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GSE53960: rat RNA-Seq transcriptomic Bodymap
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Results for Mecom
Z-value: 0.54
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Transcription factors associated with Mecom
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Mecom | rn6_v1_chr2_-_117454769_117454769 | 0.07 | 2.5e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr5_-_77408323 Show fit | 27.18 |
ENSRNOT00000046857
ENSRNOT00000046760 |
alpha-2u globulin PGCL5 major urinary protein 4 |
|
| chr5_-_77492013 Show fit | 25.97 |
ENSRNOT00000012293
|
alpha-2u globulin PGCL5 |
|
| chr5_-_52767592 Show fit | 24.48 |
ENSRNOT00000048383
|
alpha2u globulin |
|
| chr5_-_77316764 Show fit | 23.38 |
ENSRNOT00000071395
ENSRNOT00000076464 |
major urinary protein 4 |
|
| chr7_-_116201756 Show fit | 13.41 |
ENSRNOT00000091401
|
cytochrome P450, family 11, subfamily b, polypeptide 2 |
|
| chr1_+_42121636 Show fit | 11.11 |
ENSRNOT00000025616
|
myc target 1 |
|
| chr17_+_76008807 Show fit | 9.66 |
ENSRNOT00000070895
|
enoyl CoA hydratase domain containing 3 |
|
| chr17_+_15852548 Show fit | 9.46 |
ENSRNOT00000022203
|
caspase recruitment domain family, member 19 |
|
| chr9_-_76768770 Show fit | 8.23 |
ENSRNOT00000087779
ENSRNOT00000057849 |
IKAROS family zinc finger 2 |
|
| chr16_+_75966352 Show fit | 6.68 |
ENSRNOT00000022774
|
angiopoietin 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Mecom
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 13.4 | GO:0051365 | cellular response to potassium ion starvation(GO:0051365) |
| 1.0 | 9.3 | GO:0043031 | negative regulation of macrophage activation(GO:0043031) |
| 0.0 | 8.5 | GO:0006412 | translation(GO:0006412) |
| 2.2 | 6.7 | GO:0048014 | Tie signaling pathway(GO:0048014) |
| 0.1 | 5.5 | GO:0045638 | negative regulation of myeloid cell differentiation(GO:0045638) |
| 0.3 | 5.4 | GO:0090557 | establishment of endothelial intestinal barrier(GO:0090557) |
| 0.6 | 5.0 | GO:0030948 | negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948) |
| 0.2 | 5.0 | GO:0006376 | mRNA splice site selection(GO:0006376) |
| 0.2 | 4.8 | GO:0033327 | Leydig cell differentiation(GO:0033327) |
| 1.4 | 4.2 | GO:1903943 | regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 54.1 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 14.5 | GO:0031966 | mitochondrial membrane(GO:0031966) |
| 0.0 | 13.1 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.1 | 6.7 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.0 | 5.6 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.5 | 5.4 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
| 0.1 | 5.0 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.1 | 5.0 | GO:0005604 | basement membrane(GO:0005604) |
| 0.1 | 4.8 | GO:0009295 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.0 | 4.4 | GO:0005769 | early endosome(GO:0005769) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 10.1 | 50.6 | GO:0005550 | pheromone binding(GO:0005550) |
| 4.5 | 13.4 | GO:0004507 | steroid 11-beta-monooxygenase activity(GO:0004507) corticosterone 18-monooxygenase activity(GO:0047783) |
| 0.0 | 8.5 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.1 | 6.7 | GO:0030971 | receptor tyrosine kinase binding(GO:0030971) |
| 0.0 | 5.5 | GO:0003712 | transcription cofactor activity(GO:0003712) |
| 0.0 | 5.2 | GO:0004725 | protein tyrosine phosphatase activity(GO:0004725) |
| 1.7 | 5.0 | GO:0001069 | regulatory region RNA binding(GO:0001069) |
| 1.0 | 4.8 | GO:0030283 | testosterone dehydrogenase [NAD(P)] activity(GO:0030283) |
| 0.0 | 4.7 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 1.0 | 4.0 | GO:0018685 | alkane 1-monooxygenase activity(GO:0018685) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.1 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 6.7 | PID ANGIOPOIETIN RECEPTOR PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.2 | 5.4 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 5.0 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 4.1 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.0 | 4.0 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 3.6 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.1 | 3.5 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.1 | 2.8 | PID IGF1 PATHWAY | IGF1 pathway |
| 0.3 | 2.0 | ST PAC1 RECEPTOR PATHWAY | PAC1 Receptor Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 13.4 | REACTOME ENDOGENOUS STEROLS | Genes involved in Endogenous sterols |
| 0.3 | 6.7 | REACTOME TIE2 SIGNALING | Genes involved in Tie2 Signaling |
| 0.3 | 5.4 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.3 | 4.8 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.1 | 3.6 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.1 | 3.5 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.2 | 1.8 | REACTOME ANDROGEN BIOSYNTHESIS | Genes involved in Androgen biosynthesis |
| 0.1 | 1.7 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.1 | 1.4 | REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 | Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1 |
| 0.0 | 1.1 | REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER | Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter |