ISMARA results: Esrrb

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Esrrb_Esrra

Z-value: 3.14

Motif logo

Transcription factors associated with Esrrb_Esrra

Gene Symbol	Gene ID	Gene Info
Esrrb NCBI RGD Ensembl	ENSRNOG00000010259	estrogen-related receptor beta
Esrra NCBI RGD Ensembl	ENSRNOG00000021139	estrogen related receptor, alpha

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Esrra	rn6_v1_chr1_-_222177421_222177421	0.82	3.1e-78	Click!
Esrrb	rn6_v1_chr6_+_110410141_110410141	0.56	1.9e-27	Click!

Activity profile of Esrrb_Esrra motif

Sorted Z-values of Esrrb_Esrra motif

Top targets:

Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr9_+_82741920 Show fit	189.57	ENSRNOT00000027337	Slc4a3 NCBI RGD Ensembl Show fit	solute carrier family 4 member 3
chr15_+_33606124 Show fit	187.87	ENSRNOT00000065210	AC115371.1 NCBI RGD Ensembl Show fit
chr8_-_130429132 Show fit	185.75	ENSRNOT00000026261	Hhatl NCBI RGD Ensembl Show fit	hedgehog acyltransferase-like
chr1_-_263269762 Show fit	184.27	ENSRNOT00000022309	Got1 NCBI RGD Ensembl Show fit	glutamic-oxaloacetic transaminase 1
chr7_-_80796670 Show fit	177.78	ENSRNOT00000010539	Abra NCBI RGD Ensembl Show fit	actin-binding Rho activating protein
chr1_-_104157855 Show fit	149.27	ENSRNOT00000019311	Csrp3 NCBI RGD Ensembl Show fit	cysteine and glycine rich protein 3
chr7_+_123102493 Show fit	145.92	ENSRNOT00000038612	Aco2 NCBI RGD Ensembl Show fit	aconitase 2
chr13_+_52625441 Show fit	135.58	ENSRNOT00000012095	Tnni1 NCBI RGD Ensembl Show fit	troponin I1, slow skeletal type
chr13_-_85622314 Show fit	120.58	ENSRNOT00000005719	Mgst3 NCBI RGD Ensembl Show fit	microsomal glutathione S-transferase 3
chr4_-_157679962 Show fit	119.03	ENSRNOT00000050443	Gapdh NCBI RGD Ensembl Show fit	glyceraldehyde-3-phosphate dehydrogenase
chr17_-_66397653 Show fit	109.67	ENSRNOT00000024098	Actn2 NCBI RGD Ensembl Show fit	actinin alpha 2
chr8_-_128711221 Show fit	108.26	ENSRNOT00000055888	Xirp1 NCBI RGD Ensembl Show fit	xin actin-binding repeat containing 1
chr16_-_10941414 Show fit	107.09	ENSRNOT00000086627 ENSRNOT00000085414 ENSRNOT00000081631 ENSRNOT00000087521 ENSRNOT00000083623	Ldb3 NCBI RGD Ensembl Show fit	LIM domain binding 3
chrX_-_40086870 Show fit	92.35	ENSRNOT00000010027	Smpx NCBI RGD Ensembl Show fit	small muscle protein, X-linked
chr3_+_132052612 Show fit	92.03	ENSRNOT00000030148	AABR07053879.1 NCBI RGD Ensembl Show fit
chr10_+_27973681 Show fit	91.20	ENSRNOT00000004970	Gabrb2 NCBI RGD Ensembl Show fit	gamma-aminobutyric acid type A receptor beta 2 subunit
chr3_-_60813869 Show fit	90.62	ENSRNOT00000058234	Atp5g3 NCBI RGD Ensembl Show fit	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)
chr18_+_74156553 Show fit	90.30	ENSRNOT00000022892	Atp5a1 NCBI RGD Ensembl Show fit	ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
chr4_-_157331905 Show fit	89.24	ENSRNOT00000020647	Tpi1 NCBI RGD Ensembl Show fit	triosephosphate isomerase 1
chr5_+_118743632 Show fit	88.71	ENSRNOT00000013785	Pgm1 NCBI RGD Ensembl Show fit	phosphoglucomutase 1
chr9_+_20213776 Show fit	87.84	ENSRNOT00000071439	LOC100911515 NCBI RGD Ensembl Show fit	triosephosphate isomerase-like
chr1_+_72882806 Show fit	86.33	ENSRNOT00000024640	Tnni3 NCBI RGD Ensembl Show fit	troponin I3, cardiac type
chr19_-_10596851 Show fit	86.17	ENSRNOT00000021716	Coq9 NCBI RGD Ensembl Show fit	coenzyme Q9
chr3_+_113257688 Show fit	85.76	ENSRNOT00000019320	Map1a NCBI RGD Ensembl Show fit	microtubule-associated protein 1A
chr18_+_73564247 Show fit	85.18	ENSRNOT00000077679 ENSRNOT00000035317	St8sia5 NCBI RGD Ensembl Show fit	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5
chr14_-_83741969 Show fit	84.09	ENSRNOT00000026293	Inpp5j NCBI RGD Ensembl Show fit	inositol polyphosphate-5-phosphatase J
chr10_-_15235740 Show fit	83.42	ENSRNOT00000027170	Mcrip2 NCBI RGD Ensembl Show fit	MAPK regulated co-repressor interacting protein 2
chr1_+_31545631 Show fit	82.50	ENSRNOT00000018336	Sdha NCBI RGD Ensembl Show fit	succinate dehydrogenase complex flavoprotein subunit A
chr9_+_43259709 Show fit	82.44	ENSRNOT00000022487	Cox5b NCBI RGD Ensembl Show fit	cytochrome c oxidase subunit 5B
chr8_+_116094851 Show fit	82.20	ENSRNOT00000084120	RGD1307461 NCBI RGD Ensembl Show fit	similar to RIKEN cDNA 6430571L13 gene; similar to g20 protein
chr11_-_32088002 Show fit	80.93	ENSRNOT00000002732	Atp5o NCBI RGD Ensembl Show fit	ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit
chr4_+_51614676 Show fit	78.11	ENSRNOT00000060494	Asb15 NCBI RGD Ensembl Show fit	ankyrin repeat and SOCS box containing 15
chr7_+_35125424 Show fit	77.84	ENSRNOT00000085978 ENSRNOT00000010117	Ndufa12 NCBI RGD Ensembl Show fit	NADH:ubiquinone oxidoreductase subunit A12
chr6_-_75763185 Show fit	77.56	ENSRNOT00000072589	Cfl2 NCBI RGD Ensembl Show fit	cofilin 2
chr5_+_173640780 Show fit	77.50	ENSRNOT00000027476	Perm1 NCBI RGD Ensembl Show fit	PPARGC1 and ESRR induced regulator, muscle 1
chr8_+_55037750 Show fit	75.70	ENSRNOT00000013188	Timm8b NCBI RGD Ensembl Show fit	translocase of inner mitochondrial membrane 8 homolog B
chr2_+_119139717 Show fit	75.67	ENSRNOT00000016051	Ndufb5 NCBI RGD Ensembl Show fit	NADH:ubiquinone oxidoreductase subunit B5
chr8_+_59164572 Show fit	74.61	ENSRNOT00000015102	Idh3a NCBI RGD Ensembl Show fit	isocitrate dehydrogenase 3 (NAD+) alpha
chr10_-_102289837 Show fit	73.22	ENSRNOT00000044922	AABR07030729.1 NCBI RGD Ensembl Show fit
chr1_+_37507276 Show fit	72.82	ENSRNOT00000047627	Adcy2 NCBI RGD Ensembl Show fit	adenylate cyclase 2
chr4_-_176720012 Show fit	70.99	ENSRNOT00000017965	Ldhb NCBI RGD Ensembl Show fit	lactate dehydrogenase B
chr7_+_117409576 Show fit	70.99	ENSRNOT00000017067	Cyc1 NCBI RGD Ensembl Show fit	cytochrome c-1
chr2_-_14701903 Show fit	70.95	ENSRNOT00000051895	Cox7c NCBI RGD Ensembl Show fit	cytochrome c oxidase subunit 7C
chr12_-_30566032 Show fit	70.08	ENSRNOT00000093378	Gbas NCBI RGD Ensembl Show fit	glioblastoma amplified sequence
chr12_-_24365324 Show fit	69.89	ENSRNOT00000032250	Trim50 NCBI RGD Ensembl Show fit	tripartite motif-containing 50
chr4_-_41212072 Show fit	69.54	ENSRNOT00000085596	Ppp1r3a NCBI RGD Ensembl Show fit	protein phosphatase 1, regulatory subunit 3A
chr1_+_190555177 Show fit	68.84	ENSRNOT00000021514	Uqcrc2 NCBI RGD Ensembl Show fit	ubiquinol cytochrome c reductase core protein 2
chr10_-_109729019 Show fit	68.37	ENSRNOT00000054959	Ppp1r27 NCBI RGD Ensembl Show fit	protein phosphatase 1, regulatory subunit 27
chr3_+_55910177 Show fit	67.21	ENSRNOT00000009969	Klhl41 NCBI RGD Ensembl Show fit	kelch-like family member 41
chr1_+_224882439 Show fit	67.20	ENSRNOT00000024785	Chrm1 NCBI RGD Ensembl Show fit	cholinergic receptor, muscarinic 1
chr14_+_60764409 Show fit	67.03	ENSRNOT00000005168	Lgi2 NCBI RGD Ensembl Show fit	leucine-rich repeat LGI family, member 2
chr7_+_2504695 Show fit	66.24	ENSRNOT00000003965	Atp5b NCBI RGD Ensembl Show fit	ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
chr3_-_163935617 Show fit	65.86	ENSRNOT00000074023	Kcnb1 NCBI RGD Ensembl Show fit	potassium voltage-gated channel subfamily B member 1
chrX_+_63542191 Show fit	64.54	ENSRNOT00000073955	Apoo NCBI RGD Ensembl Show fit	apolipoprotein O
chr4_-_123494742 Show fit	64.23	ENSRNOT00000073268	Slc41a3 NCBI RGD Ensembl Show fit	solute carrier family 41, member 3
chr8_+_59900651 Show fit	64.22	ENSRNOT00000020410	Tmem266 NCBI RGD Ensembl Show fit	transmembrane protein 266
chr8_-_84506328 Show fit	62.57	ENSRNOT00000064754	Mlip NCBI RGD Ensembl Show fit	muscular LMNA-interacting protein
chr2_-_119140110 Show fit	61.83	ENSRNOT00000058810	AABR07009978.1 NCBI RGD Ensembl Show fit
chr14_-_84334066 Show fit	61.71	ENSRNOT00000006160	Mtfp1 NCBI RGD Ensembl Show fit	mitochondrial fission process 1
chr10_-_62698541 Show fit	61.70	ENSRNOT00000019759	Coro6 NCBI RGD Ensembl Show fit	coronin 6
chr1_-_219144610 Show fit	60.88	ENSRNOT00000023526	Ndufs8 NCBI RGD Ensembl Show fit	NADH:ubiquinone oxidoreductase core subunit S8
chr15_-_33656089 Show fit	60.84	ENSRNOT00000024186	Myh7 NCBI RGD Ensembl Show fit	myosin heavy chain 7
chr11_-_72109964 Show fit	60.25	ENSRNOT00000058917	AABR07034445.1 NCBI RGD Ensembl Show fit
chr20_+_21316826 Show fit	59.22	ENSRNOT00000000785	RGD1306739 NCBI RGD Ensembl Show fit	similar to RIKEN cDNA 1700040L02
chr1_-_170404056 Show fit	57.44	ENSRNOT00000024402	Apbb1 NCBI RGD Ensembl Show fit	amyloid beta precursor protein binding family B member 1
chr20_+_20105047 Show fit	57.34	ENSRNOT00000082181	Ank3 NCBI RGD Ensembl Show fit	ankyrin 3
chr8_-_55037604 Show fit	57.29	ENSRNOT00000059169	Sdhd NCBI RGD Ensembl Show fit	succinate dehydrogenase complex subunit D
chr14_-_84937725 Show fit	57.28	ENSRNOT00000083839	Uqcr10 NCBI RGD Ensembl Show fit	ubiquinol-cytochrome c reductase, complex III subunit X
chr1_+_153861948 Show fit	56.93	ENSRNOT00000087067	Me3 NCBI RGD Ensembl Show fit	malic enzyme 3
chr3_-_122813583 Show fit	56.23	ENSRNOT00000009681	Idh3B NCBI RGD Ensembl Show fit	isocitrate dehydrogenase 3 (NAD+) beta
chr13_-_93677377 Show fit	55.98	ENSRNOT00000004917	Fh NCBI RGD Ensembl Show fit	fumarate hydratase
chr18_-_63825408 Show fit	55.40	ENSRNOT00000043709	RGD1562758 NCBI RGD Ensembl Show fit	similar to glyceraldehyde-3-phosphate dehydrogenase
chr1_+_153861569 Show fit	55.30	ENSRNOT00000023329	Me3 NCBI RGD Ensembl Show fit	malic enzyme 3
chr12_-_44174583 Show fit	54.75	ENSRNOT00000001490	Tesc NCBI RGD Ensembl Show fit	tescalcin
chr8_+_117679278 Show fit	54.43	ENSRNOT00000042114	Uqcrc1 NCBI RGD Ensembl Show fit	ubiquinol-cytochrome c reductase core protein I
chr4_-_84740909 Show fit	54.01	ENSRNOT00000013088	Scrn1 NCBI RGD Ensembl Show fit	secernin 1
chr9_-_71830730 Show fit	53.56	ENSRNOT00000019963	Cryga NCBI RGD Ensembl Show fit	crystallin, gamma A
chr1_-_143535583 Show fit	53.34	ENSRNOT00000087785	Homer2 NCBI RGD Ensembl Show fit	homer scaffolding protein 2
chr7_-_115988036 Show fit	53.08	ENSRNOT00000076822	Lynx1 NCBI RGD Ensembl Show fit	Ly6/neurotoxin 1
chr5_-_56576676 Show fit	52.72	ENSRNOT00000029712	Ndufb6 NCBI RGD Ensembl Show fit	NADH:ubiquinone oxidoreductase subunit B6
chr11_+_70687500 Show fit	52.36	ENSRNOT00000037432	AC110981.1 NCBI RGD Ensembl Show fit
chr3_+_113318563 Show fit	52.34	ENSRNOT00000089230	Ckmt1 NCBI RGD Ensembl Show fit	creatine kinase, mitochondrial 1
chr3_+_72226613 Show fit	51.77	ENSRNOT00000010619	Timm10 NCBI RGD Ensembl Show fit	translocase of inner mitochondrial membrane 10
chr19_+_54245950 Show fit	51.19	ENSRNOT00000024033	Cox4i1 NCBI RGD Ensembl Show fit	cytochrome c oxidase subunit 4i1
chr13_-_103080920 Show fit	50.97	ENSRNOT00000034990	AABR07022022.1 NCBI RGD Ensembl Show fit
chr1_+_78876205 Show fit	50.70	ENSRNOT00000022610	Pnmal2 NCBI RGD Ensembl Show fit	paraneoplastic Ma antigen family-like 2
chr10_-_38782419 Show fit	50.67	ENSRNOT00000073964	Uqcrq NCBI RGD Ensembl Show fit	ubiquinol-cytochrome c reductase, complex III subunit VII
chr18_+_402295 Show fit	50.65	ENSRNOT00000033618	Fundc2 NCBI RGD Ensembl Show fit	FUN14 domain containing 2
chr3_-_8981362 Show fit	50.55	ENSRNOT00000086717	Crat NCBI RGD Ensembl Show fit	carnitine O-acetyltransferase
chr19_+_59186673 Show fit	50.35	ENSRNOT00000071655	Slc35f3 NCBI RGD Ensembl Show fit	solute carrier family 35, member F3
chr19_+_51317425 Show fit	50.16	ENSRNOT00000019298	Cdh13 NCBI RGD Ensembl Show fit	cadherin 13
chr5_+_159484370 Show fit	50.07	ENSRNOT00000010593	Sdhb NCBI RGD Ensembl Show fit	succinate dehydrogenase complex iron sulfur subunit B
chr9_+_20213588 Show fit	49.61	ENSRNOT00000089341	LOC100911515 NCBI RGD Ensembl Show fit	triosephosphate isomerase-like
chr2_-_140464607 Show fit	49.01	ENSRNOT00000058190	Ndufc1 NCBI RGD Ensembl Show fit	NADH:ubiquinone oxidoreductase subunit C1
chr7_-_74735650 Show fit	48.85	ENSRNOT00000014407	Cox6c NCBI RGD Ensembl Show fit	cytochrome c oxidase subunit 6C
chr19_-_10653800 Show fit	48.32	ENSRNOT00000022128	Cx3cl1 NCBI RGD Ensembl Show fit	C-X3-C motif chemokine ligand 1
chr18_-_55891710 Show fit	48.12	ENSRNOT00000064686	Synpo NCBI RGD Ensembl Show fit	synaptopodin
chr15_+_61662264 Show fit	47.84	ENSRNOT00000072969	Mtrf1 NCBI RGD Ensembl Show fit	mitochondrial translation release factor 1
chr8_+_61532465 Show fit	47.51	ENSRNOT00000023326	Cspg4 NCBI RGD Ensembl Show fit	chondroitin sulfate proteoglycan 4
chr9_-_92291220 Show fit	47.15	ENSRNOT00000093357	Dner NCBI RGD Ensembl Show fit	delta/notch-like EGF repeat containing
chr3_+_177226417 Show fit	46.70	ENSRNOT00000031328	Oprl1 NCBI RGD Ensembl Show fit	opioid related nociceptin receptor 1
chr4_+_122781095 Show fit	46.50	ENSRNOT00000008962	Hdac11 NCBI RGD Ensembl Show fit	histone deacetylase 11
chr3_+_58164931 Show fit	45.87	ENSRNOT00000002078	Dlx1 NCBI RGD Ensembl Show fit	distal-less homeobox 1
chr4_+_153774486 Show fit	45.43	ENSRNOT00000074096	Tuba8 NCBI RGD Ensembl Show fit	tubulin, alpha 8
chr3_-_81304181 Show fit	44.34	ENSRNOT00000079746	Mapk8ip1 NCBI RGD Ensembl Show fit	mitogen-activated protein kinase 8 interacting protein 1
chr3_+_57770948 Show fit	43.98	ENSRNOT00000038429	AC107446.2 NCBI RGD Ensembl Show fit
chr9_+_47536824 Show fit	43.58	ENSRNOT00000049349	Tmem182 NCBI RGD Ensembl Show fit	transmembrane protein 182
chr10_+_110139783 Show fit	43.52	ENSRNOT00000054939	Slc16a3 NCBI RGD Ensembl Show fit	solute carrier family 16 member 3
chr8_-_128266639 Show fit	43.17	ENSRNOT00000064555 ENSRNOT00000066932	Scn5a NCBI RGD Ensembl Show fit	sodium voltage-gated channel alpha subunit 5
chr12_+_47254484 Show fit	42.87	ENSRNOT00000001556	Acads NCBI RGD Ensembl Show fit	acyl-CoA dehydrogenase, C-2 to C-3 short chain
chr3_+_151126591 Show fit	42.86	ENSRNOT00000025859	Myh7b NCBI RGD Ensembl Show fit	myosin heavy chain 7B
chr4_+_67378188 Show fit	42.74	ENSRNOT00000030892	Ndufb2 NCBI RGD Ensembl Show fit	NADH:ubiquinone oxidoreductase subunit B2
chr10_-_13107771 Show fit	42.55	ENSRNOT00000005879	Flywch1 NCBI RGD Ensembl Show fit	FLYWCH-type zinc finger 1
chr10_-_25910298 Show fit	41.80	ENSRNOT00000065633 ENSRNOT00000079646	Ccng1 NCBI RGD Ensembl Show fit	cyclin G1
chr7_-_12874215 Show fit	41.26	ENSRNOT00000011837	Hcn2 NCBI RGD Ensembl Show fit	hyperpolarization activated cyclic nucleotide-gated potassium channel 2
chr16_-_32753278 Show fit	41.02	ENSRNOT00000015759	Mfap3l NCBI RGD Ensembl Show fit	microfibrillar-associated protein 3-like
chr4_+_115046693 Show fit	40.95	ENSRNOT00000031583	Bola3 NCBI RGD Ensembl Show fit	bolA family member 3
chr7_-_11018160 Show fit	40.92	ENSRNOT00000092061	Aes NCBI RGD Ensembl Show fit	amino-terminal enhancer of split
chrX_+_156340925 Show fit	40.92	ENSRNOT00000091810	Ubl4a NCBI RGD Ensembl Show fit	ubiquitin-like 4A
chr8_+_100260049 Show fit	40.89	ENSRNOT00000011090	AABR07071101.1 NCBI RGD Ensembl Show fit
chr8_+_48422036 Show fit	40.88	ENSRNOT00000036051	Usp2 NCBI RGD Ensembl Show fit	ubiquitin specific peptidase 2
chr1_+_31264755 Show fit	40.58	ENSRNOT00000028988	LOC679739 NCBI RGD Ensembl Show fit	NADH dehydrogenase (ubiquinone) Fe-S protein 6
chr5_-_128333805 Show fit	40.33	ENSRNOT00000037523	Zfyve9 NCBI RGD Ensembl Show fit	zinc finger FYVE-type containing 9
chr1_+_193537137 Show fit	39.92	ENSRNOT00000029967	AABR07005667.1 NCBI RGD Ensembl Show fit
chr5_-_157573183 Show fit	39.04	ENSRNOT00000064418	Minos1 NCBI RGD Ensembl Show fit	mitochondrial inner membrane organizing system 1
chr10_+_63659085 Show fit	38.75	ENSRNOT00000005039	Rilp NCBI RGD Ensembl Show fit	Rab interacting lysosomal protein
chr1_-_89488223 Show fit	38.74	ENSRNOT00000028624	Fxyd1 NCBI RGD Ensembl Show fit	FXYD domain-containing ion transport regulator 1
chr3_-_104504204 Show fit	38.66	ENSRNOT00000049582	Ryr3 NCBI RGD Ensembl Show fit	ryanodine receptor 3
chr17_+_36334147 Show fit	38.36	ENSRNOT00000050261	E2f3 NCBI RGD Ensembl Show fit	E2F transcription factor 3
chr3_-_151474135 Show fit	37.79	ENSRNOT00000072679	Uqcc1 NCBI RGD Ensembl Show fit	ubiquinol-cytochrome c reductase complex assembly factor 1
chr8_-_130491998 Show fit	36.75	ENSRNOT00000064114	Higd1a NCBI RGD Ensembl Show fit	HIG1 hypoxia inducible domain family, member 1A
chr18_-_1946840 Show fit	36.44	ENSRNOT00000041878	Abhd3 NCBI RGD Ensembl Show fit	abhydrolase domain containing 3
chr6_-_135412312 Show fit	36.10	ENSRNOT00000010610	Ankrd9 NCBI RGD Ensembl Show fit	ankyrin repeat domain 9
chr7_-_121029754 Show fit	35.95	ENSRNOT00000004703	Nptxr NCBI RGD Ensembl Show fit	neuronal pentraxin receptor
chr6_+_126434226 Show fit	35.60	ENSRNOT00000090857	Chga NCBI RGD Ensembl Show fit	chromogranin A
chr7_-_70319346 Show fit	35.02	ENSRNOT00000071543	Tsfm NCBI RGD Ensembl Show fit	Ts translation elongation factor, mitochondrial
chr17_+_77185053 Show fit	34.97	ENSRNOT00000091561	Optn NCBI RGD Ensembl Show fit	optineurin
chr3_-_79728879 Show fit	34.28	ENSRNOT00000012425	Ndufs3 NCBI RGD Ensembl Show fit	NADH dehydrogenase (ubiquinone) Fe-S protein 3
chr14_+_84237520 Show fit	34.02	ENSRNOT00000083580	Gal3st1 NCBI RGD Ensembl Show fit	galactose-3-O-sulfotransferase 1
chr12_-_48238887 Show fit	33.91	ENSRNOT00000078868	Acacb NCBI RGD Ensembl Show fit	acetyl-CoA carboxylase beta
chr10_-_10881844 Show fit	33.59	ENSRNOT00000087118 ENSRNOT00000004416	Mgrn1 NCBI RGD Ensembl Show fit	mahogunin ring finger 1
chr10_+_61432819 Show fit	33.59	ENSRNOT00000003687 ENSRNOT00000092478	Cluh NCBI RGD Ensembl Show fit	clustered mitochondria homolog
chr17_+_72209373 Show fit	33.26	ENSRNOT00000064802	Atp5c1 NCBI RGD Ensembl Show fit	ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
chr3_-_3476215 Show fit	32.74	ENSRNOT00000024352	Ubac1 NCBI RGD Ensembl Show fit	UBA domain containing 1
chr3_-_52664209 Show fit	32.68	ENSRNOT00000065126 ENSRNOT00000079020	Scn9a NCBI RGD Ensembl Show fit	sodium voltage-gated channel alpha subunit 9
chr2_-_178389608 Show fit	32.40	ENSRNOT00000013262	Etfdh NCBI RGD Ensembl Show fit	electron transfer flavoprotein dehydrogenase
chr4_+_146106386 Show fit	31.96	ENSRNOT00000008342	Slc6a11 NCBI RGD Ensembl Show fit	solute carrier family 6 member 11
chr2_+_112868707 Show fit	31.78	ENSRNOT00000017805	Nceh1 NCBI RGD Ensembl Show fit	neutral cholesterol ester hydrolase 1
chr17_+_42133076 Show fit	31.72	ENSRNOT00000031384	Aldh5a1 NCBI RGD Ensembl Show fit	aldehyde dehydrogenase 5 family, member A1
chr8_+_29453643 Show fit	31.63	ENSRNOT00000090643	Opcml NCBI RGD Ensembl Show fit	opioid binding protein/cell adhesion molecule-like
chr6_+_83083740 Show fit	31.58	ENSRNOT00000007600	Lrfn5 NCBI RGD Ensembl Show fit	leucine rich repeat and fibronectin type III domain containing 5
chr1_-_165606375 Show fit	31.26	ENSRNOT00000024290	Mrpl48 NCBI RGD Ensembl Show fit	mitochondrial ribosomal protein L48
chrX_+_63520991 Show fit	31.24	ENSRNOT00000071590	Apoo NCBI RGD Ensembl Show fit	apolipoprotein O
chr5_-_150323063 Show fit	31.10	ENSRNOT00000014084	Oprd1 NCBI RGD Ensembl Show fit	opioid receptor, delta 1
chr6_-_28994519 Show fit	31.03	ENSRNOT00000006668	Ubxn2a NCBI RGD Ensembl Show fit	UBX domain protein 2A
chr7_+_121311024 Show fit	30.97	ENSRNOT00000092260 ENSRNOT00000023066 ENSRNOT00000081377	Syngr1 NCBI RGD Ensembl Show fit	synaptogyrin 1
chr10_-_57268081 Show fit	30.84	ENSRNOT00000005144	Slc25a11 NCBI RGD Ensembl Show fit	solute carrier family 25 member 11
chrX_+_109996163 Show fit	30.70	ENSRNOT00000093349	Nrk NCBI RGD Ensembl Show fit	Nik related kinase
chr1_-_90091287 Show fit	30.64	ENSRNOT00000032613	Gpi NCBI RGD Ensembl Show fit	glucose-6-phosphate isomerase
chr2_-_187372652 Show fit	30.61	ENSRNOT00000025496 ENSRNOT00000083116	Bcan NCBI RGD Ensembl Show fit	brevican
chr14_+_2194933 Show fit	30.59	ENSRNOT00000061720	Cplx1 NCBI RGD Ensembl Show fit	complexin 1
chr1_+_142136452 Show fit	30.58	ENSRNOT00000016445	Hddc3 NCBI RGD Ensembl Show fit	HD domain containing 3
chr14_+_2325308 Show fit	30.32	ENSRNOT00000000072	Atp5i NCBI RGD Ensembl Show fit	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit E
chr8_-_23099042 Show fit	30.32	ENSRNOT00000019115	Ecsit NCBI RGD Ensembl Show fit	ECSIT signalling integrator
chr11_+_80736576 Show fit	30.30	ENSRNOT00000047678	Masp1 NCBI RGD Ensembl Show fit	mannan-binding lectin serine peptidase 1
chr17_-_84247038 Show fit	29.95	ENSRNOT00000068553	Nebl NCBI RGD Ensembl Show fit	nebulette
chr3_+_133232432 Show fit	29.85	ENSRNOT00000006412	Ndufaf5 NCBI RGD Ensembl Show fit	NADH:ubiquinone oxidoreductase complex assembly factor 5
chr7_-_12519154 Show fit	29.68	ENSRNOT00000093376 ENSRNOT00000077681	Gpx4 NCBI RGD Ensembl Show fit	glutathione peroxidase 4
chr19_-_37427989 Show fit	29.58	ENSRNOT00000022863	Tppp3 NCBI RGD Ensembl Show fit	tubulin polymerization-promoting protein family member 3
chr6_+_36107672 Show fit	29.45	ENSRNOT00000093003	Rdh14 NCBI RGD Ensembl Show fit	retinol dehydrogenase 14 (all-trans/9-cis/11-cis)
chrX_+_76786466 Show fit	29.36	ENSRNOT00000090665	Fgf16 NCBI RGD Ensembl Show fit	fibroblast growth factor 16
chrX_-_116792864 Show fit	29.01	ENSRNOT00000090918	Amot NCBI RGD Ensembl Show fit	angiomotin
chr18_-_56331991 Show fit	28.98	ENSRNOT00000085841 ENSRNOT00000091220	Slc6a7 NCBI RGD Ensembl Show fit	solute carrier family 6 member 7
chrX_-_116792707 Show fit	28.95	ENSRNOT00000049482	Amot NCBI RGD Ensembl Show fit	angiomotin
chr15_-_93307420 Show fit	28.72	ENSRNOT00000012195	Slitrk1 NCBI RGD Ensembl Show fit	SLIT and NTRK-like family, member 1
chr1_+_72956026 Show fit	28.72	ENSRNOT00000031462	Rdh13 NCBI RGD Ensembl Show fit	retinol dehydrogenase 13
chr9_+_90880614 Show fit	28.65	ENSRNOT00000077859 ENSRNOT00000020705 ENSRNOT00000089142	Mff NCBI RGD Ensembl Show fit	mitochondrial fission factor
chr5_+_150001281 Show fit	28.15	ENSRNOT00000034057	Mecr NCBI RGD Ensembl Show fit	mitochondrial trans-2-enoyl-CoA reductase
chr1_+_261281543 Show fit	27.84	ENSRNOT00000018890	Ankrd2 NCBI RGD Ensembl Show fit	ankyrin repeat domain 2
chr4_+_99753500 Show fit	27.82	ENSRNOT00000086291 ENSRNOT00000043199	Immt NCBI RGD Ensembl Show fit	inner membrane mitochondrial protein
chr20_-_7208292 Show fit	27.56	ENSRNOT00000083169	Nudt3 NCBI RGD Ensembl Show fit	nudix hydrolase 3
chr3_+_79860179 Show fit	27.36	ENSRNOT00000081160 ENSRNOT00000068444	Rapsn NCBI RGD Ensembl Show fit	receptor-associated protein of the synapse
chr9_+_81566074 Show fit	27.30	ENSRNOT00000074131 ENSRNOT00000046229 ENSRNOT00000090383	Pnkd NCBI RGD Ensembl Show fit	paroxysmal nonkinesigenic dyskinesia
chr2_-_123396386 Show fit	27.20	ENSRNOT00000046700	Trpc3 NCBI RGD Ensembl Show fit	transient receptor potential cation channel, subfamily C, member 3
chr3_+_123106694 Show fit	26.99	ENSRNOT00000028829	Oxt NCBI RGD Ensembl Show fit	oxytocin/neurophysin 1 prepropeptide
chr1_-_222468896 Show fit	26.95	ENSRNOT00000028754	Cox8a NCBI RGD Ensembl Show fit	cytochrome c oxidase subunit 8A
chr16_+_16949232 Show fit	26.94	ENSRNOT00000047499	AABR07024795.1 NCBI RGD Ensembl Show fit
chr4_+_7260575 Show fit	26.43	ENSRNOT00000064893	Fastk NCBI RGD Ensembl Show fit	Fas-activated serine/threonine kinase
chr5_+_156850206 Show fit	26.31	ENSRNOT00000021833	Mul1 NCBI RGD Ensembl Show fit	mitochondrial E3 ubiquitin protein ligase 1
chr20_-_48294948 Show fit	26.30	ENSRNOT00000072716	LOC683897 NCBI RGD Ensembl Show fit	similar to Protein C6orf203
chr15_-_27819376 Show fit	26.23	ENSRNOT00000067400	A930018M24Rik NCBI RGD Ensembl Show fit	RIKEN cDNA A930018M24 gene
chr1_+_167197549 Show fit	26.17	ENSRNOT00000027427	Art1 NCBI RGD Ensembl Show fit	ADP-ribosyltransferase 1
chr1_-_222350173 Show fit	25.59	ENSRNOT00000030625	Flrt1 NCBI RGD Ensembl Show fit	fibronectin leucine rich transmembrane protein 1
chr13_+_56262190 Show fit	25.45	ENSRNOT00000032908	AABR07021086.1 NCBI RGD Ensembl Show fit
chr2_+_78103387 Show fit	25.31	ENSRNOT00000063951	LOC103689968 NCBI RGD Ensembl Show fit	protein FAM134B
chr19_+_24044103 Show fit	25.29	ENSRNOT00000004621	Rnf150 NCBI RGD Ensembl Show fit	ring finger protein 150
chrX_-_72515057 Show fit	24.95	ENSRNOT00000076850 ENSRNOT00000041138	Phka1 NCBI RGD Ensembl Show fit	phosphorylase kinase, alpha 1
chr7_+_12229379 Show fit	24.87	ENSRNOT00000060811	Adamtsl5 NCBI RGD Ensembl Show fit	ADAMTS-like 5
chr19_-_11326139 Show fit	24.85	ENSRNOT00000025669	Mt3 NCBI RGD Ensembl Show fit	metallothionein 3
chr7_-_119158173 Show fit	24.65	ENSRNOT00000067483 ENSRNOT00000078528	Txn2 NCBI RGD Ensembl Show fit	thioredoxin 2

Network of associatons between targets according to the STRING database.

First level regulatory network of Esrrb_Esrra

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
80.1	240.3	GO:0006106	fumarate metabolic process(GO:0006106)
58.6	234.4	GO:0042776	mitochondrial ATP synthesis coupled proton transport(GO:0042776)
49.8	149.3	GO:1903918	regulation of actin filament severing(GO:1903918) negative regulation of actin filament severing(GO:1903919)
46.6	139.8	GO:0006121	mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
46.1	276.8	GO:0006102	isocitrate metabolic process(GO:0006102)
39.7	119.0	GO:0035606	peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
36.6	109.7	GO:2001137	actin filament uncapping(GO:0051695) phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097) positive regulation of endocytic recycling(GO:2001137)
31.0	185.8	GO:1903059	regulation of protein lipidation(GO:1903059)
20.3	60.8	GO:1905243	slow-twitch skeletal muscle fiber contraction(GO:0031444) response to 3,3',5-triiodo-L-thyronine(GO:1905242) cellular response to 3,3',5-triiodo-L-thyronine(GO:1905243)
19.4	77.6	GO:0030043	actin filament fragmentation(GO:0030043)
19.3	58.0	GO:0003365	establishment of cell polarity involved in ameboidal cell migration(GO:0003365)
18.2	54.7	GO:0032417	positive regulation of sodium:proton antiporter activity(GO:0032417)
17.8	89.2	GO:0019563	glycerol catabolic process(GO:0019563)
17.8	71.1	GO:0019254	carnitine metabolic process, CoA-linked(GO:0019254)
16.9	50.7	GO:0021539	subthalamus development(GO:0021539)
16.6	83.0	GO:0007207	adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
16.6	66.2	GO:0006933	negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
15.5	92.8	GO:0010701	positive regulation of norepinephrine secretion(GO:0010701)
15.3	45.9	GO:0021882	regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment(GO:0021882) commitment of multipotent stem cells to neuronal lineage in forebrain(GO:0021898)
14.3	57.3	GO:0010650	positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
14.3	42.9	GO:0019626	short-chain fatty acid catabolic process(GO:0019626)
13.6	135.6	GO:0014883	transition between fast and slow fiber(GO:0014883)
12.9	38.8	GO:0010796	regulation of multivesicular body size(GO:0010796)
12.8	51.1	GO:0010615	positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244)
12.6	138.6	GO:0006123	mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
12.6	50.4	GO:0015888	thiamine transport(GO:0015888)
12.0	48.1	GO:0098886	modification of dendritic spine(GO:0098886)
11.9	35.6	GO:1900738	positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738)
11.7	281.7	GO:0015985	energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
11.7	46.7	GO:1904059	regulation of locomotor rhythm(GO:1904059)
11.5	22.9	GO:1903070	negative regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903070)
11.3	34.0	GO:0006682	galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
11.2	56.0	GO:0045039	protein import into mitochondrial inner membrane(GO:0045039)
11.0	22.0	GO:1903921	protein processing in phagocytic vesicle(GO:1900756) regulation of protein processing in phagocytic vesicle(GO:1903921) positive regulation of protein processing in phagocytic vesicle(GO:1903923)
10.6	31.7	GO:0006681	galactosylceramide metabolic process(GO:0006681)
10.3	41.3	GO:1900063	regulation of peroxisome organization(GO:1900063)
10.2	112.2	GO:0006108	malate metabolic process(GO:0006108)
10.0	30.0	GO:0071691	cardiac muscle thin filament assembly(GO:0071691)
9.8	68.8	GO:0006627	protein processing involved in protein targeting to mitochondrion(GO:0006627)
9.8	29.4	GO:1904849	positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546)
9.7	38.7	GO:1903797	positive regulation of inorganic anion transmembrane transport(GO:1903797)
9.6	47.9	GO:0017062	respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551)
9.6	28.7	GO:0009644	response to high light intensity(GO:0009644)
9.1	63.4	GO:0009438	methylglyoxal metabolic process(GO:0009438)
8.8	26.3	GO:1904925	positive regulation of macromitophagy(GO:1901526) positive regulation of mitophagy in response to mitochondrial depolarization(GO:1904925)
8.5	33.9	GO:2001295	malonyl-CoA biosynthetic process(GO:2001295)
8.3	24.8	GO:0055073	cadmium ion homeostasis(GO:0055073) regulation of lysosomal membrane permeability(GO:0097213) positive regulation of lysosomal membrane permeability(GO:0097214) regulation of hydrogen peroxide catabolic process(GO:2000295)
8.2	131.9	GO:0042407	cristae formation(GO:0042407)
8.2	65.7	GO:0019388	galactose catabolic process(GO:0019388)
8.2	40.9	GO:0071816	tail-anchored membrane protein insertion into ER membrane(GO:0071816)
8.2	32.7	GO:0043179	rhythmic excitation(GO:0043179)
8.1	65.1	GO:0001920	negative regulation of receptor recycling(GO:0001920)
8.1	48.3	GO:0032914	positive regulation of transforming growth factor beta1 production(GO:0032914)
8.0	112.3	GO:0071420	cellular response to histamine(GO:0071420)
7.8	303.3	GO:0042775	mitochondrial ATP synthesis coupled electron transport(GO:0042775)
7.7	38.6	GO:1904045	cellular response to aldosterone(GO:1904045)
7.3	95.1	GO:2000291	regulation of myoblast proliferation(GO:2000291)
7.2	43.2	GO:0098912	membrane depolarization during Purkinje myocyte cell action potential(GO:0086047) membrane depolarization during bundle of His cell action potential(GO:0086048) membrane depolarization during atrial cardiac muscle cell action potential(GO:0098912)
7.0	35.0	GO:0070125	mitochondrial translational elongation(GO:0070125)
6.9	27.6	GO:1901909	diadenosine polyphosphate catabolic process(GO:0015961) diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
6.6	19.8	GO:1902037	negative regulation of hematopoietic stem cell differentiation(GO:1902037)
6.3	132.7	GO:0006098	pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682)
6.3	50.2	GO:0055095	lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096)
6.2	12.3	GO:0018171	peptidyl-cysteine oxidation(GO:0018171)
6.0	17.9	GO:0045041	protein import into mitochondrial intermembrane space(GO:0045041)
5.9	17.7	GO:1903630	regulation of aminoacyl-tRNA ligase activity(GO:1903630)
5.8	17.4	GO:0021740	trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740)
5.8	23.0	GO:0051692	cellular oligosaccharide catabolic process(GO:0051692)
5.7	17.2	GO:0009249	protein lipoylation(GO:0009249)
5.7	90.7	GO:0097031	NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
5.6	72.8	GO:1904322	response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322)
5.4	177.8	GO:0035025	positive regulation of Rho protein signal transduction(GO:0035025)
5.3	69.4	GO:0032780	negative regulation of ATPase activity(GO:0032780)
5.2	230.5	GO:0045214	sarcomere organization(GO:0045214)
5.1	30.7	GO:0060723	regulation of spongiotrophoblast cell proliferation(GO:0060721) regulation of cell proliferation involved in embryonic placenta development(GO:0060723)
5.1	81.0	GO:0006099	tricarboxylic acid cycle(GO:0006099)
5.0	161.1	GO:0015701	bicarbonate transport(GO:0015701)
4.8	33.6	GO:0043951	negative regulation of cAMP-mediated signaling(GO:0043951)
4.8	52.5	GO:0007258	JUN phosphorylation(GO:0007258)
4.7	47.2	GO:0007220	Notch receptor processing(GO:0007220)
4.6	9.3	GO:0008582	regulation of synaptic growth at neuromuscular junction(GO:0008582)
4.4	31.1	GO:0038003	opioid receptor signaling pathway(GO:0038003)
4.4	17.5	GO:0035502	metanephric part of ureteric bud development(GO:0035502) oviduct development(GO:0060066)
4.3	17.0	GO:0090074	negative regulation of protein homodimerization activity(GO:0090074)
4.2	71.0	GO:0006089	lactate metabolic process(GO:0006089)
4.1	40.7	GO:0070345	negative regulation of fat cell proliferation(GO:0070345)
4.1	32.4	GO:0033539	fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
4.0	24.1	GO:0098928	presynaptic signal transduction(GO:0098928) presynapse to nucleus signaling pathway(GO:0099526)
3.9	47.1	GO:0006390	transcription from mitochondrial promoter(GO:0006390)
3.9	23.2	GO:0015074	DNA integration(GO:0015074)
3.9	84.9	GO:0097503	sialylation(GO:0097503)
3.8	38.1	GO:0071340	skeletal muscle acetylcholine-gated channel clustering(GO:0071340)
3.7	33.6	GO:0048312	intracellular distribution of mitochondria(GO:0048312)
3.7	7.4	GO:0019747	regulation of isoprenoid metabolic process(GO:0019747)
3.7	18.4	GO:0000960	mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960)
3.6	10.9	GO:0034628	nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process from aspartate(GO:0034628)
3.4	65.3	GO:0006415	translational termination(GO:0006415)
3.4	78.4	GO:0014850	response to muscle activity(GO:0014850)
3.4	10.2	GO:2000312	regulation of kainate selective glutamate receptor activity(GO:2000312)
3.2	19.2	GO:0021759	globus pallidus development(GO:0021759)
3.2	47.5	GO:0016322	neuron remodeling(GO:0016322)
3.1	37.6	GO:0034975	protein folding in endoplasmic reticulum(GO:0034975)
3.0	51.7	GO:0031115	negative regulation of microtubule polymerization(GO:0031115)
3.0	15.1	GO:0061709	reticulophagy(GO:0061709)
3.0	27.1	GO:2000210	positive regulation of anoikis(GO:2000210)
3.0	14.8	GO:0035795	negative regulation of mitochondrial membrane permeability(GO:0035795) negative regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902109)
2.9	29.0	GO:0035524	proline transmembrane transport(GO:0035524)
2.9	8.6	GO:0032789	saturated monocarboxylic acid metabolic process(GO:0032788) unsaturated monocarboxylic acid metabolic process(GO:0032789)
2.9	5.7	GO:0072076	nephrogenic mesenchyme development(GO:0072076)
2.8	53.3	GO:0048875	chemical homeostasis within a tissue(GO:0048875)
2.8	16.8	GO:0035609	C-terminal protein deglutamylation(GO:0035609)
2.7	40.7	GO:0007183	SMAD protein complex assembly(GO:0007183)
2.7	16.2	GO:2000324	positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
2.6	99.2	GO:0000266	mitochondrial fission(GO:0000266)
2.6	23.5	GO:0030644	cellular chloride ion homeostasis(GO:0030644)
2.6	20.8	GO:0033572	transferrin transport(GO:0033572)
2.6	23.4	GO:0071318	cellular response to ATP(GO:0071318)
2.6	48.6	GO:0031581	hemidesmosome assembly(GO:0031581)
2.5	27.6	GO:0007196	adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196)
2.5	22.5	GO:0035879	plasma membrane lactate transport(GO:0035879)
2.5	7.5	GO:0021678	third ventricle development(GO:0021678) actin filament bundle distribution(GO:0070650)
2.5	7.4	GO:0032242	regulation of nucleoside transport(GO:0032242) negative regulation of neurotrophin production(GO:0032900) negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of mucus secretion(GO:0070256) negative regulation of long term synaptic depression(GO:1900453)
2.5	7.4	GO:1903774	positive regulation of viral budding via host ESCRT complex(GO:1903774)
2.4	40.9	GO:0045475	locomotor rhythm(GO:0045475)
2.4	54.5	GO:0010614	negative regulation of cardiac muscle hypertrophy(GO:0010614)
2.4	9.5	GO:0003340	negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis(GO:0003340)
2.3	27.8	GO:0045916	negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258)
2.3	20.3	GO:1902902	negative regulation of autophagosome assembly(GO:1902902)
2.2	31.0	GO:0031468	nuclear envelope reassembly(GO:0031468)
2.2	17.7	GO:0016198	axon choice point recognition(GO:0016198)
2.2	10.9	GO:0035106	operant conditioning(GO:0035106)
2.2	26.0	GO:0043457	regulation of cellular respiration(GO:0043457)
2.2	36.7	GO:0090201	negative regulation of release of cytochrome c from mitochondria(GO:0090201)
2.2	10.8	GO:0001552	ovarian follicle atresia(GO:0001552)
2.1	12.5	GO:0017196	N-terminal peptidyl-methionine acetylation(GO:0017196)
2.0	21.9	GO:1901897	regulation of relaxation of cardiac muscle(GO:1901897)
1.9	7.7	GO:0032687	negative regulation of interferon-alpha production(GO:0032687)
1.9	24.6	GO:0006662	glycerol ether metabolic process(GO:0006662)
1.8	71.8	GO:0007026	negative regulation of microtubule depolymerization(GO:0007026)
1.8	11.0	GO:0031547	brain-derived neurotrophic factor receptor signaling pathway(GO:0031547)
1.8	53.1	GO:2000272	negative regulation of receptor activity(GO:2000272)
1.8	10.5	GO:0010625	positive regulation of Schwann cell proliferation(GO:0010625)
1.7	10.5	GO:0010138	pyrimidine ribonucleotide salvage(GO:0010138) pyrimidine nucleotide salvage(GO:0032262) UMP salvage(GO:0044206)
1.7	31.0	GO:0048172	regulation of short-term neuronal synaptic plasticity(GO:0048172)
1.7	38.7	GO:0051481	negative regulation of cytosolic calcium ion concentration(GO:0051481)
1.6	140.4	GO:0098869	cellular oxidant detoxification(GO:0098869)
1.6	22.2	GO:0030150	protein import into mitochondrial matrix(GO:0030150)
1.6	10.9	GO:2001171	regulation of hypoxia-induced intrinsic apoptotic signaling pathway(GO:1903297) negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway(GO:1903298) intrinsic apoptotic signaling pathway in response to hypoxia(GO:1990144) positive regulation of ATP biosynthetic process(GO:2001171)
1.5	41.8	GO:0007095	mitotic G2 DNA damage checkpoint(GO:0007095) G2 DNA damage checkpoint(GO:0031572)
1.5	16.6	GO:0007614	short-term memory(GO:0007614)
1.5	63.1	GO:0032543	mitochondrial translation(GO:0032543)
1.5	20.6	GO:0097435	fibril organization(GO:0097435)
1.4	17.1	GO:0032836	glomerular basement membrane development(GO:0032836)
1.4	5.7	GO:1900825	regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900825)
1.3	17.3	GO:0033623	regulation of integrin activation(GO:0033623)
1.3	19.7	GO:1902259	regulation of delayed rectifier potassium channel activity(GO:1902259)
1.2	32.0	GO:0015812	gamma-aminobutyric acid transport(GO:0015812)
1.2	9.6	GO:2000467	positive regulation of glycogen (starch) synthase activity(GO:2000467)
1.2	9.5	GO:0000012	single strand break repair(GO:0000012)
1.2	7.1	GO:0021940	positive regulation of cerebellar granule cell precursor proliferation(GO:0021940)
1.1	11.5	GO:1900452	regulation of long term synaptic depression(GO:1900452)
1.1	5.6	GO:0071000	response to magnetism(GO:0071000)
1.1	10.0	GO:0098828	positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828)
1.1	26.2	GO:0006471	protein ADP-ribosylation(GO:0006471)
1.1	6.5	GO:0044351	macropinocytosis(GO:0044351)
1.1	10.8	GO:0006474	N-terminal protein amino acid acetylation(GO:0006474)
1.1	57.4	GO:0008542	visual learning(GO:0008542) positive regulation of DNA repair(GO:0045739)
1.1	15.1	GO:0051085	chaperone mediated protein folding requiring cofactor(GO:0051085)
1.0	17.7	GO:0090136	epithelial cell-cell adhesion(GO:0090136)
1.0	8.3	GO:0006465	signal peptide processing(GO:0006465)
1.0	45.5	GO:0014003	oligodendrocyte development(GO:0014003)
1.0	68.2	GO:0051965	positive regulation of synapse assembly(GO:0051965)
1.0	27.0	GO:0000188	inactivation of MAPK activity(GO:0000188)
1.0	5.9	GO:0046687	response to chromate(GO:0046687)
1.0	35.3	GO:0045333	cellular respiration(GO:0045333)
0.9	14.9	GO:1903861	positive regulation of dendrite extension(GO:1903861)
0.8	90.6	GO:0021549	cerebellum development(GO:0021549)
0.8	13.2	GO:0043267	negative regulation of potassium ion transport(GO:0043267)
0.8	7.4	GO:0018026	peptidyl-lysine monomethylation(GO:0018026)
0.8	5.6	GO:0051665	membrane raft localization(GO:0051665)
0.8	4.0	GO:0008295	spermidine biosynthetic process(GO:0008295)
0.8	8.7	GO:0060088	auditory receptor cell stereocilium organization(GO:0060088)
0.8	13.3	GO:0010971	positive regulation of G2/M transition of mitotic cell cycle(GO:0010971)
0.8	91.8	GO:0006941	striated muscle contraction(GO:0006941)
0.8	35.7	GO:0010501	RNA secondary structure unwinding(GO:0010501)
0.7	53.7	GO:1902600	hydrogen ion transmembrane transport(GO:1902600)
0.7	2.2	GO:0008594	photoreceptor cell morphogenesis(GO:0008594) post-embryonic retina morphogenesis in camera-type eye(GO:0060060)
0.7	29.6	GO:0046785	microtubule polymerization(GO:0046785)
0.7	0.7	GO:0036466	synaptic vesicle recycling via endosome(GO:0036466)
0.7	17.9	GO:0097237	cellular response to toxic substance(GO:0097237)
0.7	4.8	GO:0007182	common-partner SMAD protein phosphorylation(GO:0007182)
0.7	4.1	GO:0051775	response to redox state(GO:0051775) regulation of type B pancreatic cell development(GO:2000074) negative regulation of glucocorticoid receptor signaling pathway(GO:2000323)
0.7	6.1	GO:0035507	regulation of myosin-light-chain-phosphatase activity(GO:0035507)
0.7	30.3	GO:0051341	regulation of oxidoreductase activity(GO:0051341)
0.7	18.1	GO:0032728	positive regulation of interferon-beta production(GO:0032728)
0.6	5.1	GO:0021520	spinal cord motor neuron cell fate specification(GO:0021520)
0.6	18.0	GO:0007212	dopamine receptor signaling pathway(GO:0007212)
0.6	4.3	GO:0021860	pyramidal neuron development(GO:0021860)
0.6	3.0	GO:0021960	anterior commissure morphogenesis(GO:0021960)
0.6	23.8	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.6	5.1	GO:2000060	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000060)
0.6	35.3	GO:0002088	lens development in camera-type eye(GO:0002088)
0.5	11.4	GO:0072662	protein targeting to peroxisome(GO:0006625) peroxisomal transport(GO:0043574) protein localization to peroxisome(GO:0072662) establishment of protein localization to peroxisome(GO:0072663)
0.5	2.7	GO:1904751	positive regulation of protein localization to nucleolus(GO:1904751)
0.5	30.5	GO:0006073	glycogen metabolic process(GO:0005977) cellular glucan metabolic process(GO:0006073) glucan metabolic process(GO:0044042)
0.4	6.6	GO:0035269	protein O-linked mannosylation(GO:0035269)
0.4	19.0	GO:0006835	dicarboxylic acid transport(GO:0006835)
0.4	11.1	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.4	2.6	GO:2000819	regulation of nucleotide-excision repair(GO:2000819)
0.4	1.7	GO:1903964	monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.4	3.4	GO:0061179	negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.4	6.2	GO:0043981	histone H4-K5 acetylation(GO:0043981) histone H4-K8 acetylation(GO:0043982)
0.4	1.9	GO:0032020	ISG15-protein conjugation(GO:0032020)
0.3	11.6	GO:0046928	regulation of neurotransmitter secretion(GO:0046928)
0.3	17.6	GO:0016079	synaptic vesicle exocytosis(GO:0016079)
0.3	4.2	GO:0051386	regulation of neurotrophin TRK receptor signaling pathway(GO:0051386)
0.3	10.3	GO:0051693	actin filament capping(GO:0051693)
0.3	14.5	GO:0035249	synaptic transmission, glutamatergic(GO:0035249)
0.3	7.8	GO:0033120	positive regulation of RNA splicing(GO:0033120)
0.2	5.5	GO:0048168	regulation of neuronal synaptic plasticity(GO:0048168)
0.2	2.2	GO:0030277	maintenance of gastrointestinal epithelium(GO:0030277)
0.2	5.1	GO:0001881	receptor recycling(GO:0001881)
0.2	3.5	GO:0051560	mitochondrial calcium ion homeostasis(GO:0051560)
0.2	2.0	GO:0061525	hindgut development(GO:0061525)
0.2	4.7	GO:0010738	regulation of protein kinase A signaling(GO:0010738)
0.2	8.3	GO:0060395	SMAD protein signal transduction(GO:0060395)
0.2	1.9	GO:0007097	nuclear migration(GO:0007097)
0.2	30.0	GO:0001649	osteoblast differentiation(GO:0001649)
0.2	4.3	GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.2	9.8	GO:0010923	negative regulation of phosphatase activity(GO:0010923)
0.1	6.3	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.1	1.4	GO:0034643	establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497)
0.1	1.4	GO:0097094	craniofacial suture morphogenesis(GO:0097094)
0.1	2.0	GO:0034755	iron ion transmembrane transport(GO:0034755)
0.1	7.5	GO:0000422	mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.1	3.2	GO:0031122	cytoplasmic microtubule organization(GO:0031122)
0.1	10.7	GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.1	1.0	GO:0033139	regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033139) positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141) serine phosphorylation of STAT protein(GO:0042501)
0.1	1.0	GO:0002566	somatic diversification of immune receptors via somatic mutation(GO:0002566) somatic hypermutation of immunoglobulin genes(GO:0016446)
0.1	3.7	GO:0000186	activation of MAPKK activity(GO:0000186)
0.1	2.6	GO:0007131	reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.1	2.9	GO:0038083	peptidyl-tyrosine autophosphorylation(GO:0038083)
0.0	0.7	GO:0048488	synaptic vesicle endocytosis(GO:0048488)
0.0	2.6	GO:0001505	regulation of neurotransmitter levels(GO:0001505)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
63.3	189.9	GO:0045283	mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) fumarate reductase complex(GO:0045283)
43.6	130.8	GO:0045242	mitochondrial isocitrate dehydrogenase complex (NAD+)(GO:0005962) isocitrate dehydrogenase complex (NAD+)(GO:0045242)
25.8	206.2	GO:0045261	mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
23.1	115.7	GO:0005927	muscle tendon junction(GO:0005927)
22.3	244.9	GO:0005750	mitochondrial respiratory chain complex III(GO:0005750)
21.9	21.9	GO:0045281	respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281)
21.6	86.3	GO:1990584	cardiac Troponin complex(GO:1990584)
19.1	57.4	GO:1990812	growth cone filopodium(GO:1990812)
17.7	123.6	GO:0061617	MICOS complex(GO:0061617)
17.1	222.7	GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
16.9	135.6	GO:0005861	troponin complex(GO:0005861)
16.9	269.8	GO:0005751	mitochondrial respiratory chain complex IV(GO:0005751)
16.0	48.1	GO:0097444	spine apparatus(GO:0097444)
14.9	119.0	GO:0097452	GAIT complex(GO:0097452)
14.8	44.3	GO:0044302	dentate gyrus mossy fiber(GO:0044302)
13.8	41.3	GO:0098855	HCN channel complex(GO:0098855)
10.2	40.9	GO:0072379	BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
10.1	50.3	GO:0042719	mitochondrial intermembrane space protein transporter complex(GO:0042719)
9.1	18.2	GO:0070069	cytochrome complex(GO:0070069)
8.6	42.9	GO:0097512	cardiac myofibril(GO:0097512)
8.0	24.1	GO:1990257	piccolo-bassoon transport vesicle(GO:1990257)
8.0	136.3	GO:0005916	fascia adherens(GO:0005916)
7.9	393.1	GO:0030964	mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
7.6	91.6	GO:0005859	muscle myosin complex(GO:0005859)
7.3	87.3	GO:0045239	tricarboxylic acid cycle enzyme complex(GO:0045239)
7.1	35.6	GO:0070032	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
7.1	98.8	GO:0070469	respiratory chain(GO:0070469)
6.4	38.7	GO:0030314	junctional membrane complex(GO:0030314)
5.5	22.2	GO:0001405	presequence translocase-associated import motor(GO:0001405)
5.3	53.4	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
5.2	67.2	GO:0031143	pseudopodium(GO:0031143)
4.8	111.0	GO:1902711	GABA-A receptor complex(GO:1902711)
4.6	18.5	GO:0038037	G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor complex(GO:0097648)
4.5	86.1	GO:0032279	asymmetric synapse(GO:0032279)
4.5	605.8	GO:0030018	Z disc(GO:0030018)
4.4	62.0	GO:0032426	stereocilium tip(GO:0032426)
4.4	35.4	GO:0097450	astrocyte end-foot(GO:0097450)
4.3	29.8	GO:0031314	extrinsic component of mitochondrial inner membrane(GO:0031314)
3.8	251.9	GO:0030017	sarcomere(GO:0030017)
3.7	22.0	GO:0030478	actin cap(GO:0030478)
3.7	11.0	GO:0044308	axonal spine(GO:0044308)
3.6	35.6	GO:0042583	chromaffin granule(GO:0042583)
3.5	20.8	GO:1990712	HFE-transferrin receptor complex(GO:1990712)
3.4	37.9	GO:0001527	microfibril(GO:0001527) fibril(GO:0043205)
3.4	27.4	GO:0099634	postsynaptic specialization membrane(GO:0099634)
3.4	106.0	GO:0032590	dendrite membrane(GO:0032590)
3.1	21.9	GO:0033017	sarcoplasmic reticulum membrane(GO:0033017)
3.1	25.0	GO:0005964	phosphorylase kinase complex(GO:0005964)
2.9	72.8	GO:0008074	guanylate cyclase complex, soluble(GO:0008074)
2.8	8.3	GO:0005745	m-AAA complex(GO:0005745)
2.7	10.7	GO:0031417	NatC complex(GO:0031417)
2.6	47.5	GO:0031258	lamellipodium membrane(GO:0031258)
2.4	48.6	GO:0030056	hemidesmosome(GO:0030056)
2.3	32.7	GO:0001518	voltage-gated sodium channel complex(GO:0001518)
2.3	16.2	GO:1990635	proximal dendrite(GO:1990635)
2.3	25.4	GO:0072546	ER membrane protein complex(GO:0072546)
2.2	48.1	GO:0032809	neuronal cell body membrane(GO:0032809)
2.2	69.6	GO:0009295	nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
2.1	17.1	GO:0098642	collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
2.1	26.8	GO:0008385	IkappaB kinase complex(GO:0008385)
1.9	7.5	GO:0097513	myosin II filament(GO:0097513)
1.8	10.9	GO:0000015	phosphopyruvate hydratase complex(GO:0000015)
1.8	8.9	GO:0044300	cerebellar mossy fiber(GO:0044300)
1.8	85.2	GO:0030173	integral component of Golgi membrane(GO:0030173)
1.7	48.9	GO:0000314	organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
1.7	32.4	GO:0031305	intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
1.7	98.8	GO:0005762	organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
1.7	75.1	GO:0016235	aggresome(GO:0016235)
1.7	58.0	GO:0008180	COP9 signalosome(GO:0008180)
1.6	413.2	GO:0005743	mitochondrial inner membrane(GO:0005743)
1.6	127.6	GO:0044455	mitochondrial membrane part(GO:0044455)
1.5	80.3	GO:0043198	dendritic shaft(GO:0043198)
1.5	17.7	GO:0017101	aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
1.4	12.6	GO:0031414	N-terminal protein acetyltransferase complex(GO:0031414)
1.4	8.3	GO:0005787	signal peptidase complex(GO:0005787)
1.3	9.0	GO:0097449	astrocyte projection(GO:0097449)
1.3	12.7	GO:0030130	clathrin coat of trans-Golgi network vesicle(GO:0030130)
1.2	238.5	GO:0043679	axon terminus(GO:0043679)
1.2	201.7	GO:0043209	myelin sheath(GO:0043209)
1.1	7.6	GO:0016593	Cdc73/Paf1 complex(GO:0016593)
1.1	36.9	GO:0034707	chloride channel complex(GO:0034707)
1.0	47.2	GO:0010494	cytoplasmic stress granule(GO:0010494)
1.0	8.1	GO:0031595	nuclear proteasome complex(GO:0031595)
1.0	121.6	GO:0005759	mitochondrial matrix(GO:0005759)
1.0	75.7	GO:0001750	photoreceptor outer segment(GO:0001750)
0.9	18.4	GO:0005665	DNA-directed RNA polymerase II, core complex(GO:0005665)
0.8	15.9	GO:0048786	presynaptic active zone(GO:0048786)
0.8	10.0	GO:0060077	inhibitory synapse(GO:0060077)
0.8	4.1	GO:0005726	perichromatin fibrils(GO:0005726)
0.8	7.4	GO:0000813	ESCRT I complex(GO:0000813)
0.7	20.8	GO:0001772	immunological synapse(GO:0001772)
0.7	7.7	GO:0030285	integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.7	10.2	GO:0030057	desmosome(GO:0030057)
0.7	56.3	GO:0005776	autophagosome(GO:0005776)
0.7	40.3	GO:0031901	early endosome membrane(GO:0031901)
0.7	13.2	GO:0005790	smooth endoplasmic reticulum(GO:0005790)
0.6	5.1	GO:0019907	cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.6	6.6	GO:0016010	dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.6	50.2	GO:0005901	caveola(GO:0005901)
0.5	223.4	GO:0005635	nuclear envelope(GO:0005635)
0.5	5.6	GO:0046581	intercellular canaliculus(GO:0046581)
0.5	11.3	GO:0045120	pronucleus(GO:0045120)
0.5	9.3	GO:0005605	basal lamina(GO:0005605)
0.5	3.2	GO:0070449	elongin complex(GO:0070449)
0.4	22.0	GO:0005801	cis-Golgi network(GO:0005801)
0.4	31.8	GO:0005741	mitochondrial outer membrane(GO:0005741)
0.4	11.1	GO:0080008	Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.4	177.6	GO:0048471	perinuclear region of cytoplasm(GO:0048471)
0.4	10.7	GO:0005758	mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.3	2.0	GO:0097598	sperm cytoplasmic droplet(GO:0097598)
0.3	304.7	GO:0005739	mitochondrion(GO:0005739)
0.3	19.2	GO:0000118	histone deacetylase complex(GO:0000118)
0.3	7.8	GO:0005834	heterotrimeric G-protein complex(GO:0005834)
0.3	81.9	GO:0005578	proteinaceous extracellular matrix(GO:0005578)
0.2	4.3	GO:0060170	ciliary membrane(GO:0060170)
0.2	1.0	GO:0032389	MutLalpha complex(GO:0032389)
0.2	13.1	GO:0042579	peroxisome(GO:0005777) microbody(GO:0042579)
0.2	24.7	GO:0005769	early endosome(GO:0005769)
0.2	3.0	GO:0042734	presynaptic membrane(GO:0042734)
0.1	5.7	GO:0042383	sarcolemma(GO:0042383)
0.1	2.1	GO:0030126	COPI vesicle coat(GO:0030126)
0.1	3.2	GO:0034451	centriolar satellite(GO:0034451)
0.0	39.9	GO:0005887	integral component of plasma membrane(GO:0005887)
0.0	3.3	GO:0031248	protein acetyltransferase complex(GO:0031248) acetyltransferase complex(GO:1902493)
0.0	2.2	GO:0045095	keratin filament(GO:0045095)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
75.6	226.7	GO:0004807	triose-phosphate isomerase activity(GO:0004807)
69.9	139.8	GO:0008177	succinate dehydrogenase (ubiquinone) activity(GO:0008177)
65.3	196.0	GO:0051538	3 iron, 4 sulfur cluster binding(GO:0051538)
61.4	184.3	GO:0080130	L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
44.3	177.1	GO:0061629	RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
42.9	214.5	GO:0043532	angiostatin binding(GO:0043532)
32.7	130.8	GO:0004449	isocitrate dehydrogenase (NAD+) activity(GO:0004449)
29.8	119.0	GO:0004365	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
28.4	85.2	GO:0003828	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
28.0	84.1	GO:0052743	phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity(GO:0034485) inositol tetrakisphosphate phosphatase activity(GO:0052743)
21.9	109.7	GO:0051373	FATZ binding(GO:0051373)
21.9	21.9	GO:0000104	succinate dehydrogenase activity(GO:0000104)
21.6	86.3	GO:0030172	troponin C binding(GO:0030172)
18.7	112.2	GO:0004470	malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473)
17.7	71.0	GO:0004459	L-lactate dehydrogenase activity(GO:0004459)
17.7	88.7	GO:0004614	phosphoglucomutase activity(GO:0004614)
16.6	83.0	GO:0016907	G-protein coupled acetylcholine receptor activity(GO:0016907)
13.4	242.0	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
13.3	93.3	GO:0004111	creatine kinase activity(GO:0004111)
13.0	65.1	GO:0001155	TFIIIA-class transcription factor binding(GO:0001155)
13.0	77.8	GO:0004985	opioid receptor activity(GO:0004985)
12.5	50.2	GO:0055100	adiponectin binding(GO:0055100)
12.0	35.9	GO:0001847	opsonin receptor activity(GO:0001847)
12.0	47.8	GO:0016149	translation release factor activity, codon specific(GO:0016149)
10.3	309.8	GO:0004129	cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
9.7	38.7	GO:0005219	ryanodine-sensitive calcium-release channel activity(GO:0005219)
9.2	27.5	GO:0030337	DNA polymerase processivity factor activity(GO:0030337)
8.8	61.4	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
8.6	43.2	GO:0086062	voltage-gated sodium channel activity involved in Purkinje myocyte action potential(GO:0086062)
8.6	137.9	GO:0051371	muscle alpha-actinin binding(GO:0051371)
8.5	34.0	GO:0001733	galactosylceramide sulfotransferase activity(GO:0001733)
8.5	33.9	GO:0003989	acetyl-CoA carboxylase activity(GO:0003989)
8.1	32.4	GO:0048039	ubiquinone binding(GO:0048039)
7.9	111.0	GO:0005237	inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
7.6	53.3	GO:0030160	GKAP/Homer scaffold activity(GO:0030160)
7.0	28.1	GO:0019166	trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
6.9	27.6	GO:0008486	endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432)
6.6	32.8	GO:0004416	hydroxyacylglutathione hydrolase activity(GO:0004416)
6.5	150.3	GO:0004602	glutathione peroxidase activity(GO:0004602)
6.4	173.0	GO:0050136	NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
6.3	50.7	GO:0008121	ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
6.3	50.6	GO:0016413	O-acetyltransferase activity(GO:0016413)
6.1	170.9	GO:0005452	inorganic anion exchanger activity(GO:0005452)
5.8	23.0	GO:0052796	exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
5.7	22.9	GO:1904288	BAT3 complex binding(GO:1904288)
5.5	22.0	GO:0045159	myosin II binding(GO:0045159)
5.4	43.5	GO:0015129	lactate transmembrane transporter activity(GO:0015129)
5.3	32.0	GO:0005332	gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
5.2	20.9	GO:0033743	peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
5.0	25.0	GO:0004105	choline-phosphate cytidylyltransferase activity(GO:0004105)
4.9	68.3	GO:0030898	actin-dependent ATPase activity(GO:0030898)
4.4	30.6	GO:0016861	intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
4.1	41.3	GO:0005222	intracellular cAMP activated cation channel activity(GO:0005222)
4.0	15.9	GO:0008379	thioredoxin peroxidase activity(GO:0008379)
4.0	63.4	GO:0003995	acyl-CoA dehydrogenase activity(GO:0003995)
3.9	23.5	GO:0017040	ceramidase activity(GO:0017040)
3.9	27.4	GO:0043495	protein anchor(GO:0043495)
3.9	38.8	GO:0051959	dynein light intermediate chain binding(GO:0051959)
3.9	54.0	GO:0016805	dipeptidase activity(GO:0016805)
3.8	72.8	GO:0008179	adenylate cyclase binding(GO:0008179)
3.8	53.1	GO:0030550	acetylcholine receptor inhibitor activity(GO:0030550)
3.7	22.3	GO:0008970	phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
3.6	51.1	GO:0070679	inositol 1,4,5 trisphosphate binding(GO:0070679)
3.6	10.9	GO:0000309	nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
3.5	10.5	GO:0008184	glycogen phosphorylase activity(GO:0008184)
3.5	65.9	GO:0015271	outward rectifier potassium channel activity(GO:0015271)
3.4	24.1	GO:0045503	dynein light chain binding(GO:0045503)
3.3	26.2	GO:0003956	NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
3.3	88.2	GO:0009055	electron carrier activity(GO:0009055)
3.1	31.0	GO:0033130	acetylcholine receptor binding(GO:0033130)
3.0	9.1	GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
3.0	9.0	GO:0001641	group II metabotropic glutamate receptor activity(GO:0001641)
2.9	29.0	GO:0015193	L-proline transmembrane transporter activity(GO:0015193)
2.8	47.3	GO:0031005	filamin binding(GO:0031005)
2.8	22.2	GO:0004738	pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
2.6	7.8	GO:0031752	D5 dopamine receptor binding(GO:0031752)
2.5	20.1	GO:0015556	C4-dicarboxylate transmembrane transporter activity(GO:0015556)
2.4	53.6	GO:0005212	structural constituent of eye lens(GO:0005212)
2.4	52.5	GO:0003746	translation elongation factor activity(GO:0003746)
2.3	18.5	GO:0098988	G-protein coupled glutamate receptor activity(GO:0098988)
2.3	20.8	GO:0015450	P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
2.2	22.2	GO:0000774	adenyl-nucleotide exchange factor activity(GO:0000774)
2.2	46.2	GO:0048156	tau protein binding(GO:0048156)
2.1	14.8	GO:0003988	acetyl-CoA C-acyltransferase activity(GO:0003988)
2.0	47.2	GO:0005112	Notch binding(GO:0005112)
1.9	20.7	GO:0046870	cadmium ion binding(GO:0046870)
1.9	7.4	GO:0050252	retinol O-fatty-acyltransferase activity(GO:0050252)
1.8	10.9	GO:0004634	phosphopyruvate hydratase activity(GO:0004634)
1.8	24.9	GO:0015035	protein disulfide oxidoreductase activity(GO:0015035)
1.7	48.3	GO:0005540	hyaluronic acid binding(GO:0005540)
1.7	55.0	GO:0005104	fibroblast growth factor receptor binding(GO:0005104)
1.7	23.3	GO:0004596	peptide alpha-N-acetyltransferase activity(GO:0004596)
1.6	29.4	GO:0008106	alcohol dehydrogenase (NADP+) activity(GO:0008106)
1.6	32.7	GO:0005248	voltage-gated sodium channel activity(GO:0005248)
1.6	40.3	GO:0005545	1-phosphatidylinositol binding(GO:0005545)
1.6	133.3	GO:0005518	collagen binding(GO:0005518)
1.5	53.4	GO:0030506	ankyrin binding(GO:0030506)
1.5	27.0	GO:0033549	MAP kinase phosphatase activity(GO:0033549)
1.5	4.5	GO:0004176	ATP-dependent peptidase activity(GO:0004176)
1.5	7.4	GO:0032795	heterotrimeric G-protein binding(GO:0032795)
1.4	44.5	GO:0019212	phosphatase inhibitor activity(GO:0019212)
1.4	40.9	GO:0030332	cyclin binding(GO:0030332)
1.3	30.6	GO:0005326	neurotransmitter transporter activity(GO:0005326)
1.3	2.6	GO:0050692	DBD domain binding(GO:0050692)
1.3	7.7	GO:0035374	chondroitin sulfate binding(GO:0035374)
1.3	32.7	GO:0004407	histone deacetylase activity(GO:0004407)
1.2	9.9	GO:0005169	neurotrophin TRKB receptor binding(GO:0005169)
1.2	50.8	GO:0030507	spectrin binding(GO:0030507)
1.2	138.1	GO:0004222	metalloendopeptidase activity(GO:0004222)
1.1	5.7	GO:0015266	protein channel activity(GO:0015266)
1.1	21.6	GO:0019789	SUMO transferase activity(GO:0019789)
1.1	11.0	GO:0015386	potassium:proton antiporter activity(GO:0015386)
1.1	163.5	GO:0051015	actin filament binding(GO:0051015)
1.1	10.8	GO:0031957	very long-chain fatty acid-CoA ligase activity(GO:0031957)
1.1	38.7	GO:0017080	sodium channel regulator activity(GO:0017080)
1.1	13.9	GO:0051537	2 iron, 2 sulfur cluster binding(GO:0051537)
1.1	12.7	GO:0051400	BH domain binding(GO:0051400)
1.0	12.9	GO:0042301	phosphate ion binding(GO:0042301)
0.9	93.6	GO:0005178	integrin binding(GO:0005178)
0.9	9.5	GO:0050693	LBD domain binding(GO:0050693)
0.9	5.6	GO:0071253	connexin binding(GO:0071253)
0.9	7.4	GO:0046790	virion binding(GO:0046790)
0.9	194.7	GO:0003779	actin binding(GO:0003779)
0.9	27.0	GO:0005184	neuropeptide hormone activity(GO:0005184)
0.9	2.7	GO:0004307	ethanolaminephosphotransferase activity(GO:0004307)
0.8	19.8	GO:0017134	fibroblast growth factor binding(GO:0017134)
0.8	7.4	GO:0046975	histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.8	8.1	GO:0016909	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.7	10.9	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.7	13.2	GO:0004435	phosphatidylinositol phospholipase C activity(GO:0004435)
0.7	17.9	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
0.7	20.3	GO:0043015	gamma-tubulin binding(GO:0043015)
0.7	20.9	GO:0004683	calmodulin-dependent protein kinase activity(GO:0004683)
0.6	1.9	GO:0042296	ISG15 transferase activity(GO:0042296)
0.6	23.9	GO:0016836	hydro-lyase activity(GO:0016836)
0.6	4.0	GO:0019808	polyamine binding(GO:0019808)
0.6	27.7	GO:0016651	oxidoreductase activity, acting on NAD(P)H(GO:0016651)
0.6	6.2	GO:0043996	histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.5	5.5	GO:0043394	proteoglycan binding(GO:0043394)
0.5	56.6	GO:0001191	transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.5	42.7	GO:0051087	chaperone binding(GO:0051087)
0.5	40.5	GO:0005249	voltage-gated potassium channel activity(GO:0005249)
0.5	1.0	GO:0032135	DNA insertion or deletion binding(GO:0032135) single base insertion or deletion binding(GO:0032138)
0.5	16.2	GO:0043531	ADP binding(GO:0043531)
0.5	7.8	GO:0034236	protein kinase A catalytic subunit binding(GO:0034236)
0.5	25.8	GO:0048306	calcium-dependent protein binding(GO:0048306)
0.5	29.3	GO:0003743	translation initiation factor activity(GO:0003743)
0.4	2.7	GO:0043023	ribosomal large subunit binding(GO:0043023)
0.4	11.2	GO:0030544	Hsp70 protein binding(GO:0030544)
0.4	18.0	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.4	1.7	GO:0032896	stearoyl-CoA 9-desaturase activity(GO:0004768) palmitoyl-CoA 9-desaturase activity(GO:0032896)
0.4	2.5	GO:0008889	glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.4	10.9	GO:0004181	metallocarboxypeptidase activity(GO:0004181)
0.4	8.6	GO:0047617	acyl-CoA hydrolase activity(GO:0047617)
0.4	14.5	GO:0001784	phosphotyrosine binding(GO:0001784)
0.3	16.2	GO:0005200	structural constituent of cytoskeleton(GO:0005200)
0.3	2.0	GO:0015093	ferrous iron transmembrane transporter activity(GO:0015093)
0.3	4.3	GO:0033038	bitter taste receptor activity(GO:0033038)
0.3	5.7	GO:0070064	proline-rich region binding(GO:0070064)
0.3	2.2	GO:0004703	G-protein coupled receptor kinase activity(GO:0004703)
0.3	13.4	GO:0015078	hydrogen ion transmembrane transporter activity(GO:0015078)
0.3	5.7	GO:0008301	DNA binding, bending(GO:0008301)
0.3	1.3	GO:0004969	histamine receptor activity(GO:0004969)
0.2	0.4	GO:0047025	3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity(GO:0047025)
0.2	16.6	GO:0003727	single-stranded RNA binding(GO:0003727)
0.2	23.2	GO:0047485	protein N-terminus binding(GO:0047485)
0.2	9.5	GO:0003684	damaged DNA binding(GO:0003684)
0.2	18.9	GO:0003714	transcription corepressor activity(GO:0003714)
0.2	3.7	GO:0004709	MAP kinase kinase kinase activity(GO:0004709)
0.1	0.9	GO:0031702	type 1 angiotensin receptor binding(GO:0031702)
0.1	1.0	GO:0005132	type I interferon receptor binding(GO:0005132)
0.1	5.6	GO:0051117	ATPase binding(GO:0051117)
0.1	3.4	GO:0003899	DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062)
0.1	2.9	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1	2.6	GO:0008138	protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.1	8.4	GO:0008201	heparin binding(GO:0008201)
0.1	10.9	GO:0005057	receptor signaling protein activity(GO:0005057)
0.1	3.7	GO:0051082	unfolded protein binding(GO:0051082)
0.1	6.4	GO:0004540	ribonuclease activity(GO:0004540)
0.0	4.6	GO:0016503	pheromone receptor activity(GO:0016503)
0.0	17.8	GO:0005549	odorant binding(GO:0005549)
0.0	6.8	GO:0004842	ubiquitin-protein transferase activity(GO:0004842)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
3.5	72.8	PID LPA4 PATHWAY	LPA4-mediated signaling events
2.0	63.4	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
1.8	182.2	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
1.5	88.7	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
1.4	91.6	PID CASPASE PATHWAY	Caspase cascade in apoptosis
1.3	46.5	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
1.3	17.7	PID EPHB FWD PATHWAY	EPHB forward signaling
1.2	52.5	SIG CD40PATHWAYMAP	Genes related to CD40 signaling
1.1	48.3	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.9	18.9	ST GA13 PATHWAY	G alpha 13 Pathway
0.9	27.5	ST WNT BETA CATENIN PATHWAY	Wnt/beta-catenin Pathway
0.9	51.1	PID P53 REGULATION PATHWAY	p53 pathway
0.8	45.5	PID TGFBR PATHWAY	TGF-beta receptor signaling
0.7	19.7	ST G ALPHA I PATHWAY	G alpha i Pathway
0.7	35.1	NABA COLLAGENS	Genes encoding collagen proteins
0.6	21.9	PID IFNG PATHWAY	IFN-gamma pathway
0.6	7.8	PID S1P S1P4 PATHWAY	S1P4 pathway
0.5	27.1	PID SMAD2 3NUCLEAR PATHWAY	Regulation of nuclear SMAD2/3 signaling
0.5	17.4	PID TNF PATHWAY	TNF receptor signaling pathway
0.5	13.9	PID PI3K PLC TRK PATHWAY	Trk receptor signaling mediated by PI3K and PLC-gamma
0.5	37.4	WNT SIGNALING	Genes related to Wnt-mediated signal transduction
0.5	22.7	PID ARF6 TRAFFICKING PATHWAY	Arf6 trafficking events
0.5	17.7	PID RHOA PATHWAY	RhoA signaling pathway
0.4	6.4	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.3	16.2	PID ERBB1 DOWNSTREAM PATHWAY	ErbB1 downstream signaling
0.3	46.6	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.3	4.1	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
0.3	5.6	PID NEPHRIN NEPH1 PATHWAY	Nephrin/Neph1 signaling in the kidney podocyte
0.3	7.4	PID ERBB1 INTERNALIZATION PATHWAY	Internalization of ErbB1
0.2	6.5	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta
0.2	9.9	PID P75 NTR PATHWAY	p75(NTR)-mediated signaling
0.2	5.3	PID RHODOPSIN PATHWAY	Visual signal transduction: Rods
0.2	12.6	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network
0.2	35.4	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1	3.6	PID RET PATHWAY	Signaling events regulated by Ret tyrosine kinase
0.1	5.2	PID LKB1 PATHWAY	LKB1 signaling events
0.1	3.0	PID P73PATHWAY	p73 transcription factor network
0.1	2.9	PID KIT PATHWAY	Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1	2.8	PID NOTCH PATHWAY	Notch signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
31.5	566.7	REACTOME CITRIC ACID CYCLE TCA CYCLE	Genes involved in Citric acid cycle (TCA cycle)
21.1	338.3	REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING	Genes involved in Formation of ATP by chemiosmotic coupling
15.4	942.3	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
11.6	453.6	REACTOME GLUCONEOGENESIS	Genes involved in Gluconeogenesis
8.5	331.6	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
6.5	111.0	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
6.2	124.2	REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	Genes involved in Glycogen breakdown (glycogenolysis)
5.6	78.1	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
5.5	114.5	REACTOME PYRUVATE METABOLISM	Genes involved in Pyruvate metabolism
5.0	193.3	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import
4.9	72.8	REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY	Genes involved in Adenylate cyclase activating pathway
4.5	63.4	REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION	Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
4.0	120.6	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
3.9	51.1	REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING	Genes involved in Role of second messengers in netrin-1 signaling
3.2	111.7	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
2.9	26.2	REACTOME DEFENSINS	Genes involved in Defensins
2.8	30.3	REACTOME CREATION OF C4 AND C2 ACTIVATORS	Genes involved in Creation of C4 and C2 activators
2.6	60.9	REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	Genes involved in Na+/Cl- dependent neurotransmitter transporters
2.4	55.4	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
2.4	40.7	REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX	Genes involved in CDC6 association with the ORC:origin complex
2.3	50.6	REACTOME PEROXISOMAL LIPID METABOLISM	Genes involved in Peroxisomal lipid metabolism
2.2	52.3	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
2.2	106.9	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels
2.1	84.3	REACTOME AMINE LIGAND BINDING RECEPTORS	Genes involved in Amine ligand-binding receptors
2.0	56.5	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
1.8	39.1	REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE	Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
1.7	36.7	REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION	Genes involved in GABA synthesis, release, reuptake and degradation
1.7	181.8	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
1.6	39.1	REACTOME DEADENYLATION OF MRNA	Genes involved in Deadenylation of mRNA
1.5	39.6	REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS	Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
1.3	40.3	REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	Genes involved in Downregulation of TGF-beta receptor signaling
1.3	17.5	REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION	Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
1.3	45.0	REACTOME GLYCOSPHINGOLIPID METABOLISM	Genes involved in Glycosphingolipid metabolism
1.2	7.4	REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS	Genes involved in Membrane binding and targetting of GAG proteins
1.0	39.2	REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	Genes involved in Synthesis of PIPs at the plasma membrane
1.0	17.3	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
1.0	24.4	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
0.9	12.4	REACTOME ERKS ARE INACTIVATED	Genes involved in ERKs are inactivated
0.8	12.2	REACTOME P38MAPK EVENTS	Genes involved in p38MAPK events
0.8	10.5	REACTOME PYRIMIDINE CATABOLISM	Genes involved in Pyrimidine catabolism
0.7	8.1	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.7	16.4	REACTOME RNA POL III TRANSCRIPTION TERMINATION	Genes involved in RNA Polymerase III Transcription Termination
0.7	21.8	REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS	Genes involved in Interactions of Vpr with host cellular proteins
0.7	17.7	REACTOME CYTOSOLIC TRNA AMINOACYLATION	Genes involved in Cytosolic tRNA aminoacylation
0.6	11.9	REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS	Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.6	41.3	REACTOME POTASSIUM CHANNELS	Genes involved in Potassium Channels
0.6	35.1	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.6	4.1	REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION	Genes involved in RORA Activates Circadian Expression
0.6	8.5	REACTOME NEPHRIN INTERACTIONS	Genes involved in Nephrin interactions
0.6	7.8	REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS	Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.5	11.5	REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING	Genes involved in p75 NTR receptor-mediated signalling
0.5	30.3	REACTOME TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION	Genes involved in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
0.5	2.9	REACTOME SIGNALING BY ERBB2	Genes involved in Signaling by ERBB2
0.5	13.2	REACTOME PLC BETA MEDIATED EVENTS	Genes involved in PLC beta mediated events
0.4	73.2	REACTOME PEPTIDE LIGAND BINDING RECEPTORS	Genes involved in Peptide ligand-binding receptors
0.4	0.4	REACTOME TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS	Genes involved in TGF-beta receptor signaling activates SMADs
0.4	6.8	REACTOME RNA POL I TRANSCRIPTION TERMINATION	Genes involved in RNA Polymerase I Transcription Termination
0.4	6.5	REACTOME ACTIVATION OF RAC	Genes involved in Activation of Rac
0.4	11.3	REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS	Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.3	5.5	REACTOME HS GAG DEGRADATION	Genes involved in HS-GAG degradation
0.3	60.1	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.2	3.9	REACTOME RNA POL I RNA POL III AND MITOCHONDRIAL TRANSCRIPTION	Genes involved in RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
0.2	4.0	REACTOME METABOLISM OF POLYAMINES	Genes involved in Metabolism of polyamines
0.2	3.1	REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	Genes involved in AKT phosphorylates targets in the cytosol
0.2	6.3	REACTOME NUCLEAR SIGNALING BY ERBB4	Genes involved in Nuclear signaling by ERBB4
0.2	2.2	REACTOME ACYL CHAIN REMODELLING OF PG	Genes involved in Acyl chain remodelling of PG
0.2	7.4	REACTOME TRIGLYCERIDE BIOSYNTHESIS	Genes involved in Triglyceride Biosynthesis
0.2	4.4	REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING	Genes involved in Transferrin endocytosis and recycling
0.1	2.6	REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS	Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.1	5.4	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors
0.1	4.1	REACTOME G ALPHA I SIGNALLING EVENTS	Genes involved in G alpha (i) signalling events
0.1	0.6	REACTOME SHC MEDIATED SIGNALLING	Genes involved in SHC-mediated signalling
0.1	1.1	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.0	0.7	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Results for Esrrb_Esrra

Z-value: 3.14

Motif logo

Transcription factors associated with Esrrb_Esrra

Activity-expression correlation:

Activity profile of Esrrb_Esrra motif

Sorted Z-values of Esrrb_Esrra motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Esrrb_Esrra

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: