ISMARA results: E2f8

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for E2f8

Z-value: 1.21

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Transcription factors associated with E2f8

Gene Symbol	Gene ID	Gene Info
E2f8 NCBI RGD Ensembl	ENSRNOG00000022537	E2F transcription factor 8

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
E2f8	rn6_v1_chr1_-_104202591_104202591	0.83	1.5e-83	Click!

Activity profile of E2f8 motif

Sorted Z-values of E2f8 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr3_+_159421671 Show fit	69.78	ENSRNOT00000010343	Mybl2 NCBI RGD Ensembl Show fit	myeloblastosis oncogene-like 2
chr9_-_10757720 Show fit	62.39	ENSRNOT00000083848	Uhrf1 NCBI RGD Ensembl Show fit	ubiquitin-like with PHD and ring finger domains 1
chr9_-_10757954 Show fit	61.85	ENSRNOT00000075265	Uhrf1 NCBI RGD Ensembl Show fit	ubiquitin-like with PHD and ring finger domains 1
chr19_+_14523554 Show fit	56.81	ENSRNOT00000084271 ENSRNOT00000064731	Mcm5 NCBI RGD Ensembl Show fit	minichromosome maintenance complex component 5
chr12_-_38274036 Show fit	51.21	ENSRNOT00000063990	Kntc1 NCBI RGD Ensembl Show fit	kinetochore associated 1
chr6_+_43884678 Show fit	49.47	ENSRNOT00000091551	Rrm2 NCBI RGD Ensembl Show fit	ribonucleotide reductase regulatory subunit M2
chr13_-_45068077 Show fit	40.43	ENSRNOT00000004969	Mcm6 NCBI RGD Ensembl Show fit	minichromosome maintenance complex component 6
chr1_+_257614731 Show fit	36.85	ENSRNOT00000075680	LOC100911660 NCBI RGD Ensembl Show fit	lymphocyte-specific helicase-like
chr1_+_257901985 Show fit	36.20	ENSRNOT00000073015	Hells NCBI RGD Ensembl Show fit	helicase, lymphoid specific
chr1_+_257766691 Show fit	35.48	ENSRNOT00000088148	Hells NCBI RGD Ensembl Show fit	helicase, lymphoid specific

Showing 1 to 10 of 70 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of E2f8

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
24.5	195.9	GO:0010216	maintenance of DNA methylation(GO:0010216)
2.9	82.1	GO:0006270	DNA replication initiation(GO:0006270)
11.2	78.1	GO:0006268	DNA unwinding involved in DNA replication(GO:0006268)
1.1	69.8	GO:0090307	mitotic spindle assembly(GO:0090307)
0.1	58.9	GO:0007017	microtubule-based process(GO:0007017)
3.1	49.5	GO:0009263	deoxyribonucleotide biosynthetic process(GO:0009263)
0.5	47.3	GO:0007093	mitotic cell cycle checkpoint(GO:0007093)
7.2	43.0	GO:1990086	lens fiber cell apoptotic process(GO:1990086)
11.7	35.0	GO:0044330	canonical Wnt signaling pathway involved in positive regulation of wound healing(GO:0044330) metanephric cap development(GO:0072185) metanephric cap morphogenesis(GO:0072186) metanephric cap mesenchymal cell proliferation involved in metanephros development(GO:0090094) response to putrescine(GO:1904585) cellular response to putrescine(GO:1904586)
1.2	32.7	GO:0006335	DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)

Showing 1 to 10 of 34 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.5	159.2	GO:0000791	euchromatin(GO:0000791)
12.3	135.6	GO:0042555	MCM complex(GO:0042555)
2.3	71.7	GO:0005721	pericentric heterochromatin(GO:0005721)
0.4	59.9	GO:0036064	ciliary basal body(GO:0036064)
17.1	51.2	GO:1990423	RZZ complex(GO:1990423)
12.4	49.5	GO:0005971	ribonucleoside-diphosphate reductase complex(GO:0005971)
0.1	33.8	GO:0016607	nuclear speck(GO:0016607)
10.9	32.7	GO:0033186	CAF-1 complex(GO:0033186)
1.9	32.6	GO:0008250	oligosaccharyltransferase complex(GO:0008250)
0.1	21.4	GO:0005667	transcription factor complex(GO:0005667)

Showing 1 to 10 of 32 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
31.1	124.2	GO:0044729	hemi-methylated DNA-binding(GO:0044729)
5.5	77.5	GO:0003688	DNA replication origin binding(GO:0003688)
7.0	69.8	GO:0001135	transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.5	59.9	GO:0005200	structural constituent of cytoskeleton(GO:0005200)
0.1	58.0	GO:0003682	chromatin binding(GO:0003682)
0.0	57.9	GO:0005524	ATP binding(GO:0005524)
1.8	55.7	GO:0004003	ATP-dependent DNA helicase activity(GO:0004003)
0.1	54.7	GO:0008270	zinc ion binding(GO:0008270)
8.2	49.5	GO:0016728	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.2	43.0	GO:0001047	core promoter binding(GO:0001047)

Showing 1 to 10 of 33 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.6	223.2	PID E2F PATHWAY	E2F transcription factor network
1.1	71.7	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
1.2	28.0	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.6	22.4	PID ATR PATHWAY	ATR signaling pathway
0.4	16.6	PID ARF6 PATHWAY	Arf6 signaling events
0.2	15.3	PID CMYB PATHWAY	C-MYB transcription factor network
1.2	15.1	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.4	11.0	PID FANCONI PATHWAY	Fanconi anemia pathway
0.2	6.3	PID HIV NEF PATHWAY	HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.2	4.3	PID FAS PATHWAY	FAS (CD95) signaling pathway

Showing 1 to 10 of 10 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
12.1	133.2	REACTOME UNWINDING OF DNA	Genes involved in Unwinding of DNA
3.8	82.6	REACTOME G1 S SPECIFIC TRANSCRIPTION	Genes involved in G1/S-Specific Transcription
3.1	50.0	REACTOME G0 AND EARLY G1	Genes involved in G0 and Early G1
1.4	35.0	REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION	Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.3	32.6	REACTOME ASPARAGINE N LINKED GLYCOSYLATION	Genes involved in Asparagine N-linked glycosylation
2.5	25.3	REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX	Genes involved in CDC6 association with the ORC:origin complex
0.3	24.2	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.7	19.2	REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS	Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.5	11.0	REACTOME FANCONI ANEMIA PATHWAY	Genes involved in Fanconi Anemia pathway
0.9	9.9	REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS	Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs

Showing 1 to 10 of 15 entries

Results for E2f8

Z-value: 1.21

Motif logo

Transcription factors associated with E2f8

Activity-expression correlation:

Activity profile of E2f8 motif

Sorted Z-values of E2f8 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of E2f8

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: