ISMARA results: Meis2

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Meis2

Z-value: 1.12

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Transcription factors associated with Meis2

Gene Symbol	Gene ID	Gene Info
Meis2 NCBI RGD Ensembl	ENSRNOG00000004730	Meis homeobox 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Meis2	rn6_v1_chr3_-_107760550_107760589	-0.28	4.6e-07	Click!

Activity profile of Meis2 motif

Sorted Z-values of Meis2 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr7_-_118108864 Show fit	32.96	ENSRNOT00000006184	Mb NCBI RGD Ensembl Show fit	myoglobin
chr9_-_73958480 Show fit	24.20	ENSRNOT00000017838	Myl1 NCBI RGD Ensembl Show fit	myosin, light chain 1
chr13_-_47397890 Show fit	21.48	ENSRNOT00000005505	C4bpb NCBI RGD Ensembl Show fit	complement component 4 binding protein, beta
chr9_+_14529218 Show fit	21.34	ENSRNOT00000016893	Apobec2 NCBI RGD Ensembl Show fit	apolipoprotein B mRNA editing enzyme catalytic subunit 2
chrX_-_23187341 Show fit	19.38	ENSRNOT00000000180	Alas2 NCBI RGD Ensembl Show fit	5'-aminolevulinate synthase 2
chr10_-_15590220 Show fit	18.22	ENSRNOT00000048977	Hba-a2 NCBI RGD Ensembl Show fit	hemoglobin alpha, adult chain 2
chr3_-_176666282 Show fit	17.64	ENSRNOT00000016947	Eef1a2 NCBI RGD Ensembl Show fit	eukaryotic translation elongation factor 1 alpha 2
chr4_-_99125111 Show fit	17.20	ENSRNOT00000009184	Smyd1 NCBI RGD Ensembl Show fit	SET and MYND domain containing 1
chr1_-_168972725 Show fit	16.25	ENSRNOT00000090422	Hbb NCBI RGD Ensembl Show fit	hemoglobin subunit beta
chr2_-_105089659 Show fit	15.59	ENSRNOT00000043381	Cpb1 NCBI RGD Ensembl Show fit	carboxypeptidase B1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Meis2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	199.5	GO:0007608	sensory perception of smell(GO:0007608)
0.6	43.5	GO:0032094	response to food(GO:0032094)
11.0	33.0	GO:0031444	slow-twitch skeletal muscle fiber contraction(GO:0031444)
8.0	31.9	GO:1901423	response to benzene(GO:1901423)
2.0	26.3	GO:0015671	oxygen transport(GO:0015671)
7.2	21.5	GO:0045959	negative regulation of complement activation, classical pathway(GO:0045959)
5.3	21.3	GO:0016554	cytidine to uridine editing(GO:0016554)
2.1	21.3	GO:0071688	striated muscle myosin thick filament assembly(GO:0071688)
0.2	20.2	GO:0042157	lipoprotein metabolic process(GO:0042157)
2.9	17.2	GO:0035795	negative regulation of mitochondrial membrane permeability(GO:0035795)

Showing 1 to 10 of 239 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	51.3	GO:0005743	mitochondrial inner membrane(GO:0005743)
0.0	47.1	GO:0005615	extracellular space(GO:0005615)
10.6	42.6	GO:0031838	haptoglobin-hemoglobin complex(GO:0031838)
1.9	27.8	GO:0032982	myosin filament(GO:0032982)
0.0	24.7	GO:0005739	mitochondrion(GO:0005739)
0.7	23.1	GO:0033017	sarcoplasmic reticulum membrane(GO:0033017)
1.0	21.5	GO:0044217	other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)
0.0	18.1	GO:0005874	microtubule(GO:0005874)
5.9	17.6	GO:0005853	eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0	17.6	GO:0005789	endoplasmic reticulum membrane(GO:0005789)

Showing 1 to 10 of 107 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	115.7	GO:0004984	olfactory receptor activity(GO:0004984)
0.2	63.3	GO:0005549	odorant binding(GO:0005549)
0.2	51.8	GO:0008236	serine-type peptidase activity(GO:0008236)
14.2	42.6	GO:0031720	haptoglobin binding(GO:0031720)
2.1	34.1	GO:0051371	muscle alpha-actinin binding(GO:0051371)
2.7	33.0	GO:0005344	oxygen transporter activity(GO:0005344)
1.1	29.5	GO:0004181	metallocarboxypeptidase activity(GO:0004181)
0.1	24.8	GO:0003779	actin binding(GO:0003779)
0.8	23.5	GO:0008395	steroid hydroxylase activity(GO:0008395)
0.1	23.4	GO:0030414	peptidase inhibitor activity(GO:0030414)

Showing 1 to 10 of 188 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	21.1	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.3	18.1	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.4	17.7	PID UPA UPAR PATHWAY	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.2	8.5	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta
0.4	8.4	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.4	8.2	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1	7.7	PID AR PATHWAY	Coregulation of Androgen receptor activity
0.1	7.3	PID A6B1 A6B4 INTEGRIN PATHWAY	a6b1 and a6b4 Integrin signaling
0.5	7.2	ST TYPE I INTERFERON PATHWAY	Type I Interferon (alpha/beta IFN) Pathway
0.0	6.9	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Showing 1 to 10 of 40 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.1	81.7	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.5	27.5	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.6	22.8	REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D	Genes involved in Metabolism of steroid hormones and vitamins A and D
1.5	21.5	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
1.1	19.4	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins
0.7	18.8	REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	Genes involved in Degradation of the extracellular matrix
1.3	15.1	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.2	14.4	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors
0.1	13.0	REACTOME G ALPHA I SIGNALLING EVENTS	Genes involved in G alpha (i) signalling events
0.7	12.5	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling

Showing 1 to 10 of 82 entries

Results for Meis2

Z-value: 1.12

Motif logo

Transcription factors associated with Meis2

Activity-expression correlation:

Activity profile of Meis2 motif

Sorted Z-values of Meis2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Meis2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: