ISMARA results: Foxd2

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Foxd2

Z-value: 0.95

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Transcription factors associated with Foxd2

Gene Symbol	Gene ID	Gene Info
Foxd2 NCBI RGD Ensembl	ENSRNOG00000007759	forkhead box D2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Foxd2	rn6_v1_chr5_-_133709712_133709712	0.30	2.6e-08	Click!

Activity profile of Foxd2 motif

Sorted Z-values of Foxd2 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr9_+_95501778 Show fit	64.03	ENSRNOT00000086805	Spp2 NCBI RGD Ensembl Show fit	secreted phosphoprotein 2
chr19_+_15081590 Show fit	35.17	ENSRNOT00000024187	Ces1f NCBI RGD Ensembl Show fit	carboxylesterase 1F
chr19_+_15081158 Show fit	34.37	ENSRNOT00000074070	Ces1f NCBI RGD Ensembl Show fit	carboxylesterase 1F
chr7_-_30105132 Show fit	34.28	ENSRNOT00000091227	Nr1h4 NCBI RGD Ensembl Show fit	nuclear receptor subfamily 1, group H, member 4
chr4_-_176294997 Show fit	33.91	ENSRNOT00000015112 ENSRNOT00000051461 ENSRNOT00000000026 ENSRNOT00000039877 ENSRNOT00000049303	Slc21a4 NCBI RGD Ensembl Show fit	kidney specific organic anion transporter
chr14_+_85113578 Show fit	32.79	ENSRNOT00000011158	Nipsnap1 NCBI RGD Ensembl Show fit	nipsnap homolog 1
chr1_-_253000760 Show fit	30.47	ENSRNOT00000030024	Slc16a12 NCBI RGD Ensembl Show fit	solute carrier family 16, member 12
chr6_+_80188943 Show fit	24.64	ENSRNOT00000059335	Mia2 NCBI RGD Ensembl Show fit	melanoma inhibitory activity 2
chr6_-_127620296 Show fit	21.70	ENSRNOT00000012577	Serpina1 NCBI RGD Ensembl Show fit	serpin family A member 1
chr10_+_3411380 Show fit	20.70	ENSRNOT00000004346	RGD1305733 NCBI RGD Ensembl Show fit	similar to RIKEN cDNA 2900011O08

Showing 1 to 10 of 161 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Foxd2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	53.8	GO:0046849	bone remodeling(GO:0046849)
11.4	34.3	GO:0034971	histone H3-R17 methylation(GO:0034971)
8.5	33.9	GO:0051958	methotrexate transport(GO:0051958)
1.1	30.5	GO:0072337	modified amino acid transport(GO:0072337)
0.2	27.6	GO:0019233	sensory perception of pain(GO:0019233)
4.1	24.6	GO:0070973	protein localization to endoplasmic reticulum exit site(GO:0070973)
7.2	21.7	GO:0033986	response to methanol(GO:0033986)
5.2	20.7	GO:1903976	negative regulation of glial cell migration(GO:1903976)
0.7	20.7	GO:0006958	complement activation, classical pathway(GO:0006958)
2.9	20.4	GO:0051799	negative regulation of hair follicle development(GO:0051799)

Showing 1 to 10 of 93 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	69.5	GO:0005788	endoplasmic reticulum lumen(GO:0005788)
0.1	68.2	GO:0005887	integral component of plasma membrane(GO:0005887)
0.0	55.3	GO:0005615	extracellular space(GO:0005615)
1.0	34.3	GO:0005719	nuclear euchromatin(GO:0005719)
0.1	32.6	GO:0097060	synaptic membrane(GO:0097060)
0.0	30.9	GO:0070062	extracellular exosome(GO:0070062)
0.2	30.1	GO:0030426	growth cone(GO:0030426)
1.2	24.6	GO:0070971	endoplasmic reticulum exit site(GO:0070971)
0.0	23.5	GO:0005829	cytosol(GO:0005829)
0.4	20.7	GO:0044295	axonal growth cone(GO:0044295)

Showing 1 to 10 of 59 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	54.3	GO:0052689	carboxylic ester hydrolase activity(GO:0052689)
8.6	34.3	GO:0038181	bile acid receptor activity(GO:0038181)
8.5	33.9	GO:0015350	methotrexate transporter activity(GO:0015350)
1.0	32.8	GO:0042165	neurotransmitter binding(GO:0042165)
1.5	30.5	GO:0051184	cofactor transporter activity(GO:0051184) modified amino acid transmembrane transporter activity(GO:0072349)
0.0	28.8	GO:0005509	calcium ion binding(GO:0005509)
4.1	24.6	GO:0042954	lipoprotein transporter activity(GO:0042954)
0.2	21.2	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
1.5	18.2	GO:0070008	serine-type exopeptidase activity(GO:0070008)
3.5	17.7	GO:0016841	ammonia-lyase activity(GO:0016841)

Showing 1 to 10 of 73 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	34.3	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.5	29.0	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.3	15.3	PID IL6 7 PATHWAY	IL6-mediated signaling events
0.2	13.2	PID TGFBR PATHWAY	TGF-beta receptor signaling
0.0	12.0	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.2	11.4	PID TRKR PATHWAY	Neurotrophic factor-mediated Trk receptor signaling
0.6	11.0	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.2	7.7	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.2	7.6	PID ALK1 PATHWAY	ALK1 signaling events
0.3	5.0	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family

Showing 1 to 10 of 20 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	22.0	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.2	21.7	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.7	20.9	REACTOME SULFUR AMINO ACID METABOLISM	Genes involved in Sulfur amino acid metabolism
1.5	20.7	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.2	18.3	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.9	18.2	REACTOME INTRINSIC PATHWAY	Genes involved in Intrinsic Pathway
0.1	17.7	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives
1.4	15.3	REACTOME CREATION OF C4 AND C2 ACTIVATORS	Genes involved in Creation of C4 and C2 activators
0.8	11.4	REACTOME ROLE OF DCC IN REGULATING APOPTOSIS	Genes involved in Role of DCC in regulating apoptosis
1.1	11.3	REACTOME COMPLEMENT CASCADE	Genes involved in Complement cascade

Showing 1 to 10 of 35 entries

Results for Foxd2

Z-value: 0.95

Motif logo

Transcription factors associated with Foxd2

Activity-expression correlation:

Activity profile of Foxd2 motif

Sorted Z-values of Foxd2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Foxd2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: