ISMARA results: Id4

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Id4

Z-value: 2.23

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Transcription factors associated with Id4

Gene Symbol	Gene ID	Gene Info
Id4 NCBI RGD Ensembl	ENSRNOG00000016099	inhibitor of DNA binding 4, HLH protein

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Id4	rn6_v1_chr17_-_16695126_16695126	0.34	4.2e-10	Click!

Activity profile of Id4 motif

Sorted Z-values of Id4 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr7_+_94130852 Show fit	120.00	ENSRNOT00000011485	Mal2 NCBI RGD Ensembl Show fit	mal, T-cell differentiation protein 2
chr1_-_54748763 Show fit	103.80	ENSRNOT00000074549	LOC100911027 NCBI RGD Ensembl Show fit	protein MAL2-like
chr1_-_102106127 Show fit	87.96	ENSRNOT00000028685	Kcnj11 NCBI RGD Ensembl Show fit	potassium voltage-gated channel subfamily J member 11
chr15_+_37806836 Show fit	68.16	ENSRNOT00000076285	Il17d NCBI RGD Ensembl Show fit	interleukin 17D
chr1_-_80331626 Show fit	65.88	ENSRNOT00000022577	AABR07002677.1 NCBI RGD Ensembl Show fit
chr9_-_80166807 Show fit	62.79	ENSRNOT00000079493	Igfbp5 NCBI RGD Ensembl Show fit	insulin-like growth factor binding protein 5
chr14_-_80169431 Show fit	61.51	ENSRNOT00000079769 ENSRNOT00000058315	Ablim2 NCBI RGD Ensembl Show fit	actin binding LIM protein family, member 2
chr5_+_151692108 Show fit	60.58	ENSRNOT00000086144	Fam46b NCBI RGD Ensembl Show fit	family with sequence similarity 46, member B
chr10_+_47281786 Show fit	59.70	ENSRNOT00000089123	Kcnj12 NCBI RGD Ensembl Show fit	potassium voltage-gated channel subfamily J member 12
chr8_-_130429132 Show fit	57.09	ENSRNOT00000026261	Hhatl NCBI RGD Ensembl Show fit	hedgehog acyltransferase-like

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Id4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
25.2	226.4	GO:0001766	membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
3.3	128.9	GO:0035640	exploration behavior(GO:0035640)
9.5	123.0	GO:0032836	glomerular basement membrane development(GO:0032836)
3.0	111.5	GO:0003009	skeletal muscle contraction(GO:0003009)
8.9	107.4	GO:0001778	plasma membrane repair(GO:0001778)
8.1	97.7	GO:0071316	cellular response to nicotine(GO:0071316)
3.2	95.1	GO:0010107	potassium ion import(GO:0010107)
18.6	92.9	GO:0002159	desmosome assembly(GO:0002159)
0.4	76.4	GO:0007517	muscle organ development(GO:0007517)
2.8	76.0	GO:0045662	negative regulation of myoblast differentiation(GO:0045662)

Showing 1 to 10 of 453 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.4	268.6	GO:0030016	myofibril(GO:0030016)
4.8	267.2	GO:0031672	A band(GO:0031672)
0.1	248.6	GO:0016021	integral component of membrane(GO:0016021)
0.2	239.5	GO:0005739	mitochondrion(GO:0005739)
0.6	192.7	GO:0098857	membrane raft(GO:0045121) membrane microdomain(GO:0098857)
1.8	190.5	GO:0031225	anchored component of membrane(GO:0031225)
0.4	164.9	GO:0031012	extracellular matrix(GO:0031012)
15.4	123.0	GO:0098642	collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.7	115.9	GO:0043204	perikaryon(GO:0043204)
9.6	115.1	GO:0005861	troponin complex(GO:0005861)

Showing 1 to 10 of 183 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
5.5	253.5	GO:0008307	structural constituent of muscle(GO:0008307)
18.9	226.4	GO:0019911	structural constituent of myelin sheath(GO:0019911)
1.9	209.1	GO:0005178	integrin binding(GO:0005178)
3.0	196.4	GO:0005201	extracellular matrix structural constituent(GO:0005201)
1.3	154.1	GO:0004222	metalloendopeptidase activity(GO:0004222)
2.8	144.3	GO:0035255	ionotropic glutamate receptor binding(GO:0035255)
11.7	93.7	GO:0004689	phosphorylase kinase activity(GO:0004689)
1.5	93.1	GO:0032947	protein complex scaffold(GO:0032947)
1.7	91.5	GO:0015459	potassium channel regulator activity(GO:0015459)
22.0	88.0	GO:0015272	ATP-activated inward rectifier potassium channel activity(GO:0015272)

Showing 1 to 10 of 283 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.0	306.6	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.9	215.6	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
3.5	159.3	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
3.2	118.6	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.7	117.3	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
2.3	103.1	SIG CD40PATHWAYMAP	Genes related to CD40 signaling
1.5	94.3	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
3.4	92.4	PID INTEGRIN CS PATHWAY	Integrin family cell surface interactions
2.2	87.1	PID NCADHERIN PATHWAY	N-cadherin signaling events
1.5	81.9	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks

Showing 1 to 10 of 62 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
8.8	341.5	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
5.0	213.0	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
4.8	177.6	REACTOME INWARDLY RECTIFYING K CHANNELS	Genes involved in Inwardly rectifying K+ channels
2.2	173.8	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
3.8	134.3	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.9	121.3	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
5.1	101.9	REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	Genes involved in Glycogen breakdown (glycogenolysis)
4.7	99.7	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.9	94.7	REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production
4.0	93.0	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo

Showing 1 to 10 of 111 entries

Results for Id4

Z-value: 2.23

Motif logo

Transcription factors associated with Id4

Activity-expression correlation:

Activity profile of Id4 motif

Sorted Z-values of Id4 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Id4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: