2743097580.291.3e-07Click!

Activity profile of Rad21_Smc3 motif

Sorted Z-values of Rad21_Smc3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr15_+_32244416 74.36 ENSRNOT00000012019
ENSRNOT00000060254

chr6_-_138662365 70.04 ENSRNOT00000066209
ENSRNOT00000084892
immunoglobulin heavy constant mu
chr1_+_82480195 68.99 ENSRNOT00000028051
transforming growth factor, beta 1
chr15_+_57241968 65.57 ENSRNOT00000082191
lymphocyte cytosolic protein 1
chr15_+_31948035 62.57 ENSRNOT00000071627

chr13_+_51958834 58.92 ENSRNOT00000007833
protein tyrosine phosphatase, non-receptor type 7
chr6_-_139041654 57.00 ENSRNOT00000075664

chr6_-_138900915 56.93 ENSRNOT00000075363

chr15_+_30270740 55.37 ENSRNOT00000070991

chr15_+_31950986 54.10 ENSRNOT00000080233

chr20_-_5212624 54.07 ENSRNOT00000074261
antigen peptide transporter 2
chr6_-_139747579 52.71 ENSRNOT00000075502

chr20_+_3995544 51.54 ENSRNOT00000000527
transporter 2, ATP binding cassette subfamily B member
chr6_-_140215907 50.06 ENSRNOT00000086370

chr6_-_138536162 48.16 ENSRNOT00000083031

chr6_+_137959171 47.22 ENSRNOT00000006835
cysteine rich protein 1
chr15_+_31719866 46.57 ENSRNOT00000072127

chr6_-_138772736 46.13 ENSRNOT00000071492

chr15_-_29903755 46.01 ENSRNOT00000066802

chr6_-_141008427 45.58 ENSRNOT00000074472

chr12_-_22127021 45.52 ENSRNOT00000076261
Sin3A-associated protein 25
chr6_-_138948424 45.04 ENSRNOT00000072566

chr15_+_31579478 44.85 ENSRNOT00000071642

chr6_-_142372031 44.58 ENSRNOT00000063929

chr20_-_3374344 43.52 ENSRNOT00000082999
protein phosphatase 1, regulatory subunit 18
chr9_+_40975836 42.59 ENSRNOT00000084470
protein tyrosine phosphatase, non-receptor type 18
chr8_-_62424303 42.31 ENSRNOT00000091223
c-src tyrosine kinase
chr6_-_138631997 42.28 ENSRNOT00000073304

chr6_+_139523495 42.17 ENSRNOT00000075467

chr3_+_114772603 42.14 ENSRNOT00000073569
hypothetical LOC302884
chr12_-_22126858 42.12 ENSRNOT00000084480
Sin3A-associated protein 25
chr15_-_29341843 41.90 ENSRNOT00000047082
rCG61261-like
chr6_-_138679506 41.32 ENSRNOT00000075376

chr9_-_92775816 40.51 ENSRNOT00000029635
similar to Nuclear autoantigen Sp-100 (Speckled 100 kDa)
chr6_-_138507135 40.36 ENSRNOT00000071078

chr6_-_138931262 40.02 ENSRNOT00000078126
ENSRNOT00000042118
Ighg protein-like
chr15_-_29987717 39.71 ENSRNOT00000071501

chr6_+_139486942 39.63 ENSRNOT00000080320

chr6_-_139710905 39.59 ENSRNOT00000077430

chr6_-_139004980 39.45 ENSRNOT00000085427
ENSRNOT00000087351

chr15_+_29157294 39.34 ENSRNOT00000085162

chr8_-_48564722 38.42 ENSRNOT00000067902
Cbl proto-oncogene
chr15_+_31436302 38.14 ENSRNOT00000071012

chr6_-_138954577 37.98 ENSRNOT00000042728

chr6_-_138764901 37.40 ENSRNOT00000075175

chr15_-_30157685 37.40 ENSRNOT00000085082

chr10_+_55013703 37.08 ENSRNOT00000032785
phosphoinositide-3-kinase, regulatory subunit 5
chr6_+_139293294 36.52 ENSRNOT00000050297
ENSRNOT00000081817
Ighg protein-like
chr6_-_140418831 36.25 ENSRNOT00000086301

chr19_+_37652969 36.09 ENSRNOT00000041970
capping protein regulator and myosin 1 linker 2
chr15_+_31282047 35.92 ENSRNOT00000081826

chr15_-_30147793 35.46 ENSRNOT00000060399

chr15_+_31462806 34.52 ENSRNOT00000072946

chr15_+_31167860 34.44 ENSRNOT00000065401
rCG61261-like
chr15_+_31895223 34.20 ENSRNOT00000092202

chr13_-_110257367 34.17 ENSRNOT00000005576
denticleless E3 ubiquitin protein ligase homolog
chr15_+_31178339 33.85 ENSRNOT00000089064

chr15_-_29532988 33.76 ENSRNOT00000074782

chr1_-_1116926 33.58 ENSRNOT00000062027
retinoic acid early transcript 1L
chr15_+_31057655 33.49 ENSRNOT00000073618

chr6_-_142060032 32.76 ENSRNOT00000064717

chr14_-_45797887 32.72 ENSRNOT00000029209
TBC1 domain family member 1
chr20_+_11365697 32.20 ENSRNOT00000001611
autoimmune regulator
chr2_+_248249468 31.60 ENSRNOT00000022648
guanylate binding protein 4
chr9_+_98505259 31.45 ENSRNOT00000051810
erythroferrone
chr5_-_150520884 31.20 ENSRNOT00000085482
regulator of chromosome condensation 1
chr6_-_138685656 30.89 ENSRNOT00000041706

chr15_+_30462669 30.88 ENSRNOT00000060357
similar to T cell receptor alpha chain
chr14_-_2867397 30.76 ENSRNOT00000030428
ribosomal protein L5
chr20_-_10680283 30.64 ENSRNOT00000001579
salt-inducible kinase 1
chr15_-_29446332 29.97 ENSRNOT00000082901

chr4_+_170958196 29.76 ENSRNOT00000007905
phosphodiesterase 6H
chr15_+_32386816 29.57 ENSRNOT00000060322

chr15_+_31395772 29.37 ENSRNOT00000075087

chr6_-_138550417 29.28 ENSRNOT00000071945

chr20_+_3935529 29.21 ENSRNOT00000072458
class II histocompatibility antigen, M alpha chain
chr15_-_30174197 28.09 ENSRNOT00000074419
T-cell receptor alpha chain V region PHDS58-like
chr15_-_29369504 28.04 ENSRNOT00000060297

chrX_-_105390580 27.65 ENSRNOT00000077547
Bruton tyrosine kinase
chr17_+_77224112 26.77 ENSRNOT00000024178
minichromosome maintenance 10 replication initiation factor
chr6_-_139637187 26.66 ENSRNOT00000089454
Ighg protein-like
chr20_-_5244386 26.50 ENSRNOT00000070886
RT1 class II, locus DMa
chr15_+_30735921 26.26 ENSRNOT00000078887

chr10_-_84920886 26.24 ENSRNOT00000068083
Sp2 transcription factor
chr15_+_31642169 26.15 ENSRNOT00000072362

chr15_-_29360198 26.15 ENSRNOT00000072745
T-cell receptor alpha chain V region PHDS58-like
chr11_-_55044581 25.82 ENSRNOT00000046330
MORC family CW-type zinc finger 1
chr10_+_4536180 25.18 ENSRNOT00000003309
zinc finger CCCH type containing 7 A
chr6_+_139531330 25.07 ENSRNOT00000083025

chr15_+_29108981 25.05 ENSRNOT00000073133

chr15_+_30802299 24.78 ENSRNOT00000072418

chr1_-_4653210 24.71 ENSRNOT00000019121
RAB32, member RAS oncogene family
chr18_+_27576129 24.32 ENSRNOT00000070930
lysine demethylase 3B
chr15_-_29922522 24.24 ENSRNOT00000081778

chr1_-_82004538 24.15 ENSRNOT00000087572
POU class 2 homeobox 2
chr15_-_29728771 23.68 ENSRNOT00000073056

chr15_-_29993639 23.58 ENSRNOT00000071822

chr1_+_221773254 23.43 ENSRNOT00000028646
RAS guanyl releasing protein 2
chr15_+_30785248 23.40 ENSRNOT00000089085

chr10_-_70241254 23.00 ENSRNOT00000038376
RAD51 paralog D
chr17_-_71105286 22.94 ENSRNOT00000025901
protein kinase C, theta
chr15_-_29680444 22.92 ENSRNOT00000075008

chr15_-_30296451 22.63 ENSRNOT00000067263

chr1_-_198450688 22.61 ENSRNOT00000027392
Paxip1-associated glutamate-rich protein 1
chr5_-_159602251 22.20 ENSRNOT00000011394
NECAP endocytosis associated 2
chrX_-_72078551 22.20 ENSRNOT00000076978
ribosomal protein S4, X-linked
chr15_+_29096865 21.78 ENSRNOT00000077709

chr15_+_31243097 21.75 ENSRNOT00000042721
RGD1359684 protein-like
chr8_+_71822129 21.72 ENSRNOT00000089147
death-associated protein kinase 2
chr10_-_19715832 21.52 ENSRNOT00000040278
similar to ribosomal protein S10
chr9_-_10441834 21.46 ENSRNOT00000043704
ribosomal protein L36
chr5_+_122508388 21.44 ENSRNOT00000038410
Tctex1 domain containing 1
chr15_+_29073755 21.19 ENSRNOT00000075409

chr1_-_198460126 21.19 ENSRNOT00000082940
ENSRNOT00000086019
MYC associated zinc finger protein
chr16_-_22411225 21.12 ENSRNOT00000016204
similar to ribosomal protein S10
chr13_-_110784209 20.85 ENSRNOT00000071698
TNF receptor-associated factor 5
chr15_+_31456265 20.85 ENSRNOT00000075092

chr6_-_139997537 20.59 ENSRNOT00000073207

chr20_-_32416044 20.49 ENSRNOT00000067004
cell division cycle and apoptosis regulator 1
chr1_-_101131413 20.40 ENSRNOT00000093729
fms-related tyrosine kinase 3 ligand
chr16_-_20890949 20.36 ENSRNOT00000081977
homer scaffolding protein 3
chr5_+_169506138 20.29 ENSRNOT00000014904
ribosomal protein L22
chr9_-_82327534 20.28 ENSRNOT00000024444
nonhomologous end-joining factor 1
chr4_-_170841187 20.13 ENSRNOT00000007485
ADP-ribosyltransferase 4
chr12_-_46845079 20.07 ENSRNOT00000047466
ENSRNOT00000064115
paxillin
chr15_+_30612409 20.05 ENSRNOT00000072977

chr1_-_198706852 20.02 ENSRNOT00000024074
dCTP pyrophosphatase 1
chr15_+_32188736 19.79 ENSRNOT00000081436

chr1_+_105113595 19.69 ENSRNOT00000020853
ENSRNOT00000079655
protein arginine methyltransferase 3
chr4_+_145489869 19.60 ENSRNOT00000082618
Fanconi anemia, complementation group D2
chr3_+_170994038 19.21 ENSRNOT00000081823
SPO11, initiator of meiotic double stranded breaks
chr3_+_148150698 18.70 ENSRNOT00000087075
ENSRNOT00000010251
histocompatibility minor 13
chr1_-_157700064 18.48 ENSRNOT00000031974
DNA damage-induced apoptosis suppressor
chr20_+_4020317 18.43 ENSRNOT00000000526
RT1 class II, locus DOb
chr17_+_9631925 17.77 ENSRNOT00000018114
DEAD-box helicase 41
chr15_+_30750093 17.65 ENSRNOT00000071830

chr15_+_32296119 17.60 ENSRNOT00000072496

chr6_-_139033819 17.29 ENSRNOT00000091961

chr16_+_73584521 17.25 ENSRNOT00000024301
GINS complex subunit 4
chr16_+_1979191 17.15 ENSRNOT00000014382
peptidylprolyl isomerase F
chr4_+_115024927 16.59 ENSRNOT00000090987
MOB kinase activator 1A
chr12_-_46794797 16.54 ENSRNOT00000001518
ribosomal protein lateral stalk subunit P0
chr1_-_89258935 16.29 ENSRNOT00000003180
ribosomal protein L36-like
chr19_-_15733412 16.25 ENSRNOT00000014831
iroquois homeobox 6
chr15_+_30910039 16.20 ENSRNOT00000072686

chr15_+_34282936 16.14 ENSRNOT00000026364
interferon regulatory factor 9
chr13_-_60496511 16.10 ENSRNOT00000004495
cell division cycle 73
chr15_+_30862478 15.96 ENSRNOT00000071566

chr8_-_21661259 15.86 ENSRNOT00000068308
F-box and leucine-rich repeat protein 12
chr15_-_29623597 15.82 ENSRNOT00000074483

chr16_+_9563218 15.76 ENSRNOT00000035915
Rho GTPase activating protein 22
chr15_+_31852416 15.74 ENSRNOT00000060380

chr13_+_67611708 15.70 ENSRNOT00000063833
translocated promoter region, nuclear basket protein
chr19_-_10620671 15.66 ENSRNOT00000021842
C-C motif chemokine ligand 17
chr10_-_70259553 15.65 ENSRNOT00000011320
notchless homolog 1
chr9_+_16702460 15.48 ENSRNOT00000061432
protein tyrosine kinase 7
chr1_+_219144205 15.27 ENSRNOT00000083942
unc-93 homolog B1 (C. elegans)
chr12_-_42376426 15.25 ENSRNOT00000057258
2'-5'-oligoadenylate synthase 1A-like
chr1_-_101426852 15.20 ENSRNOT00000028217
RuvB-like AAA ATPase 2
chr10_+_55492404 15.06 ENSRNOT00000005588
ENSRNOT00000078038
ribosomal protein L26
chr15_-_29841388 15.04 ENSRNOT00000084501

chr2_-_199771896 14.89 ENSRNOT00000043937
chromodomain helicase DNA binding protein 1-like
chr10_+_103703404 14.88 ENSRNOT00000086469
RAB37, member RAS oncogene family
chr8_-_83693472 14.80 ENSRNOT00000015947
family with sequence similarity 83, member B
chr12_+_13299859 14.65 ENSRNOT00000039191
similar to Protein C7orf26 homolog
chr6_+_52751106 14.44 ENSRNOT00000014373
TWIST neighbor
chr18_+_36829062 14.43 ENSRNOT00000025467
ENSRNOT00000086979
transcription elongation regulator 1
chr15_+_32076297 14.30 ENSRNOT00000060310

chr7_+_34744483 14.28 ENSRNOT00000007465
ubiquitin specific peptidase 44
chr11_-_67756799 14.03 ENSRNOT00000030975
poly (ADP-ribose) polymerase family, member 9
chr3_-_80873887 13.98 ENSRNOT00000024280
diacylglycerol kinase zeta
chr8_+_132553218 13.76 ENSRNOT00000006554
LIM domains containing 1
chr15_+_30926938 13.73 ENSRNOT00000075625

chr3_-_72071895 13.67 ENSRNOT00000082857
selenoprotein H
chr20_+_7818289 13.61 ENSRNOT00000042539
peroxisome proliferator-activated receptor delta
chr1_+_85386470 13.54 ENSRNOT00000093332
ENSRNOT00000044326
pleckstrin homology and RhoGEF domain containing G2
chr15_+_30827300 13.54 ENSRNOT00000073533

chr20_-_4316715 13.53 ENSRNOT00000031704
complement C4B (Chido blood group)
chr6_-_99576196 13.36 ENSRNOT00000040565
similar to ribosomal protein S17
chr3_+_103866144 13.32 ENSRNOT00000007688
katanin regulatory subunit B1 like 1
chr9_-_53732858 13.11 ENSRNOT00000029204
nuclear envelope integral membrane protein 2
chr1_-_101131012 13.10 ENSRNOT00000082283
ENSRNOT00000093498
ENSRNOT00000093559
fms-related tyrosine kinase 3 ligand
ribosomal protein L13A
chr1_-_21586910 12.79 ENSRNOT00000032424
mediator complex subunit 23
chr1_+_44019059 12.76 ENSRNOT00000065733
ENSRNOT00000083425
SR-related CTD-associated factor 8
chr12_+_23151180 12.76 ENSRNOT00000059486
cut-like homeobox 1
chr3_-_52998650 12.53 ENSRNOT00000009988
similar to 40S ribosomal protein S3
chr11_+_77815181 12.51 ENSRNOT00000002640
claudin 1
chr12_+_660011 12.51 ENSRNOT00000040830
PDS5 cohesin associated factor B
chr10_-_85049331 12.46 ENSRNOT00000012538
T-box 21
chr12_+_13716596 12.28 ENSRNOT00000080216
actin, beta
chr15_+_31141142 12.20 ENSRNOT00000060304
uncharacterized LOC103693854
chr16_+_19767264 12.18 ENSRNOT00000051802
ENSRNOT00000092073
occludin/ELL domain containing 1
chr3_+_147772165 12.07 ENSRNOT00000008713
TBC1 domain family, member 20
chr6_-_128989812 11.99 ENSRNOT00000085943
ankyrin repeat and SOCS box protein 2-like
chr1_-_220867815 11.77 ENSRNOT00000028015
MUS81 structure-specific endonuclease subunit
chr9_+_81402124 11.73 ENSRNOT00000046019
RUN and FYVE domain containing 4
chr1_+_40529045 11.70 ENSRNOT00000026564
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
chr15_+_19429508 11.64 ENSRNOT00000047113
ribosomal protein S10-like
chr10_+_13084304 11.59 ENSRNOT00000066310
RGD1561157
chr3_-_83335960 11.52 ENSRNOT00000013914
apoptosis inhibitor 5

Network of associatons between targets according to the STRING database.

First level regulatory network of Rad21_Smc3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
23.0 69.0 GO:1900126 negative regulation of hyaluronan biosynthetic process(GO:1900126)
17.2 51.5 GO:0046967 antigen processing and presentation of exogenous peptide antigen via MHC class Ib(GO:0002477) antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent(GO:0002481) antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway(GO:0002488) antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent(GO:0002489) positive regulation of antigen processing and presentation of peptide antigen(GO:0002585) regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589) cytosol to ER transport(GO:0046967) peptide antigen transport(GO:0046968)
10.8 54.1 GO:0002483 antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
10.7 32.2 GO:0002458 peripheral T cell tolerance induction(GO:0002458) peripheral tolerance induction(GO:0002465) regulation of thymocyte migration(GO:2000410)
10.3 30.8 GO:1903630 regulation of aminoacyl-tRNA ligase activity(GO:1903630)
9.4 47.2 GO:0060741 prostate gland stromal morphogenesis(GO:0060741)
9.2 18.4 GO:0002583 regulation of antigen processing and presentation of peptide antigen(GO:0002583) negative regulation of antigen processing and presentation of peptide antigen(GO:0002584) regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002586)
9.0 36.1 GO:2000813 negative regulation of barbed-end actin filament capping(GO:2000813)
8.4 33.5 GO:0090290 positive regulation of osteoclast proliferation(GO:0090290)
8.0 24.1 GO:0002380 immunoglobulin secretion involved in immune response(GO:0002380)
7.2 21.7 GO:2000424 regulation of eosinophil chemotaxis(GO:2000422) positive regulation of eosinophil chemotaxis(GO:2000424)
7.1 42.3 GO:0042997 negative regulation of low-density lipoprotein particle clearance(GO:0010989) negative regulation of Golgi to plasma membrane protein transport(GO:0042997)
7.0 7.0 GO:0002578 negative regulation of antigen processing and presentation(GO:0002578) regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002580) negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581)
6.9 27.6 GO:0071226 peripheral B cell selection(GO:0002343) B cell affinity maturation(GO:0002344) cellular response to molecule of fungal origin(GO:0071226)
6.2 18.7 GO:1904211 membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211)
6.1 30.6 GO:0032792 negative regulation of CREB transcription factor activity(GO:0032792)
5.8 29.0 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
5.8 23.0 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
5.7 22.9 GO:2000318 positive regulation of T-helper 17 type immune response(GO:2000318)
5.7 17.2 GO:1902445 regulation of mitochondrial membrane permeability involved in programmed necrotic cell death(GO:1902445)
5.5 65.6 GO:0051639 actin filament network formation(GO:0051639)
5.4 16.3 GO:0060489 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
5.3 21.2 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
5.2 15.7 GO:0010847 MAPK import into nucleus(GO:0000189) regulation of chromatin assembly(GO:0010847) positive regulation of chromatin assembly or disassembly(GO:0045799)
5.1 15.2 GO:0071733 transcriptional activation by promoter-enhancer looping(GO:0071733) regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899) gene looping(GO:0090202) dsDNA loop formation(GO:0090579)
5.0 15.1 GO:1902167 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:1902167)
5.0 20.0 GO:0009223 pyrimidine deoxyribonucleotide catabolic process(GO:0009223)
4.5 22.6 GO:0071557 histone H3-K27 demethylation(GO:0071557)
4.4 26.5 GO:0002399 MHC class II protein complex assembly(GO:0002399) peptide antigen assembly with MHC class II protein complex(GO:0002503)
4.3 12.8 GO:2000409 positive regulation of T cell extravasation(GO:2000409)
4.2 12.5 GO:1903348 positive regulation of bicellular tight junction assembly(GO:1903348) response to butyrate(GO:1903544)
4.0 12.1 GO:1902953 positive regulation of ER to Golgi vesicle-mediated transport(GO:1902953)
4.0 7.9 GO:0006407 rRNA export from nucleus(GO:0006407)
3.9 11.7 GO:0015942 formate metabolic process(GO:0015942)
3.8 19.2 GO:1990918 meiotic DNA double-strand break processing(GO:0000706) double-strand break repair involved in meiotic recombination(GO:1990918)
3.7 25.8 GO:2000143 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529) negative regulation of DNA-templated transcription, initiation(GO:2000143)
3.5 10.6 GO:2000359 regulation of binding of sperm to zona pellucida(GO:2000359) negative regulation of binding of sperm to zona pellucida(GO:2000360)
3.5 38.4 GO:0090649 response to oxygen-glucose deprivation(GO:0090649) cellular response to oxygen-glucose deprivation(GO:0090650)
3.4 10.2 GO:1990167 protein K27-linked deubiquitination(GO:1990167)
3.4 10.1 GO:0032298 positive regulation of DNA-dependent DNA replication initiation(GO:0032298)
3.3 30.0 GO:2000270 negative regulation of fibroblast apoptotic process(GO:2000270)
3.3 16.5 GO:1904401 cellular response to Thyroid stimulating hormone(GO:1904401)
3.3 19.7 GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919)
3.3 19.6 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
3.2 9.7 GO:1904569 regulation of selenocysteine incorporation(GO:1904569)
3.1 24.7 GO:1903232 melanosome assembly(GO:1903232)
3.0 3.0 GO:0035711 T-helper 1 cell activation(GO:0035711)
2.7 2.7 GO:0046078 dUMP metabolic process(GO:0046078)
2.6 44.5 GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002504)
2.6 7.8 GO:0021898 regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment(GO:0021882) commitment of multipotent stem cells to neuronal lineage in forebrain(GO:0021898)
2.6 7.8 GO:0090164 asymmetric Golgi ribbon formation(GO:0090164)
2.6 35.8 GO:0019985 translesion synthesis(GO:0019985)
2.5 10.1 GO:1904690 regulation of cap-independent translational initiation(GO:1903677) positive regulation of cap-independent translational initiation(GO:1903679) regulation of cytoplasmic translational initiation(GO:1904688) positive regulation of cytoplasmic translational initiation(GO:1904690)
2.5 9.9 GO:0034760 regulation of iron ion transmembrane transport(GO:0034759) negative regulation of iron ion transmembrane transport(GO:0034760) regulation of cytochrome-c oxidase activity(GO:1904959)
2.4 7.3 GO:1901165 positive regulation of trophoblast cell migration(GO:1901165)
2.3 18.7 GO:2000288 positive regulation of myoblast proliferation(GO:2000288)
2.3 13.8 GO:0035331 negative regulation of hippo signaling(GO:0035331)
2.3 9.1 GO:0090625 mRNA cleavage involved in gene silencing by siRNA(GO:0090625)
2.2 15.7 GO:0061484 hematopoietic stem cell homeostasis(GO:0061484) negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001268)
2.2 4.5 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
2.1 6.2 GO:0098749 cerebellar neuron development(GO:0098749)
1.9 9.7 GO:0016095 polyprenol catabolic process(GO:0016095)
1.9 19.4 GO:0010891 negative regulation of sequestering of triglyceride(GO:0010891) positive regulation of triglyceride catabolic process(GO:0010898)
1.8 7.2 GO:0051958 methotrexate transport(GO:0051958)
1.8 23.1 GO:0090178 regulation of establishment of planar polarity involved in neural tube closure(GO:0090178)
1.7 13.5 GO:2000427 positive regulation of apoptotic cell clearance(GO:2000427)
1.6 8.1 GO:0006030 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
1.5 4.5 GO:0010909 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909)
1.5 16.3 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
1.5 8.8 GO:0046602 regulation of mitotic centrosome separation(GO:0046602)
1.5 16.1 GO:0045351 type I interferon biosynthetic process(GO:0045351)
1.5 16.1 GO:0033523 histone H2B ubiquitination(GO:0033523)
1.5 4.4 GO:0006990 positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990) N-terminal peptidyl-lysine acetylation(GO:0018076)
1.4 5.8 GO:0060431 primary lung bud formation(GO:0060431)
1.4 8.6 GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
1.4 14.0 GO:0060330 regulation of response to interferon-gamma(GO:0060330)
1.3 49.4 GO:0035458 cellular response to interferon-beta(GO:0035458)
1.3 31.5 GO:2000193 positive regulation of fatty acid transport(GO:2000193)
1.2 11.2 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
1.2 9.9 GO:0009912 auditory receptor cell fate commitment(GO:0009912) inner ear receptor cell fate commitment(GO:0060120)
1.2 24.3 GO:0033169 histone H3-K9 demethylation(GO:0033169)
1.2 27.6 GO:0035329 hippo signaling(GO:0035329)
1.2 14.3 GO:0090231 regulation of spindle checkpoint(GO:0090231) regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
1.2 10.7 GO:1902414 protein localization to cell junction(GO:1902414)
1.1 12.5 GO:0048304 positive regulation of isotype switching to IgG isotypes(GO:0048304)
1.1 9.1 GO:0033299 secretion of lysosomal enzymes(GO:0033299)
1.1 26.8 GO:0006270 DNA replication initiation(GO:0006270)
1.1 22.9 GO:0060396 growth hormone receptor signaling pathway(GO:0060396)
1.1 5.4 GO:0008295 spermidine biosynthetic process(GO:0008295)
1.1 5.4 GO:2000327 regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
1.1 29.8 GO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway(GO:0045745)
1.1 9.5 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
1.0 9.4 GO:0000050 urea cycle(GO:0000050)
1.0 6.2 GO:0010825 positive regulation of centrosome duplication(GO:0010825) positive regulation of centrosome cycle(GO:0046607)
1.0 6.0 GO:0032202 telomere assembly(GO:0032202)
1.0 6.7 GO:0006297 nucleotide-excision repair, DNA gap filling(GO:0006297)
1.0 3.8 GO:1904430 negative regulation of t-circle formation(GO:1904430)
0.9 3.8 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.9 9.0 GO:0035372 protein localization to microtubule(GO:0035372)
0.9 9.0 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.9 0.9 GO:0006649 phospholipid transfer to membrane(GO:0006649)
0.9 5.2 GO:0034454 microtubule anchoring at centrosome(GO:0034454)
0.9 2.6 GO:0071461 cellular response to redox state(GO:0071461)
0.8 27.7 GO:0006303 double-strand break repair via nonhomologous end joining(GO:0006303)
0.8 2.5 GO:0018283 metal incorporation into metallo-sulfur cluster(GO:0018282) iron incorporation into metallo-sulfur cluster(GO:0018283)
0.8 10.4 GO:1902018 negative regulation of cilium assembly(GO:1902018)
0.8 18.7 GO:0006471 protein ADP-ribosylation(GO:0006471)
0.8 45.0 GO:0002181 cytoplasmic translation(GO:0002181)
0.8 1.5 GO:0000957 mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960)
0.7 3.0 GO:0032919 spermine acetylation(GO:0032919)
0.7 19.1 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.7 9.4 GO:0032957 inositol trisphosphate metabolic process(GO:0032957)
0.7 7.1 GO:0071985 multivesicular body sorting pathway(GO:0071985)
0.7 37.1 GO:0043551 regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.7 82.1 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.7 4.7 GO:1901838 positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901838)
0.6 3.1 GO:0042270 protection from natural killer cell mediated cytotoxicity(GO:0042270)
0.6 9.7 GO:0051599 response to hydrostatic pressure(GO:0051599)
0.6 3.0 GO:0071630 nucleus-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071630)
0.6 5.9 GO:0034472 snRNA 3'-end processing(GO:0034472)
0.6 5.1 GO:0006335 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.6 12.5 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.6 5.6 GO:0071481 cellular response to X-ray(GO:0071481)
0.6 31.2 GO:0051290 protein heterotetramerization(GO:0051290)
0.6 6.1 GO:0071712 ER-associated misfolded protein catabolic process(GO:0071712)
0.6 12.2 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.5 2.0 GO:0071955 recycling endosome to Golgi transport(GO:0071955)
0.5 13.4 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.5 16.0 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.5 14.0 GO:0031571 mitotic G1 DNA damage checkpoint(GO:0031571) G1 DNA damage checkpoint(GO:0044783)
0.4 2.2 GO:0097039 protein linear polyubiquitination(GO:0097039)
0.4 2.2 GO:0036233 glycine import(GO:0036233)
0.4 2.2 GO:0060591 chondroblast differentiation(GO:0060591)
0.4 2.1 GO:1903899 positive regulation of PERK-mediated unfolded protein response(GO:1903899)
0.4 13.2 GO:0032508 DNA duplex unwinding(GO:0032508)
0.4 5.4 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
0.4 4.9 GO:0007289 spermatid nucleus differentiation(GO:0007289)
0.4 1.2 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.4 2.0 GO:0033625 positive regulation of integrin activation(GO:0033625)
0.4 5.1 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.4 24.7 GO:1902017 regulation of cilium assembly(GO:1902017)
0.4 4.5 GO:0022615 protein to membrane docking(GO:0022615)
0.4 1.8 GO:0071104 response to interleukin-9(GO:0071104)
0.4 1.8 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.3 2.3 GO:0036089 cleavage furrow formation(GO:0036089)
0.3 12.3 GO:0043044 ATP-dependent chromatin remodeling(GO:0043044)
0.3 2.6 GO:0015886 heme transport(GO:0015886)
0.3 14.4 GO:0006360 transcription from RNA polymerase I promoter(GO:0006360)
0.3 10.0 GO:0006958 complement activation, classical pathway(GO:0006958)
0.3 1.9 GO:0016584 nucleosome positioning(GO:0016584)
0.3 1.9 GO:0015860 purine nucleoside transmembrane transport(GO:0015860)
0.3 0.9 GO:2001137 positive regulation of endocytic recycling(GO:2001137)
0.3 4.3 GO:0019184 nonribosomal peptide biosynthetic process(GO:0019184)
0.3 1.8 GO:0045078 interferon-gamma biosynthetic process(GO:0042095) regulation of interferon-gamma biosynthetic process(GO:0045072) positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.3 14.9 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.3 1.7 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.3 8.4 GO:0000578 embryonic axis specification(GO:0000578)
0.3 8.6 GO:0060065 uterus development(GO:0060065)
0.3 6.2 GO:0051973 positive regulation of telomerase activity(GO:0051973)
0.3 1.9 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.3 5.5 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.3 4.1 GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001241)
0.3 1.5 GO:0097490 trunk segmentation(GO:0035290) trunk neural crest cell migration(GO:0036484) ventral trunk neural crest cell migration(GO:0036486) sympathetic neuron projection extension(GO:0097490) sympathetic neuron projection guidance(GO:0097491)
0.3 3.3 GO:0071420 cellular response to histamine(GO:0071420)
0.2 2.0 GO:0000055 ribosomal large subunit export from nucleus(GO:0000055)
0.2 6.6 GO:0002717 positive regulation of natural killer cell mediated immunity(GO:0002717) positive regulation of natural killer cell mediated cytotoxicity(GO:0045954)
0.2 20.6 GO:0048144 fibroblast proliferation(GO:0048144)
0.2 14.1 GO:0071277 cellular response to calcium ion(GO:0071277)
0.2 1.3 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.2 6.1 GO:0006284 base-excision repair(GO:0006284)
0.2 3.8 GO:0030825 positive regulation of cGMP metabolic process(GO:0030825) positive regulation of cGMP biosynthetic process(GO:0030828)
0.2 3.5 GO:0045475 locomotor rhythm(GO:0045475)
0.2 2.4 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.2 1.8 GO:0021942 radial glia guided migration of Purkinje cell(GO:0021942)
0.2 2.5 GO:0051014 actin filament severing(GO:0051014)
0.2 5.5 GO:0070207 protein homotrimerization(GO:0070207)
0.2 5.8 GO:0033119 negative regulation of RNA splicing(GO:0033119)
0.2 3.3 GO:0019433 triglyceride catabolic process(GO:0019433)
0.2 1.8 GO:0097240 meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic attachment of telomere to nuclear envelope(GO:0070197) chromosome attachment to the nuclear envelope(GO:0097240)
0.2 2.0 GO:0007210 serotonin receptor signaling pathway(GO:0007210)
0.2 14.4 GO:0045727 positive regulation of translation(GO:0045727)
0.2 3.1 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.2 10.5 GO:0006338 chromatin remodeling(GO:0006338)
0.2 6.0 GO:0032456 endocytic recycling(GO:0032456)
0.1 7.5 GO:0006611 protein export from nucleus(GO:0006611)
0.1 1.5 GO:0035855 megakaryocyte development(GO:0035855)
0.1 2.2 GO:0042659 regulation of cell fate specification(GO:0042659)
0.1 13.0 GO:0051092 positive regulation of NF-kappaB transcription factor activity(GO:0051092)
0.1 1.2 GO:0048820 hair follicle maturation(GO:0048820)
0.1 5.1 GO:0060976 coronary vasculature development(GO:0060976)
0.1 1.5 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.1 0.8 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.1 0.5 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.1 3.3 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.1 4.1 GO:0035019 somatic stem cell population maintenance(GO:0035019)
0.1 4.8 GO:0000380 alternative mRNA splicing, via spliceosome(GO:0000380)
0.1 4.6 GO:0061077 chaperone-mediated protein folding(GO:0061077)
0.1 1.6 GO:0055070 copper ion homeostasis(GO:0055070)
0.1 5.3 GO:0006334 nucleosome assembly(GO:0006334)
0.1 1.4 GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902230)
0.1 7.0 GO:0030317 sperm motility(GO:0030317)
0.1 2.2 GO:2001238 positive regulation of extrinsic apoptotic signaling pathway(GO:2001238)
0.1 2.7 GO:0007622 rhythmic behavior(GO:0007622) circadian behavior(GO:0048512)
0.1 0.5 GO:0006228 UTP biosynthetic process(GO:0006228)
0.1 13.1 GO:0006417 regulation of translation(GO:0006417)
0.1 4.3 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.1 2.7 GO:0090280 positive regulation of calcium ion import(GO:0090280)
0.1 5.8 GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity(GO:0051091)
0.1 8.8 GO:0051607 defense response to virus(GO:0051607)
0.1 2.8 GO:0046686 response to cadmium ion(GO:0046686)
0.1 2.1 GO:0021762 substantia nigra development(GO:0021762)
0.1 8.4 GO:0045471 response to ethanol(GO:0045471)
0.0 10.0 GO:0008380 RNA splicing(GO:0008380)
0.0 1.4 GO:0007131 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.0 1.4 GO:0034629 cellular protein complex localization(GO:0034629)
0.0 0.1 GO:0061304 retinal blood vessel morphogenesis(GO:0061304)
0.0 2.7 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.0 1.4 GO:0001510 RNA methylation(GO:0001510)
0.0 0.1 GO:1900620 acetylcholine biosynthetic process(GO:0008292) acetate ester biosynthetic process(GO:1900620)
0.0 0.7 GO:0031639 plasminogen activation(GO:0031639)
0.0 0.3 GO:0009083 branched-chain amino acid catabolic process(GO:0009083)
0.0 1.1 GO:0007173 epidermal growth factor receptor signaling pathway(GO:0007173)
0.0 0.4 GO:0030517 negative regulation of axon extension(GO:0030517)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
15.1 105.6 GO:0042825 TAP complex(GO:0042825)
12.4 37.1 GO:0005944 phosphatidylinositol 3-kinase complex, class IB(GO:0005944)
7.9 31.6 GO:0020005 symbiont-containing vacuole membrane(GO:0020005)
6.8 34.2 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
6.8 20.3 GO:0032807 DNA ligase IV complex(GO:0032807)
5.8 17.3 GO:0000811 GINS complex(GO:0000811)
5.4 16.3 GO:0060187 cell pole(GO:0060187)
4.6 74.1 GO:0042613 MHC class II protein complex(GO:0042613)
4.6 23.0 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
4.1 12.4 GO:0036488 CHOP-C/EBP complex(GO:0036488)
4.1 24.7 GO:0031904 endosome lumen(GO:0031904)
3.7 11.0 GO:0071149 TEAD-2-YAP complex(GO:0071149)
3.6 36.1 GO:0044354 F-actin capping protein complex(GO:0008290) pinosome(GO:0044352) macropinosome(GO:0044354)
3.4 10.1 GO:0097124 cyclin A2-CDK2 complex(GO:0097124)
3.2 38.4 GO:0016600 flotillin complex(GO:0016600)
3.1 25.1 GO:0031298 replication fork protection complex(GO:0031298)
2.9 11.8 GO:0048476 Holliday junction resolvase complex(GO:0048476)
2.7 18.7 GO:0071556 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
2.6 42.1 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
2.5 15.2 GO:0097255 R2TP complex(GO:0097255)
2.3 16.1 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
2.1 8.6 GO:0002947 tumor necrosis factor receptor superfamily complex(GO:0002947)
1.9 54.1 GO:0001891 phagocytic cup(GO:0001891)
1.9 25.1 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
1.9 3.8 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
1.9 13.1 GO:0097452 GAIT complex(GO:0097452)
1.7 22.6 GO:0044666 MLL3/4 complex(GO:0044666)
1.7 20.9 GO:0035631 CD40 receptor complex(GO:0035631)
1.6 22.8 GO:0031332 RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
1.6 11.0 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
1.6 15.7 GO:0044615 nuclear pore nuclear basket(GO:0044615)
1.5 12.3 GO:0097433 dense body(GO:0097433)
1.5 15.3 GO:0032009 early phagosome(GO:0032009)
1.4 5.6 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
1.3 6.7 GO:0043625 delta DNA polymerase complex(GO:0043625)
1.2 14.4 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
1.0 27.6 GO:0042629 mast cell granule(GO:0042629)
1.0 20.4 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.9 4.7 GO:0034455 t-UTP complex(GO:0034455)
0.9 8.3 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.9 7.2 GO:0016589 NURF complex(GO:0016589)
0.9 19.6 GO:0030057 desmosome(GO:0030057)
0.9 42.8 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.9 84.0 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.9 7.0 GO:0005577 fibrinogen complex(GO:0005577)
0.8 13.5 GO:0044217 other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)
0.8 22.2 GO:0030125 clathrin vesicle coat(GO:0030125)
0.8 4.5 GO:0030681 nucleolar ribonuclease P complex(GO:0005655) ribonuclease P complex(GO:0030677) multimeric ribonuclease P complex(GO:0030681)
0.8 4.5 GO:0070820 tertiary granule(GO:0070820)
0.7 2.2 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.7 25.5 GO:0001772 immunological synapse(GO:0001772)
0.7 74.4 GO:0005902 microvillus(GO:0005902)
0.7 49.2 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.7 7.8 GO:0071564 npBAF complex(GO:0071564)
0.6 1.9 GO:0031010 ISWI-type complex(GO:0031010)
0.6 8.8 GO:0030127 COPII vesicle coat(GO:0030127)
0.6 4.3 GO:0016461 unconventional myosin complex(GO:0016461)
0.6 17.2 GO:0005753 mitochondrial proton-transporting ATP synthase complex(GO:0005753)
0.6 6.1 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.5 9.7 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.5 5.0 GO:0032797 SMN complex(GO:0032797)
0.4 8.8 GO:0000242 pericentriolar material(GO:0000242)
0.4 3.2 GO:0071541 eukaryotic 43S preinitiation complex(GO:0016282) eukaryotic 48S preinitiation complex(GO:0033290) eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.4 2.3 GO:0071817 MMXD complex(GO:0071817)
0.4 4.9 GO:0030914 STAGA complex(GO:0030914)
0.4 5.9 GO:0032039 integrator complex(GO:0032039)
0.4 3.6 GO:0070187 telosome(GO:0070187)
0.3 7.6 GO:0001673 male germ cell nucleus(GO:0001673)
0.3 11.6 GO:0060077 inhibitory synapse(GO:0060077)
0.3 1.2 GO:0034991 nuclear meiotic cohesin complex(GO:0034991)
0.3 47.1 GO:0005840 ribosome(GO:0005840)
0.3 20.2 GO:0005811 lipid particle(GO:0005811)
0.3 12.6 GO:0016592 mediator complex(GO:0016592)
0.3 1.8 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.2 47.3 GO:0005681 spliceosomal complex(GO:0005681)
0.2 1.9 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.2 2.7 GO:0090544 BAF-type complex(GO:0090544)
0.2 15.2 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.2 11.4 GO:0016328 lateral plasma membrane(GO:0016328)
0.2 6.9 GO:0005844 polysome(GO:0005844)
0.2 2.5 GO:0030665 clathrin-coated vesicle membrane(GO:0030665)
0.2 17.5 GO:0000781 chromosome, telomeric region(GO:0000781)
0.2 1.5 GO:0031209 SCAR complex(GO:0031209)
0.2 88.1 GO:0000785 chromatin(GO:0000785)
0.2 7.1 GO:0005637 nuclear inner membrane(GO:0005637)
0.2 1.4 GO:0061700 GATOR2 complex(GO:0061700)
0.1 15.2 GO:0005814 centriole(GO:0005814)
0.1 9.0 GO:0072686 mitotic spindle(GO:0072686)
0.1 0.5 GO:0034774 secretory granule lumen(GO:0034774)
0.1 7.8 GO:0032587 ruffle membrane(GO:0032587)
0.1 11.1 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 5.4 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 2.0 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.1 2.5 GO:0015030 Cajal body(GO:0015030)
0.1 4.5 GO:0001726 ruffle(GO:0001726)
0.1 0.3 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.1 4.7 GO:0042641 actomyosin(GO:0042641)
0.1 43.0 GO:0005730 nucleolus(GO:0005730)
0.1 1.7 GO:0002102 podosome(GO:0002102)
0.1 1.4 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.8 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 1.8 GO:0016605 PML body(GO:0016605)
0.0 0.9 GO:0045171 intercellular bridge(GO:0045171)
0.0 1.9 GO:0005776 autophagosome(GO:0005776)
0.0 0.2 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.0 0.1 GO:0005606 laminin-1 complex(GO:0005606)
0.0 1.2 GO:0045178 basal part of cell(GO:0045178)
0.0 2.9 GO:0005802 trans-Golgi network(GO:0005802)
0.0 0.6 GO:0035097 histone methyltransferase complex(GO:0035097)
0.0 0.2 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 3.6 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
21.1 105.6 GO:0015440 peptide-transporting ATPase activity(GO:0015440)
13.8 69.0 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
8.2 24.7 GO:0035651 AP-3 adaptor complex binding(GO:0035651)
7.8 31.2 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
7.1 42.6 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
6.2 37.1 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
4.8 19.2 GO:0061505 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
4.7 47.2 GO:0003680 AT DNA binding(GO:0003680)
3.9 15.5 GO:0071936 coreceptor activity involved in Wnt signaling pathway(GO:0071936)
3.8 23.0 GO:0000150 recombinase activity(GO:0000150)
3.4 30.8 GO:0055104 ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948)
3.3 19.7 GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity(GO:0035242)
3.1 53.2 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
3.1 18.7 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
3.1 9.2 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
3.1 30.6 GO:0008140 cAMP response element binding protein binding(GO:0008140)
3.0 9.1 GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
3.0 20.9 GO:0001849 complement component C1q binding(GO:0001849)
2.5 15.2 GO:0043141 ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
2.5 20.1 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
2.5 20.0 GO:0032552 deoxyribonucleotide binding(GO:0032552)
2.5 17.2 GO:0016018 cyclosporin A binding(GO:0016018)
2.4 9.7 GO:0047751 3-oxo-5-alpha-steroid 4-dehydrogenase activity(GO:0003865) cholestenone 5-alpha-reductase activity(GO:0047751)
2.3 11.7 GO:0004488 methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
2.3 18.5 GO:0034046 poly(G) binding(GO:0034046)
2.1 44.9 GO:0023026 MHC class II protein complex binding(GO:0023026)
2.0 9.9 GO:0032767 copper-exporting ATPase activity(GO:0004008) copper-dependent protein binding(GO:0032767) copper-transporting ATPase activity(GO:0043682)
1.9 26.8 GO:0003688 DNA replication origin binding(GO:0003688)
1.9 7.5 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
1.8 56.7 GO:0070064 proline-rich region binding(GO:0070064)
1.8 7.2 GO:0015350 methotrexate transporter activity(GO:0015350)
1.7 15.7 GO:0043495 protein anchor(GO:0043495)
1.6 9.7 GO:0035368 selenocysteine insertion sequence binding(GO:0035368)
1.6 14.4 GO:0001054 RNA polymerase I activity(GO:0001054)
1.6 9.4 GO:0001013 RNA polymerase I regulatory region DNA binding(GO:0001013)
1.6 17.3 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
1.5 6.1 GO:0000405 bubble DNA binding(GO:0000405)
1.4 10.1 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
1.4 7.0 GO:0070052 collagen V binding(GO:0070052)
1.4 15.3 GO:0035325 Toll-like receptor binding(GO:0035325)
1.4 12.3 GO:0030957 Tat protein binding(GO:0030957)
1.3 8.1 GO:0004568 chitinase activity(GO:0004568)
1.3 39.9 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
1.3 11.8 GO:0048256 crossover junction endodeoxyribonuclease activity(GO:0008821) flap endonuclease activity(GO:0048256)
1.3 19.6 GO:0070182 DNA polymerase binding(GO:0070182)
1.3 37.9 GO:0043175 RNA polymerase core enzyme binding(GO:0043175)
1.3 3.8 GO:0042296 ISG15 transferase activity(GO:0042296)
1.3 20.1 GO:0051400 BH domain binding(GO:0051400)
1.2 6.1 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
1.2 24.3 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
1.2 17.0 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
1.2 14.0 GO:0001727 lipid kinase activity(GO:0001727)
1.2 5.8 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
1.1 22.9 GO:0004697 protein kinase C activity(GO:0004697)
1.1 22.6 GO:0004806 triglyceride lipase activity(GO:0004806)
1.0 5.1 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
1.0 20.9 GO:0031996 thioesterase binding(GO:0031996)
1.0 3.0 GO:0019809 spermidine binding(GO:0019809)
0.9 15.1 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.9 9.1 GO:0051766 inositol trisphosphate kinase activity(GO:0051766)
0.9 3.4 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.8 3.4 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.8 13.8 GO:0003993 acid phosphatase activity(GO:0003993)
0.8 3.8 GO:0008502 melatonin receptor activity(GO:0008502)
0.7 3.5 GO:0004977 melanocortin receptor activity(GO:0004977)
0.7 9.0 GO:0005522 profilin binding(GO:0005522)
0.7 33.3 GO:0045182 translation regulator activity(GO:0045182)
0.7 9.5 GO:0070410 co-SMAD binding(GO:0070410)
0.6 4.4 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.6 11.0 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.6 22.6 GO:0030331 estrogen receptor binding(GO:0030331)
0.6 12.5 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.6 10.7 GO:0005523 tropomyosin binding(GO:0005523)
0.6 149.6 GO:0003735 structural constituent of ribosome(GO:0003735)
0.6 13.6 GO:0036041 long-chain fatty acid binding(GO:0036041)
0.6 27.8 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.6 7.8 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.5 4.3 GO:0004300 enoyl-CoA hydratase activity(GO:0004300)
0.5 34.5 GO:0004004 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186)
0.5 27.6 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.5 3.4 GO:0035375 zymogen binding(GO:0035375)
0.5 2.8 GO:0061133 endopeptidase activator activity(GO:0061133)
0.5 10.7 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.5 11.5 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.5 10.1 GO:0035173 histone kinase activity(GO:0035173)
0.5 4.5 GO:0004526 ribonuclease P activity(GO:0004526)
0.4 15.7 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.4 32.3 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.4 3.1 GO:0048273 mitogen-activated protein kinase p38 binding(GO:0048273)
0.4 9.9 GO:0005112 Notch binding(GO:0005112)
0.4 2.5 GO:0016530 metallochaperone activity(GO:0016530)
0.4 3.3 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
0.4 3.6 GO:0008301 DNA binding, bending(GO:0008301)
0.4 8.3 GO:0070001 aspartic-type peptidase activity(GO:0070001)
0.4 69.9 GO:0051015 actin filament binding(GO:0051015)
0.4 7.8 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.4 3.1 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.4 1.2 GO:0036033 mediator complex binding(GO:0036033)
0.4 34.6 GO:0042826 histone deacetylase binding(GO:0042826)
0.4 20.4 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.4 5.6 GO:0043274 phospholipase binding(GO:0043274)
0.3 27.7 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.3 39.5 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.3 22.1 GO:0043566 structure-specific DNA binding(GO:0043566)
0.3 2.6 GO:0015232 heme transporter activity(GO:0015232)
0.3 13.9 GO:0004177 aminopeptidase activity(GO:0004177)
0.3 8.8 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.3 8.3 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.3 17.4 GO:0003725 double-stranded RNA binding(GO:0003725)
0.2 2.0 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.2 3.3 GO:0008327 methyl-CpG binding(GO:0008327)
0.2 5.8 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.2 7.2 GO:0008094 DNA-dependent ATPase activity(GO:0008094)
0.2 1.5 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.2 9.6 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.2 7.7 GO:0001047 core promoter binding(GO:0001047)
0.2 32.9 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.2 3.6 GO:0042162 telomeric DNA binding(GO:0042162)
0.2 1.4 GO:0019958 C-X-C chemokine binding(GO:0019958)
0.2 31.1 GO:0005179 hormone activity(GO:0005179)
0.2 11.3 GO:0002039 p53 binding(GO:0002039)
0.2 2.5 GO:0070034 telomerase RNA binding(GO:0070034)
0.2 0.9 GO:0090555 phosphatidylethanolamine-translocating ATPase activity(GO:0090555)
0.2 2.6 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.2 1.9 GO:0005346 adenine nucleotide transmembrane transporter activity(GO:0000295) purine ribonucleotide transmembrane transporter activity(GO:0005346)
0.2 1.8 GO:0005000 vasopressin receptor activity(GO:0005000)
0.2 3.3 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.2 0.3 GO:0070698 type I activin receptor binding(GO:0070698)
0.1 4.1 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.1 1.5 GO:0045499 chemorepellent activity(GO:0045499)
0.1 4.5 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 13.8 GO:0003714 transcription corepressor activity(GO:0003714)
0.1 0.5 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.1 1.2 GO:0070063 RNA polymerase binding(GO:0070063)
0.1 5.5 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 4.9 GO:0004402 histone acetyltransferase activity(GO:0004402) peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.1 2.2 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.1 1.4 GO:0008649 rRNA methyltransferase activity(GO:0008649)
0.1 2.1 GO:0002162 dystroglycan binding(GO:0002162)
0.1 2.2 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.1 3.3 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.1 1.2 GO:0034483 heparan sulfate sulfotransferase activity(GO:0034483)
0.1 1.6 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.1 13.8 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.1 25.4 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.1 7.1 GO:0042393 histone binding(GO:0042393)
0.1 6.9 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.1 0.9 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.0 8.6 GO:0004866 endopeptidase inhibitor activity(GO:0004866)
0.0 2.9 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 1.5 GO:0099589 G-protein coupled serotonin receptor activity(GO:0004993) serotonin receptor activity(GO:0099589)
0.0 1.3 GO:0043022 ribosome binding(GO:0043022)
0.0 0.5 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.0 2.0 GO:0001948 glycoprotein binding(GO:0001948)
0.0 1.8 GO:0004896 cytokine receptor activity(GO:0004896)
0.0 1.2 GO:0030674 protein binding, bridging(GO:0030674)
0.0 0.1 GO:0043208 glycosphingolipid binding(GO:0043208)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
3.8 69.0 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
3.5 56.3 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
2.2 127.1 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells
1.6 64.7 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
1.4 29.8 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
1.3 24.1 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.9 48.7 PID ILK PATHWAY Integrin-linked kinase signaling
0.8 2.5 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.8 14.2 PID IL27 PATHWAY IL27-mediated signaling events
0.8 26.6 PID BARD1 PATHWAY BARD1 signaling events
0.7 23.5 PID IFNG PATHWAY IFN-gamma pathway
0.7 19.6 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.7 24.1 PID BCR 5PATHWAY BCR signaling pathway
0.7 38.4 PID P53 REGULATION PATHWAY p53 pathway
0.7 12.5 PID NECTIN PATHWAY Nectin adhesion pathway
0.6 22.2 SIG CHEMOTAXIS Genes related to chemotaxis
0.5 7.9 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.4 8.6 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.4 31.2 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.3 13.6 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.3 11.6 PID TNF PATHWAY TNF receptor signaling pathway
0.3 4.9 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.3 15.7 PID IL4 2PATHWAY IL4-mediated signaling events
0.3 11.2 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.2 8.5 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.2 5.5 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.2 5.1 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.2 14.0 PID P73PATHWAY p73 transcription factor network
0.2 18.6 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.2 4.1 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.2 7.8 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.2 9.5 PID AR PATHWAY Coregulation of Androgen receptor activity
0.2 2.2 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.2 7.2 PID PLK1 PATHWAY PLK1 signaling events
0.1 2.2 PID IL6 7 PATHWAY IL6-mediated signaling events
0.1 3.3 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 3.6 PID TELOMERASE PATHWAY Regulation of Telomerase
0.1 3.1 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 1.7 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.1 26.1 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.1 2.8 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 2.2 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.1 2.7 PID E2F PATHWAY E2F transcription factor network
0.1 1.2 PID ATM PATHWAY ATM pathway
0.0 0.3 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling
0.0 1.4 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
3.8 42.3 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
3.4 60.4 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
3.0 38.4 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
3.0 56.1 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
2.8 19.6 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
1.6 158.0 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
1.6 17.3 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
1.6 21.7 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
1.4 23.4 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
1.4 36.9 REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX Genes involved in Activation of the pre-replicative complex
1.2 24.4 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
1.2 37.1 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade
1.2 15.3 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
1.1 9.9 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
1.1 20.5 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
1.1 27.6 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
1.0 22.9 REACTOME DOWNSTREAM TCR SIGNALING Genes involved in Downstream TCR signaling
0.9 47.7 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.8 9.7 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.8 16.6 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.8 3.1 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.7 9.6 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.6 34.3 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA
0.6 8.6 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.5 14.5 REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.5 5.1 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.4 12.5 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.4 3.6 REACTOME TELOMERE MAINTENANCE Genes involved in Telomere Maintenance
0.4 11.0 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.4 9.5 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.4 5.8 REACTOME CD28 DEPENDENT PI3K AKT SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.4 4.4 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.4 28.0 REACTOME LATE PHASE OF HIV LIFE CYCLE Genes involved in Late Phase of HIV Life Cycle
0.4 3.8 REACTOME INTEGRATION OF PROVIRUS Genes involved in Integration of provirus
0.4 17.5 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.3 15.7 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.3 13.5 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.2 13.7 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.2 3.1 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.2 13.6 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.2 3.3 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.2 2.7 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.2 3.8 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.2 2.0 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.2 2.2 REACTOME SIGNALING BY FGFR1 MUTANTS Genes involved in Signaling by FGFR1 mutants
0.2 3.0 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.2 9.0 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 2.2 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.1 11.5 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 12.1 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.1 2.1 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1 2.2 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.1 1.9 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 5.5 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 6.3 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.1 1.9 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1 2.0 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.9 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.3 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 1.5 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.3 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 1.9 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis