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GSE53960: rat RNA-Seq transcriptomic Bodymap
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Results for Pitx3
Z-value: 1.07
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Transcription factors associated with Pitx3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Pitx3 | rn6_v1_chr1_-_265899958_265899958 | 0.27 | 1.0e-06 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Pitx3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.3 | 42.6 | GO:0071688 | striated muscle myosin thick filament assembly(GO:0071688) |
| 4.8 | 33.5 | GO:0014886 | transition between slow and fast fiber(GO:0014886) |
| 0.2 | 31.2 | GO:0010952 | positive regulation of peptidase activity(GO:0010952) |
| 4.2 | 29.1 | GO:0010890 | positive regulation of sequestering of triglyceride(GO:0010890) |
| 7.0 | 28.1 | GO:0015811 | L-cystine transport(GO:0015811) |
| 0.1 | 26.7 | GO:0006898 | receptor-mediated endocytosis(GO:0006898) |
| 1.1 | 26.4 | GO:0060314 | regulation of ryanodine-sensitive calcium-release channel activity(GO:0060314) |
| 0.1 | 25.0 | GO:0007160 | cell-matrix adhesion(GO:0007160) |
| 8.2 | 24.5 | GO:0000053 | argininosuccinate metabolic process(GO:0000053) |
| 0.7 | 24.5 | GO:0007202 | activation of phospholipase C activity(GO:0007202) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 208.1 | GO:0070062 | extracellular exosome(GO:0070062) |
| 0.2 | 62.2 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.1 | 44.8 | GO:0045177 | apical part of cell(GO:0045177) |
| 3.5 | 42.6 | GO:0005859 | muscle myosin complex(GO:0005859) |
| 0.3 | 30.9 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.4 | 29.1 | GO:0005811 | lipid particle(GO:0005811) |
| 0.4 | 26.4 | GO:0016529 | sarcoplasmic reticulum(GO:0016529) |
| 0.3 | 25.5 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 1.5 | 24.5 | GO:0070852 | cell body fiber(GO:0070852) |
| 0.2 | 22.9 | GO:0030018 | Z disc(GO:0030018) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 51.1 | GO:0005525 | GTP binding(GO:0005525) |
| 3.3 | 42.6 | GO:0097493 | structural molecule activity conferring elasticity(GO:0097493) |
| 0.3 | 41.3 | GO:0008201 | heparin binding(GO:0008201) |
| 1.1 | 41.0 | GO:0043236 | laminin binding(GO:0043236) |
| 0.1 | 33.6 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.6 | 31.4 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 0.9 | 31.2 | GO:0016504 | peptidase activator activity(GO:0016504) |
| 7.0 | 28.1 | GO:0015184 | L-cystine transmembrane transporter activity(GO:0015184) |
| 0.3 | 26.8 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.6 | 24.7 | GO:0016655 | oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor(GO:0016655) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 34.4 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.2 | 23.4 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.5 | 21.2 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.3 | 19.6 | PID E2F PATHWAY | E2F transcription factor network |
| 0.4 | 16.8 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
| 0.4 | 16.7 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.4 | 13.8 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.4 | 13.3 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.2 | 12.6 | PID FGF PATHWAY | FGF signaling pathway |
| 1.1 | 12.3 | ST JAK STAT PATHWAY | Jak-STAT Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 60.8 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 1.3 | 50.2 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.7 | 43.2 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.2 | 37.9 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.4 | 37.0 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.9 | 34.5 | REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT | Genes involved in ABC-family proteins mediated transport |
| 2.4 | 21.6 | REACTOME ABACAVIR TRANSPORT AND METABOLISM | Genes involved in Abacavir transport and metabolism |
| 0.1 | 21.3 | REACTOME G ALPHA Q SIGNALLING EVENTS | Genes involved in G alpha (q) signalling events |
| 0.2 | 20.3 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.3 | 18.9 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |