ISMARA results: Homez

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Homez

Z-value: 0.82

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Transcription factors associated with Homez

Gene Symbol	Gene ID	Gene Info
Homez NCBI RGD Ensembl	ENSRNOG00000014887	homeobox and leucine zipper encoding

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Homez	rn6_v1_chr15_-_33527031_33527031	0.63	9.0e-37	Click!

Activity profile of Homez motif

Sorted Z-values of Homez motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr2_+_200778122 Show fit	42.77	ENSRNOT00000091845	Hao2 NCBI RGD Ensembl Show fit	hydroxyacid oxidase 2
chr1_-_54854353 Show fit	26.37	ENSRNOT00000072895	Smok2a NCBI RGD Ensembl Show fit	sperm motility kinase 2A
chr17_+_9746485 Show fit	22.44	ENSRNOT00000072298	Pfn3 NCBI RGD Ensembl Show fit	profilin 3
chr8_+_117906014 Show fit	22.27	ENSRNOT00000056180	Spink8 NCBI RGD Ensembl Show fit	serine peptidase inhibitor, Kazal type 8
chr2_+_154921999 Show fit	20.92	ENSRNOT00000057620	LOC691044 NCBI RGD Ensembl Show fit	similar to GTPase activating protein testicular GAP1
chr1_-_54036068 Show fit	20.75	ENSRNOT00000075019	RGD1560718 NCBI RGD Ensembl Show fit	similar to putative protein kinase
chr18_-_15089988 Show fit	18.68	ENSRNOT00000074116	Mep1b NCBI RGD Ensembl Show fit	meprin A subunit beta
chr18_+_47294292 Show fit	18.60	ENSRNOT00000020109	Ftmt NCBI RGD Ensembl Show fit	ferritin mitochondrial
chr19_+_568287 Show fit	18.58	ENSRNOT00000016419	Cdh16 NCBI RGD Ensembl Show fit	cadherin 16
chr4_+_96831880 Show fit	17.94	ENSRNOT00000068400	RSA-14-44 NCBI RGD Ensembl Show fit	RSA-14-44 protein

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Homez

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.5	49.2	GO:0035404	histone-serine phosphorylation(GO:0035404)
14.3	42.8	GO:0018924	mandelate metabolic process(GO:0018924)
1.4	25.9	GO:1900004	negative regulation of serine-type endopeptidase activity(GO:1900004) negative regulation of serine-type peptidase activity(GO:1902572)
0.1	24.6	GO:0007283	spermatogenesis(GO:0007283)
0.6	20.2	GO:0007339	binding of sperm to zona pellucida(GO:0007339)
1.4	18.6	GO:0006880	intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.5	18.3	GO:1901998	toxin transport(GO:1901998)
6.0	17.9	GO:0097498	endothelial tube lumen extension(GO:0097498)
5.8	17.5	GO:0016598	protein arginylation(GO:0016598)
2.6	15.9	GO:0097500	receptor localization to nonmotile primary cilium(GO:0097500)

Showing 1 to 10 of 186 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.7	49.2	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.3	46.9	GO:0005777	peroxisome(GO:0005777) microbody(GO:0042579)
0.3	43.4	GO:0001669	acrosomal vesicle(GO:0001669)
0.1	32.9	GO:0005813	centrosome(GO:0005813)
0.1	23.7	GO:0016607	nuclear speck(GO:0016607)
0.1	21.6	GO:0016323	basolateral plasma membrane(GO:0016323)
0.1	18.3	GO:0005923	bicellular tight junction(GO:0005923)
0.4	17.9	GO:0032154	cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.2	17.7	GO:0005902	microvillus(GO:0005902)
4.2	16.6	GO:0034774	secretory granule lumen(GO:0034774)

Showing 1 to 10 of 98 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.3	49.2	GO:0004679	AMP-activated protein kinase activity(GO:0004679)
14.3	42.8	GO:0052853	very-long-chain-(S)-2-hydroxy-acid oxidase activity(GO:0052852) long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity(GO:0052853) medium-chain-(S)-2-hydroxy-acid oxidase activity(GO:0052854)
0.3	32.9	GO:0004222	metalloendopeptidase activity(GO:0004222)
0.0	21.3	GO:0004674	protein serine/threonine kinase activity(GO:0004674)
0.9	18.6	GO:0008199	ferric iron binding(GO:0008199)
0.2	15.8	GO:0003743	translation initiation factor activity(GO:0003743)
3.8	15.3	GO:0015350	methotrexate transporter activity(GO:0015350)
0.0	13.3	GO:0008289	lipid binding(GO:0008289)
0.4	13.1	GO:0061631	ubiquitin conjugating enzyme activity(GO:0061631)
1.4	12.7	GO:0022833	mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)

Showing 1 to 10 of 120 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	21.9	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.1	13.0	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2	11.1	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.1	9.4	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.4	8.4	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.1	8.4	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.8	7.8	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.2	6.7	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.1	4.6	PID ATF2 PATHWAY	ATF-2 transcription factor network
0.2	4.5	PID CONE PATHWAY	Visual signal transduction: Cones

Showing 1 to 10 of 34 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	11.4	REACTOME REGULATION OF BETA CELL DEVELOPMENT	Genes involved in Regulation of beta-cell development
0.3	10.8	REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS	Genes involved in Phase 1 - Functionalization of compounds
0.8	9.8	REACTOME ANDROGEN BIOSYNTHESIS	Genes involved in Androgen biosynthesis
0.7	8.6	REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION	Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.4	8.5	REACTOME PEROXISOMAL LIPID METABOLISM	Genes involved in Peroxisomal lipid metabolism
0.5	8.1	REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.4	7.8	REACTOME STEROID HORMONES	Genes involved in Steroid hormones
0.4	6.6	REACTOME AMINE DERIVED HORMONES	Genes involved in Amine-derived hormones
0.1	5.4	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.2	4.7	REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION	Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription

Showing 1 to 10 of 46 entries

Results for Homez

Z-value: 0.82

Motif logo

Transcription factors associated with Homez

Activity-expression correlation:

Activity profile of Homez motif

Sorted Z-values of Homez motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Homez

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: