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GSE53960: rat RNA-Seq transcriptomic Bodymap
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Results for Ppara
Z-value: 1.80
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Transcription factors associated with Ppara
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Ppara | rn6_v1_chr7_+_126619196_126619196 | 0.03 | 5.5e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr17_-_66397653 Show fit | 106.59 |
ENSRNOT00000024098
|
actinin alpha 2 |
|
| chr10_+_11240138 Show fit | 96.61 |
ENSRNOT00000048687
|
sarcalumenin |
|
| chr8_-_130429132 Show fit | 86.33 |
ENSRNOT00000026261
|
hedgehog acyltransferase-like |
|
| chr8_-_84522588 Show fit | 83.20 |
ENSRNOT00000076213
|
muscular LMNA-interacting protein |
|
| chr15_+_33606124 Show fit | 76.61 |
ENSRNOT00000065210
|
|
|
| chr19_-_56677084 Show fit | 74.11 |
ENSRNOT00000024084
|
actin, alpha 1, skeletal muscle |
|
| chr7_-_80796670 Show fit | 73.16 |
ENSRNOT00000010539
|
actin-binding Rho activating protein |
|
| chr10_-_8498422 Show fit | 61.33 |
ENSRNOT00000082332
|
RNA binding protein, fox-1 homolog 1 |
|
| chr8_-_84506328 Show fit | 60.26 |
ENSRNOT00000064754
|
muscular LMNA-interacting protein |
|
| chr18_+_73564247 Show fit | 53.41 |
ENSRNOT00000077679
ENSRNOT00000035317 |
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Ppara
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.4 | 159.7 | GO:0022900 | electron transport chain(GO:0022900) |
| 5.0 | 130.9 | GO:0010614 | negative regulation of cardiac muscle hypertrophy(GO:0010614) |
| 5.0 | 123.9 | GO:0015985 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
| 35.5 | 106.6 | GO:2001137 | actin filament uncapping(GO:0051695) phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097) positive regulation of endocytic recycling(GO:2001137) |
| 19.5 | 97.5 | GO:0007197 | adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207) |
| 24.2 | 96.6 | GO:0014873 | response to muscle activity involved in regulation of muscle adaptation(GO:0014873) |
| 8.2 | 90.4 | GO:0006108 | malate metabolic process(GO:0006108) |
| 3.7 | 88.3 | GO:2001014 | regulation of skeletal muscle cell differentiation(GO:2001014) |
| 14.4 | 86.3 | GO:1903059 | regulation of protein lipidation(GO:1903059) |
| 7.3 | 80.7 | GO:0006122 | mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.4 | 349.7 | GO:0070469 | respiratory chain(GO:0070469) |
| 1.8 | 275.6 | GO:0030018 | Z disc(GO:0030018) |
| 0.2 | 191.9 | GO:0005739 | mitochondrion(GO:0005739) |
| 6.3 | 133.0 | GO:0005865 | striated muscle thin filament(GO:0005865) |
| 1.1 | 119.7 | GO:0016605 | PML body(GO:0016605) |
| 9.3 | 112.2 | GO:0045275 | respiratory chain complex III(GO:0045275) |
| 1.2 | 110.4 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.2 | 85.8 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
| 0.3 | 79.2 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 1.4 | 76.4 | GO:0030017 | sarcomere(GO:0030017) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 145.5 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 4.8 | 129.9 | GO:0008137 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 1.0 | 119.9 | GO:0001191 | transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191) |
| 0.5 | 108.4 | GO:0008022 | protein C-terminus binding(GO:0008022) |
| 21.3 | 106.6 | GO:0051373 | FATZ binding(GO:0051373) |
| 19.5 | 97.5 | GO:0016907 | G-protein coupled acetylcholine receptor activity(GO:0016907) |
| 15.1 | 90.4 | GO:0004470 | malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473) |
| 2.7 | 80.4 | GO:0016676 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.2 | 72.3 | GO:0005525 | GTP binding(GO:0005525) |
| 9.0 | 72.1 | GO:0008121 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 92.6 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.7 | 50.7 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.8 | 38.7 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 1.5 | 30.7 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 0.9 | 23.7 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.3 | 18.6 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 1.2 | 16.9 | PID ALK2 PATHWAY | ALK2 signaling events |
| 0.3 | 14.5 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.2 | 12.6 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.6 | 12.4 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.2 | 402.9 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 6.1 | 239.8 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 2.4 | 93.5 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 2.4 | 93.2 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 5.2 | 78.3 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 4.6 | 74.1 | REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
| 1.8 | 70.8 | REACTOME AMINE LIGAND BINDING RECEPTORS | Genes involved in Amine ligand-binding receptors |
| 5.2 | 67.1 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 3.6 | 60.7 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 2.2 | 60.6 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |