ISMARA results: Hsf2

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Hsf2

Z-value: 1.04

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Transcription factors associated with Hsf2

Gene Symbol	Gene ID	Gene Info
Hsf2 NCBI RGD Ensembl	ENSRNOG00000000808	heat shock transcription factor 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Hsf2	rn6_v1_chr20_+_38935820_38935820	0.78	1.6e-65	Click!

Activity profile of Hsf2 motif

Sorted Z-values of Hsf2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr2_+_200793571 Show fit	31.98	ENSRNOT00000091444	Hao2 NCBI RGD Ensembl Show fit	hydroxyacid oxidase 2
chr14_-_6679878 Show fit	25.94	ENSRNOT00000075989 ENSRNOT00000067875	Spp1 NCBI RGD Ensembl Show fit	secreted phosphoprotein 1
chr1_+_219964429 Show fit	25.93	ENSRNOT00000088288	Sptbn2 NCBI RGD Ensembl Show fit	spectrin, beta, non-erythrocytic 2
chr10_+_99388130 Show fit	21.62	ENSRNOT00000006238	Kcnj16 NCBI RGD Ensembl Show fit	potassium voltage-gated channel subfamily J member 16
chr9_-_80166807 Show fit	20.09	ENSRNOT00000079493	Igfbp5 NCBI RGD Ensembl Show fit	insulin-like growth factor binding protein 5
chr18_+_69841053 Show fit	19.92	ENSRNOT00000071545 ENSRNOT00000030613 ENSRNOT00000075543	Mro NCBI RGD Ensembl Show fit	maestro
chr18_-_1946840 Show fit	19.07	ENSRNOT00000041878	Abhd3 NCBI RGD Ensembl Show fit	abhydrolase domain containing 3
chr14_-_64535170 Show fit	17.55	ENSRNOT00000082338	Gba3 NCBI RGD Ensembl Show fit	glucosidase, beta, acid 3
chr1_+_153861569 Show fit	16.70	ENSRNOT00000023329	Me3 NCBI RGD Ensembl Show fit	malic enzyme 3
chr10_-_13115294 Show fit	15.78	ENSRNOT00000005899	NEWGENE_6497122 NCBI RGD Ensembl Show fit	FLYWCH family member 2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Hsf2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	47.1	GO:0050911	detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
10.7	32.0	GO:0018924	mandelate metabolic process(GO:0018924)
7.8	31.3	GO:1904204	regulation of skeletal muscle hypertrophy(GO:1904204)
1.6	27.8	GO:0070262	peptidyl-serine dephosphorylation(GO:0070262)
0.5	27.5	GO:0048791	calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
2.4	26.2	GO:0007016	cytoskeletal anchoring at plasma membrane(GO:0007016)
8.6	25.9	GO:0006710	androgen catabolic process(GO:0006710)
2.2	25.9	GO:0016081	synaptic vesicle docking(GO:0016081)
6.3	25.4	GO:1903015	regulation of exo-alpha-sialidase activity(GO:1903015)
0.8	24.5	GO:0010107	potassium ion import(GO:0010107)

Showing 1 to 10 of 286 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	46.1	GO:0005739	mitochondrion(GO:0005739)
0.3	44.1	GO:0005923	bicellular tight junction(GO:0005923)
0.1	39.6	GO:0045177	apical part of cell(GO:0045177)
0.2	39.1	GO:0005777	peroxisome(GO:0005777) microbody(GO:0042579)
0.3	37.9	GO:0031514	motile cilium(GO:0031514)
5.2	31.3	GO:0042567	insulin-like growth factor ternary complex(GO:0042567)
1.1	30.3	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
1.6	26.2	GO:0005916	fascia adherens(GO:0005916)
2.6	25.9	GO:0008091	spectrin(GO:0008091)
3.9	23.4	GO:0005787	signal peptidase complex(GO:0005787)

Showing 1 to 10 of 128 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	68.5	GO:0005200	structural constituent of cytoskeleton(GO:0005200)
0.0	47.1	GO:0004984	olfactory receptor activity(GO:0004984)
10.7	32.0	GO:0052854	very-long-chain-(S)-2-hydroxy-acid oxidase activity(GO:0052852) long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity(GO:0052853) medium-chain-(S)-2-hydroxy-acid oxidase activity(GO:0052854)
3.5	31.3	GO:0031995	insulin-like growth factor II binding(GO:0031995)
0.4	30.2	GO:0019888	protein phosphatase regulator activity(GO:0019888)
0.1	29.9	GO:0000287	magnesium ion binding(GO:0000287)
1.3	25.5	GO:0005247	voltage-gated chloride channel activity(GO:0005247)
0.4	25.3	GO:0005544	calcium-dependent phospholipid binding(GO:0005544)
8.3	24.9	GO:0018479	benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
1.0	23.4	GO:0005242	inward rectifier potassium channel activity(GO:0005242)

Showing 1 to 10 of 195 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	29.2	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.5	27.7	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.3	23.8	ST INTEGRIN SIGNALING PATHWAY	Integrin Signaling Pathway
0.2	15.6	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.3	13.8	PID ATR PATHWAY	ATR signaling pathway
0.3	12.5	PID PI3K PLC TRK PATHWAY	Trk receptor signaling mediated by PI3K and PLC-gamma
0.3	11.8	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.5	11.7	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
0.3	11.4	PID ER NONGENOMIC PATHWAY	Plasma membrane estrogen receptor signaling
0.5	9.3	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network

Showing 1 to 10 of 36 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.3	46.9	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
1.5	31.3	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.4	26.5	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.6	20.9	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.7	19.9	REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS	Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.5	17.6	REACTOME GLYCOSPHINGOLIPID METABOLISM	Genes involved in Glycosphingolipid metabolism
0.5	16.2	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.8	13.5	REACTOME ENDOGENOUS STEROLS	Genes involved in Endogenous sterols
0.5	13.1	REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS	Genes involved in CREB phosphorylation through the activation of Ras
0.6	12.9	REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	Genes involved in Na+/Cl- dependent neurotransmitter transporters

Showing 1 to 10 of 69 entries

Results for Hsf2

Z-value: 1.04

Motif logo

Transcription factors associated with Hsf2

Activity-expression correlation:

Activity profile of Hsf2 motif

Sorted Z-values of Hsf2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Hsf2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: