ISMARA results: Klf12_Klf14

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Klf12_Klf14_Sp4

Z-value: 1.36

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Transcription factors associated with Klf12_Klf14_Sp4

Gene Symbol	Gene ID	Gene Info
Klf12 NCBI RGD Ensembl	ENSRNOG00000009145	Kruppel-like factor 12
Klf14 NCBI RGD Ensembl	ENSRNOG00000027557	Kruppel-like factor 14
Sp4 NCBI RGD Ensembl	ENSRNOG00000005472	Sp4 transcription factor

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Klf12	rn6_v1_chr15_-_84676125_84676125	-0.47	1.2e-18	Click!
Klf14	rn6_v1_chr4_-_58250798_58250798	-0.20	3.9e-04	Click!
Sp4	rn6_v1_chr6_-_146195819_146195819	-0.04	5.1e-01	Click!

Activity profile of Klf12_Klf14_Sp4 motif

Sorted Z-values of Klf12_Klf14_Sp4 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr12_+_12227010 Show fit	60.79	ENSRNOT00000060843 ENSRNOT00000092610	Baiap2l1 NCBI RGD Ensembl Show fit	BAI1-associated protein 2-like 1
chr2_+_77868412 Show fit	49.85	ENSRNOT00000065897 ENSRNOT00000014022	Myo10 NCBI RGD Ensembl Show fit	myosin X
chr1_+_103172987 Show fit	38.62	ENSRNOT00000018688	Tmem86a NCBI RGD Ensembl Show fit	transmembrane protein 86A
chr1_-_80544825 Show fit	37.40	ENSRNOT00000057802 ENSRNOT00000040060 ENSRNOT00000067049 ENSRNOT00000052387 ENSRNOT00000073352	Relb NCBI RGD Ensembl Show fit	RELB proto-oncogene, NF-kB subunit
chr3_-_14538241 Show fit	37.04	ENSRNOT00000025904	Stom NCBI RGD Ensembl Show fit	stomatin
chr20_+_13799102 Show fit	35.53	ENSRNOT00000001669	Gstt1 NCBI RGD Ensembl Show fit	glutathione S-transferase theta 1
chr12_+_2180150 Show fit	31.68	ENSRNOT00000001322	Stxbp2 NCBI RGD Ensembl Show fit	syntaxin binding protein 2
chr1_-_142615673 Show fit	30.80	ENSRNOT00000018021	Iqgap1 NCBI RGD Ensembl Show fit	IQ motif containing GTPase activating protein 1
chr8_+_5967463 Show fit	30.46	ENSRNOT00000086251	Tmem123 NCBI RGD Ensembl Show fit	transmembrane protein 123
chr19_-_37370429 Show fit	29.05	ENSRNOT00000022497	Kctd19 NCBI RGD Ensembl Show fit	potassium channel tetramerization domain containing 19

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Klf12_Klf14_Sp4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.6	69.1	GO:0051764	actin crosslink formation(GO:0051764)
1.0	66.3	GO:0046847	filopodium assembly(GO:0046847)
2.9	49.0	GO:1902894	negative regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902894)
1.2	47.2	GO:0000281	mitotic cytokinesis(GO:0000281)
4.2	46.1	GO:0085020	protein K6-linked ubiquitination(GO:0085020)
3.6	39.9	GO:0044829	positive regulation by host of viral genome replication(GO:0044829)
2.6	39.5	GO:0032688	negative regulation of interferon-beta production(GO:0032688)
1.5	38.7	GO:0044253	positive regulation of multicellular organismal metabolic process(GO:0044253)
6.1	36.5	GO:1900086	positive regulation of peptidyl-tyrosine autophosphorylation(GO:1900086)
1.0	36.5	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)

Showing 1 to 10 of 751 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	102.5	GO:0009897	external side of plasma membrane(GO:0009897)
0.4	96.3	GO:0000790	nuclear chromatin(GO:0000790)
0.3	94.4	GO:0005925	focal adhesion(GO:0005925)
1.0	73.1	GO:0005811	lipid particle(GO:0005811)
0.8	72.9	GO:0005913	cell-cell adherens junction(GO:0005913)
0.6	64.3	GO:0030496	midbody(GO:0030496)
2.8	53.2	GO:0032433	filopodium tip(GO:0032433)
0.4	49.3	GO:0001650	fibrillar center(GO:0001650)
6.1	48.5	GO:0000796	condensin complex(GO:0000796)
5.2	46.7	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)

Showing 1 to 10 of 286 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.2	88.4	GO:0098641	cadherin binding involved in cell-cell adhesion(GO:0098641)
0.5	75.7	GO:0001047	core promoter binding(GO:0001047)
0.4	75.3	GO:0061135	endopeptidase inhibitor activity(GO:0004866) endopeptidase regulator activity(GO:0061135)
0.4	65.3	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.2	63.0	GO:0030695	GTPase regulator activity(GO:0030695)
1.7	56.7	GO:0031492	nucleosomal DNA binding(GO:0031492)
9.3	55.9	GO:0015173	aromatic amino acid transmembrane transporter activity(GO:0015173)
1.1	52.4	GO:0070063	RNA polymerase binding(GO:0070063)
0.2	51.4	GO:0004252	serine-type endopeptidase activity(GO:0004252)
16.6	49.9	GO:0060002	plus-end directed microfilament motor activity(GO:0060002)

Showing 1 to 10 of 445 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.0	77.3	PID BARD1 PATHWAY	BARD1 signaling events
1.3	66.9	PID ILK PATHWAY	Integrin-linked kinase signaling
1.3	59.6	PID AURORA B PATHWAY	Aurora B signaling
0.6	58.4	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
1.2	48.1	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
1.3	47.9	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.9	40.9	PID MET PATHWAY	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.7	39.3	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
1.3	37.6	PID IL3 PATHWAY	IL3-mediated signaling events
0.6	36.7	PID PDGFRB PATHWAY	PDGFR-beta signaling pathway

Showing 1 to 10 of 105 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	95.2	REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production
2.0	79.5	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
2.5	54.2	REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI	Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.4	48.0	REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX	Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
1.5	46.2	REACTOME IL RECEPTOR SHC SIGNALING	Genes involved in Interleukin receptor SHC signaling
1.6	43.5	REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION	Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
2.2	40.1	REACTOME REGULATION OF IFNG SIGNALING	Genes involved in Regulation of IFNG signaling
0.8	38.5	REACTOME NETRIN1 SIGNALING	Genes involved in Netrin-1 signaling
2.0	37.4	REACTOME REGULATION OF KIT SIGNALING	Genes involved in Regulation of KIT signaling
0.6	37.0	REACTOME MRNA SPLICING	Genes involved in mRNA Splicing

Showing 1 to 10 of 142 entries

Results for Klf12_Klf14_Sp4

Z-value: 1.36

Motif logo

Transcription factors associated with Klf12_Klf14_Sp4

Activity-expression correlation:

Activity profile of Klf12_Klf14_Sp4 motif

Sorted Z-values of Klf12_Klf14_Sp4 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Klf12_Klf14_Sp4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: