ISMARA results: Nfix

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Nfix

Z-value: 0.80

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Transcription factors associated with Nfix

Gene Symbol	Gene ID	Gene Info

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Nf1x	rn6_v1_chr19_-_25914689_25914696	0.35	9.0e-11	Click!

Activity profile of Nfix motif

Sorted Z-values of Nfix motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr10_+_53740841 Show fit	53.70	ENSRNOT00000004295	Myh2 NCBI RGD Ensembl Show fit	myosin heavy chain 2
chr14_-_19191863 Show fit	37.92	ENSRNOT00000003921	Alb NCBI RGD Ensembl Show fit	albumin
chr8_+_50537009 Show fit	28.10	ENSRNOT00000080658	Apoa4 NCBI RGD Ensembl Show fit	apolipoprotein A4
chr13_+_83073544 Show fit	27.99	ENSRNOT00000066119 ENSRNOT00000079796 ENSRNOT00000077070	Dpt NCBI RGD Ensembl Show fit	dermatopontin
chr13_+_83073866 Show fit	27.53	ENSRNOT00000075996	Dpt NCBI RGD Ensembl Show fit	dermatopontin
chr17_-_389967 Show fit	26.43	ENSRNOT00000023865	Fbp2 NCBI RGD Ensembl Show fit	fructose-bisphosphatase 2
chr10_+_53778662 Show fit	26.21	ENSRNOT00000045718	Myh2 NCBI RGD Ensembl Show fit	myosin heavy chain 2
chr2_-_188596222 Show fit	24.27	ENSRNOT00000027920	Efna1 NCBI RGD Ensembl Show fit	ephrin A1
chr2_-_233743866 Show fit	23.00	ENSRNOT00000087062	Enpep NCBI RGD Ensembl Show fit	glutamyl aminopeptidase
chr7_+_38819771 Show fit	22.37	ENSRNOT00000006109	Lum NCBI RGD Ensembl Show fit	lumican

Showing 1 to 10 of 146 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Nfix

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
6.1	79.9	GO:0001778	plasma membrane repair(GO:0001778)
1.2	56.3	GO:0030199	collagen fibril organization(GO:0030199)
6.3	37.9	GO:0044004	killing by symbiont of host cells(GO:0001907) disruption by symbiont of host cell(GO:0044004) response to platinum ion(GO:0070541)
11.2	33.7	GO:0006480	N-terminal protein amino acid methylation(GO:0006480)
9.4	28.1	GO:0034445	regulation of plasma lipoprotein particle oxidation(GO:0034444) negative regulation of plasma lipoprotein particle oxidation(GO:0034445) multicellular organism lipid catabolic process(GO:0044240)
6.9	27.8	GO:0014809	regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
6.6	26.4	GO:0046351	disaccharide biosynthetic process(GO:0046351)
6.1	24.3	GO:0014028	notochord formation(GO:0014028)
4.5	22.5	GO:0002003	angiotensin maturation(GO:0002003)
4.5	22.4	GO:0032914	positive regulation of transforming growth factor beta1 production(GO:0032914)

Showing 1 to 10 of 71 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
8.9	79.9	GO:0005826	actomyosin contractile ring(GO:0005826)
0.1	52.8	GO:0031012	extracellular matrix(GO:0031012)
0.3	38.9	GO:0005604	basement membrane(GO:0005604)
0.5	35.5	GO:0045095	keratin filament(GO:0045095)
2.6	31.8	GO:0005583	fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
2.2	28.1	GO:0042627	chylomicron(GO:0042627)
0.2	26.4	GO:0030018	Z disc(GO:0030018)
0.1	23.8	GO:0016607	nuclear speck(GO:0016607)
1.8	23.0	GO:0031983	vesicle lumen(GO:0031983)
2.0	20.0	GO:0097550	transcriptional preinitiation complex(GO:0097550)

Showing 1 to 10 of 39 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	73.0	GO:0003779	actin binding(GO:0003779)
2.0	37.9	GO:0015643	toxic substance binding(GO:0015643)
1.5	34.2	GO:0070006	metalloaminopeptidase activity(GO:0070006)
11.2	33.7	GO:0071885	N-terminal protein N-methyltransferase activity(GO:0071885)
4.0	28.1	GO:0060228	phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
1.5	26.4	GO:0050308	sugar-phosphatase activity(GO:0050308)
0.6	24.3	GO:0046875	ephrin receptor binding(GO:0046875)
0.7	22.7	GO:0015020	glucuronosyltransferase activity(GO:0015020)
0.3	22.2	GO:0005518	collagen binding(GO:0005518)
4.0	20.0	GO:0031798	type 1 metabotropic glutamate receptor binding(GO:0031798)

Showing 1 to 10 of 49 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.7	85.7	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.3	71.5	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.7	38.2	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.8	24.3	PID EPHA2 FWD PATHWAY	EPHA2 forward signaling
0.5	23.2	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.5	20.0	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.0	11.1	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.3	10.8	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.2	10.1	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.2	9.4	PID SYNDECAN 1 PATHWAY	Syndecan-1-mediated signaling events

Showing 1 to 10 of 20 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.8	37.9	REACTOME TRANSPORT OF ORGANIC ANIONS	Genes involved in Transport of organic anions
0.9	34.4	REACTOME GLUCONEOGENESIS	Genes involved in Gluconeogenesis
1.6	22.4	REACTOME KERATAN SULFATE DEGRADATION	Genes involved in Keratan sulfate degradation
0.4	22.0	REACTOME NUCLEAR SIGNALING BY ERBB4	Genes involved in Nuclear signaling by ERBB4
1.0	18.7	REACTOME GLUCURONIDATION	Genes involved in Glucuronidation
0.1	11.7	REACTOME SIGNALING BY PDGF	Genes involved in Signaling by PDGF
0.4	10.1	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.2	9.4	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.2	9.3	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.3	7.0	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling

Showing 1 to 10 of 21 entries

Results for Nfix

Z-value: 0.80

Motif logo

Transcription factors associated with Nfix

Activity-expression correlation:

Activity profile of Nfix motif

Sorted Z-values of Nfix motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Nfix

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: