ISMARA results: Nr2f2

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Nr2f2

Z-value: 1.76

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Transcription factors associated with Nr2f2

Gene Symbol	Gene ID	Gene Info
Nr2f2 NCBI RGD Ensembl	ENSRNOG00000010308	nuclear receptor subfamily 2, group F, member 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Nr2f2	rn6_v1_chr1_-_131460473_131460473	0.22	5.2e-05	Click!

Activity profile of Nr2f2 motif

Sorted Z-values of Nr2f2 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr16_-_32868680 Show fit	58.55	ENSRNOT00000015974 ENSRNOT00000082392	Aadat NCBI RGD Ensembl Show fit	aminoadipate aminotransferase
chr12_+_943006 Show fit	57.36	ENSRNOT00000001449	Kl NCBI RGD Ensembl Show fit	Klotho
chr5_-_137372993 Show fit	48.33	ENSRNOT00000092823	Tmem125 NCBI RGD Ensembl Show fit	transmembrane protein 125
chr9_-_88357182 Show fit	47.70	ENSRNOT00000041176	Col4a4 NCBI RGD Ensembl Show fit	collagen type IV alpha 4 chain
chrX_-_142131545 Show fit	40.73	ENSRNOT00000077402	Fgf13 NCBI RGD Ensembl Show fit	fibroblast growth factor 13
chr16_+_20521956 Show fit	40.68	ENSRNOT00000026597	Pgpep1 NCBI RGD Ensembl Show fit	pyroglutamyl-peptidase I
chr3_-_2689084 Show fit	39.83	ENSRNOT00000020926	Ptgds NCBI RGD Ensembl Show fit	prostaglandin D2 synthase
chr10_+_92337879 Show fit	38.88	ENSRNOT00000042984	Mapt NCBI RGD Ensembl Show fit	microtubule-associated protein tau
chr14_-_115052450 Show fit	38.30	ENSRNOT00000067998	Acyp2 NCBI RGD Ensembl Show fit	acylphosphatase 2
chr9_-_88356716 Show fit	38.11	ENSRNOT00000077503	Col4a4 NCBI RGD Ensembl Show fit	collagen type IV alpha 4 chain

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Nr2f2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
6.6	86.2	GO:0032836	glomerular basement membrane development(GO:0032836)
19.5	58.6	GO:0033512	L-lysine catabolic process to acetyl-CoA via saccharopine(GO:0033512)
7.2	57.4	GO:0090080	positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway(GO:0090080)
5.8	40.7	GO:0045196	establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
10.0	39.8	GO:2000255	negative regulation of male germ cell proliferation(GO:2000255)
4.9	38.9	GO:0090258	negative regulation of mitochondrial fission(GO:0090258)
1.0	38.7	GO:0002675	positive regulation of acute inflammatory response(GO:0002675)
4.8	38.0	GO:0071267	amino acid salvage(GO:0043102) L-methionine salvage(GO:0071267)
0.8	36.7	GO:0006749	glutathione metabolic process(GO:0006749)
3.0	36.5	GO:0006108	malate metabolic process(GO:0006108)

Showing 1 to 10 of 222 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	258.0	GO:0005739	mitochondrion(GO:0005739)
0.4	109.0	GO:0005743	mitochondrial inner membrane(GO:0005743)
0.3	100.5	GO:0045177	apical part of cell(GO:0045177)
10.7	85.8	GO:0005587	collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.7	70.5	GO:0005604	basement membrane(GO:0005604)
0.8	69.1	GO:0099501	synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.2	62.7	GO:0031012	extracellular matrix(GO:0031012)
2.5	57.6	GO:1902711	GABA-A receptor complex(GO:1902711)
1.4	55.9	GO:0005834	heterotrimeric G-protein complex(GO:0005834)
0.5	54.0	GO:0005791	rough endoplasmic reticulum(GO:0005791)

Showing 1 to 10 of 117 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.5	98.6	GO:0005201	extracellular matrix structural constituent(GO:0005201)
1.8	62.9	GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor(GO:0016655)
14.6	58.6	GO:0016212	kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137)
2.2	57.6	GO:0004890	GABA-A receptor activity(GO:0004890)
19.1	57.4	GO:0004566	beta-glucuronidase activity(GO:0004566)
0.6	51.7	GO:0003777	microtubule motor activity(GO:0003777)
5.8	46.6	GO:0008172	S-methyltransferase activity(GO:0008172)
0.2	45.1	GO:0004252	serine-type endopeptidase activity(GO:0004252)
1.5	44.4	GO:0005501	retinoid binding(GO:0005501)
0.4	44.1	GO:0004222	metalloendopeptidase activity(GO:0004222)

Showing 1 to 10 of 176 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.7	133.1	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
3.6	46.5	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
1.4	40.0	PID CONE PATHWAY	Visual signal transduction: Cones
0.1	28.1	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2	27.1	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.6	24.8	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.8	22.2	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.9	20.6	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.1	19.4	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.6	18.8	PID PRL SIGNALING EVENTS PATHWAY	Signaling events mediated by PRL

Showing 1 to 10 of 34 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.2	96.1	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
2.2	88.5	REACTOME GLUCONEOGENESIS	Genes involved in Gluconeogenesis
6.5	58.6	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism
3.4	57.6	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
2.4	55.9	REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA	Genes involved in G beta:gamma signalling through PLC beta
0.8	54.8	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
1.7	51.7	REACTOME KINESINS	Genes involved in Kinesins
2.3	50.6	REACTOME PEROXISOMAL LIPID METABOLISM	Genes involved in Peroxisomal lipid metabolism
1.8	47.8	REACTOME FGFR LIGAND BINDING AND ACTIVATION	Genes involved in FGFR ligand binding and activation
0.2	39.3	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives

Showing 1 to 10 of 72 entries

Results for Nr2f2

Z-value: 1.76

Motif logo

Transcription factors associated with Nr2f2

Activity-expression correlation:

Activity profile of Nr2f2 motif

Sorted Z-values of Nr2f2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Nr2f2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: