ISMARA results: Elf3

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Elf3

Z-value: 1.36

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Transcription factors associated with Elf3

Gene Symbol	Gene ID	Gene Info
Elf3 NCBI RGD Ensembl	ENSRNOG00000006330	E74-like factor 3

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Elf3	rn6_v1_chr13_-_52088780_52088780	0.52	9.7e-24	Click!

Activity profile of Elf3 motif

Sorted Z-values of Elf3 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr10_+_47930633 Show fit	57.00	ENSRNOT00000003515	Grap NCBI RGD Ensembl Show fit	GRB2-related adaptor protein
chr14_-_86796378 Show fit	51.78	ENSRNOT00000092021	Myo1g NCBI RGD Ensembl Show fit	myosin IG
chr13_+_50164563 Show fit	49.42	ENSRNOT00000029533	Lax1 NCBI RGD Ensembl Show fit	lymphocyte transmembrane adaptor 1
chrX_+_134979646 Show fit	48.02	ENSRNOT00000006035	Sash3 NCBI RGD Ensembl Show fit	SAM and SH3 domain containing 3
chr13_-_111917587 Show fit	40.87	ENSRNOT00000007649	Traf3ip3 NCBI RGD Ensembl Show fit	TRAF3 interacting protein 3
chr9_+_43331155 Show fit	38.82	ENSRNOT00000023036	Zap70 NCBI RGD Ensembl Show fit	zeta chain of T cell receptor associated protein kinase 70
chr6_-_138508753 Show fit	36.43	ENSRNOT00000006888	Ighm NCBI RGD Ensembl Show fit	immunoglobulin heavy constant mu
chr4_-_78342863 Show fit	34.67	ENSRNOT00000049038	Gimap6 NCBI RGD Ensembl Show fit	GTPase, IMAP family member 6
chr7_+_12782491 Show fit	33.24	ENSRNOT00000065093	Cnn2 NCBI RGD Ensembl Show fit	calponin 2
chr3_+_161018511 Show fit	33.12	ENSRNOT00000019804 ENSRNOT00000039664	Wfdc2 NCBI RGD Ensembl Show fit	WAP four-disulfide core domain 2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Elf3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.2	75.5	GO:0038083	peptidyl-tyrosine autophosphorylation(GO:0038083)
8.6	51.8	GO:0038096	immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096)
1.8	48.1	GO:0000188	inactivation of MAPK activity(GO:0000188)
3.7	48.0	GO:0002726	positive regulation of T cell cytokine production(GO:0002726)
5.8	40.4	GO:0045084	positive regulation of interleukin-12 biosynthetic process(GO:0045084)
12.9	38.8	GO:0043366	beta selection(GO:0043366)
0.6	38.4	GO:0072676	lymphocyte migration(GO:0072676)
8.4	33.5	GO:0035696	monocyte extravasation(GO:0035696)
1.7	33.2	GO:0050765	negative regulation of phagocytosis(GO:0050765)
0.1	33.1	GO:0010951	negative regulation of endopeptidase activity(GO:0010951)

Showing 1 to 10 of 150 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	117.3	GO:0005576	extracellular region(GO:0005576)
0.8	109.9	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.3	86.1	GO:0009897	external side of plasma membrane(GO:0009897)
0.2	60.2	GO:0000790	nuclear chromatin(GO:0000790)
0.5	53.2	GO:0000786	nucleosome(GO:0000786)
1.8	51.8	GO:0001891	phagocytic cup(GO:0001891)
0.3	45.5	GO:0098857	membrane raft(GO:0045121) membrane microdomain(GO:0098857)
2.2	38.8	GO:0042101	T cell receptor complex(GO:0042101)
10.7	32.0	GO:0030690	Noc1p-Noc2p complex(GO:0030690)
4.9	29.4	GO:0048237	rough endoplasmic reticulum lumen(GO:0048237)

Showing 1 to 10 of 75 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.2	123.4	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.2	97.7	GO:0005525	GTP binding(GO:0005525)
0.2	54.8	GO:0030246	carbohydrate binding(GO:0030246)
0.1	53.0	GO:0046982	protein heterodimerization activity(GO:0046982)
2.2	51.8	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.1	46.9	GO:0003690	double-stranded DNA binding(GO:0003690)
0.1	43.5	GO:0003779	actin binding(GO:0003779)
0.1	39.3	GO:0001077	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
1.0	38.6	GO:0042169	SH2 domain binding(GO:0042169)
7.5	37.7	GO:0043120	tumor necrosis factor binding(GO:0043120)

Showing 1 to 10 of 105 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	55.0	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
1.1	40.0	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
1.0	33.8	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
2.9	32.0	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
2.2	31.3	ST INTERFERON GAMMA PATHWAY	Interferon gamma pathway.
0.7	27.0	PID AURORA A PATHWAY	Aurora A signaling
0.7	26.5	PID FCER1 PATHWAY	Fc-epsilon receptor I signaling in mast cells
1.2	23.0	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.7	22.3	PID IL2 1PATHWAY	IL2-mediated signaling events
1.1	21.7	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling

Showing 1 to 10 of 38 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	54.2	REACTOME SIGNALING BY SCF KIT	Genes involved in Signaling by SCF-KIT
1.8	47.8	REACTOME PACKAGING OF TELOMERE ENDS	Genes involved in Packaging Of Telomere Ends
4.9	38.8	REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE	Genes involved in Translocation of ZAP-70 to Immunological synapse
0.2	36.3	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
1.8	35.1	REACTOME INFLAMMASOMES	Genes involved in Inflammasomes
1.2	33.8	REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
2.9	32.0	REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10	Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
2.4	31.3	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
1.5	28.5	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
1.1	22.3	REACTOME TIE2 SIGNALING	Genes involved in Tie2 Signaling

Showing 1 to 10 of 53 entries

Results for Elf3

Z-value: 1.36

Motif logo

Transcription factors associated with Elf3

Activity-expression correlation:

Activity profile of Elf3 motif

Sorted Z-values of Elf3 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Elf3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: