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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Fos

Z-value: 1.22

Motif logo

Transcription factors associated with Fos

Gene Symbol Gene ID Gene Info
ENSRNOG00000008015 FBJ osteosarcoma oncogene

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Fosrn6_v1_chr6_+_109300433_1093004330.482.9e-20Click!

Activity profile of Fos motif

Sorted Z-values of Fos motif

Promoter Log-likelihood Transcript Gene Gene Info
chr13_-_70626252 72.32 ENSRNOT00000036947
laminin subunit gamma 2
chr13_-_70625842 67.61 ENSRNOT00000092499
laminin subunit gamma 2
chr1_+_79989019 57.47 ENSRNOT00000020428
dystrophia myotonica-protein kinase
chr16_-_18766174 37.49 ENSRNOT00000084813
surfactant protein D
chr10_-_88122233 32.80 ENSRNOT00000083895
ENSRNOT00000005285
keratin 14
chr3_-_92749121 32.65 ENSRNOT00000008760
CD44 molecule (Indian blood group)
chr16_-_10941414 29.96 ENSRNOT00000086627
ENSRNOT00000085414
ENSRNOT00000081631
ENSRNOT00000087521
ENSRNOT00000083623
LIM domain binding 3
chr5_+_164796185 29.29 ENSRNOT00000010779
natriuretic peptide B
chr1_+_199555722 28.74 ENSRNOT00000054983
integrin subunit alpha X
chr18_+_3861539 28.13 ENSRNOT00000015363
laminin subunit alpha 3
chr4_+_169161585 27.94 ENSRNOT00000079785
epithelial membrane protein 1
chr4_+_169147243 27.76 ENSRNOT00000011580
epithelial membrane protein 1
chr2_-_187863503 27.57 ENSRNOT00000093036
ENSRNOT00000026705
ENSRNOT00000082174
lamin A/C
chr20_+_12658065 27.37 ENSRNOT00000072951
ENSRNOT00000001679
collagen type VI alpha 1 chain
chr8_+_5606592 27.04 ENSRNOT00000011727
matrix metallopeptidase 12
chr4_+_78694447 26.91 ENSRNOT00000011945
glycoprotein nmb
chr10_-_87067456 25.57 ENSRNOT00000014163
C-C motif chemokine receptor 7
chr17_-_55300998 25.05 ENSRNOT00000064331
supervillin
chr10_-_88163712 24.67 ENSRNOT00000005382
ENSRNOT00000084493
keratin 17
chr2_-_227207584 24.41 ENSRNOT00000065361
ENSRNOT00000080215
myozenin 2
chr1_-_197770669 24.04 ENSRNOT00000023563
linker for activation of T cells
chr3_+_55910177 23.73 ENSRNOT00000009969
kelch-like family member 41
chr8_+_5893249 23.15 ENSRNOT00000014041
matrix metallopeptidase 7
chr13_+_89975267 23.09 ENSRNOT00000006266
ENSRNOT00000000053
CD244 molecule
chr2_+_225310624 22.40 ENSRNOT00000015836
coagulation factor III, tissue factor
chr1_+_81230612 22.14 ENSRNOT00000026489
potassium calcium-activated channel subfamily N member 4
chr8_+_75687100 22.00 ENSRNOT00000038677
annexin A2
chr1_+_81230989 21.60 ENSRNOT00000077952
potassium calcium-activated channel subfamily N member 4
chr7_-_11648322 20.75 ENSRNOT00000026871
growth arrest and DNA-damage-inducible, beta
chr8_-_33661049 19.74 ENSRNOT00000068037
Fli-1 proto-oncogene, ETS transcription factor
chr15_+_87704340 19.71 ENSRNOT00000034987
sciellin
chr1_+_91152635 19.08 ENSRNOT00000073438
dermokine-like
chr20_+_295250 18.87 ENSRNOT00000000955
chloride intracellular channel 2
chr1_-_198232344 18.81 ENSRNOT00000080988
aldolase, fructose-bisphosphate A
chr17_-_55346279 18.53 ENSRNOT00000025037
supervillin
chr3_+_37545238 18.36 ENSRNOT00000070792
TNF alpha induced protein 6
chr20_+_5040337 18.27 ENSRNOT00000068435
chloride intracellular channel 1
chr10_-_88152064 17.97 ENSRNOT00000019477
keratin 16
chr14_-_85484275 17.91 ENSRNOT00000083770
kringle containing transmembrane protein 1
chr4_+_71740532 17.80 ENSRNOT00000023537
zyxin
chr4_-_131694755 17.76 ENSRNOT00000013271
forkhead box P1
chr18_-_68551558 17.74 ENSRNOT00000016369
RAB27B, member RAS oncogene family
chr5_-_159293673 17.11 ENSRNOT00000009081
peptidyl arginine deiminase 4
chrX_+_51286737 16.96 ENSRNOT00000035692
dystrophin
chr1_+_72420352 16.86 ENSRNOT00000066307
SH3 domain binding kinase family, member 3
chr1_+_140601791 16.82 ENSRNOT00000091588
interferon stimulated exonuclease gene 20
chr10_-_88050622 16.43 ENSRNOT00000019037
keratin 15
chr14_+_44889287 16.06 ENSRNOT00000091312
ENSRNOT00000032273
transmembrane protein 156
chr9_-_100306194 16.02 ENSRNOT00000087584
similar to hypothetical protein FLJ22671
chr3_+_55623634 16.00 ENSRNOT00000080525
dehydrogenase/reductase 9
chr13_+_27449934 15.81 ENSRNOT00000003409
serpin family B member 2
chr2_-_186480278 15.54 ENSRNOT00000031743
kin of IRRE like (Drosophila)
chrX_+_28593405 15.49 ENSRNOT00000071708
thymosin beta 4, X-linked
chr7_-_143863186 15.48 ENSRNOT00000017096
retinoic acid receptor, gamma
chr1_-_252461461 15.33 ENSRNOT00000026093
ankyrin repeat domain 22
chr13_-_100928811 14.61 ENSRNOT00000045326
calpain 2
chr1_-_89474252 14.34 ENSRNOT00000028597
FXYD domain-containing ion transport regulator 5
chr20_+_31102476 14.03 ENSRNOT00000078719
leucine rich repeat containing 20
chr1_-_89473904 13.92 ENSRNOT00000089474
FXYD domain-containing ion transport regulator 5
chr10_+_83655460 13.91 ENSRNOT00000008011
G protein subunit gamma transducin 2
chr8_+_119228612 13.49 ENSRNOT00000078439
ENSRNOT00000043737
leucine rich repeat containing 2
chr6_+_50528823 13.48 ENSRNOT00000008321
laminin subunit beta 1
chr8_+_55603968 13.14 ENSRNOT00000066848
POU class 2 associating factor 1
chr3_-_14019204 13.02 ENSRNOT00000072400
ENSRNOT00000092918
TNF receptor-associated factor 1
chr8_+_48571323 12.44 ENSRNOT00000059776
coiled-coil domain containing 153
chr1_+_218466289 11.91 ENSRNOT00000017948
MAS related GPR family member F
chr18_+_30826260 11.87 ENSRNOT00000065235
protocadherin gamma subfamily B, 1
chr2_-_192671059 11.73 ENSRNOT00000012174
small proline-rich protein 1A
chr5_-_144274981 11.70 ENSRNOT00000065871
MAP7 domain containing 1
chr5_-_151824633 11.61 ENSRNOT00000043959
stratifin
chr3_-_2411544 11.31 ENSRNOT00000012406
torsin family 4, member A
chr2_+_150756185 11.09 ENSRNOT00000088461
ENSRNOT00000036808
muscleblind-like splicing regulator 1
chr12_+_39553903 10.94 ENSRNOT00000001738
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
chr9_+_15166118 10.93 ENSRNOT00000020432
MyoD family inhibitor
chr7_-_93280009 10.78 ENSRNOT00000064877
sterile alpha motif domain containing 12
chr11_-_33003021 10.76 ENSRNOT00000084134
runt-related transcription factor 1
chr9_-_17835240 10.71 ENSRNOT00000026988
NFKB inhibitor epsilon
chr18_+_14756684 10.62 ENSRNOT00000076085
ENSRNOT00000076129
microtubule-associated protein, RP/EB family, member 2
chr18_+_56364620 10.58 ENSRNOT00000068535
ENSRNOT00000086033
platelet derived growth factor receptor beta
chr5_+_139394794 10.24 ENSRNOT00000045954
sex comb on midleg homolog 1 (Drosophila)
chr1_-_124803363 10.15 ENSRNOT00000066380
Kruppel-like factor 13
chr2_-_187863349 10.01 ENSRNOT00000084455
lamin A/C
chr5_+_59008933 9.62 ENSRNOT00000023060
carbonic anhydrase 9
chr1_-_19376301 9.60 ENSRNOT00000015547
Rho GTPase activating protein 18
chr7_+_54213319 9.52 ENSRNOT00000005286
nucleosome assembly protein 1-like 1
chr1_+_89215266 9.41 ENSRNOT00000093612
ENSRNOT00000084799
dermokine
chr11_+_85430400 9.37 ENSRNOT00000083198

chr10_-_64657089 9.18 ENSRNOT00000080703
active BCR-related
chr4_+_83713666 9.16 ENSRNOT00000086473
cAMP responsive element binding protein 5
chr6_+_129438158 9.04 ENSRNOT00000005953
bradykinin receptor B1
chr12_-_17519954 8.94 ENSRNOT00000089418
Sad1 and UNC84 domain containing 1
chr12_+_24761210 8.69 ENSRNOT00000002003
claudin 4
chr8_-_128249538 8.63 ENSRNOT00000082892
sodium voltage-gated channel alpha subunit 5
chr19_+_41631715 8.62 ENSRNOT00000022749
carbohydrate sulfotransferase 4
chr10_+_11338306 8.60 ENSRNOT00000033695
protein FAM100A-like
chr5_+_169181418 8.48 ENSRNOT00000004508
kelch-like family member 21
chr10_+_105499569 8.44 ENSRNOT00000088457
sphingosine kinase 1
chr8_-_82492243 8.33 ENSRNOT00000013852
tropomodulin 3
chr18_+_36371041 8.01 ENSRNOT00000025408
SH3 domain containing ring finger 2
chr10_-_82229140 7.97 ENSRNOT00000004400
epsin 3
chr13_-_95348913 7.72 ENSRNOT00000057879
AKT serine/threonine kinase 3
chrX_+_110007214 7.67 ENSRNOT00000093539
Nik related kinase
chrX_+_105537602 7.60 ENSRNOT00000029833
armadillo repeat containing, X-linked 1
chr10_+_10889488 7.59 ENSRNOT00000071746
UBA-like domain containing 1
chr8_+_49342067 7.43 ENSRNOT00000021693
myelin protein zero-like 2
chr1_+_89202527 7.42 ENSRNOT00000028526
suprabasin
chr8_-_128665988 7.17 ENSRNOT00000050543
cysteine and serine rich nuclear protein 1
chr9_-_17206994 7.00 ENSRNOT00000026195
GTP binding protein 2
chrX_-_115073890 6.92 ENSRNOT00000006638
calpain 6
chr11_+_27364916 6.89 ENSRNOT00000002151
BTB domain and CNC homolog 1
chr1_+_267483145 6.88 ENSRNOT00000088962
SWI5-dependent homologous recombination repair protein 1
chr3_-_166994286 6.82 ENSRNOT00000081593
zinc finger protein 217
chr3_-_166993940 6.63 ENSRNOT00000034669
zinc finger protein 217
chr5_+_58636083 6.52 ENSRNOT00000067281
unc-13 homolog B
chr3_+_164665532 6.50 ENSRNOT00000014309
protein tyrosine phosphatase, non-receptor type 1
chr10_-_71382058 6.45 ENSRNOT00000043148
dual specificity phosphatase 14
chr1_+_220826560 6.45 ENSRNOT00000027891
FOS like 1, AP-1 transcription factor subunit
chr1_+_14224393 6.43 ENSRNOT00000016037
PERP, TP53 apoptosis effector
chr9_+_18564927 6.31 ENSRNOT00000061014
runt-related transcription factor 2
chr8_-_120446455 6.11 ENSRNOT00000085161
ENSRNOT00000042854
ENSRNOT00000037199
cAMP regulated phosphoprotein 21
chr11_+_87435185 5.97 ENSRNOT00000002558
purinergic receptor P2X 6
chr5_-_153924896 5.94 ENSRNOT00000065247
grainyhead-like transcription factor 3
chr2_+_198040536 5.89 ENSRNOT00000028744
acidic nuclear phosphoprotein 32 family member E
chr1_-_170318935 5.83 ENSRNOT00000024119
protein kinase C, delta binding protein
chr7_-_115963046 5.80 ENSRNOT00000007923
secreted Ly6/Plaur domain containing 1
chr13_-_83425641 5.76 ENSRNOT00000063870
T-box 19
chr10_-_35005287 5.73 ENSRNOT00000032386
nedd4 binding protein 3
chr6_+_42092467 5.47 ENSRNOT00000060499
E2F transcription factor 6
chr15_+_2733114 5.39 ENSRNOT00000074545
dual specificity protein phosphatase 13
chr13_+_92264231 5.30 ENSRNOT00000066509
ENSRNOT00000004716
spectrin, alpha, erythrocytic 1
chr16_-_2226121 5.28 ENSRNOT00000091513
sarcolemma associated protein
chr1_-_24191908 5.26 ENSRNOT00000061157
serum/glucocorticoid regulated kinase 1
chr4_+_129574264 5.05 ENSRNOT00000010185
ADP-ribosylation factor like GTPase 6 interacting protein 5
chr2_-_60657712 5.03 ENSRNOT00000040348
retinoic acid induced 14
chr5_+_161889342 4.88 ENSRNOT00000040481
ribosomal protein S20-like
chr7_+_11152038 4.88 ENSRNOT00000006168
nuclear factor I/C
chr20_+_6205903 4.79 ENSRNOT00000092333
ENSRNOT00000092655
potassium channel tetramerization domain containing 20
chr9_+_117737611 4.75 ENSRNOT00000022396
zinc finger protein 161
chr1_+_220428481 4.74 ENSRNOT00000027335
ras and Rab interactor 1
chr7_+_23854846 4.63 ENSRNOT00000037290
BPI fold containing family C
chr1_-_78180216 4.61 ENSRNOT00000071576
complement component 5a receptor 2
chr8_-_115179191 4.50 ENSRNOT00000017224
poly (ADP-ribose) polymerase family, member 3
chr10_-_37099004 4.46 ENSRNOT00000075465
Nedd4 binding protein 3
chr3_+_22964230 4.44 ENSRNOT00000041813
ribosomal protein S20-like
chr16_+_1749191 4.39 ENSRNOT00000014004
zinc finger, MIZ-type containing 1
chr1_+_87066289 4.35 ENSRNOT00000027645
calpain 12
chr1_+_84293102 4.22 ENSRNOT00000028468
SERTA domain containing 1
chr5_-_19559244 4.20 ENSRNOT00000014289
ENSRNOT00000089666
neutral sphingomyelinase activation associated factor
chr1_+_198199622 4.18 ENSRNOT00000026688
glycerophosphodiester phosphodiesterase domain containing 3
chr4_-_155401480 4.15 ENSRNOT00000020735
apolipoprotein B mRNA editing enzyme catalytic subunit 1
chr2_+_203200427 4.14 ENSRNOT00000020566
V-set domain containing T cell activation inhibitor 1
chr4_-_39102807 4.14 ENSRNOT00000052063
thrombospondin type 1 domain containing 7A
chrX_-_15627235 4.09 ENSRNOT00000013369
WD repeat domain 45
chr3_-_81911197 3.98 ENSRNOT00000066526
PR/SET domain 11
chr1_+_220335254 3.97 ENSRNOT00000072261
Ras and Rab interactor 1
chr19_+_55094585 3.81 ENSRNOT00000068452
zinc finger protein, multitype 1
chr4_+_9882904 3.79 ENSRNOT00000016909
DnaJ heat shock protein family (Hsp40) member C2
chr17_-_84488480 3.69 ENSRNOT00000000158
ENSRNOT00000075983
nebulette
chr18_+_27923572 3.65 ENSRNOT00000008041
catenin alpha 1
chr1_+_197999336 3.63 ENSRNOT00000023555
apolipoprotein B receptor
chr13_+_88606894 3.63 ENSRNOT00000048692
SH2 domain containing 1B
chr1_+_197999037 3.57 ENSRNOT00000091065
apolipoprotein B receptor
chr13_-_47440682 3.56 ENSRNOT00000037679
ENSRNOT00000005729
ENSRNOT00000050354
ENSRNOT00000050859
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
chrX_-_71127237 3.56 ENSRNOT00000076403
ENSRNOT00000076635
ENSRNOT00000068098
sorting nexin 12
chr1_+_137799185 3.53 ENSRNOT00000083590
ENSRNOT00000092778
ATP/GTP binding protein-like 1
chr8_+_43628182 3.47 ENSRNOT00000090359
olfactory receptor 1320
chr15_+_2526368 3.17 ENSRNOT00000048713
ENSRNOT00000074803
dual specificity phosphatase 13
dual specificity phosphatase 13
chr10_-_56491715 3.07 ENSRNOT00000020970
potassium channel tetramerization domain containing 11
chr6_-_99400822 3.03 ENSRNOT00000089594
zinc finger and BTB domain containing 25
chr3_+_113976687 2.97 ENSRNOT00000022437
eukaryotic translation initiation factor 3, subunit J
chr15_-_27968358 2.94 ENSRNOT00000040616
ribonuclease A family member 9
chr2_-_123972356 2.91 ENSRNOT00000023348
interleukin 21
chr3_-_164055561 2.90 ENSRNOT00000064849
beta-1,4-galactosyltransferase 5
chr20_+_5008508 2.84 ENSRNOT00000001153
von Willebrand factor A domain containing 7
chr12_+_16988136 2.81 ENSRNOT00000078925
ENSRNOT00000036744
MICAL-like 2
chr14_+_104250617 2.75 ENSRNOT00000079874
sprouty-related, EVH1 domain containing 2
chr10_+_104582955 2.74 ENSRNOT00000009733
unkempt family zinc finger
chr5_+_135687538 2.74 ENSRNOT00000091664

chr1_+_199941161 2.71 ENSRNOT00000027616
Bcl2-associated athanogene 3
chr20_-_3419831 2.69 ENSRNOT00000046798
mediator of DNA damage checkpoint 1
chr16_+_90325304 2.67 ENSRNOT00000057310
solute carrier family 10 member 2
chr8_-_85840818 2.57 ENSRNOT00000013608
eukaryotic translation elongation factor 1 alpha 1
chr11_-_24641820 2.48 ENSRNOT00000044081
ENSRNOT00000048854
amyloid beta precursor protein
chr13_+_51384389 2.46 ENSRNOT00000087025
lysine demethylase 5B
chr18_+_36596585 2.38 ENSRNOT00000036613
RNA binding motif protein 27
chr13_-_67206688 2.37 ENSRNOT00000003630
ENSRNOT00000090693
phospholipase A2 group IVA
chr2_+_188748359 2.28 ENSRNOT00000028038
SHC adaptor protein 1
chr7_-_2712723 2.21 ENSRNOT00000004363
interleukin 23 subunit alpha
chr7_+_99954492 2.02 ENSRNOT00000005885
tribbles pseudokinase 1
chr7_+_3332788 1.97 ENSRNOT00000010180
Cd63 molecule
chrX_+_69730242 1.96 ENSRNOT00000075980
ENSRNOT00000076425
ectodysplasin-A
chr9_+_20951260 1.95 ENSRNOT00000016906
adhesion G protein-coupled receptor F4
chr6_-_107678156 1.87 ENSRNOT00000014158
ELM2 and Myb/SANT domain containing 1
chr4_-_99546905 1.82 ENSRNOT00000077447
lysine demethylase 3A
chr3_+_8643936 1.60 ENSRNOT00000077797
SET nuclear proto-oncogene
chr3_+_1452644 1.54 ENSRNOT00000007949
interleukin 1 receptor antagonist
chr10_-_90312386 1.41 ENSRNOT00000028445
solute carrier family 4 member 1
chr7_+_143122269 1.38 ENSRNOT00000082542
ENSRNOT00000045495
ENSRNOT00000081386
ENSRNOT00000067422
keratin 86
chr4_+_7314369 1.28 ENSRNOT00000029724
autophagy related 9B
chr1_+_240908483 1.26 ENSRNOT00000019367
Kruppel-like factor 9

Network of associatons between targets according to the STRING database.

First level regulatory network of Fos

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
14.9 74.4 GO:0014722 regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722)
12.9 38.6 GO:1904178 sterol regulatory element binding protein import into nucleus(GO:0035105) negative regulation of adipose tissue development(GO:1904178)
9.0 27.0 GO:0072642 type I interferon secretion(GO:0072641) interferon-alpha secretion(GO:0072642) regulation of interferon-alpha secretion(GO:1902739) positive regulation of interferon-alpha secretion(GO:1902741)
8.2 32.7 GO:1900623 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
7.7 23.1 GO:0002780 antimicrobial peptide biosynthetic process(GO:0002777) antibacterial peptide biosynthetic process(GO:0002780)
7.7 23.1 GO:0071613 granzyme B production(GO:0071613) regulation of granzyme B production(GO:0071661) positive regulation of granzyme B production(GO:0071663)
7.5 37.5 GO:0050828 regulation of liquid surface tension(GO:0050828)
7.5 22.4 GO:0002541 activation of plasma proteins involved in acute inflammatory response(GO:0002541)
7.1 28.5 GO:1903575 cornified envelope assembly(GO:1903575)
6.7 139.9 GO:0070831 basement membrane assembly(GO:0070831)
6.4 25.6 GO:2000525 regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
5.9 17.8 GO:0061470 T follicular helper cell differentiation(GO:0061470)
5.6 16.8 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
5.5 32.8 GO:0045110 intermediate filament bundle assembly(GO:0045110)
5.2 15.5 GO:0003430 growth plate cartilage chondrocyte growth(GO:0003430)
5.1 15.4 GO:2000645 negative regulation of receptor catabolic process(GO:2000645)
4.5 13.5 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
4.4 43.7 GO:0050862 positive regulation of T cell receptor signaling pathway(GO:0050862)
4.2 29.3 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
3.6 10.9 GO:1903233 positive regulation of endoplasmic reticulum calcium ion concentration(GO:0032470) regulation of calcium ion-dependent exocytosis of neurotransmitter(GO:1903233) calcium ion import into sarcoplasmic reticulum(GO:1990036)
3.6 10.8 GO:2000872 positive regulation of progesterone secretion(GO:2000872)
3.4 17.1 GO:0036414 protein citrullination(GO:0018101) histone citrullination(GO:0036414)
3.1 66.0 GO:0031424 keratinization(GO:0031424)
3.1 55.7 GO:0032060 bleb assembly(GO:0032060)
3.1 9.2 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314)
3.0 8.9 GO:0021817 nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration(GO:0021817) nuclear migration along microtubule(GO:0030473) nuclear matrix anchoring at nuclear membrane(GO:0090292)
2.7 10.8 GO:0007296 vitellogenesis(GO:0007296)
2.7 18.9 GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity(GO:0060315)
2.6 10.6 GO:0038086 cell migration involved in vasculogenesis(GO:0035441) VEGF-activated platelet-derived growth factor receptor signaling pathway(GO:0038086) positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway(GO:0038091) metanephric glomerulus morphogenesis(GO:0072275) metanephric glomerulus vasculature morphogenesis(GO:0072276) metanephric glomerular capillary formation(GO:0072277)
2.6 15.5 GO:2000483 negative regulation of interleukin-8 secretion(GO:2000483)
2.2 8.6 GO:0042339 keratan sulfate metabolic process(GO:0042339)
2.0 16.0 GO:0042904 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
2.0 23.7 GO:0031272 regulation of pseudopodium assembly(GO:0031272)
1.8 17.7 GO:0071985 multivesicular body sorting pathway(GO:0071985)
1.7 8.4 GO:0019371 cyclooxygenase pathway(GO:0019371)
1.7 28.1 GO:0031581 hemidesmosome assembly(GO:0031581)
1.6 6.5 GO:1903898 regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202) negative regulation of PERK-mediated unfolded protein response(GO:1903898)
1.5 4.6 GO:0071623 negative regulation of granulocyte chemotaxis(GO:0071623) negative regulation of neutrophil chemotaxis(GO:0090024)
1.5 10.7 GO:0042940 D-amino acid transport(GO:0042940)
1.5 4.5 GO:1990166 protein localization to site of double-strand break(GO:1990166)
1.4 8.6 GO:0086047 membrane depolarization during Purkinje myocyte cell action potential(GO:0086047) membrane depolarization during bundle of His cell action potential(GO:0086048) membrane depolarization during atrial cardiac muscle cell action potential(GO:0098912)
1.4 7.0 GO:0072344 rescue of stalled ribosome(GO:0072344)
1.4 4.1 GO:0090310 negative regulation of methylation-dependent chromatin silencing(GO:0090310)
1.3 18.8 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
1.3 3.8 GO:0071733 mitral valve formation(GO:0003192) transcriptional activation by promoter-enhancer looping(GO:0071733) gene looping(GO:0090202) dsDNA loop formation(GO:0090579)
1.3 5.0 GO:0002036 regulation of L-glutamate transport(GO:0002036)
1.2 27.4 GO:0070208 protein heterotrimerization(GO:0070208)
1.2 3.7 GO:0071691 cardiac muscle thin filament assembly(GO:0071691)
1.2 20.7 GO:0000185 activation of MAPKKK activity(GO:0000185)
1.2 3.6 GO:2001045 negative regulation of integrin-mediated signaling pathway(GO:2001045)
1.1 2.2 GO:0043382 positive regulation of memory T cell differentiation(GO:0043382)
1.1 5.3 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
1.1 6.3 GO:0002051 osteoblast fate commitment(GO:0002051)
1.0 14.6 GO:0016540 protein autoprocessing(GO:0016540)
1.0 8.3 GO:0051694 pointed-end actin filament capping(GO:0051694)
1.0 10.5 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.9 25.4 GO:0031954 positive regulation of protein autophosphorylation(GO:0031954)
0.9 19.7 GO:0035855 megakaryocyte development(GO:0035855)
0.9 54.4 GO:0030239 myofibril assembly(GO:0030239)
0.9 5.3 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.8 12.4 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.8 2.3 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.7 14.6 GO:0061436 establishment of skin barrier(GO:0061436)
0.7 10.2 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.7 6.4 GO:0002934 desmosome organization(GO:0002934)
0.7 3.6 GO:1903336 negative regulation of vacuolar transport(GO:1903336)
0.7 7.1 GO:0010839 negative regulation of keratinocyte proliferation(GO:0010839)
0.7 4.1 GO:0072602 interleukin-4 secretion(GO:0072602)
0.7 2.0 GO:0061153 trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
0.7 68.3 GO:0007229 integrin-mediated signaling pathway(GO:0007229)
0.6 9.5 GO:0014010 Schwann cell proliferation(GO:0014010)
0.6 7.7 GO:0007256 activation of JNKK activity(GO:0007256)
0.6 3.5 GO:0035609 C-terminal protein deglutamylation(GO:0035609)
0.5 10.9 GO:0060707 trophoblast giant cell differentiation(GO:0060707)
0.5 26.4 GO:2000649 regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.5 2.0 GO:0045658 regulation of neutrophil differentiation(GO:0045658)
0.5 2.5 GO:0051124 synaptic growth at neuromuscular junction(GO:0051124)
0.5 2.9 GO:0002729 positive regulation of natural killer cell cytokine production(GO:0002729)
0.5 2.4 GO:2001280 positive regulation of prostaglandin biosynthetic process(GO:0031394) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.4 3.6 GO:0033133 positive regulation of glucokinase activity(GO:0033133) positive regulation of hexokinase activity(GO:1903301)
0.4 7.7 GO:0010765 positive regulation of sodium ion transport(GO:0010765)
0.4 18.3 GO:0070527 platelet aggregation(GO:0070527)
0.4 11.1 GO:0006376 mRNA splice site selection(GO:0006376)
0.4 14.0 GO:0030728 ovulation(GO:0030728)
0.4 15.7 GO:0045103 intermediate filament-based process(GO:0045103)
0.3 1.4 GO:0035937 estrogen secretion(GO:0035937) estradiol secretion(GO:0035938) regulation of estrogen secretion(GO:2000861) regulation of estradiol secretion(GO:2000864)
0.3 1.3 GO:1902534 single-organism membrane invagination(GO:1902534)
0.3 1.2 GO:0000414 regulation of histone H3-K36 methylation(GO:0000414)
0.3 5.9 GO:0043486 histone exchange(GO:0043486)
0.3 1.8 GO:0046292 formaldehyde metabolic process(GO:0046292)
0.3 0.6 GO:0072126 positive regulation of glomerular mesangial cell proliferation(GO:0072126)
0.3 1.4 GO:0010037 response to carbon dioxide(GO:0010037)
0.3 9.0 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.3 1.1 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
0.3 19.5 GO:0030216 keratinocyte differentiation(GO:0030216)
0.3 9.6 GO:0006730 one-carbon metabolic process(GO:0006730)
0.3 12.9 GO:0007588 excretion(GO:0007588)
0.2 8.5 GO:0034629 cellular protein complex localization(GO:0034629)
0.2 17.9 GO:0030279 negative regulation of ossification(GO:0030279)
0.2 6.0 GO:0033198 response to ATP(GO:0033198)
0.2 7.2 GO:0060325 face morphogenesis(GO:0060325)
0.2 3.1 GO:0007406 negative regulation of neuroblast proliferation(GO:0007406)
0.2 2.7 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.2 34.6 GO:0007519 skeletal muscle tissue development(GO:0007519)
0.2 1.2 GO:0038203 TORC2 signaling(GO:0038203)
0.2 9.2 GO:0060612 adipose tissue development(GO:0060612)
0.2 5.3 GO:0006779 porphyrin-containing compound biosynthetic process(GO:0006779)
0.2 2.7 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.2 4.8 GO:0003170 heart valve development(GO:0003170)
0.2 5.8 GO:0021983 pituitary gland development(GO:0021983)
0.1 0.4 GO:2000015 regulation of determination of dorsal identity(GO:2000015)
0.1 0.4 GO:1903660 vacuolar transmembrane transport(GO:0034486) chaperone-mediated protein transport involved in chaperone-mediated autophagy(GO:0061741) negative regulation of complement-dependent cytotoxicity(GO:1903660)
0.1 2.6 GO:1903427 negative regulation of reactive oxygen species biosynthetic process(GO:1903427)
0.1 2.7 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.1 1.2 GO:0007614 short-term memory(GO:0007614)
0.1 6.9 GO:0071391 cellular response to estrogen stimulus(GO:0071391)
0.1 7.4 GO:0071594 T cell differentiation in thymus(GO:0033077) thymocyte aggregation(GO:0071594)
0.1 0.4 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.1 3.8 GO:2000279 negative regulation of DNA biosynthetic process(GO:2000279)
0.1 10.4 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.1 2.8 GO:0070830 bicellular tight junction assembly(GO:0070830)
0.1 2.3 GO:0045907 positive regulation of vasoconstriction(GO:0045907)
0.1 4.9 GO:0042475 odontogenesis of dentin-containing tooth(GO:0042475)
0.1 9.6 GO:0008360 regulation of cell shape(GO:0008360)
0.1 6.9 GO:0001578 microtubule bundle formation(GO:0001578)
0.1 4.2 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.1 0.4 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
0.0 1.2 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.0 0.4 GO:0032825 positive regulation of natural killer cell differentiation(GO:0032825)
0.0 9.9 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.0 6.1 GO:2001236 regulation of extrinsic apoptotic signaling pathway(GO:2001236)
0.0 0.8 GO:2000272 negative regulation of receptor activity(GO:2000272)
0.0 1.5 GO:0034605 cellular response to heat(GO:0034605)
0.0 7.2 GO:0006898 receptor-mediated endocytosis(GO:0006898)
0.0 4.0 GO:0009952 anterior/posterior pattern specification(GO:0009952)
0.0 0.3 GO:0030225 macrophage differentiation(GO:0030225)
0.0 4.1 GO:0090305 nucleic acid phosphodiester bond hydrolysis(GO:0090305)
0.0 1.6 GO:0043524 negative regulation of neuron apoptotic process(GO:0043524)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
38.4 153.4 GO:0005607 laminin-2 complex(GO:0005607)
10.9 32.7 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
4.8 38.6 GO:0005638 lamin filament(GO:0005638)
4.7 28.1 GO:0005610 laminin-5 complex(GO:0005610)
3.6 10.9 GO:0014801 longitudinal sarcoplasmic reticulum(GO:0014801) calcium ion-transporting ATPase complex(GO:0090534)
3.3 19.7 GO:0032585 multivesicular body membrane(GO:0032585)
2.9 38.3 GO:0031143 pseudopodium(GO:0031143)
2.7 22.0 GO:0035749 myelin sheath adaxonal region(GO:0035749)
2.3 6.9 GO:0032798 Swi5-Sfr1 complex(GO:0032798)
2.1 57.5 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
1.4 60.5 GO:0043034 costamere(GO:0043034)
1.3 8.9 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
1.2 8.5 GO:0005827 polar microtubule(GO:0005827)
1.1 18.8 GO:0035686 sperm fibrous sheath(GO:0035686)
1.1 37.5 GO:0005771 multivesicular body(GO:0005771)
1.0 74.2 GO:0045095 keratin filament(GO:0045095)
0.9 5.3 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.9 24.0 GO:0042629 mast cell granule(GO:0042629)
0.8 28.8 GO:0008305 integrin complex(GO:0008305)
0.8 6.5 GO:0044305 calyx of Held(GO:0044305)
0.8 6.5 GO:0097443 sorting endosome(GO:0097443)
0.8 10.6 GO:0043202 lysosomal lumen(GO:0043202)
0.7 37.1 GO:0034707 chloride channel complex(GO:0034707)
0.6 2.5 GO:1990761 growth cone lamellipodium(GO:1990761) growth cone filopodium(GO:1990812)
0.5 70.8 GO:0030018 Z disc(GO:0030018)
0.5 11.5 GO:0001533 cornified envelope(GO:0001533)
0.5 5.9 GO:0000812 Swr1 complex(GO:0000812)
0.5 10.2 GO:0010369 chromocenter(GO:0010369)
0.4 8.7 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.4 3.6 GO:0005915 zonula adherens(GO:0005915)
0.4 10.6 GO:0035371 microtubule plus-end(GO:0035371)
0.4 36.8 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.4 6.0 GO:0005639 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.3 13.9 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.3 8.3 GO:0005865 striated muscle thin filament(GO:0005865)
0.3 16.8 GO:0015030 Cajal body(GO:0015030)
0.3 16.8 GO:0097517 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.2 13.4 GO:0000118 histone deacetylase complex(GO:0000118)
0.2 0.7 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.2 28.3 GO:0042383 sarcolemma(GO:0042383)
0.2 15.5 GO:0043198 dendritic shaft(GO:0043198)
0.2 5.5 GO:0044665 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.2 4.6 GO:0009925 basal plasma membrane(GO:0009925)
0.2 48.1 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 2.8 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.1 0.4 GO:0036488 CHOP-C/EBP complex(GO:0036488) CHOP-ATF3 complex(GO:1990622)
0.1 8.3 GO:0005905 clathrin-coated pit(GO:0005905)
0.1 6.9 GO:0005876 spindle microtubule(GO:0005876)
0.1 1.2 GO:0044666 MLL3/4 complex(GO:0044666)
0.1 4.5 GO:0035861 site of double-strand break(GO:0035861)
0.1 2.4 GO:0042588 zymogen granule(GO:0042588)
0.1 32.2 GO:0016324 apical plasma membrane(GO:0016324)
0.1 10.8 GO:0005604 basement membrane(GO:0005604)
0.1 5.0 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 0.9 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.1 24.4 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 1.2 GO:0031932 TORC2 complex(GO:0031932)
0.1 11.7 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 6.4 GO:0042734 presynaptic membrane(GO:0042734)
0.1 9.0 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.1 15.5 GO:0031965 nuclear membrane(GO:0031965)
0.1 2.6 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.1 2.7 GO:0005844 polysome(GO:0005844)
0.1 1.3 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.1 30.7 GO:0016604 nuclear body(GO:0016604)
0.1 7.4 GO:0031012 extracellular matrix(GO:0031012)
0.0 12.1 GO:0005667 transcription factor complex(GO:0005667)
0.0 5.3 GO:0008021 synaptic vesicle(GO:0008021)
0.0 4.0 GO:0001650 fibrillar center(GO:0001650)
0.0 2.0 GO:0045177 apical part of cell(GO:0045177)
0.0 1.2 GO:0000776 kinetochore(GO:0000776)
0.0 0.1 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
6.6 32.8 GO:1990254 keratin filament binding(GO:1990254)
6.2 43.7 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
4.9 24.4 GO:0051373 FATZ binding(GO:0051373)
4.4 22.0 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
4.3 17.1 GO:0034618 arginine binding(GO:0034618)
4.1 24.7 GO:0042289 MHC class II protein binding(GO:0042289)
3.7 11.1 GO:0001069 regulatory region RNA binding(GO:0001069)
3.5 10.6 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
3.4 26.9 GO:0045545 syndecan binding(GO:0045545)
3.4 16.8 GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
3.3 32.7 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
2.8 8.4 GO:0008481 sphinganine kinase activity(GO:0008481)
2.7 27.4 GO:0048407 platelet-derived growth factor binding(GO:0048407)
2.7 18.8 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
2.6 25.6 GO:0019957 C-C chemokine binding(GO:0019957)
2.3 16.0 GO:0047035 testosterone dehydrogenase (NAD+) activity(GO:0047035)
2.0 5.9 GO:0019212 phosphatase inhibitor activity(GO:0019212)
1.9 30.0 GO:0051371 muscle alpha-actinin binding(GO:0051371)
1.7 8.6 GO:0086062 voltage-gated sodium channel activity involved in Purkinje myocyte action potential(GO:0086062)
1.7 46.6 GO:0008157 protein phosphatase 1 binding(GO:0008157)
1.5 4.6 GO:0001847 opsonin receptor activity(GO:0001847)
1.5 37.5 GO:0001530 lipopolysaccharide binding(GO:0001530)
1.5 13.5 GO:0043208 glycosphingolipid binding(GO:0043208)
1.4 7.2 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)
1.4 8.6 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
1.4 4.2 GO:0016230 sphingomyelin phosphodiesterase activator activity(GO:0016230)
1.3 25.9 GO:0005521 lamin binding(GO:0005521)
1.3 15.5 GO:0003708 retinoic acid receptor activity(GO:0003708)
1.2 29.3 GO:0051428 peptide hormone receptor binding(GO:0051428)
1.0 166.7 GO:0008201 heparin binding(GO:0008201)
1.0 18.3 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.9 24.0 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.9 23.1 GO:0042288 MHC class I protein binding(GO:0042288)
0.9 2.7 GO:1990715 mRNA CDS binding(GO:1990715)
0.9 58.6 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.9 6.0 GO:0004931 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.8 10.9 GO:0044548 S100 protein binding(GO:0044548)
0.8 5.3 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.8 12.0 GO:0005523 tropomyosin binding(GO:0005523)
0.7 9.6 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.7 18.4 GO:0005540 hyaluronic acid binding(GO:0005540)
0.7 2.9 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.7 6.5 GO:0019992 diacylglycerol binding(GO:0019992)
0.7 17.7 GO:0031489 myosin V binding(GO:0031489)
0.7 4.1 GO:0004126 cytidine deaminase activity(GO:0004126)
0.7 12.2 GO:0031996 thioesterase binding(GO:0031996)
0.6 13.7 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.6 2.3 GO:0048408 epidermal growth factor binding(GO:0048408)
0.6 15.5 GO:0003785 actin monomer binding(GO:0003785)
0.5 19.6 GO:0050681 androgen receptor binding(GO:0050681)
0.5 4.5 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.5 6.9 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.5 18.9 GO:0004364 glutathione transferase activity(GO:0004364)
0.4 2.7 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.4 16.6 GO:0017080 sodium channel regulator activity(GO:0017080)
0.4 6.4 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.4 2.7 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.4 15.5 GO:0017022 myosin binding(GO:0017022)
0.3 6.6 GO:0004622 lysophospholipase activity(GO:0004622)
0.3 10.8 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.3 3.6 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873) fructose-2,6-bisphosphate 2-phosphatase activity(GO:0004331)
0.3 50.0 GO:0051015 actin filament binding(GO:0051015)
0.3 6.5 GO:0046875 ephrin receptor binding(GO:0046875)
0.2 22.4 GO:0004896 cytokine receptor activity(GO:0004896)
0.2 21.4 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.2 15.6 GO:0005518 collagen binding(GO:0005518)
0.2 13.1 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.2 1.4 GO:0034647 histone demethylase activity (H3-trimethyl-K4 specific)(GO:0034647) histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)
0.2 1.5 GO:0019966 interleukin-1 binding(GO:0019966)
0.2 6.3 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.2 0.7 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.2 6.9 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.1 11.6 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.1 3.5 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 17.3 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 0.4 GO:0002134 UTP binding(GO:0002134) sulfonylurea receptor binding(GO:0017098) pyrimidine ribonucleoside binding(GO:0032551)
0.1 2.6 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 2.0 GO:0055103 ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.1 0.4 GO:0004082 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.1 2.0 GO:0048018 receptor agonist activity(GO:0048018)
0.1 4.2 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.1 9.2 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 5.9 GO:0031490 chromatin DNA binding(GO:0031490)
0.1 3.8 GO:0030544 Hsp70 protein binding(GO:0030544)
0.1 2.7 GO:0030291 protein serine/threonine kinase inhibitor activity(GO:0030291)
0.1 1.4 GO:0030506 ankyrin binding(GO:0030506)
0.1 0.6 GO:0004875 complement receptor activity(GO:0004875)
0.1 38.2 GO:0005198 structural molecule activity(GO:0005198)
0.1 0.4 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 0.8 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.0 3.0 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 10.8 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 10.4 GO:0003924 GTPase activity(GO:0003924)
0.0 0.4 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.0 7.7 GO:0008022 protein C-terminus binding(GO:0008022)
0.0 3.4 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 7.7 GO:0042277 peptide binding(GO:0042277)
0.0 1.1 GO:0005080 protein kinase C binding(GO:0005080)
0.0 2.9 GO:0004540 ribonuclease activity(GO:0004540)
0.0 2.2 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 12.0 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
10.7 181.5 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
1.8 32.7 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
1.7 24.0 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
1.1 28.8 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
1.0 61.6 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
1.0 44.8 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.9 10.7 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.9 13.0 PID HIV NEF PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.8 21.4 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.8 19.0 PID S1P S1P1 PATHWAY S1P1 pathway
0.8 42.4 PID HNF3A PATHWAY FOXA1 transcription factor network
0.8 20.7 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.8 49.8 PID AR PATHWAY Coregulation of Androgen receptor activity
0.7 10.0 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.6 36.7 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.6 17.9 PID WNT SIGNALING PATHWAY Wnt signaling network
0.6 15.5 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.5 9.2 ST G ALPHA S PATHWAY G alpha s Pathway
0.5 13.9 PID CONE PATHWAY Visual signal transduction: Cones
0.3 6.5 PID IGF1 PATHWAY IGF1 pathway
0.3 14.6 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.3 7.8 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.2 7.6 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.2 14.8 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.2 9.2 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.2 4.2 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.2 12.2 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.2 6.3 PID FGF PATHWAY FGF signaling pathway
0.2 4.0 PID RAS PATHWAY Regulation of Ras family activation
0.1 22.0 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 20.4 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 2.4 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.1 2.2 PID IL23 PATHWAY IL23-mediated signaling events
0.1 1.4 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.1 2.3 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1 2.7 PID ATM PATHWAY ATM pathway
0.1 3.8 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.1 11.5 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 1.1 PID TNF PATHWAY TNF receptor signaling pathway
0.0 1.2 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 0.4 PID ARF 3PATHWAY Arf1 pathway
0.0 0.4 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 0.4 PID ATF2 PATHWAY ATF-2 transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 32.7 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
1.8 180.4 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization
1.0 7.7 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
1.0 24.0 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.8 37.9 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.7 22.4 REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE Genes involved in Formation of Fibrin Clot (Clotting Cascade)
0.6 27.4 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.6 44.4 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.6 13.9 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta
0.5 20.6 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.5 25.6 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.4 10.9 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.4 13.9 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.4 17.0 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.4 43.7 REACTOME POTASSIUM CHANNELS Genes involved in Potassium Channels
0.3 2.4 REACTOME ADP SIGNALLING THROUGH P2RY1 Genes involved in ADP signalling through P2Y purinoceptor 1
0.3 16.8 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.3 6.5 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.3 8.4 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.2 2.9 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.2 6.3 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.2 2.7 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.1 7.7 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.1 0.7 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.1 10.6 REACTOME DOWNSTREAM SIGNAL TRANSDUCTION Genes involved in Downstream signal transduction
0.1 2.7 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.1 9.6 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.1 1.5 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.1 5.9 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 9.6 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.0 2.6 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 0.4 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 2.6 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 4.1 REACTOME MRNA PROCESSING Genes involved in mRNA Processing