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GSE53960: rat RNA-Seq transcriptomic Bodymap
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Results for Foxd1
Z-value: 0.97
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Transcription factors associated with Foxd1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Foxd1 | rn6_v1_chr2_+_28460068_28460068 | -0.11 | 5.4e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_+_58814805 Show fit | 39.11 |
ENSRNOT00000005909
|
tetraspanin 8 |
|
| chr5_+_152533349 Show fit | 38.89 |
ENSRNOT00000067524
|
tripartite motif containing 63 |
|
| chr2_+_198683159 Show fit | 33.96 |
ENSRNOT00000028793
|
thioredoxin interacting protein |
|
| chr1_+_225184939 Show fit | 27.91 |
ENSRNOT00000079456
|
AHNAK nucleoprotein |
|
| chr17_+_81922329 Show fit | 26.78 |
ENSRNOT00000031542
|
calcium voltage-gated channel auxiliary subunit beta 2 |
|
| chr14_+_83560541 Show fit | 24.62 |
ENSRNOT00000057738
ENSRNOT00000085228 |
phosphoinositide-3-kinase interacting protein 1 |
|
| chr4_+_169161585 Show fit | 23.15 |
ENSRNOT00000079785
|
epithelial membrane protein 1 |
|
| chr16_-_61091169 Show fit | 22.97 |
ENSRNOT00000016328
|
dual specificity phosphatase 4 |
|
| chr4_+_169147243 Show fit | 22.96 |
ENSRNOT00000011580
|
epithelial membrane protein 1 |
|
| chr20_-_4863011 Show fit | 22.10 |
ENSRNOT00000079503
|
lymphotoxin beta |
Network of associatons between targets according to the STRING database.
First level regulatory network of Foxd1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 46.1 | GO:0032060 | bleb assembly(GO:0032060) |
| 2.7 | 42.5 | GO:0038166 | angiotensin-activated signaling pathway(GO:0038166) |
| 7.8 | 38.9 | GO:0014878 | response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878) |
| 1.5 | 34.0 | GO:0002347 | response to tumor cell(GO:0002347) |
| 0.1 | 28.6 | GO:0051260 | protein homooligomerization(GO:0051260) |
| 8.9 | 26.8 | GO:1904879 | positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879) |
| 1.8 | 26.5 | GO:0035970 | peptidyl-threonine dephosphorylation(GO:0035970) |
| 4.1 | 24.6 | GO:0043553 | negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553) |
| 1.2 | 23.6 | GO:0021527 | spinal cord association neuron differentiation(GO:0021527) |
| 1.2 | 23.0 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 59.7 | GO:0005654 | nucleoplasm(GO:0005654) |
| 1.8 | 58.3 | GO:0031430 | M band(GO:0031430) |
| 0.1 | 41.2 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.5 | 36.6 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.1 | 29.0 | GO:0009986 | cell surface(GO:0009986) |
| 0.8 | 27.9 | GO:0043034 | costamere(GO:0043034) |
| 0.2 | 27.0 | GO:0031674 | I band(GO:0031674) |
| 2.2 | 26.8 | GO:1990454 | L-type voltage-gated calcium channel complex(GO:1990454) |
| 0.1 | 26.3 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.1 | 22.3 | GO:0009897 | external side of plasma membrane(GO:0009897) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.2 | 58.2 | GO:0031432 | titin binding(GO:0031432) |
| 8.8 | 43.8 | GO:0043120 | tumor necrosis factor binding(GO:0043120) |
| 1.9 | 42.5 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
| 0.3 | 39.1 | GO:0005178 | integrin binding(GO:0005178) |
| 0.1 | 31.9 | GO:0003712 | transcription cofactor activity(GO:0003712) |
| 0.0 | 28.2 | GO:0001071 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 2.1 | 27.9 | GO:0097493 | structural molecule activity conferring elasticity(GO:0097493) |
| 4.5 | 26.8 | GO:0086056 | voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056) |
| 7.7 | 23.0 | GO:0008330 | protein tyrosine/threonine phosphatase activity(GO:0008330) |
| 0.1 | 22.8 | GO:0031625 | ubiquitin protein ligase binding(GO:0031625) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 58.4 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.6 | 33.3 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 2.0 | 27.5 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.4 | 25.7 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.6 | 24.3 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.4 | 23.3 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.6 | 19.5 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.4 | 19.4 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.4 | 18.3 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.3 | 16.6 | PID E2F PATHWAY | E2F transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 41.0 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 2.8 | 34.0 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.2 | 28.2 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 1.0 | 27.5 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.9 | 26.8 | REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE | Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline |
| 1.6 | 23.0 | REACTOME ERKS ARE INACTIVATED | Genes involved in ERKs are inactivated |
| 7.1 | 21.4 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.5 | 14.5 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.6 | 14.4 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.3 | 13.2 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |