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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Hoxa4

Z-value: 1.50

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Transcription factors associated with Hoxa4

Gene Symbol Gene ID Gene Info
Hoxa4
ENSRNOG00000027365 homeo box A4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hoxa4rn6_v1_chr4_-_82160240_821602400.062.9e-01Click!

Activity profile of Hoxa4 motif

Sorted Z-values of Hoxa4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_63836017 127.06 ENSRNOT00000030978
AABR07052585.1

chr12_+_49761120 78.12 ENSRNOT00000070961
Myo18b
myosin XVIIIb
chr11_+_66713888 76.43 ENSRNOT00000003340
Fbxo40
F-box protein 40
chr10_+_53740841 65.70 ENSRNOT00000004295
Myh2
myosin heavy chain 2
chr15_-_27819376 63.01 ENSRNOT00000067400
A930018M24Rik
RIKEN cDNA A930018M24 gene
chr8_-_130429132 62.93 ENSRNOT00000026261
Hhatl
hedgehog acyltransferase-like
chr13_+_52889737 56.35 ENSRNOT00000074366
Cacna1s
calcium voltage-gated channel subunit alpha1 S
chr10_+_53818818 54.67 ENSRNOT00000057260
Myh8
myosin heavy chain 8
chr10_+_53778662 52.75 ENSRNOT00000045718
Myh2
myosin heavy chain 2
chr4_-_15859132 51.63 ENSRNOT00000082161
Cacna2d1
calcium voltage-gated channel auxiliary subunit alpha2delta 1
chr15_+_4064706 43.97 ENSRNOT00000011956
Synpo2l
synaptopodin 2-like
chr10_-_8654892 43.00 ENSRNOT00000066534
Rbfox1
RNA binding protein, fox-1 homolog 1
chr9_-_53315915 42.37 ENSRNOT00000038093
Mstn
myostatin
chr2_+_219598162 40.82 ENSRNOT00000020297
Lrrc39
leucine rich repeat containing 39
chr3_+_168345152 38.05 ENSRNOT00000017654
Dok5
docking protein 5
chr12_-_5685448 35.68 ENSRNOT00000077167
Fry
FRY microtubule binding protein
chrX_-_23144324 34.05 ENSRNOT00000000178
ENSRNOT00000081239
Pfkfb1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr4_+_172942020 33.02 ENSRNOT00000072450
Lmo3
LIM domain only 3
chr13_-_98478327 32.55 ENSRNOT00000030135
Coq8a
coenzyme Q8A
chr8_+_110982777 31.27 ENSRNOT00000010992
Ky
kyphoscoliosis peptidase
chr15_+_2734068 29.58 ENSRNOT00000017663
Dusp13
dual specificity phosphatase 13
chr15_+_11298478 29.20 ENSRNOT00000007672
Lrrc3b
leucine rich repeat containing 3B
chr2_-_98610368 28.57 ENSRNOT00000011641
Zfhx4
zinc finger homeobox 4
chr10_-_34439470 27.98 ENSRNOT00000072081
Btnl9
butyrophilin-like 9
chr7_+_70807867 26.15 ENSRNOT00000010639
Stac3
SH3 and cysteine rich domain 3
chr6_-_8344574 24.78 ENSRNOT00000009660
Prepl
prolyl endopeptidase-like
chr1_-_99632845 24.66 ENSRNOT00000049123
LOC103691107
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 pseudogene
chr3_-_48536235 24.56 ENSRNOT00000083536
Fap
fibroblast activation protein, alpha
chr1_+_90729274 23.42 ENSRNOT00000047207
RGD1560088
similar to NADH:ubiquinone oxidoreductase B15 subunit
chr1_-_192057612 21.11 ENSRNOT00000024471
Ndufab1
NADH:ubiquinone oxidoreductase subunit AB1
chrX_-_42329232 20.61 ENSRNOT00000045705
LOC100361934
NADH dehydrogenase (ubiquinone) 1 beta subcomplex 4
chr4_+_100166863 20.41 ENSRNOT00000014505
Sftpb
surfactant protein B
chrX_+_157759624 20.37 ENSRNOT00000003192
LOC686087
similar to motile sperm domain containing 1
chr2_-_104461863 20.08 ENSRNOT00000016953
Crh
corticotropin releasing hormone
chr2_+_42829413 19.17 ENSRNOT00000065528
Actbl2
actin, beta-like 2
chr2_+_252771017 18.74 ENSRNOT00000075452
ENSRNOT00000055318
Ttll7
tubulin tyrosine ligase like 7
chr1_-_275882444 18.67 ENSRNOT00000083215
Gpam
glycerol-3-phosphate acyltransferase, mitochondrial
chr16_+_54332660 18.55 ENSRNOT00000037685
Mtus1
microtubule associated tumor suppressor 1
chrM_+_5323 17.96 ENSRNOT00000050156
Mt-co1
mitochondrially encoded cytochrome c oxidase 1
chrM_+_3904 17.86 ENSRNOT00000040993
Mt-nd2
mitochondrially encoded NADH dehydrogenase 2
chr18_+_30527705 16.76 ENSRNOT00000027168
Pcdhb14
protocadherin beta 14
chr14_-_13058172 16.47 ENSRNOT00000002746
ENSRNOT00000071706
Prdm8
PR/SET domain 8
chr16_-_27472687 16.15 ENSRNOT00000046984
AABR07025074.1

chr20_+_25990656 15.95 ENSRNOT00000081254
Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr14_+_7949239 15.86 ENSRNOT00000044617
Ndufb4l1
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4-like 1
chr7_-_69982592 15.22 ENSRNOT00000040010
RGD1564306
similar to developmental pluripotency associated 5
chr10_-_98469799 15.19 ENSRNOT00000087502
ENSRNOT00000088646
Abca9
ATP binding cassette subfamily A member 9
chr13_-_36290531 14.47 ENSRNOT00000071388
Steap3
STEAP3 metalloreductase
chr16_-_74700815 14.17 ENSRNOT00000081297
Thsd1
thrombospondin type 1 domain containing 1
chr2_+_196334626 13.69 ENSRNOT00000050914
ENSRNOT00000028645
ENSRNOT00000090729
Sema6c
semaphorin 6C
chr4_+_119225040 13.45 ENSRNOT00000012365
Bmp10
bone morphogenetic protein 10
chr4_+_129574264 13.32 ENSRNOT00000010185
Arl6ip5
ADP-ribosylation factor like GTPase 6 interacting protein 5
chrX_+_107496072 13.22 ENSRNOT00000003283
Plp1
proteolipid protein 1
chr2_-_46544457 13.20 ENSRNOT00000015680
Fst
follistatin
chr11_-_782954 13.19 ENSRNOT00000040065
Epha3
Eph receptor A3
chr13_+_90943255 13.12 ENSRNOT00000011539
Vsig8
V-set and immunoglobulin domain containing 8
chr1_-_255557055 12.63 ENSRNOT00000033780
Fgfbp3
fibroblast growth factor binding protein 3
chr11_-_4397361 12.52 ENSRNOT00000046370
Cadm2
cell adhesion molecule 2
chr10_+_13836128 12.22 ENSRNOT00000012720
Pgp
phosphoglycolate phosphatase
chr4_-_166869399 12.16 ENSRNOT00000007521
Tas2r121
taste receptor, type 2, member 121
chr10_+_89251370 12.07 ENSRNOT00000076820
Aoc3
amine oxidase, copper containing 3
chr7_-_143408276 11.92 ENSRNOT00000013122
ENSRNOT00000091540
Krt73
keratin 73
chr15_-_62200837 10.80 ENSRNOT00000017599
Pcdh8
protocadherin 8
chr1_-_174620064 10.35 ENSRNOT00000016224
Tmem41b
transmembrane protein 41B
chr13_-_97838228 10.25 ENSRNOT00000003618
Tfb2m
transcription factor B2, mitochondrial
chr7_+_12619774 10.05 ENSRNOT00000015257
Med16
mediator complex subunit 16
chr4_+_56744561 9.98 ENSRNOT00000009737
Atp6v1f
ATPase H+ transporting V1 subunit F
chr20_+_25990304 9.95 ENSRNOT00000033980
Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr9_+_81566074 9.88 ENSRNOT00000074131
ENSRNOT00000046229
ENSRNOT00000090383
Pnkd
paroxysmal nonkinesigenic dyskinesia
chr20_-_11638483 9.77 ENSRNOT00000067800
Krtap12-2
keratin associated protein 12-2
chr14_-_10395047 9.43 ENSRNOT00000002936
Gpat3
glycerol-3-phosphate acyltransferase 3
chr1_+_228395558 9.00 ENSRNOT00000065411
Osbp
oxysterol binding protein
chr3_-_71798531 8.70 ENSRNOT00000088170
Calcrl
calcitonin receptor like receptor
chr11_-_71136673 8.64 ENSRNOT00000042240
Fyttd1
forty-two-three domain containing 1
chr5_-_105582375 8.59 ENSRNOT00000083373
Slc24a2
solute carrier family 24 member 2
chr14_-_2032593 8.41 ENSRNOT00000000037
Fgfrl1
fibroblast growth factor receptor-like 1
chr18_+_30820321 8.41 ENSRNOT00000060472
Pcdhga3
protocadherin gamma subfamily A, 3
chr5_-_711033 8.40 ENSRNOT00000024199
Crispld1
cysteine-rich secretory protein LCCL domain containing 1
chr20_-_34679779 8.29 ENSRNOT00000078420
Cep85l
centrosomal protein 85-like
chr10_+_39850818 8.24 ENSRNOT00000012671
Fnip1
folliculin interacting protein 1
chr8_+_48718329 7.96 ENSRNOT00000089763
Slc37a4
solute carrier family 37 member 4
chr18_+_30509393 7.87 ENSRNOT00000043846
Pcdhb12
protocadherin beta 12
chr18_-_17716880 7.73 ENSRNOT00000061151
Celf4
CUGBP, Elav-like family member 4
chr11_-_62451149 7.65 ENSRNOT00000093686
ENSRNOT00000081443
Zbtb20
zinc finger and BTB domain containing 20
chr10_-_87954055 7.59 ENSRNOT00000018048
Krt34
keratin 34
chr10_-_87248572 7.43 ENSRNOT00000066637
ENSRNOT00000085677
Krt26
keratin 26
chr12_+_24367199 7.16 ENSRNOT00000001971
Fkbp6
FK506 binding protein 6
chr6_-_51019407 7.07 ENSRNOT00000011659
Gpr22
G protein-coupled receptor 22
chr1_-_173469699 6.84 ENSRNOT00000040345
Olr281
olfactory receptor 281
chr6_+_73358112 6.76 ENSRNOT00000041373
Arhgap5
Rho GTPase activating protein 5
chrX_+_76083549 6.73 ENSRNOT00000003573
Magee1
MAGE family member E1
chr3_+_95715193 6.65 ENSRNOT00000089525
Pax6
paired box 6
chrX_-_13279082 6.51 ENSRNOT00000051898
ENSRNOT00000060857
Tspan7
tetraspanin 7
chr3_+_56862691 6.37 ENSRNOT00000087712
Gad1
glutamate decarboxylase 1
chr18_+_30387937 6.23 ENSRNOT00000027210
Pcdhb4
protocadherin beta 4
chr3_-_161115313 6.20 ENSRNOT00000043716
Wfdc9
WAP four-disulfide core domain 9
chr6_+_8219385 6.16 ENSRNOT00000040509
Ppm1b
protein phosphatase, Mg2+/Mn2+ dependent, 1B
chr16_+_8823872 6.02 ENSRNOT00000027186
Drgx
dorsal root ganglia homeobox
chr1_-_149603272 5.74 ENSRNOT00000045582
Olr13
olfactory receptor 13
chr2_+_207930796 5.39 ENSRNOT00000047827
Kcnd3
potassium voltage-gated channel subfamily D member 3
chr17_+_60287203 5.27 ENSRNOT00000025585
Armc4
armadillo repeat containing 4
chr4_+_86135050 5.01 ENSRNOT00000081561
Ccdc129
coiled-coil domain containing 129
chr8_-_122311431 5.00 ENSRNOT00000033126
Fbxl2
F-box and leucine-rich repeat protein 2
chr17_+_38457783 4.87 ENSRNOT00000059757
Prl5a2
prolactin family 5, subfamily a, member 2
chr6_-_51018050 4.76 ENSRNOT00000082691
Gpr22
G protein-coupled receptor 22
chr6_+_97168453 4.72 ENSRNOT00000085790
Syt16
synaptotagmin 16
chr20_-_11620945 4.56 ENSRNOT00000079725
Krtap12-2
keratin associated protein 12-2
chr3_-_66417741 4.50 ENSRNOT00000007662
Neurod1
neuronal differentiation 1
chr1_+_167857056 4.39 ENSRNOT00000074214
LOC684208
similar to olfactory receptor 557
chr1_+_173012247 4.28 ENSRNOT00000073864
LOC100912217
olfactory receptor 10A3-like
chr9_+_3896337 4.08 ENSRNOT00000079166
LOC103693189
protein tyrosine phosphatase type IVA 1
chr2_+_3750094 4.04 ENSRNOT00000064743
Mctp1
multiple C2 and transmembrane domain containing 1
chr13_+_109909053 3.83 ENSRNOT00000090541
AC125873.1

chr18_-_786674 3.82 ENSRNOT00000021955
Cetn1
centrin 1
chr10_-_87286387 3.76 ENSRNOT00000044206
Krt28
keratin 28
chr8_+_94686938 3.72 ENSRNOT00000013285
Ripply2
ripply transcriptional repressor 2
chr12_-_47482961 3.70 ENSRNOT00000001600
Oasl2
2'-5' oligoadenylate synthetase-like 2
chr1_-_22404002 3.63 ENSRNOT00000044098
Taar8a
trace amine-associated receptor 8a
chr3_-_74991168 3.51 ENSRNOT00000049273
Olr550
olfactory receptor 550
chr7_-_4216833 3.40 ENSRNOT00000003174
Olr982
olfactory receptor 982
chr4_+_87167514 3.01 ENSRNOT00000007821
Fkbp9
FK506 binding protein 9
chrX_+_9436707 2.97 ENSRNOT00000004187
Cask
calcium/calmodulin dependent serine protein kinase
chr4_+_134398354 2.94 ENSRNOT00000077970
AABR07061577.1

chr2_-_1561464 2.88 ENSRNOT00000062055
ENSRNOT00000062054
ENSRNOT00000062052
Cast
calpastatin
chr6_-_67084234 2.80 ENSRNOT00000050372
Nova1
NOVA alternative splicing regulator 1
chr7_+_144647587 2.79 ENSRNOT00000022398
Hoxc4
homeo box C4
chr7_-_7753978 2.76 ENSRNOT00000048223
Olr1029
olfactory receptor 1029
chr1_-_163611299 2.72 ENSRNOT00000043788
Emsy
EMSY BRCA2-interacting transcriptional repressor
chr8_+_115511974 2.61 ENSRNOT00000067683
Timm8a1
translocase of inner mitochondrial membrane 8 homolog A1 (yeast)
chr10_+_78111050 2.60 ENSRNOT00000079364
Cox11
COX11 cytochrome c oxidase copper chaperone
chr7_+_15621989 2.55 ENSRNOT00000051928
Olr1095
olfactory receptor 1095
chr7_-_6754349 2.50 ENSRNOT00000085061
Olr956
olfactory receptor 956
chr3_+_31802999 2.43 ENSRNOT00000041305
AABR07051996.1

chr4_+_108301129 2.37 ENSRNOT00000007993
LRRTM1
leucine rich repeat transmembrane neuronal 1
chr4_-_167145096 2.24 ENSRNOT00000028970
Tas2r116
taste receptor, type 2, member 116
chr1_-_173456488 2.11 ENSRNOT00000044753
Olr282
olfactory receptor 282
chr3_+_76468294 2.10 ENSRNOT00000037779
Olr619
olfactory receptor 619
chr16_+_60925093 1.82 ENSRNOT00000015813
Tnks
tankyrase
chr2_+_193627243 1.82 ENSRNOT00000082934
AABR07012331.1

chr15_-_20783063 1.80 ENSRNOT00000083268
Bmp4
bone morphogenetic protein 4
chr6_+_48452369 1.67 ENSRNOT00000044310
Myt1l
myelin transcription factor 1-like
chr18_+_12056113 1.64 ENSRNOT00000038450
Dsg4
desmoglein 4
chr2_-_177924970 1.63 ENSRNOT00000029340
Rapgef2
Rap guanine nucleotide exchange factor 2
chr9_-_4945352 1.50 ENSRNOT00000082530
Sult1c3
sulfotransferase family 1C member 3
chr2_+_62198562 1.49 ENSRNOT00000087636
Zfr
zinc finger RNA binding protein
chr13_-_76049363 1.35 ENSRNOT00000075865
ENSRNOT00000007455
Brinp2
BMP/retinoic acid inducible neural specific 2
chrX_+_156552528 1.20 ENSRNOT00000086429
Tex28
testis expressed 28
chr20_-_32628953 1.16 ENSRNOT00000000451
Gprc6a
G protein-coupled receptor, class C, group 6, member A
chr1_-_169230360 1.15 ENSRNOT00000022740
Olr142
olfactory receptor 142
chr1_-_156327352 1.06 ENSRNOT00000074282
LOC100911776
coiled-coil domain-containing protein 89-like
chr8_+_116715755 1.06 ENSRNOT00000090239
Camkv
CaM kinase-like vesicle-associated
chr2_+_24546536 1.03 ENSRNOT00000014036
Otp
orthopedia homeobox
chr1_+_201429771 0.95 ENSRNOT00000027836
Plekha1
pleckstrin homology domain containing A1
chr3_-_76279104 0.92 ENSRNOT00000007796
Olr608
olfactory receptor 608
chr4_-_167130996 0.92 ENSRNOT00000040860
Tas2r110
taste receptor, type 2, member 110
chr9_-_74048244 0.90 ENSRNOT00000018293
Lancl1
LanC like 1
chr1_-_129776276 0.87 ENSRNOT00000051402
Arrdc4
arrestin domain containing 4
chr19_-_26053762 0.80 ENSRNOT00000004646
MAST1
microtubule associated serine/threonine kinase 1
chr1_+_154606490 0.75 ENSRNOT00000024095
Ccdc89
coiled-coil domain containing 89
chr7_-_107223047 0.65 ENSRNOT00000007250
ENSRNOT00000084875
Lrrc6
leucine rich repeat containing 6
chr13_+_98311827 0.62 ENSRNOT00000082844
Cdc42bpa
CDC42 binding protein kinase alpha
chr5_-_69517277 0.47 ENSRNOT00000079848
Olr850
olfactory receptor 850
chr9_+_37593032 0.45 ENSRNOT00000051890
AABR07067274.1

chr9_-_88748866 0.35 ENSRNOT00000071906
Rpl30l1
ribosomal protein L30-like 1
chr8_+_90304148 0.30 ENSRNOT00000001195
AABR07070892.1

chr3_-_77605962 0.27 ENSRNOT00000090062
Olr665
olfactory receptor 665
chr2_-_155381839 0.25 ENSRNOT00000057657
Vom2r47
vomeronasal 2 receptor, 47
chr1_+_169074475 0.25 ENSRNOT00000050248
Olr132
olfactory receptor 132
chr10_-_29450644 0.24 ENSRNOT00000087937
Adra1b
adrenoceptor alpha 1B
chr5_-_12199283 0.12 ENSRNOT00000007769
Pcmtd1
protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1
chr4_-_82160240 0.08 ENSRNOT00000038775
ENSRNOT00000058985
Hoxa4
homeo box A4
chr10_+_62566732 0.05 ENSRNOT00000021368
Taok1
TAO kinase 1
chr2_+_46140482 0.05 ENSRNOT00000072858
Olr1262
olfactory receptor 1262
chr2_-_118882562 0.03 ENSRNOT00000058860
Kcnmb3
potassium calcium-activated channel subfamily M regulatory beta subunit 3

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxa4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
10.5 62.9 GO:1903059 regulation of protein lipidation(GO:1903059)
9.1 118.5 GO:0001778 plasma membrane repair(GO:0001778)
8.9 35.7 GO:1904428 negative regulation of tubulin deacetylation(GO:1904428)
8.6 51.6 GO:1901843 membrane depolarization during bundle of His cell action potential(GO:0086048) positive regulation of high voltage-gated calcium channel activity(GO:1901843)
8.2 24.6 GO:0097325 melanocyte proliferation(GO:0097325)
8.0 56.3 GO:0002074 extraocular skeletal muscle development(GO:0002074)
7.0 21.1 GO:0009249 protein lipoylation(GO:0009249)
6.7 79.9 GO:0048739 cardiac muscle fiber development(GO:0048739)
6.1 54.7 GO:0030049 muscle filament sliding(GO:0030049)
6.1 42.4 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816) negative regulation of skeletal muscle cell differentiation(GO:2001015)
5.0 20.1 GO:0070093 hormone-mediated apoptotic signaling pathway(GO:0008628) positive regulation of cortisol secretion(GO:0051464) negative regulation of glucagon secretion(GO:0070093)
4.8 14.5 GO:1902167 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:1902167)
4.7 33.0 GO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360)
4.4 13.2 GO:0097156 fasciculation of motor neuron axon(GO:0097156)
4.3 34.0 GO:0033133 positive regulation of glucokinase activity(GO:0033133)
4.1 20.4 GO:0050828 regulation of liquid surface tension(GO:0050828)
4.1 12.2 GO:0006114 glycerol biosynthetic process(GO:0006114)
3.1 28.1 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024)
2.8 8.4 GO:0060988 lipid tube assembly(GO:0060988)
2.7 13.5 GO:0060298 atrial cardiac muscle tissue development(GO:0003228) atrial cardiac muscle tissue morphogenesis(GO:0055009) positive regulation of sarcomere organization(GO:0060298)
2.5 43.0 GO:2001014 regulation of skeletal muscle cell differentiation(GO:2001014)
2.3 11.6 GO:0002036 regulation of L-glutamate transport(GO:0002036)
2.2 38.1 GO:0051386 regulation of neurotrophin TRK receptor signaling pathway(GO:0051386)
2.2 6.6 GO:1904937 pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918) sensory neuron migration(GO:1904937)
2.0 32.6 GO:1901663 ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
2.0 9.9 GO:0061727 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
1.9 13.2 GO:0046882 negative regulation of follicle-stimulating hormone secretion(GO:0046882)
1.9 18.7 GO:0018095 protein polyglutamylation(GO:0018095)
1.8 12.6 GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
1.6 16.5 GO:0021540 corpus callosum morphogenesis(GO:0021540)
1.5 18.0 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
1.5 17.8 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004) positive regulation of amyloid precursor protein catabolic process(GO:1902993)
1.4 8.2 GO:0002904 positive regulation of B cell apoptotic process(GO:0002904)
1.3 6.4 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
1.1 8.0 GO:0035166 post-embryonic hemopoiesis(GO:0035166)
1.1 7.4 GO:2000675 negative regulation of type B pancreatic cell apoptotic process(GO:2000675)
1.0 7.7 GO:0090394 negative regulation of excitatory postsynaptic potential(GO:0090394) regulation of retina development in camera-type eye(GO:1902866)
0.9 13.2 GO:0042759 long-chain fatty acid biosynthetic process(GO:0042759)
0.9 2.8 GO:1990790 response to glial cell derived neurotrophic factor(GO:1990790) cellular response to glial cell derived neurotrophic factor(GO:1990792)
0.8 17.9 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.8 10.3 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.7 4.5 GO:0006499 N-terminal protein myristoylation(GO:0006499)
0.7 18.6 GO:0010758 regulation of macrophage chemotaxis(GO:0010758)
0.7 12.1 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
0.7 8.4 GO:0060539 diaphragm development(GO:0060539)
0.7 8.7 GO:0034285 response to sucrose(GO:0009744) response to disaccharide(GO:0034285)
0.6 2.6 GO:0033131 regulation of glucokinase activity(GO:0033131)
0.6 26.1 GO:0048741 skeletal muscle fiber development(GO:0048741)
0.6 1.8 GO:0070212 protein poly-ADP-ribosylation(GO:0070212) regulation of telomeric DNA binding(GO:1904742)
0.5 6.0 GO:0021559 trigeminal nerve development(GO:0021559)
0.4 5.4 GO:0097623 potassium ion export across plasma membrane(GO:0097623)
0.4 5.3 GO:0003356 regulation of cilium movement(GO:0003352) regulation of cilium beat frequency(GO:0003356)
0.4 11.9 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.4 7.2 GO:0034587 piRNA metabolic process(GO:0034587)
0.4 23.6 GO:0007528 neuromuscular junction development(GO:0007528)
0.4 1.6 GO:1900377 negative regulation of melanin biosynthetic process(GO:0048022) negative regulation of secondary metabolite biosynthetic process(GO:1900377)
0.4 55.6 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.4 9.0 GO:0044126 regulation of growth of symbiont in host(GO:0044126) modulation of growth of symbiont involved in interaction with host(GO:0044144)
0.3 2.4 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.3 10.0 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991)
0.3 3.7 GO:0032525 somite rostral/caudal axis specification(GO:0032525)
0.3 7.6 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.2 9.3 GO:0060325 face morphogenesis(GO:0060325)
0.2 0.2 GO:0001982 baroreceptor response to decreased systemic arterial blood pressure(GO:0001982)
0.2 3.0 GO:0010839 negative regulation of keratinocyte proliferation(GO:0010839)
0.2 6.8 GO:0002053 positive regulation of mesenchymal cell proliferation(GO:0002053)
0.2 10.1 GO:0030521 androgen receptor signaling pathway(GO:0030521)
0.2 14.5 GO:0032233 positive regulation of actin filament bundle assembly(GO:0032233)
0.2 1.0 GO:0021979 hypothalamus cell differentiation(GO:0021979)
0.2 8.6 GO:0060292 long term synaptic depression(GO:0060292)
0.2 5.0 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.1 8.6 GO:0006406 mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.1 15.0 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.1 0.6 GO:0060287 epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.1 34.8 GO:0042692 muscle cell differentiation(GO:0042692)
0.1 4.7 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.1 0.6 GO:0007097 nuclear migration(GO:0007097)
0.1 3.0 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.1 3.8 GO:0034605 cellular response to heat(GO:0034605)
0.1 0.8 GO:0050912 detection of chemical stimulus involved in sensory perception of taste(GO:0050912)
0.0 1.8 GO:0050909 sensory perception of taste(GO:0050909)
0.0 0.9 GO:0051443 positive regulation of ubiquitin-protein transferase activity(GO:0051443)
0.0 6.1 GO:0007411 axon guidance(GO:0007411)
0.0 6.5 GO:0050900 leukocyte migration(GO:0050900)
0.0 32.6 GO:0050907 detection of chemical stimulus involved in sensory perception(GO:0050907) detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 2.8 GO:0050684 regulation of mRNA processing(GO:0050684)
0.0 1.3 GO:0007050 cell cycle arrest(GO:0007050)
0.0 2.0 GO:0006626 protein targeting to mitochondrion(GO:0006626)
0.0 1.1 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
13.2 118.5 GO:0005826 actomyosin contractile ring(GO:0005826)
8.7 78.1 GO:0016461 unconventional myosin complex(GO:0016461)
3.9 54.7 GO:0032982 myosin filament(GO:0032982)
3.5 24.6 GO:0071438 invadopodium membrane(GO:0071438)
2.5 29.5 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
1.7 56.3 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
1.5 20.4 GO:0097208 alveolar lamellar body(GO:0097208)
1.1 18.0 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
1.0 20.1 GO:0043196 varicosity(GO:0043196)
0.8 10.0 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.8 39.0 GO:0005747 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.6 88.7 GO:0030018 Z disc(GO:0030018)
0.6 6.7 GO:0090665 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.4 14.5 GO:0005771 multivesicular body(GO:0005771)
0.3 12.5 GO:0032809 neuronal cell body membrane(GO:0032809)
0.2 3.0 GO:0005652 nuclear lamina(GO:0005652)
0.2 28.4 GO:0005882 intermediate filament(GO:0005882)
0.2 43.0 GO:0005802 trans-Golgi network(GO:0005802)
0.2 10.3 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.2 6.4 GO:0060077 inhibitory synapse(GO:0060077)
0.2 5.3 GO:0097546 ciliary base(GO:0097546)
0.1 1.6 GO:0030057 desmosome(GO:0030057)
0.1 30.4 GO:0030427 site of polarized growth(GO:0030427)
0.1 8.7 GO:0044291 cell-cell contact zone(GO:0044291)
0.1 18.7 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.1 3.6 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.1 18.8 GO:0045211 postsynaptic membrane(GO:0045211)
0.1 7.9 GO:0005902 microvillus(GO:0005902)
0.1 4.2 GO:0000795 synaptonemal complex(GO:0000795)
0.1 5.0 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 5.4 GO:0005901 caveola(GO:0005901)
0.1 11.5 GO:0043209 myelin sheath(GO:0043209)
0.0 6.8 GO:0000139 Golgi membrane(GO:0000139)
0.0 2.6 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 13.6 GO:0044445 cytosolic part(GO:0044445)
0.0 20.0 GO:0005794 Golgi apparatus(GO:0005794)
0.0 1.6 GO:0005770 late endosome(GO:0005770)
0.0 5.0 GO:0005769 early endosome(GO:0005769)
0.0 249.0 GO:0016021 integral component of membrane(GO:0016021)
0.0 1.5 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 28.5 GO:0005615 extracellular space(GO:0005615)
0.0 1.0 GO:0032587 ruffle membrane(GO:0032587)
0.0 0.6 GO:0042641 actomyosin(GO:0042641)
0.0 1.1 GO:0030659 cytoplasmic vesicle membrane(GO:0030659)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
17.2 51.6 GO:0086057 voltage-gated calcium channel activity involved in bundle of His cell action potential(GO:0086057)
7.0 21.1 GO:0031177 phosphopantetheine binding(GO:0031177)
5.0 20.1 GO:0051431 corticotropin-releasing hormone receptor 2 binding(GO:0051431)
4.9 34.0 GO:0070095 fructose-6-phosphate binding(GO:0070095)
4.7 28.1 GO:0004366 glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
3.7 18.7 GO:0070739 protein-glutamic acid ligase activity(GO:0070739)
3.6 14.5 GO:0000293 ferric-chelate reductase activity(GO:0000293)
3.4 10.3 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
2.9 8.7 GO:0001605 adrenomedullin receptor activity(GO:0001605)
2.5 54.7 GO:0000146 microfilament motor activity(GO:0000146)
2.5 24.6 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
2.1 24.8 GO:0070008 serine-type exopeptidase activity(GO:0070008)
2.0 12.2 GO:0098519 nucleotide phosphatase activity, acting on free nucleotides(GO:0098519)
2.0 9.9 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
1.9 13.5 GO:0031433 telethonin binding(GO:0031433)
1.8 16.5 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
1.8 34.2 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
1.4 38.5 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
1.3 13.2 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
1.3 6.4 GO:0004351 glutamate decarboxylase activity(GO:0004351)
1.2 8.6 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
1.2 8.2 GO:0042030 ATPase inhibitor activity(GO:0042030)
1.1 8.0 GO:0015119 hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
1.1 10.1 GO:0030375 thyroid hormone receptor coactivator activity(GO:0030375)
1.1 13.2 GO:0019911 structural constituent of myelin sheath(GO:0019911)
1.1 12.1 GO:0008131 primary amine oxidase activity(GO:0008131)
1.1 5.4 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
1.1 13.7 GO:0030215 semaphorin receptor binding(GO:0030215)
1.1 8.4 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
1.0 13.2 GO:0048185 activin binding(GO:0048185)
0.9 12.2 GO:0033038 bitter taste receptor activity(GO:0033038)
0.8 44.2 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.8 10.2 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.8 32.6 GO:0043531 ADP binding(GO:0043531)
0.8 3.8 GO:0032795 heterotrimeric G-protein binding(GO:0032795)
0.7 29.1 GO:0005158 insulin receptor binding(GO:0005158)
0.7 6.6 GO:0003680 AT DNA binding(GO:0003680)
0.6 77.9 GO:0003774 motor activity(GO:0003774)
0.6 33.7 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.6 18.0 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.6 12.6 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.5 10.0 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.4 3.7 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.4 1.5 GO:0004027 alcohol sulfotransferase activity(GO:0004027)
0.3 76.4 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.3 132.9 GO:0003779 actin binding(GO:0003779)
0.3 9.0 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.3 28.3 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.3 1.6 GO:0031697 beta-1 adrenergic receptor binding(GO:0031697)
0.2 6.8 GO:0042169 SH2 domain binding(GO:0042169)
0.2 3.6 GO:0001594 trace-amine receptor activity(GO:0001594)
0.2 3.0 GO:0042043 neurexin family protein binding(GO:0042043)
0.2 1.7 GO:0050897 cobalt ion binding(GO:0050897)
0.1 34.9 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.1 8.8 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 2.8 GO:0071837 HMG box domain binding(GO:0071837)
0.1 15.2 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.1 4.5 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 4.5 GO:0030145 manganese ion binding(GO:0030145)
0.1 0.2 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.1 1.8 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.1 25.1 GO:0004857 enzyme inhibitor activity(GO:0004857)
0.1 2.3 GO:0099589 G-protein coupled serotonin receptor activity(GO:0004993) serotonin receptor activity(GO:0099589)
0.1 0.8 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.1 1.0 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.1 0.8 GO:0008527 taste receptor activity(GO:0008527)
0.1 2.6 GO:0005507 copper ion binding(GO:0005507)
0.1 0.9 GO:0043295 glutathione binding(GO:0043295)
0.0 22.2 GO:0005509 calcium ion binding(GO:0005509)
0.0 4.9 GO:0005179 hormone activity(GO:0005179)
0.0 1.1 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 0.1 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0 5.4 GO:0001664 G-protein coupled receptor binding(GO:0001664)
0.0 3.3 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 30.1 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 8.4 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.0 2.6 GO:0008022 protein C-terminus binding(GO:0008022)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 118.5 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.7 29.1 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.3 8.4 PID CONE PATHWAY Visual signal transduction: Cones
0.3 11.3 PID EPHA FWDPATHWAY EPHA forward signaling
0.3 15.0 PID BMP PATHWAY BMP receptor signaling
0.2 65.6 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.2 18.7 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.2 3.0 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.1 31.3 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 18.4 NABA MATRISOME ASSOCIATED Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors
0.1 6.8 PID RHOA REG PATHWAY Regulation of RhoA activity
0.1 10.3 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.1 5.6 PID CDC42 PATHWAY CDC42 signaling events
0.0 1.0 PID PI3KCI PATHWAY Class I PI3K signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 54.7 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
1.3 56.3 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.9 34.0 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.8 24.5 REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING Genes involved in Transferrin endocytosis and recycling
0.8 15.2 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.6 18.7 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.5 4.5 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.4 12.5 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.4 6.6 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.3 21.1 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.3 28.8 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.2 9.0 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.2 6.4 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.2 8.0 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.1 3.0 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 5.4 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.1 8.6 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 4.2 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.1 1.2 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 4.1 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation