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GSE53960: rat RNA-Seq transcriptomic Bodymap
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Results for Nr2f1_Nr4a1
Z-value: 1.37
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Transcription factors associated with Nr2f1_Nr4a1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nr4a1 | rn6_v1_chr7_+_142912316_142912316 | -0.27 | 6.4e-07 | Click! |
| Nr2f1 | rn6_v1_chr2_-_5579894_5579894 | -0.03 | 6.3e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr8_-_50531423 Show fit | 83.11 |
ENSRNOT00000090985
ENSRNOT00000074942 |
apolipoprotein C3 |
|
| chr2_-_243407608 Show fit | 52.15 |
ENSRNOT00000014631
|
microsomal triglyceride transfer protein |
|
| chr5_+_118743632 Show fit | 47.87 |
ENSRNOT00000013785
|
phosphoglucomutase 1 |
|
| chr2_-_178389608 Show fit | 47.69 |
ENSRNOT00000013262
|
electron transfer flavoprotein dehydrogenase |
|
| chr10_+_63659085 Show fit | 46.95 |
ENSRNOT00000005039
|
Rab interacting lysosomal protein |
|
| chr17_-_66397653 Show fit | 46.23 |
ENSRNOT00000024098
|
actinin alpha 2 |
|
| chr2_-_23256158 Show fit | 45.75 |
ENSRNOT00000015336
|
betaine-homocysteine S-methyltransferase |
|
| chrX_-_23144324 Show fit | 45.34 |
ENSRNOT00000000178
ENSRNOT00000081239 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 |
|
| chr19_-_56677084 Show fit | 43.77 |
ENSRNOT00000024084
|
actin, alpha 1, skeletal muscle |
|
| chr3_-_60813869 Show fit | 41.06 |
ENSRNOT00000058234
|
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9) |
Network of associatons between targets according to the STRING database.
First level regulatory network of Nr2f1_Nr4a1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.0 | 123.9 | GO:0015986 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
| 27.7 | 83.1 | GO:0010903 | negative regulation of very-low-density lipoprotein particle remodeling(GO:0010903) regulation of high-density lipoprotein particle clearance(GO:0010982) |
| 7.7 | 77.0 | GO:0033539 | fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539) |
| 0.1 | 69.4 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 15.8 | 63.3 | GO:2001295 | malonyl-CoA biosynthetic process(GO:2001295) |
| 14.0 | 56.2 | GO:0042776 | mitochondrial ATP synthesis coupled proton transport(GO:0042776) |
| 0.3 | 52.8 | GO:0007596 | blood coagulation(GO:0007596) |
| 6.5 | 52.1 | GO:0034196 | acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197) |
| 6.0 | 47.9 | GO:0019388 | galactose catabolic process(GO:0019388) |
| 15.8 | 47.5 | GO:0006121 | mitochondrial electron transport, succinate to ubiquinone(GO:0006121) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 191.2 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 3.3 | 167.5 | GO:0030964 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.7 | 157.2 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.8 | 125.4 | GO:0030018 | Z disc(GO:0030018) |
| 0.5 | 101.3 | GO:0005770 | late endosome(GO:0005770) |
| 15.9 | 95.2 | GO:0034363 | intermediate-density lipoprotein particle(GO:0034363) |
| 5.8 | 92.2 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
| 10.4 | 82.9 | GO:0000275 | mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261) |
| 0.0 | 79.5 | GO:0070062 | extracellular exosome(GO:0070062) |
| 26.4 | 79.1 | GO:0045257 | mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) fumarate reductase complex(GO:0045283) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.5 | 104.0 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 5.8 | 103.8 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 3.0 | 92.2 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 27.7 | 83.1 | GO:0070653 | high-density lipoprotein particle receptor binding(GO:0070653) |
| 26.4 | 79.1 | GO:0008177 | succinate dehydrogenase (ubiquinone) activity(GO:0008177) |
| 2.8 | 75.2 | GO:0008137 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 15.8 | 63.3 | GO:0003989 | acetyl-CoA carboxylase activity(GO:0003989) |
| 0.8 | 52.7 | GO:0038024 | cargo receptor activity(GO:0038024) |
| 12.6 | 50.3 | GO:0070546 | L-phenylalanine aminotransferase activity(GO:0070546) |
| 5.0 | 49.9 | GO:0051959 | dynein light intermediate chain binding(GO:0051959) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 107.7 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.3 | 71.4 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.9 | 56.5 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.8 | 54.8 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.5 | 40.7 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.5 | 26.2 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 2.2 | 24.0 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
| 0.5 | 21.0 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.4 | 19.5 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.6 | 18.1 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.3 | 471.4 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 10.4 | 176.1 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 4.2 | 168.3 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 6.6 | 106.2 | REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
| 3.1 | 69.1 | REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE | Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle |
| 2.4 | 66.1 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 1.8 | 60.3 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 1.5 | 57.9 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 3.0 | 56.7 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 1.9 | 56.2 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |