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GSE53960: rat RNA-Seq transcriptomic Bodymap
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Results for Mef2c
Z-value: 5.08
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Transcription factors associated with Mef2c
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Mef2c | rn6_v1_chr2_+_11658568_11658568 | 0.60 | 2.0e-32 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr10_+_86337728 Show fit | 584.02 |
ENSRNOT00000085408
|
titin-cap |
|
| chr4_-_41212072 Show fit | 515.82 |
ENSRNOT00000085596
|
protein phosphatase 1, regulatory subunit 3A |
|
| chr1_-_104166367 Show fit | 500.33 |
ENSRNOT00000092211
|
cysteine and glycine rich protein 3 |
|
| chr7_-_118108864 Show fit | 498.21 |
ENSRNOT00000006184
|
myoglobin |
|
| chr8_+_119030875 Show fit | 446.26 |
ENSRNOT00000028458
|
myosin light chain 3 |
|
| chr1_-_199624783 Show fit | 445.63 |
ENSRNOT00000026908
|
cytochrome c oxidase subunit 6A2 |
|
| chr2_-_227207584 Show fit | 436.63 |
ENSRNOT00000065361
ENSRNOT00000080215 |
myozenin 2 |
|
| chr3_+_53563194 Show fit | 423.58 |
ENSRNOT00000048300
|
xin actin-binding repeat containing 2 |
|
| chr10_+_54352270 Show fit | 404.75 |
ENSRNOT00000036752
|
dehydrogenase/reductase 7C |
|
| chr1_-_25839198 Show fit | 404.65 |
ENSRNOT00000090388
ENSRNOT00000092757 ENSRNOT00000042072 |
triadin |
Network of associatons between targets according to the STRING database.
First level regulatory network of Mef2c
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 33.3 | 1367.2 | GO:0003009 | skeletal muscle contraction(GO:0003009) |
| 1.8 | 1363.8 | GO:0016567 | protein ubiquitination(GO:0016567) |
| 271.1 | 1084.4 | GO:0035995 | detection of muscle stretch(GO:0035995) |
| 16.1 | 726.2 | GO:0030239 | myofibril assembly(GO:0030239) |
| 166.1 | 498.2 | GO:0031444 | slow-twitch skeletal muscle fiber contraction(GO:0031444) |
| 27.7 | 470.6 | GO:2001014 | regulation of skeletal muscle cell differentiation(GO:2001014) |
| 17.2 | 446.3 | GO:0002026 | regulation of the force of heart contraction(GO:0002026) |
| 37.1 | 445.6 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 7.6 | 423.6 | GO:0055008 | cardiac muscle tissue morphogenesis(GO:0055008) |
| 21.3 | 404.7 | GO:0010880 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum(GO:0010880) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 25.3 | 3335.1 | GO:0030018 | Z disc(GO:0030018) |
| 32.0 | 1631.1 | GO:0031672 | A band(GO:0031672) |
| 108.8 | 1305.6 | GO:0005861 | troponin complex(GO:0005861) |
| 190.9 | 572.6 | GO:0014701 | junctional sarcoplasmic reticulum membrane(GO:0014701) |
| 143.1 | 572.3 | GO:0033018 | sarcoplasmic reticulum lumen(GO:0033018) |
| 13.4 | 537.9 | GO:0016529 | sarcoplasmic reticulum(GO:0016529) |
| 6.1 | 456.2 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 27.9 | 445.6 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
| 69.4 | 416.1 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 134.9 | 404.7 | GO:0014801 | longitudinal sarcoplasmic reticulum(GO:0014801) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.3 | 1337.6 | GO:0003779 | actin binding(GO:0003779) |
| 2.5 | 1199.1 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 204.1 | 1020.6 | GO:0051373 | FATZ binding(GO:0051373) |
| 124.3 | 870.1 | GO:0031014 | troponin T binding(GO:0031014) |
| 1.3 | 826.2 | GO:0005509 | calcium ion binding(GO:0005509) |
| 45.7 | 730.7 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 4.2 | 680.8 | GO:0044325 | ion channel binding(GO:0044325) |
| 8.6 | 549.1 | GO:0005080 | protein kinase C binding(GO:0005080) |
| 43.2 | 518.3 | GO:0031432 | titin binding(GO:0031432) |
| 125.1 | 500.3 | GO:0031433 | telethonin binding(GO:0031433) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 26.3 | 813.8 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 6.6 | 282.9 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 4.5 | 233.1 | PID BMP PATHWAY | BMP receptor signaling |
| 3.1 | 232.1 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 10.0 | 179.7 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 1.7 | 83.7 | PID INSULIN PATHWAY | Insulin Pathway |
| 0.3 | 69.6 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.8 | 62.1 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.8 | 58.7 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.3 | 45.0 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 60.9 | 2373.5 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 3.2 | 882.5 | REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION | Genes involved in Class I MHC mediated antigen processing & presentation |
| 20.5 | 409.7 | REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 20.9 | 356.0 | REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 15.1 | 241.8 | REACTOME PURINE SALVAGE | Genes involved in Purine salvage |
| 6.2 | 241.1 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 16.7 | 234.2 | REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 6.1 | 219.5 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 22.5 | 179.7 | REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 | Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0) |
| 5.0 | 174.2 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |