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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Mecom

Z-value: 0.54

Motif logo

Transcription factors associated with Mecom

Gene Symbol Gene ID Gene Info
ENSRNOG00000012645 MDS1 and EVI1 complex locus

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Mecomrn6_v1_chr2_-_117454769_1174547690.072.5e-01Click!

Activity profile of Mecom motif

Sorted Z-values of Mecom motif

Promoter Log-likelihood Transcript Gene Gene Info
chr5_-_77408323 27.18 ENSRNOT00000046857
ENSRNOT00000046760
alpha-2u globulin PGCL5
major urinary protein 4
chr5_-_77492013 25.97 ENSRNOT00000012293
alpha-2u globulin PGCL5
chr5_-_52767592 24.48 ENSRNOT00000048383
alpha2u globulin
chr5_-_77316764 23.38 ENSRNOT00000071395
ENSRNOT00000076464
major urinary protein 4
chr7_-_116201756 13.41 ENSRNOT00000091401
cytochrome P450, family 11, subfamily b, polypeptide 2
chr1_+_42121636 11.11 ENSRNOT00000025616
myc target 1
chr17_+_76008807 9.66 ENSRNOT00000070895
enoyl CoA hydratase domain containing 3
chr17_+_15852548 9.46 ENSRNOT00000022203
caspase recruitment domain family, member 19
chr9_-_76768770 8.23 ENSRNOT00000087779
ENSRNOT00000057849
IKAROS family zinc finger 2
chr16_+_75966352 6.68 ENSRNOT00000022774
angiopoietin 2
chr11_+_60383431 5.58 ENSRNOT00000093295
Cd200 molecule
chr3_-_107760550 5.48 ENSRNOT00000077091
ENSRNOT00000051638
Meis homeobox 2
chr13_+_89826254 5.43 ENSRNOT00000006141
F11 receptor
chr20_-_27657983 5.31 ENSRNOT00000057313
family with sequence similarity 26, member E
chr2_+_150756185 5.02 ENSRNOT00000088461
ENSRNOT00000036808
muscleblind-like splicing regulator 1
chr16_+_10727571 5.02 ENSRNOT00000084422
multimerin 2
chrX_+_21696772 4.80 ENSRNOT00000043559
hydroxysteroid (17-beta) dehydrogenase 10
chr8_+_14060394 4.46 ENSRNOT00000014827
single-pass membrane protein with coiled-coil domains 4
chr5_+_148051126 4.14 ENSRNOT00000074415
protein tyrosine phosphatase type IVA, member 2
chr10_+_57251253 4.05 ENSRNOT00000043171
60S ribosomal protein L36a
chr5_+_134492756 4.02 ENSRNOT00000012888
ENSRNOT00000057095
ENSRNOT00000051385
cytochrome P450, family 4, subfamily a, polypeptide 1
chr6_+_128050250 3.97 ENSRNOT00000077517
ENSRNOT00000013961
Ab1-233
chr4_-_118578815 3.97 ENSRNOT00000080502
annexin A4
chr7_+_97559841 3.95 ENSRNOT00000007326
zinc fingers and homeoboxes 2
chr8_-_109560747 3.84 ENSRNOT00000087334
protein phosphatase 2, regulatory subunit B'', alpha
chr9_-_20154077 3.77 ENSRNOT00000082904
adhesion G protein-coupled receptor F5
chr5_+_57239086 3.70 ENSRNOT00000060714
serine peptidase inhibitor, Kazal type 4
chr1_-_14412807 3.60 ENSRNOT00000074583
TNF alpha induced protein 3
chr11_+_44877859 3.54 ENSRNOT00000060838
collagen type VIII alpha 1 chain
chr19_-_38344845 3.43 ENSRNOT00000072666

chr5_-_12172009 3.39 ENSRNOT00000061903
protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1
chr4_-_82202096 3.26 ENSRNOT00000081824
homeobox protein Hox-A10-like
chr8_+_71514281 2.92 ENSRNOT00000022256
NS5A (hepatitis C virus) transactivated protein 9
chr9_-_121972055 2.80 ENSRNOT00000089735
clusterin-like protein 1
chr1_+_128924966 2.80 ENSRNOT00000019267
insulin-like growth factor 1 receptor
chr1_+_93242050 2.66 ENSRNOT00000013741
similar to 60S ribosomal protein L27a
chr1_-_227506822 2.62 ENSRNOT00000091506
membrane spanning 4-domains A7
chr7_+_12471824 2.50 ENSRNOT00000068197
strawberry notch homolog 2
chr20_+_3242470 2.46 ENSRNOT00000078110
ENSRNOT00000041502
RT1 class I, locus T24, gene 2
RT1 class I, locus T24, gene 1
chr17_+_25082056 2.27 ENSRNOT00000037041

chr5_+_116973159 2.27 ENSRNOT00000046475
uncharacterized LOC100912024
chr4_+_1658278 2.19 ENSRNOT00000073845
olfactory receptor 1250
chr1_+_264507985 2.19 ENSRNOT00000085811
paired box 2
chr5_+_69851171 2.15 ENSRNOT00000047780

chr13_+_98615287 1.98 ENSRNOT00000004032
inositol-trisphosphate 3-kinase B
chr3_+_158847203 1.92 ENSRNOT00000071502
olfactory receptor 8B8-like
chr5_+_50381244 1.81 ENSRNOT00000012385
glycoprotein hormones, alpha polypeptide
chr8_+_113603533 1.76 ENSRNOT00000017280
mitochondrial ribosomal protein L3
chr14_+_63095720 1.69 ENSRNOT00000006071
PPARG coactivator 1 alpha
chr5_+_173148884 1.51 ENSRNOT00000041753
hCG1994130-like
chr1_+_79727597 1.50 ENSRNOT00000034790

chr9_+_51302151 1.49 ENSRNOT00000085908
GULP, engulfment adaptor PTB domain containing 1
chr15_-_55209342 1.44 ENSRNOT00000021752
RB transcriptional corepressor 1
chr17_+_39411721 1.17 ENSRNOT00000080680
ENSRNOT00000022705
ENSRNOT00000022659
prolactin family 8, subfamily a, member 4
chr11_-_82366505 1.10 ENSRNOT00000041326
similar to ribosomal protein L27a
chr9_-_61033553 1.09 ENSRNOT00000002864
ENSRNOT00000082681
general transcription factor IIIC subunit 3
chr1_-_20155960 1.08 ENSRNOT00000061389
sterile alpha motif domain containing 3
chr17_+_39455908 1.06 ENSRNOT00000068163
prolactin family 8, subfamily a, member 3
chr4_+_6282278 1.05 ENSRNOT00000010349
lysine methyltransferase 2C
chr7_-_50034932 1.04 ENSRNOT00000081885
protein tyrosine phosphatase, receptor type, Q
chr5_+_154265097 1.04 ENSRNOT00000012342
cannabinoid receptor 2
chr13_-_35048444 1.02 ENSRNOT00000009963
GLI family zinc finger 2
chr3_-_44177689 1.00 ENSRNOT00000006387
cytohesin 1 interacting protein
chr10_+_106800142 0.99 ENSRNOT00000074899
hypothetical protein LOC688282
chr8_+_43763859 0.93 ENSRNOT00000080504
olfactory receptor 1328
chr7_+_58419197 0.88 ENSRNOT00000085829
zinc finger, C3H1-type containing
chr1_-_274107138 0.85 ENSRNOT00000078670
survival motor neuron domain containing 1
chr8_-_32609212 0.80 ENSRNOT00000011329
transmembrane protein 45b
chr6_-_36876805 0.79 ENSRNOT00000006482
mesogenin 1
chr10_+_34519790 0.79 ENSRNOT00000052360
mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
chr3_-_29993715 0.79 ENSRNOT00000085801
zinc finger E-box binding homeobox 2
chr13_+_92504374 0.79 ENSRNOT00000033697
olfactory receptor 1602
chr1_-_94404211 0.72 ENSRNOT00000019463
URI1, prefoldin-like chaperone
chr7_-_117719331 0.66 ENSRNOT00000088696
cysteine and histidine rich 1
chr6_+_8284878 0.65 ENSRNOT00000009581
solute carrier family 3 member 1
chr10_-_87437455 0.47 ENSRNOT00000051080
keratin 39
chr12_-_12330929 0.47 ENSRNOT00000001336
brain protein I3
chrX_-_111191932 0.45 ENSRNOT00000088050
ENSRNOT00000083613
MORC family CW-type zinc finger 4
chr10_-_36452378 0.43 ENSRNOT00000004872
PROP paired-like homeobox 1
chr2_-_196582997 0.42 ENSRNOT00000081672

chr8_+_40345160 0.41 ENSRNOT00000076308
olfactory receptor 1200
chr19_+_38846201 0.37 ENSRNOT00000030768
ENSRNOT00000063977
transport and golgi organization 6 homolog
chr2_-_187786700 0.34 ENSRNOT00000092257
ENSRNOT00000092612
ENSRNOT00000068360
solute carrier family 25, member 44
chr9_-_26932201 0.34 ENSRNOT00000017081
minichromosome maintenance complex component 3
chr2_-_77784522 0.32 ENSRNOT00000030328
similar to RIKEN cDNA 0610040D20
chr1_-_167765552 0.32 ENSRNOT00000024954
Bcl2-like 1, pseudogene 1
chr4_-_131694755 0.31 ENSRNOT00000013271
forkhead box P1
chr10_+_52334240 0.30 ENSRNOT00000005518
zinc finger protein 18
chr3_+_147952879 0.24 ENSRNOT00000031922
defensin beta 20
chr7_+_13673934 0.24 ENSRNOT00000048564
olfactory receptor 1085
chr1_-_217677997 0.22 ENSRNOT00000092824
PTPRF interacting protein alpha 1
chr15_+_34520142 0.18 ENSRNOT00000074659
NYN domain and retroviral integrase containing
chr20_+_1787174 0.13 ENSRNOT00000072824
ENSRNOT00000041883
olfactory receptor 1738
chr3_+_72990358 0.12 ENSRNOT00000091920
olfactory receptor 444
chr3_-_148312420 0.12 ENSRNOT00000047416
ENSRNOT00000081272
Bcl2-like 1
chr18_+_79813759 0.11 ENSRNOT00000021768
zinc finger protein 516
chr1_+_230377079 0.08 ENSRNOT00000042937
olfactory receptor 367
chr3_-_4341771 0.05 ENSRNOT00000034694
similar to ribosomal protein S13
chr4_+_52147641 0.03 ENSRNOT00000009458
hyaluronoglucosaminidase 4
chr20_+_6205903 0.02 ENSRNOT00000092333
ENSRNOT00000092655
potassium channel tetramerization domain containing 20
chr8_+_43722228 0.00 ENSRNOT00000084016
olfactory receptor 1325

Network of associatons between targets according to the STRING database.

First level regulatory network of Mecom

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 13.4 GO:0051365 cellular response to potassium ion starvation(GO:0051365)
2.2 6.7 GO:0048014 Tie signaling pathway(GO:0048014)
1.4 4.2 GO:1903943 regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
1.3 3.8 GO:0090249 cell motility involved in somitogenic axis elongation(GO:0090247) regulation of cell motility involved in somitogenic axis elongation(GO:0090249)
1.2 3.6 GO:0070433 negative regulation of toll-like receptor 3 signaling pathway(GO:0034140) toll-like receptor 5 signaling pathway(GO:0034146) negative regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070425) negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070433) protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
1.0 9.3 GO:0043031 negative regulation of macrophage activation(GO:0043031)
1.0 4.0 GO:0048252 lauric acid metabolic process(GO:0048252)
0.8 2.5 GO:0071348 cellular response to interleukin-11(GO:0071348)
0.7 2.2 GO:0035566 regulation of metanephros size(GO:0035566)
0.7 4.0 GO:2000483 negative regulation of interleukin-8 secretion(GO:2000483)
0.6 1.7 GO:2000182 cellular response to nitrite(GO:0071250) response to nitrite(GO:0080033) response to resveratrol(GO:1904638) regulation of progesterone biosynthetic process(GO:2000182)
0.6 5.0 GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948)
0.4 2.0 GO:0033030 negative regulation of neutrophil apoptotic process(GO:0033030)
0.3 1.0 GO:0021508 floor plate formation(GO:0021508)
0.3 5.4 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.3 0.8 GO:0009227 nucleotide-sugar catabolic process(GO:0009227)
0.2 4.8 GO:0033327 Leydig cell differentiation(GO:0033327)
0.2 5.0 GO:0006376 mRNA splice site selection(GO:0006376)
0.1 0.4 GO:0048850 hypophysis morphogenesis(GO:0048850)
0.1 1.0 GO:0038171 cannabinoid signaling pathway(GO:0038171)
0.1 1.8 GO:0046884 follicle-stimulating hormone secretion(GO:0046884)
0.1 0.3 GO:0061470 T follicular helper cell differentiation(GO:0061470)
0.1 1.1 GO:0061029 eyelid development in camera-type eye(GO:0061029)
0.1 0.2 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.1 4.0 GO:0035019 somatic stem cell population maintenance(GO:0035019)
0.1 3.5 GO:0035987 endodermal cell differentiation(GO:0035987)
0.1 5.5 GO:0045638 negative regulation of myeloid cell differentiation(GO:0045638)
0.1 0.8 GO:0007379 segment specification(GO:0007379)
0.1 1.0 GO:0050910 detection of mechanical stimulus involved in sensory perception of sound(GO:0050910)
0.1 1.1 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.1 2.5 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.0 0.1 GO:1905218 cellular response to astaxanthin(GO:1905218)
0.0 4.1 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 0.2 GO:0015074 DNA integration(GO:0015074)
0.0 1.5 GO:0006911 phagocytosis, engulfment(GO:0006911)
0.0 2.7 GO:0008213 protein methylation(GO:0006479) protein alkylation(GO:0008213)
0.0 0.2 GO:0090005 negative regulation of establishment of protein localization to plasma membrane(GO:0090005)
0.0 8.5 GO:0006412 translation(GO:0006412)
0.0 0.3 GO:0006270 DNA replication initiation(GO:0006270)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.8 GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.5 5.4 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.2 1.4 GO:0035189 Rb-E2F complex(GO:0035189)
0.2 1.1 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.1 3.8 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 5.0 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 4.8 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 1.1 GO:0044666 MLL3/4 complex(GO:0044666)
0.1 1.0 GO:0097542 ciliary tip(GO:0097542)
0.1 6.7 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 2.2 GO:0034451 centriolar satellite(GO:0034451)
0.1 1.7 GO:0005719 nuclear euchromatin(GO:0005719)
0.1 5.0 GO:0005604 basement membrane(GO:0005604)
0.0 5.6 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 3.5 GO:0005581 collagen trimer(GO:0005581)
0.0 0.7 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 54.1 GO:0005615 extracellular space(GO:0005615)
0.0 0.3 GO:0042555 MCM complex(GO:0042555)
0.0 1.8 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 14.5 GO:0031966 mitochondrial membrane(GO:0031966)
0.0 1.0 GO:0032421 stereocilium bundle(GO:0032421)
0.0 4.4 GO:0005769 early endosome(GO:0005769)
0.0 0.8 GO:0015030 Cajal body(GO:0015030)
0.0 3.2 GO:0031965 nuclear membrane(GO:0031965)
0.0 13.1 GO:0005739 mitochondrion(GO:0005739)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
10.1 50.6 GO:0005550 pheromone binding(GO:0005550)
4.5 13.4 GO:0004507 steroid 11-beta-monooxygenase activity(GO:0004507) corticosterone 18-monooxygenase activity(GO:0047783)
1.7 5.0 GO:0001069 regulatory region RNA binding(GO:0001069)
1.0 4.0 GO:0018685 alkane 1-monooxygenase activity(GO:0018685)
1.0 4.8 GO:0030283 testosterone dehydrogenase [NAD(P)] activity(GO:0030283)
0.8 3.4 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.6 3.6 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.3 2.8 GO:0043559 insulin binding(GO:0043559)
0.3 1.4 GO:0061676 importin-alpha family protein binding(GO:0061676)
0.3 1.1 GO:0000995 transcription factor activity, core RNA polymerase III binding(GO:0000995)
0.3 1.0 GO:0004949 cannabinoid receptor activity(GO:0004949)
0.2 2.2 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.2 2.0 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.1 4.0 GO:0051059 NF-kappaB binding(GO:0051059)
0.1 6.7 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.1 2.7 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 2.5 GO:0042605 peptide antigen binding(GO:0042605)
0.0 5.2 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 1.1 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 3.7 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 8.5 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.4 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 3.8 GO:0030674 protein binding, bridging(GO:0030674)
0.0 4.7 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 4.0 GO:0005179 hormone activity(GO:0005179)
0.0 0.1 GO:0051434 BH3 domain binding(GO:0051434)
0.0 5.5 GO:0003712 transcription cofactor activity(GO:0003712)
0.0 0.3 GO:0050681 androgen receptor binding(GO:0050681)
0.0 0.8 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.0 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.2 5.4 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.1 4.1 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.1 2.8 PID IGF1 PATHWAY IGF1 pathway
0.1 3.6 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.1 6.7 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.1 11.1 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.1 3.5 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.1 1.7 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.1 1.0 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.5 PID ARF6 PATHWAY Arf6 signaling events
0.0 1.4 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 4.0 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 5.0 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.8 PID REG GR PATHWAY Glucocorticoid receptor regulatory network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 13.4 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.3 6.7 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.3 5.4 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.3 4.8 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.2 1.8 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.1 3.6 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.1 1.4 REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.1 1.7 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.1 3.5 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 1.1 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter
0.0 0.3 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.0 0.8 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.0 0.7 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane