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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Mef2c

Z-value: 5.08

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Transcription factors associated with Mef2c

Gene Symbol Gene ID Gene Info
Mef2c
ENSRNOG00000033134 myocyte enhancer factor 2C

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Mef2crn6_v1_chr2_+_11658568_116585680.602.0e-32Click!

Activity profile of Mef2c motif

Sorted Z-values of Mef2c motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr10_+_86337728 584.02 ENSRNOT00000085408
Tcap
titin-cap
chr4_-_41212072 515.82 ENSRNOT00000085596
Ppp1r3a
protein phosphatase 1, regulatory subunit 3A
chr1_-_104166367 500.33 ENSRNOT00000092211
Csrp3
cysteine and glycine rich protein 3
chr7_-_118108864 498.21 ENSRNOT00000006184
Mb
myoglobin
chr8_+_119030875 446.26 ENSRNOT00000028458
Myl3
myosin light chain 3
chr1_-_199624783 445.63 ENSRNOT00000026908
Cox6a2
cytochrome c oxidase subunit 6A2
chr2_-_227207584 436.63 ENSRNOT00000065361
ENSRNOT00000080215
Myoz2
myozenin 2
chr3_+_53563194 423.58 ENSRNOT00000048300
Xirp2
xin actin-binding repeat containing 2
chr10_+_54352270 404.75 ENSRNOT00000036752
Dhrs7c
dehydrogenase/reductase 7C
chr1_-_25839198 404.65 ENSRNOT00000090388
ENSRNOT00000092757
ENSRNOT00000042072
Trdn
triadin
chr15_+_4064706 368.15 ENSRNOT00000011956
Synpo2l
synaptopodin 2-like
chr10_-_56558487 356.01 ENSRNOT00000023256
Slc2a4
solute carrier family 2 member 4
chr9_+_47536824 340.33 ENSRNOT00000049349
Tmem182
transmembrane protein 182
chr9_-_73948583 339.92 ENSRNOT00000018097
Myl1
myosin, light chain 1
chr12_+_49761120 337.44 ENSRNOT00000070961
Myo18b
myosin XVIIIb
chr1_+_221756286 327.11 ENSRNOT00000028636
Pygm
glycogen phosphorylase, muscle associated
chrX_-_31780425 318.84 ENSRNOT00000004693
Asb9
ankyrin repeat and SOCS box-containing 9
chr13_+_52624878 312.10 ENSRNOT00000076054
ENSRNOT00000076299
Tnni1
troponin I1, slow skeletal type
chr1_+_31531143 309.58 ENSRNOT00000034704
Lrrc14b
leucine rich repeat containing 14B
chr3_+_55910177 307.57 ENSRNOT00000009969
Klhl41
kelch-like family member 41
chr1_+_215609036 303.72 ENSRNOT00000076187
Tnni2
troponin I2, fast skeletal type
chr1_+_215666628 302.31 ENSRNOT00000040598
ENSRNOT00000066135
ENSRNOT00000051425
ENSRNOT00000080339
ENSRNOT00000066896
ENSRNOT00000063918
Tnnt3
troponin T3, fast skeletal type
chr2_+_204512302 299.49 ENSRNOT00000021846
Casq2
calsequestrin 2
chr2_-_45518502 288.57 ENSRNOT00000014627
Hspb3
heat shock protein family B (small) member 3
chr1_-_277181345 282.74 ENSRNOT00000038017
ENSRNOT00000038038
Nrap
nebulin-related anchoring protein
chrX_+_159158194 282.54 ENSRNOT00000043820
ENSRNOT00000001169
ENSRNOT00000083502
Fhl1
four and a half LIM domains 1
chr16_-_10941414 278.78 ENSRNOT00000086627
ENSRNOT00000085414
ENSRNOT00000081631
ENSRNOT00000087521
ENSRNOT00000083623
Ldb3
LIM domain binding 3
chr1_-_143398093 276.13 ENSRNOT00000078916
Fsd2
fibronectin type III and SPRY domain containing 2
chr13_-_90602365 272.85 ENSRNOT00000009344
Casq1
calsequestrin 1
chr1_+_215609645 264.02 ENSRNOT00000076140
ENSRNOT00000027487
Tnni2
troponin I2, fast skeletal type
chr2_+_205568935 241.75 ENSRNOT00000025248
Ampd1
adenosine monophosphate deaminase 1
chrX_-_64726210 240.70 ENSRNOT00000076012
ENSRNOT00000086265
Asb12
ankyrin repeat and SOCS box-containing 12
chr10_+_110138586 234.19 ENSRNOT00000086096
Slc16a3
solute carrier family 16 member 3
chr5_+_152533349 234.04 ENSRNOT00000067524
Trim63
tripartite motif containing 63
chr7_-_98197087 233.84 ENSRNOT00000010484
ENSRNOT00000079961
Klhl38
kelch-like family member 38
chr2_+_198655437 233.12 ENSRNOT00000028781
Hfe2
hemochromatosis type 2 (juvenile)
chr10_+_53778662 232.68 ENSRNOT00000045718
Myh2
myosin heavy chain 2
chr4_-_99125111 229.27 ENSRNOT00000009184
Smyd1
SET and MYND domain containing 1
chr9_+_98490608 222.36 ENSRNOT00000027232
Klhl30
kelch-like family member 30
chr8_+_110982777 221.27 ENSRNOT00000010992
Ky
kyphoscoliosis peptidase
chr9_-_97151832 218.38 ENSRNOT00000040169
Asb18
ankyrin repeat and SOCS box-containing 18
chr4_+_144192989 214.86 ENSRNOT00000007523
Lmcd1
LIM and cysteine-rich domains 1
chr5_+_148528725 210.82 ENSRNOT00000017325
Fabp3
fatty acid binding protein 3
chr5_-_22769907 207.36 ENSRNOT00000047805
ENSRNOT00000076167
ENSRNOT00000076507
ENSRNOT00000076113
ENSRNOT00000083779
Asph
aspartate-beta-hydroxylase
chr16_-_64806050 206.25 ENSRNOT00000015725
Dusp26
dual specificity phosphatase 26
chr15_-_27819376 202.56 ENSRNOT00000067400
A930018M24Rik
RIKEN cDNA A930018M24 gene
chr9_-_50762082 186.86 ENSRNOT00000015492
Mettl21c
methyltransferase like 21C
chr7_+_70807867 185.08 ENSRNOT00000010639
Stac3
SH3 and cysteine rich domain 3
chr12_-_23841049 179.73 ENSRNOT00000031555
Hspb1
heat shock protein family B (small) member 1
chr4_+_7158448 176.53 ENSRNOT00000076953
Asb10
ankyrin repeat and SOCS box-containing 10
chr10_-_82785142 174.90 ENSRNOT00000005381
Sgca
sarcoglycan, alpha
chr8_+_130416355 173.33 ENSRNOT00000026234
Klhl40
kelch-like family member 40
chr2_+_119197239 172.10 ENSRNOT00000048030
Usp13
ubiquitin specific peptidase 13
chr10_-_62699723 169.64 ENSRNOT00000086706
Coro6
coronin 6
chr3_+_79940561 169.17 ENSRNOT00000016652
Mybpc3
myosin binding protein C, cardiac
chr5_+_90338795 168.55 ENSRNOT00000077864
ENSRNOT00000058882
LOC298139
similar to RIKEN cDNA 2310003M01
chr6_+_73553210 167.91 ENSRNOT00000006562
Akap6
A-kinase anchoring protein 6
chr1_+_101397828 163.80 ENSRNOT00000028189
Kcna7
potassium voltage-gated channel subfamily A member 7
chr10_-_8654892 163.02 ENSRNOT00000066534
Rbfox1
RNA binding protein, fox-1 homolog 1
chr14_-_17171580 160.14 ENSRNOT00000085525
Art3
ADP-ribosyltransferase 3
chr2_+_219598162 159.52 ENSRNOT00000020297
Lrrc39
leucine rich repeat containing 39
chr4_+_71675383 157.03 ENSRNOT00000051265
Clcn1
chloride voltage-gated channel 1
chr5_+_154598758 154.38 ENSRNOT00000015776
Tcea3
transcription elongation factor A3
chr3_+_112228919 154.03 ENSRNOT00000011761
Capn3
calpain 3
chr17_-_78735324 148.91 ENSRNOT00000036299
Cdnf
cerebral dopamine neurotrophic factor
chr17_-_55346279 139.80 ENSRNOT00000025037
Svil
supervillin
chr8_-_87419564 135.77 ENSRNOT00000015365
Filip1
filamin A interacting protein 1
chr7_-_49741540 134.57 ENSRNOT00000006523
Myf6
myogenic factor 6
chrX_-_157013443 133.18 ENSRNOT00000082711
Srpk3
SRSF protein kinase 3
chr7_+_11383116 131.44 ENSRNOT00000066348
Nmrk2
nicotinamide riboside kinase 2
chr3_+_112228720 130.18 ENSRNOT00000079079
Capn3
calpain 3
chr4_+_14001761 128.01 ENSRNOT00000076519
Cd36
CD36 molecule
chr13_+_52662996 123.41 ENSRNOT00000047682
Tnnt2
troponin T2, cardiac type
chr1_-_198233215 122.11 ENSRNOT00000087928
Aldoa
aldolase, fructose-bisphosphate A
chr13_+_51126459 119.98 ENSRNOT00000042046
ENSRNOT00000087240
Myog
myogenin
chr1_-_198233588 119.01 ENSRNOT00000088473
Aldoa
aldolase, fructose-bisphosphate A
chr9_-_19372673 118.33 ENSRNOT00000073667
ENSRNOT00000079517
Clic5
chloride intracellular channel 5
chr3_+_58965552 117.27 ENSRNOT00000002068
Map3k20
mitogen-activated protein kinase kinase kinase 20
chr14_-_43072843 114.72 ENSRNOT00000064263
Limch1
LIM and calponin homology domains 1
chr10_+_39655455 113.48 ENSRNOT00000058817
Acsl6
acyl-CoA synthetase long-chain family member 6
chr2_-_172361779 111.42 ENSRNOT00000085876
Schip1
schwannomin interacting protein 1
chr1_+_219250265 99.36 ENSRNOT00000024353
Doc2g
double C2-like domains, gamma
chr9_+_82571269 96.20 ENSRNOT00000026941
Speg
SPEG complex locus
chr2_-_261337163 90.68 ENSRNOT00000030341
Tnni3k
TNNI3 interacting kinase
chr19_+_52313795 88.13 ENSRNOT00000021630
Wfdc1
WAP four-disulfide core domain 1
chr15_+_2766710 87.50 ENSRNOT00000017483
Dupd1
dual specificity phosphatase and pro isomerase domain containing 1
chr3_-_51054378 83.73 ENSRNOT00000089243
Grb14
growth factor receptor bound protein 14
chr2_-_104958034 82.56 ENSRNOT00000080699
Gyg1
glycogenin 1
chr20_+_20378861 72.28 ENSRNOT00000091044
Ank3
ankyrin 3
chr16_-_73827488 70.67 ENSRNOT00000064070
Ank1
ankyrin 1
chr2_-_247988462 69.90 ENSRNOT00000022387
Pdlim5
PDZ and LIM domain 5
chr3_+_151126591 67.21 ENSRNOT00000025859
Myh7b
myosin heavy chain 7B
chr8_-_72204730 64.73 ENSRNOT00000023810
Fbxl22
F-box and leucine-rich repeat protein 22
chr3_-_64024205 56.97 ENSRNOT00000037015
Ccdc141
coiled-coil domain containing 141
chr4_+_85551502 56.16 ENSRNOT00000087191
ENSRNOT00000015692
Aqp1
aquaporin 1
chr2_+_242634399 54.71 ENSRNOT00000035700
Emcn
endomucin
chr9_+_111028575 52.48 ENSRNOT00000043451
Pam
peptidylglycine alpha-amidating monooxygenase
chr9_-_9702306 51.80 ENSRNOT00000082341
Trip10
thyroid hormone receptor interactor 10
chr9_+_111028824 50.38 ENSRNOT00000041418
ENSRNOT00000056457
Pam
peptidylglycine alpha-amidating monooxygenase
chr1_-_56683731 50.23 ENSRNOT00000014552
Thbs2
thrombospondin 2
chr3_-_161299024 48.71 ENSRNOT00000021216
Neurl2
neuralized E3 ubiquitin protein ligase 2
chr4_+_148782479 47.56 ENSRNOT00000018133
LOC500300
similar to hypothetical protein MGC6835
chr12_+_17734133 41.28 ENSRNOT00000042117
Pdgfa
platelet derived growth factor subunit A
chrX_+_14498119 40.54 ENSRNOT00000051135
Xk
X-linked Kx blood group
chr13_-_81214494 38.53 ENSRNOT00000004950
ENSRNOT00000082385
Prrx1
paired related homeobox 1
chr20_-_9291610 38.25 ENSRNOT00000000650
Glo1
glyoxalase 1
chr6_-_137733026 37.04 ENSRNOT00000019213
Jag2
jagged 2
chr20_+_20236151 31.21 ENSRNOT00000079630
Ank3
ankyrin 3
chr10_-_86688730 30.94 ENSRNOT00000055333
Nr1d1
nuclear receptor subfamily 1, group D, member 1
chr3_+_60026747 29.18 ENSRNOT00000081881
Scrn3
secernin 3
chr5_-_160219812 26.86 ENSRNOT00000016333
Plekhm2
pleckstrin homology and RUN domain containing M2
chr4_+_89079014 23.78 ENSRNOT00000087451
Herc3
HECT and RLD domain containing E3 ubiquitin protein ligase 3
chr17_+_36334147 22.99 ENSRNOT00000050261
E2f3
E2F transcription factor 3
chr14_+_63095720 22.11 ENSRNOT00000006071
Ppargc1a
PPARG coactivator 1 alpha
chr10_-_76039964 19.04 ENSRNOT00000003164
Msi2
musashi RNA-binding protein 2
chr6_+_64252020 18.54 ENSRNOT00000047296
ENSRNOT00000082105
Pnpla8
patatin-like phospholipase domain containing 8
chr4_+_159563798 18.18 ENSRNOT00000081426
Fgf6
fibroblast growth factor 6
chr7_+_132857628 17.64 ENSRNOT00000005438
Lrrk2
leucine-rich repeat kinase 2
chr18_-_58423196 11.28 ENSRNOT00000025556
Piezo2
piezo-type mechanosensitive ion channel component 2
chr6_-_136550371 10.64 ENSRNOT00000065971
Rd3l
retinal degeneration 3-like
chr4_-_85329362 9.94 ENSRNOT00000014925
Crhr2
corticotropin releasing hormone receptor 2
chr5_-_139748489 9.79 ENSRNOT00000078741
Nfyc
nuclear transcription factor Y subunit gamma
chr17_+_39510936 9.16 ENSRNOT00000087330
Prl8a7
prolactin family 8, subfamily a, member 7
chr11_-_74315248 8.52 ENSRNOT00000002346
Hes1
hes family bHLH transcription factor 1
chr19_-_11669578 7.68 ENSRNOT00000026373
Gnao1
G protein subunit alpha o1
chr2_-_187854363 6.42 ENSRNOT00000092993
Lmna
lamin A/C
chr1_-_221370322 4.43 ENSRNOT00000028431
Capn1
calpain 1
chr3_+_75412372 2.79 ENSRNOT00000057483
Olr560
olfactory receptor 560
chr11_+_86520992 2.69 ENSRNOT00000040954
Gp1bb
glycoprotein Ib platelet beta subunit

Network of associatons between targets according to the STRING database.

First level regulatory network of Mef2c

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
271.1 1084.4 GO:0035995 detection of muscle stretch(GO:0035995)
166.1 498.2 GO:0031444 slow-twitch skeletal muscle fiber contraction(GO:0031444)
134.9 404.6 GO:0090158 endoplasmic reticulum membrane organization(GO:0090158)
94.7 284.2 GO:1990091 sodium-dependent self proteolysis(GO:1990091)
75.2 376.1 GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878)
70.3 210.8 GO:2001245 regulation of phosphatidylcholine biosynthetic process(GO:2001245)
68.8 206.3 GO:1902310 positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
68.2 272.9 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
59.9 179.7 GO:1903544 cellular response to interleukin-11(GO:0071348) response to butyrate(GO:1903544)
49.9 299.5 GO:0071313 cellular response to caffeine(GO:0071313)
43.0 172.1 GO:1904378 protein K29-linked deubiquitination(GO:0035523) maintenance of unfolded protein(GO:0036506) protein K6-linked deubiquitination(GO:0044313) maintenance of unfolded protein involved in ERAD pathway(GO:1904378)
42.0 167.9 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
41.5 207.4 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
41.1 123.4 GO:0032972 regulation of muscle filament sliding speed(GO:0032972)
40.3 241.8 GO:0032264 IMP salvage(GO:0032264)
37.8 113.5 GO:0010747 positive regulation of plasma membrane long-chain fatty acid transport(GO:0010747)
37.1 445.6 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
34.7 173.3 GO:0098528 skeletal muscle fiber differentiation(GO:0098528)
33.3 1367.2 GO:0003009 skeletal muscle contraction(GO:0003009)
30.7 337.4 GO:0048739 cardiac muscle fiber development(GO:0048739)
27.7 470.6 GO:2001014 regulation of skeletal muscle cell differentiation(GO:2001014)
26.8 401.8 GO:0031034 myosin filament assembly(GO:0031034)
26.0 234.2 GO:0035879 plasma membrane lactate transport(GO:0035879)
25.9 103.5 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
25.7 102.9 GO:0031179 peptide modification(GO:0031179)
25.6 128.0 GO:0072564 blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
22.4 134.6 GO:0048743 positive regulation of skeletal muscle fiber development(GO:0048743)
21.3 404.7 GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum(GO:0010880)
18.7 56.2 GO:0072237 metanephric proximal tubule development(GO:0072237)
18.2 327.1 GO:0044247 glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
17.9 214.9 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
17.2 241.1 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
17.2 446.3 GO:0002026 regulation of the force of heart contraction(GO:0002026)
16.7 83.7 GO:0060283 negative regulation of oocyte development(GO:0060283) negative regulation of oocyte maturation(GO:1900194)
16.1 726.2 GO:0030239 myofibril assembly(GO:0030239)
15.9 174.9 GO:0014894 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
14.8 237.5 GO:0016540 protein autoprocessing(GO:0016540)
13.8 41.3 GO:1990401 regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling(GO:0060683) embryonic lung development(GO:1990401)
13.2 356.0 GO:0044381 glucose import in response to insulin stimulus(GO:0044381)
13.1 157.0 GO:0098870 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
11.5 229.3 GO:0045663 positive regulation of myoblast differentiation(GO:0045663)
10.3 30.9 GO:0060086 circadian temperature homeostasis(GO:0060086)
9.1 45.6 GO:0060120 auditory receptor cell fate commitment(GO:0009912) inner ear receptor cell fate commitment(GO:0060120)
9.1 118.3 GO:0002024 diet induced thermogenesis(GO:0002024)
7.6 423.6 GO:0055008 cardiac muscle tissue morphogenesis(GO:0055008)
6.8 40.5 GO:0010961 cellular magnesium ion homeostasis(GO:0010961)
6.5 90.7 GO:1903779 regulation of cardiac conduction(GO:1903779)
6.4 160.1 GO:0006471 protein ADP-ribosylation(GO:0006471)
6.4 300.2 GO:0003254 regulation of membrane depolarization(GO:0003254)
6.0 131.4 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
5.6 111.4 GO:0008210 estrogen metabolic process(GO:0008210)
5.5 38.5 GO:0048664 neuron fate determination(GO:0048664)
5.2 344.0 GO:0032233 positive regulation of actin filament bundle assembly(GO:0032233)
5.1 121.7 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
4.7 102.6 GO:0055013 cardiac muscle cell development(GO:0055013)
4.6 18.5 GO:0046338 phosphatidylethanolamine catabolic process(GO:0046338)
4.5 26.9 GO:1903527 positive regulation of membrane tubulation(GO:1903527)
4.4 287.3 GO:0060048 cardiac muscle contraction(GO:0060048)
4.4 219.9 GO:0007528 neuromuscular junction development(GO:0007528)
4.1 148.9 GO:0071542 dopaminergic neuron differentiation(GO:0071542)
3.8 38.2 GO:0009438 methylglyoxal metabolic process(GO:0009438)
3.3 117.3 GO:0007257 activation of JUN kinase activity(GO:0007257)
3.2 283.3 GO:0031032 actomyosin structure organization(GO:0031032)
2.8 133.2 GO:0000245 spliceosomal complex assembly(GO:0000245)
2.5 9.9 GO:2000293 gastric motility(GO:0035482) regulation of defecation(GO:2000292) negative regulation of defecation(GO:2000293)
2.4 154.4 GO:0006414 translational elongation(GO:0006414)
2.4 70.7 GO:0072661 protein targeting to plasma membrane(GO:0072661)
2.0 17.7 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
1.9 57.0 GO:0051642 centrosome localization(GO:0051642)
1.8 1363.8 GO:0016567 protein ubiquitination(GO:0016567)
1.8 99.4 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
1.4 186.9 GO:0018022 peptidyl-lysine methylation(GO:0018022)
1.3 64.2 GO:0061045 negative regulation of wound healing(GO:0061045)
1.1 18.2 GO:0001502 cartilage condensation(GO:0001502)
0.8 26.4 GO:0005978 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.8 87.5 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.7 50.2 GO:0016525 negative regulation of angiogenesis(GO:0016525)
0.4 124.4 GO:0051260 protein homooligomerization(GO:0051260)
0.3 11.3 GO:0050974 detection of mechanical stimulus involved in sensory perception(GO:0050974)
0.2 7.7 GO:0051926 negative regulation of calcium ion transport(GO:0051926)
0.1 89.1 GO:0007010 cytoskeleton organization(GO:0007010)
0.1 18.6 GO:0006887 exocytosis(GO:0006887)
0.0 2.7 GO:0007596 blood coagulation(GO:0007596)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
190.9 572.6 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
143.1 572.3 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
134.9 404.7 GO:0014801 longitudinal sarcoplasmic reticulum(GO:0014801)
108.8 1305.6 GO:0005861 troponin complex(GO:0005861)
69.4 416.1 GO:0097512 cardiac myofibril(GO:0097512)
66.3 331.5 GO:0005927 muscle tendon junction(GO:0005927)
38.9 233.1 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
35.6 356.0 GO:0032593 insulin-responsive compartment(GO:0032593)
35.1 316.1 GO:0016461 unconventional myosin complex(GO:0016461)
32.0 1631.1 GO:0031672 A band(GO:0031672)
29.1 174.9 GO:0016012 sarcoglycan complex(GO:0016012)
27.9 445.6 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
25.3 3335.1 GO:0030018 Z disc(GO:0030018)
18.9 207.4 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
14.0 56.2 GO:0020005 symbiont-containing vacuole membrane(GO:0020005)
13.4 537.9 GO:0016529 sarcoplasmic reticulum(GO:0016529)
7.9 339.9 GO:0016459 myosin complex(GO:0016459)
6.4 139.8 GO:0043034 costamere(GO:0043034)
6.1 456.2 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
4.8 275.4 GO:0034707 chloride channel complex(GO:0034707)
4.4 17.6 GO:0097487 multivesicular body, internal vesicle(GO:0097487)
2.2 50.2 GO:0031091 platelet alpha granule(GO:0031091)
1.9 51.8 GO:0001891 phagocytic cup(GO:0001891)
1.5 163.8 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
1.4 128.0 GO:0031526 brush border membrane(GO:0031526)
1.4 9.8 GO:0016602 CCAAT-binding factor complex(GO:0016602)
1.3 255.3 GO:0005802 trans-Golgi network(GO:0005802)
0.8 22.1 GO:0097440 apical dendrite(GO:0097440)
0.8 6.4 GO:0005638 lamin filament(GO:0005638)
0.8 305.4 GO:0015629 actin cytoskeleton(GO:0015629)
0.7 113.5 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.7 9.9 GO:0070852 cell body fiber(GO:0070852)
0.6 145.5 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.5 179.3 GO:0005924 cell-substrate adherens junction(GO:0005924) focal adhesion(GO:0005925)
0.5 38.4 GO:0005902 microvillus(GO:0005902)
0.5 99.4 GO:0070382 exocytic vesicle(GO:0070382)
0.5 110.6 GO:0010008 endosome membrane(GO:0010008)
0.4 19.0 GO:0005844 polysome(GO:0005844)
0.4 214.9 GO:0031012 extracellular matrix(GO:0031012)
0.4 129.0 GO:0016607 nuclear speck(GO:0016607)
0.3 18.2 GO:0042383 sarcolemma(GO:0042383)
0.2 7.7 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 30.9 GO:0016604 nuclear body(GO:0016604)
0.1 67.5 GO:0005794 Golgi apparatus(GO:0005794)
0.1 70.2 GO:0005856 cytoskeleton(GO:0005856)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
204.1 1020.6 GO:0051373 FATZ binding(GO:0051373)
125.1 500.3 GO:0031433 telethonin binding(GO:0031433)
124.3 870.1 GO:0031014 troponin T binding(GO:0031014)
109.0 327.1 GO:0008184 glycogen phosphorylase activity(GO:0008184)
68.8 206.3 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
61.7 123.4 GO:0030172 troponin C binding(GO:0030172)
60.4 241.8 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
56.5 338.8 GO:0070538 oleic acid binding(GO:0070538)
45.7 730.7 GO:0051371 muscle alpha-actinin binding(GO:0051371)
45.3 90.7 GO:0031013 troponin I binding(GO:0031013)
43.2 518.3 GO:0031432 titin binding(GO:0031432)
43.0 172.1 GO:1904288 BAT3 complex binding(GO:1904288)
39.6 356.0 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
38.9 233.1 GO:0098821 BMP receptor activity(GO:0098821)
34.4 241.1 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
33.2 498.2 GO:0005344 oxygen transporter activity(GO:0005344)
29.3 234.2 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
25.7 102.9 GO:0016842 amidine-lyase activity(GO:0016842)
20.0 160.1 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
18.7 167.9 GO:0043495 protein anchor(GO:0043495)
14.9 446.3 GO:0003785 actin monomer binding(GO:0003785)
14.9 445.6 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
14.6 423.6 GO:0051393 alpha-actinin binding(GO:0051393)
14.3 314.0 GO:0004745 retinol dehydrogenase activity(GO:0004745)
14.1 70.7 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
11.8 82.6 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
11.2 56.2 GO:0015166 polyol transmembrane transporter activity(GO:0015166) glycerol transmembrane transporter activity(GO:0015168)
9.5 113.5 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
8.6 549.1 GO:0005080 protein kinase C binding(GO:0005080)
8.3 157.0 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
7.0 154.4 GO:0003746 translation elongation factor activity(GO:0003746)
5.9 17.6 GO:0034211 GTP-dependent protein kinase activity(GO:0034211)
4.5 117.3 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
4.2 680.8 GO:0044325 ion channel binding(GO:0044325)
3.3 1337.6 GO:0003779 actin binding(GO:0003779)
3.2 38.2 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
3.2 337.4 GO:0003774 motor activity(GO:0003774)
3.1 83.7 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
2.9 168.6 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
2.9 186.9 GO:0016279 lysine N-methyltransferase activity(GO:0016278) protein-lysine N-methyltransferase activity(GO:0016279)
2.7 38.4 GO:0048407 platelet-derived growth factor binding(GO:0048407)
2.7 441.7 GO:0003714 transcription corepressor activity(GO:0003714)
2.6 128.5 GO:0070888 E-box binding(GO:0070888)
2.5 9.9 GO:0015056 corticotrophin-releasing factor receptor activity(GO:0015056) corticotropin-releasing hormone receptor activity(GO:0043404)
2.5 1199.1 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
2.3 18.5 GO:0047499 calcium-independent phospholipase A2 activity(GO:0047499)
2.2 29.2 GO:0016805 dipeptidase activity(GO:0016805)
2.1 30.9 GO:0001222 transcription corepressor binding(GO:0001222)
1.7 87.5 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
1.5 99.4 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
1.4 11.3 GO:0008381 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
1.4 109.0 GO:0005254 chloride channel activity(GO:0005254)
1.3 826.2 GO:0005509 calcium ion binding(GO:0005509)
1.3 7.7 GO:0031852 mu-type opioid receptor binding(GO:0031852) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
1.2 22.1 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922) alpha-tubulin binding(GO:0043014)
1.1 167.1 GO:0008083 growth factor activity(GO:0008083)
0.4 6.4 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.2 117.4 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.2 77.8 GO:0016773 phosphotransferase activity, alcohol group as acceptor(GO:0016773)
0.2 40.4 GO:0008022 protein C-terminus binding(GO:0008022)
0.1 2.3 GO:0071837 HMG box domain binding(GO:0071837)
0.0 5.0 GO:0005179 hormone activity(GO:0005179)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
26.3 813.8 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
10.0 179.7 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
6.6 282.9 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
4.5 233.1 PID BMP PATHWAY BMP receptor signaling
3.1 232.1 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
1.8 30.9 PID CIRCADIAN PATHWAY Circadian rhythm pathway
1.7 83.7 PID INSULIN PATHWAY Insulin Pathway
0.8 22.1 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.8 62.1 PID CMYB PATHWAY C-MYB transcription factor network
0.8 58.7 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.8 41.3 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.7 37.0 PID NOTCH PATHWAY Notch signaling pathway
0.6 7.7 PID S1P S1P4 PATHWAY S1P4 pathway
0.4 18.2 PID FGF PATHWAY FGF signaling pathway
0.3 17.7 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.3 69.6 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.3 45.0 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2 9.8 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.1 6.4 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.1 4.4 PID PTP1B PATHWAY Signaling events mediated by PTP1B

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
60.9 2373.5 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
22.5 179.7 REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
20.9 356.0 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
20.5 409.7 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
16.7 234.2 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
15.1 241.8 REACTOME PURINE SALVAGE Genes involved in Purine salvage
6.3 113.5 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
6.2 241.1 REACTOME GLYCOLYSIS Genes involved in Glycolysis
6.1 219.5 REACTOME MYOGENESIS Genes involved in Myogenesis
5.0 174.2 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
4.7 56.2 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
4.1 37.0 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
4.0 83.7 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
3.3 163.8 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
3.2 882.5 REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION Genes involved in Class I MHC mediated antigen processing & presentation
2.3 121.6 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
2.0 47.4 REACTOME SIGNALING BY PDGF Genes involved in Signaling by PDGF
2.0 53.1 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
1.4 18.2 REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.7 18.5 REACTOME ACYL CHAIN REMODELLING OF PE Genes involved in Acyl chain remodelling of PE
0.6 17.7 REACTOME G1 PHASE Genes involved in G1 Phase
0.3 7.7 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.2 8.5 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
0.2 2.7 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.2 17.3 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 6.4 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)