ISMARA results: Fos

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Fos

Z-value: 1.22

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Transcription factors associated with Fos

Gene Symbol	Gene ID	Gene Info
Fos NCBI RGD Ensembl	ENSRNOG00000008015	FBJ osteosarcoma oncogene

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Fos	rn6_v1_chr6_+_109300433_109300433	0.48	2.9e-20	Click!

Activity profile of Fos motif

Sorted Z-values of Fos motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr13_-_70626252 Show fit	72.32	ENSRNOT00000036947	Lamc2 NCBI RGD Ensembl Show fit	laminin subunit gamma 2
chr13_-_70625842 Show fit	67.61	ENSRNOT00000092499	Lamc2 NCBI RGD Ensembl Show fit	laminin subunit gamma 2
chr1_+_79989019 Show fit	57.47	ENSRNOT00000020428	Dmpk NCBI RGD Ensembl Show fit	dystrophia myotonica-protein kinase
chr16_-_18766174 Show fit	37.49	ENSRNOT00000084813	Sftpd NCBI RGD Ensembl Show fit	surfactant protein D
chr10_-_88122233 Show fit	32.80	ENSRNOT00000083895 ENSRNOT00000005285	Krt14 NCBI RGD Ensembl Show fit	keratin 14
chr3_-_92749121 Show fit	32.65	ENSRNOT00000008760	Cd44 NCBI RGD Ensembl Show fit	CD44 molecule (Indian blood group)
chr16_-_10941414 Show fit	29.96	ENSRNOT00000086627 ENSRNOT00000085414 ENSRNOT00000081631 ENSRNOT00000087521 ENSRNOT00000083623	Ldb3 NCBI RGD Ensembl Show fit	LIM domain binding 3
chr5_+_164796185 Show fit	29.29	ENSRNOT00000010779	Nppb NCBI RGD Ensembl Show fit	natriuretic peptide B
chr1_+_199555722 Show fit	28.74	ENSRNOT00000054983	Itgax NCBI RGD Ensembl Show fit	integrin subunit alpha X
chr18_+_3861539 Show fit	28.13	ENSRNOT00000015363	Lama3 NCBI RGD Ensembl Show fit	laminin subunit alpha 3

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Fos

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
6.7	139.9	GO:0070831	basement membrane assembly(GO:0070831)
14.9	74.4	GO:0014722	regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722)
0.7	68.3	GO:0007229	integrin-mediated signaling pathway(GO:0007229)
3.1	66.0	GO:0031424	keratinization(GO:0031424)
3.1	55.7	GO:0032060	bleb assembly(GO:0032060)
0.9	54.4	GO:0030239	myofibril assembly(GO:0030239)
4.4	43.7	GO:0050862	positive regulation of T cell receptor signaling pathway(GO:0050862)
12.9	38.6	GO:1904178	sterol regulatory element binding protein import into nucleus(GO:0035105) negative regulation of adipose tissue development(GO:1904178)
7.5	37.5	GO:0050828	regulation of liquid surface tension(GO:0050828)
0.2	34.6	GO:0007519	skeletal muscle tissue development(GO:0007519)

Showing 1 to 10 of 138 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
38.4	153.4	GO:0005607	laminin-2 complex(GO:0005607)
1.0	74.2	GO:0045095	keratin filament(GO:0045095)
0.5	70.8	GO:0030018	Z disc(GO:0030018)
1.4	60.5	GO:0043034	costamere(GO:0043034)
2.1	57.5	GO:0031307	integral component of mitochondrial outer membrane(GO:0031307)
0.2	48.1	GO:0009897	external side of plasma membrane(GO:0009897)
4.8	38.6	GO:0005638	lamin filament(GO:0005638)
2.9	38.3	GO:0031143	pseudopodium(GO:0031143)
1.1	37.5	GO:0005771	multivesicular body(GO:0005771)
0.7	37.1	GO:0034707	chloride channel complex(GO:0034707)

Showing 1 to 10 of 72 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	166.7	GO:0008201	heparin binding(GO:0008201)
0.9	58.6	GO:0019888	protein phosphatase regulator activity(GO:0019888)
0.3	50.0	GO:0051015	actin filament binding(GO:0051015)
1.7	46.6	GO:0008157	protein phosphatase 1 binding(GO:0008157)
6.2	43.7	GO:0016286	small conductance calcium-activated potassium channel activity(GO:0016286)
0.1	38.2	GO:0005198	structural molecule activity(GO:0005198)
1.5	37.5	GO:0001530	lipopolysaccharide binding(GO:0001530)
6.6	32.8	GO:1990254	keratin filament binding(GO:1990254)
3.3	32.7	GO:0005114	type II transforming growth factor beta receptor binding(GO:0005114)
1.9	30.0	GO:0051371	muscle alpha-actinin binding(GO:0051371)

Showing 1 to 10 of 101 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
10.7	181.5	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
1.0	61.6	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.8	49.8	PID AR PATHWAY	Coregulation of Androgen receptor activity
1.0	44.8	PID SYNDECAN 1 PATHWAY	Syndecan-1-mediated signaling events
0.8	42.4	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.6	36.7	PID CASPASE PATHWAY	Caspase cascade in apoptosis
1.8	32.7	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
1.1	28.8	PID INTEGRIN CS PATHWAY	Integrin family cell surface interactions
1.7	24.0	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.1	22.0	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins

Showing 1 to 10 of 43 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.8	180.4	REACTOME CELL JUNCTION ORGANIZATION	Genes involved in Cell junction organization
0.6	44.4	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
0.4	43.7	REACTOME POTASSIUM CHANNELS	Genes involved in Potassium Channels
0.8	37.9	REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S	Genes involved in Activation of Chaperone Genes by XBP1(S)
2.5	32.7	REACTOME HYALURONAN UPTAKE AND DEGRADATION	Genes involved in Hyaluronan uptake and degradation
0.6	27.4	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.5	25.6	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
1.0	24.0	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.7	22.4	REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE	Genes involved in Formation of Fibrin Clot (Clotting Cascade)
0.5	20.6	REACTOME GLYCOLYSIS	Genes involved in Glycolysis

Showing 1 to 10 of 34 entries

Results for Fos

Z-value: 1.22

Motif logo

Transcription factors associated with Fos

Activity-expression correlation:

Activity profile of Fos motif

Sorted Z-values of Fos motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Fos

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: