ISMARA results: Foxp1

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Foxp1_Foxj2

Z-value: 1.30

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Transcription factors associated with Foxp1_Foxj2

Gene Symbol	Gene ID	Gene Info
Foxp1 NCBI RGD Ensembl	ENSRNOG00000009184	forkhead box P1
Foxj2 NCBI RGD Ensembl	ENSRNOG00000009000	forkhead box J2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Foxp1	rn6_v1_chr4_-_131694755_131694755	-0.37	1.2e-11	Click!
Foxj2	rn6_v1_chr4_+_155653718_155653718	-0.35	9.9e-11	Click!

Activity profile of Foxp1_Foxj2 motif

Sorted Z-values of Foxp1_Foxj2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr5_-_64818813 Show fit	65.73	ENSRNOT00000009111 ENSRNOT00000086505	Aldob NCBI RGD Ensembl Show fit	aldolase, fructose-bisphosphate B
chr14_-_19072677 Show fit	63.66	ENSRNOT00000060548	LOC360919 NCBI RGD Ensembl Show fit	similar to alpha-fetoprotein
chr2_-_182035032 Show fit	59.95	ENSRNOT00000009813	Fgb NCBI RGD Ensembl Show fit	fibrinogen beta chain
chr4_+_154391647 Show fit	58.39	ENSRNOT00000081488 ENSRNOT00000079192	Mug1 NCBI RGD Ensembl Show fit	murinoglobulin 1
chr13_+_89597138 Show fit	56.69	ENSRNOT00000004662	Apoa2 NCBI RGD Ensembl Show fit	apolipoprotein A2
chr12_+_10636275 Show fit	52.93	ENSRNOT00000001285	Cyp3a18 NCBI RGD Ensembl Show fit	cytochrome P450, family 3, subfamily a, polypeptide 18
chr1_-_263803150 Show fit	51.38	ENSRNOT00000017840	Cyp2c23 NCBI RGD Ensembl Show fit	cytochrome P450, family 2, subfamily c, polypeptide 23
chr11_+_61605937 Show fit	50.04	ENSRNOT00000093455 ENSRNOT00000093242	Gramd1c NCBI RGD Ensembl Show fit	GRAM domain containing 1C
chr4_+_154505826 Show fit	49.77	ENSRNOT00000044408	Mug1 NCBI RGD Ensembl Show fit	murinoglobulin 1
chr10_+_96639924 Show fit	46.15	ENSRNOT00000004756	Apoh NCBI RGD Ensembl Show fit	apolipoprotein H

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Foxp1_Foxj2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.7	152.6	GO:0006953	acute-phase response(GO:0006953)
4.5	120.8	GO:0019373	epoxygenase P450 pathway(GO:0019373)
0.1	119.3	GO:0050911	detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
18.4	92.1	GO:0043152	induction of bacterial agglutination(GO:0043152)
5.0	90.3	GO:0042730	fibrinolysis(GO:0042730)
5.8	80.8	GO:0016338	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.4	79.3	GO:0031668	cellular response to extracellular stimulus(GO:0031668)
19.8	79.2	GO:0007597	blood coagulation, intrinsic pathway(GO:0007597)
22.9	68.7	GO:0006116	NADH oxidation(GO:0006116)
6.7	66.5	GO:0015697	quaternary ammonium group transport(GO:0015697)

Showing 1 to 10 of 408 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	502.9	GO:0005789	endoplasmic reticulum membrane(GO:0005789)
0.3	266.7	GO:0005887	integral component of plasma membrane(GO:0005887)
2.3	265.9	GO:0072562	blood microparticle(GO:0072562)
0.2	205.8	GO:0005615	extracellular space(GO:0005615)
7.9	102.8	GO:0042627	chylomicron(GO:0042627)
11.1	89.1	GO:0005577	fibrinogen complex(GO:0005577)
0.0	78.7	GO:0070062	extracellular exosome(GO:0070062)
10.9	76.2	GO:0005579	membrane attack complex(GO:0005579)
13.1	65.7	GO:0097425	smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
1.0	47.8	GO:0030173	integral component of Golgi membrane(GO:0030173)

Showing 1 to 10 of 159 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.9	324.1	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
4.5	120.8	GO:0008392	arachidonic acid epoxygenase activity(GO:0008392)
0.5	99.5	GO:0004252	serine-type endopeptidase activity(GO:0004252)
3.0	91.5	GO:0015020	glucuronosyltransferase activity(GO:0015020)
4.0	83.3	GO:0008395	steroid hydroxylase activity(GO:0008395)
4.0	75.9	GO:1900750	oligopeptide binding(GO:1900750)
10.0	70.0	GO:0004332	fructose-bisphosphate aldolase activity(GO:0004332)
5.8	69.2	GO:0004499	N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.1	62.0	GO:0004984	olfactory receptor activity(GO:0004984)
0.9	61.2	GO:0098531	RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)

Showing 1 to 10 of 281 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	143.2	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
2.4	133.8	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.8	120.2	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
3.5	107.6	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
1.1	49.1	PID UPA UPAR PATHWAY	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.8	36.4	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.9	32.3	PID GLYPICAN 1PATHWAY	Glypican 1 network
0.7	28.4	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.4	25.8	PID MET PATHWAY	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.6	25.1	PID CD40 PATHWAY	CD40/CD40L signaling

Showing 1 to 10 of 55 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.5	152.0	REACTOME COMPLEMENT CASCADE	Genes involved in Complement cascade
9.1	145.4	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
2.2	85.2	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
1.9	74.0	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.5	68.7	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives
1.9	57.6	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
6.4	57.3	REACTOME ABACAVIR TRANSPORT AND METABOLISM	Genes involved in Abacavir transport and metabolism
3.3	56.7	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
1.1	52.9	REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS	Genes involved in Phase 1 - Functionalization of compounds
1.6	52.1	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions

Showing 1 to 10 of 107 entries

Results for Foxp1_Foxj2

Z-value: 1.30

Motif logo

Transcription factors associated with Foxp1_Foxj2

Activity-expression correlation:

Activity profile of Foxp1_Foxj2 motif

Sorted Z-values of Foxp1_Foxj2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Foxp1_Foxj2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: