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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for E2f8

Z-value: 1.21

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Transcription factors associated with E2f8

Gene Symbol Gene ID Gene Info
E2f8
ENSRNOG00000022537 E2F transcription factor 8

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
E2f8rn6_v1_chr1_-_104202591_1042025910.831.5e-83Click!

Activity profile of E2f8 motif

Sorted Z-values of E2f8 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_+_159421671 69.78 ENSRNOT00000010343
Mybl2
myeloblastosis oncogene-like 2
chr9_-_10757720 62.39 ENSRNOT00000083848
Uhrf1
ubiquitin-like with PHD and ring finger domains 1
chr9_-_10757954 61.85 ENSRNOT00000075265
Uhrf1
ubiquitin-like with PHD and ring finger domains 1
chr19_+_14523554 56.81 ENSRNOT00000084271
ENSRNOT00000064731
Mcm5
minichromosome maintenance complex component 5
chr12_-_38274036 51.21 ENSRNOT00000063990
Kntc1
kinetochore associated 1
chr6_+_43884678 49.47 ENSRNOT00000091551
Rrm2
ribonucleotide reductase regulatory subunit M2
chr13_-_45068077 40.43 ENSRNOT00000004969
Mcm6
minichromosome maintenance complex component 6
chr1_+_257614731 36.85 ENSRNOT00000075680
LOC100911660
lymphocyte-specific helicase-like
chr1_+_257901985 36.20 ENSRNOT00000073015
Hells
helicase, lymphoid specific
chr1_+_257766691 35.48 ENSRNOT00000088148
Hells
helicase, lymphoid specific
chr1_+_257615088 35.19 ENSRNOT00000083183
LOC100911660
lymphocyte-specific helicase-like
chr4_-_157798868 35.03 ENSRNOT00000044425
Tuba3b
tubulin, alpha 3B
chr7_+_102586313 34.98 ENSRNOT00000006188
Myc
myelocytomatosis oncogene
chr9_-_11027506 32.70 ENSRNOT00000071107
Chaf1a
chromatin assembly factor 1 subunit A
chr8_-_39201588 32.62 ENSRNOT00000011226
Stt3a
STT3A, catalytic subunit of the oligosaccharyltransferase complex
chr10_-_4910305 31.36 ENSRNOT00000033122
Rmi2
RecQ mediated genome instability 2
chr2_-_190100276 28.00 ENSRNOT00000015351
S100a9
S100 calcium binding protein A9
chr5_+_154522119 25.25 ENSRNOT00000072618
E2f2
E2F transcription factor 2
chr4_+_179905116 24.89 ENSRNOT00000052352
Tuba3a
tubulin, alpha 3A
chr12_-_21720094 24.68 ENSRNOT00000032838
LOC100910636
zinc finger CW-type PWWP domain protein 1-like
chr4_-_120840111 22.37 ENSRNOT00000022231
Mcm2
minichromosome maintenance complex component 2
chr4_+_62703779 19.24 ENSRNOT00000014832
Nup205
nucleoporin 205
chr3_-_150073721 17.79 ENSRNOT00000022428
E2f1
E2F transcription factor 1
chr14_+_48726045 16.59 ENSRNOT00000086646
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr2_+_197682000 15.95 ENSRNOT00000066821
Hormad1
HORMA domain containing 1
chr10_+_67325347 15.66 ENSRNOT00000079002
ENSRNOT00000085914
Suz12
suppressor of zeste 12 homolog (Drosophila)
chr11_+_89511191 15.26 ENSRNOT00000002510
Mcm4
minichromosome maintenance complex component 4
chr5_+_152681101 15.13 ENSRNOT00000076052
ENSRNOT00000022574
Stmn1
stathmin 1
chr12_+_660011 14.99 ENSRNOT00000040830
Pds5b
PDS5 cohesin associated factor B
chr2_-_28423762 14.24 ENSRNOT00000022864
Btf3
basic transcription factor 3
chr5_-_147375009 14.22 ENSRNOT00000009436
S100pbp
S100P binding protein
chr1_+_220009397 13.88 ENSRNOT00000084410
Rbm4b
RNA binding motif protein 4B
chr19_+_37652969 12.68 ENSRNOT00000041970
Carmil2
capping protein regulator and myosin 1 linker 2
chr9_-_61975640 12.04 ENSRNOT00000085744
Boll
boule homolog, RNA binding protein
chr8_+_111790678 11.64 ENSRNOT00000013265
Topbp1
topoisomerase (DNA) II binding protein 1
chr9_-_64573660 11.38 ENSRNOT00000021299
LOC108348134
protein boule-like
chr12_-_16395029 11.27 ENSRNOT00000001700
Nudt1
nudix hydrolase 1
chr14_+_110676090 10.96 ENSRNOT00000029513
Fancl
Fanconi anemia, complementation group L
chr5_+_147375350 10.05 ENSRNOT00000010674
Yars
tyrosyl-tRNA synthetase
chr14_+_82356916 9.91 ENSRNOT00000040229
Slbp
stem-loop binding protein
chrX_-_112159458 9.88 ENSRNOT00000087403
Tex13b
testis expressed 13B
chr9_-_61974898 9.67 ENSRNOT00000091519
Boll
boule homolog, RNA binding protein
chr15_+_31469953 9.57 ENSRNOT00000077849
AABR07017825.4

chr9_-_64573076 8.81 ENSRNOT00000084658
LOC108348134
protein boule-like
chr15_+_30621374 8.70 ENSRNOT00000090632
AABR07017748.2

chr1_+_221558093 8.34 ENSRNOT00000077274
Majin
membrane anchored junction protein
chr10_+_86819472 8.22 ENSRNOT00000081424
Cdc6
cell division cycle 6
chr10_+_86819929 7.09 ENSRNOT00000038228
Cdc6
cell division cycle 6
chr4_+_149970237 7.07 ENSRNOT00000019529
Hnrnpf
heterogeneous nuclear ribonucleoprotein F
chr20_-_5485837 6.32 ENSRNOT00000092272
ENSRNOT00000000559
ENSRNOT00000092597
Daxx
death-domain associated protein
chr4_+_149970567 6.30 ENSRNOT00000091765
Hnrnpf
heterogeneous nuclear ribonucleoprotein F
chr6_+_128973956 5.38 ENSRNOT00000075399
Fam181a
family with sequence similarity 181, member A
chr5_-_144996431 5.23 ENSRNOT00000016992
Zmym4
zinc finger MYM-type containing 4
chr8_-_36314811 5.18 ENSRNOT00000013243
St3gal4
ST3 beta-galactoside alpha-2,3-sialyltransferase 4
chr7_+_73273985 4.78 ENSRNOT00000077730
Pop1
POP1 homolog, ribonuclease P/MRP subunit
chr14_+_106393959 4.53 ENSRNOT00000092168
Wdpcp
WD repeat containing planar cell polarity effector
chr4_+_157554794 4.43 ENSRNOT00000024116
Ing4
inhibitor of growth family, member 4
chr14_+_44580216 4.30 ENSRNOT00000088674
ENSRNOT00000003907
Rfc1
replication factor C subunit 1
chr2_+_24546536 3.72 ENSRNOT00000014036
Otp
orthopedia homeobox
chr10_+_90622992 3.23 ENSRNOT00000032856
Meioc
meiosis specific with coiled-coil domain
chr7_-_125497691 3.01 ENSRNOT00000049445
AABR07058578.1

chrX_-_15504165 2.63 ENSRNOT00000006233
Otud5
OTU deubiquitinase 5
chr3_-_151486693 1.80 ENSRNOT00000073736
ENSRNOT00000071099
Gdf5
growth differentiation factor 5
chr13_+_96195836 1.40 ENSRNOT00000042547
RGD1563812
similar to basic transcription factor 3
chr10_+_93354003 1.22 ENSRNOT00000008140
Mettl2b
methyltransferase like 2B
chr5_+_147185474 1.16 ENSRNOT00000000134
Ak2
adenylate kinase 2
chr6_+_95816749 0.77 ENSRNOT00000008880
Six6
SIX homeobox 6
chr1_-_200163106 0.70 ENSRNOT00000027644
Mcmbp
minichromosome maintenance complex binding protein
chr2_+_186630278 0.12 ENSRNOT00000021604
LOC365839
similar to elongation protein 4 homolog
chr1_+_174767960 0.03 ENSRNOT00000013362
Wee1
WEE1 G2 checkpoint kinase

Network of associatons between targets according to the STRING database.

First level regulatory network of E2f8

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
24.5 195.9 GO:0010216 maintenance of DNA methylation(GO:0010216)
11.7 35.0 GO:0044330 canonical Wnt signaling pathway involved in positive regulation of wound healing(GO:0044330) metanephric cap development(GO:0072185) metanephric cap morphogenesis(GO:0072186) metanephric cap mesenchymal cell proliferation involved in metanephros development(GO:0090094) response to putrescine(GO:1904585) cellular response to putrescine(GO:1904586)
11.2 78.1 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
9.3 28.0 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
7.2 43.0 GO:1990086 lens fiber cell apoptotic process(GO:1990086)
4.7 32.6 GO:0043686 co-translational protein modification(GO:0043686)
3.8 15.1 GO:0070495 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
3.2 12.7 GO:2000813 negative regulation of barbed-end actin filament capping(GO:2000813)
3.1 49.5 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
2.9 82.1 GO:0006270 DNA replication initiation(GO:0006270)
2.8 11.3 GO:0046061 dATP catabolic process(GO:0046061)
2.3 16.0 GO:0042138 meiotic DNA double-strand break formation(GO:0042138)
2.1 6.3 GO:0071454 cellular response to anoxia(GO:0071454)
1.7 9.9 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
1.6 15.7 GO:0098532 histone H3-K27 trimethylation(GO:0098532)
1.5 4.5 GO:0016476 regulation of embryonic cell shape(GO:0016476)
1.4 19.2 GO:0051292 nuclear pore complex assembly(GO:0051292)
1.2 32.7 GO:0006335 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
1.2 4.8 GO:0001682 tRNA 5'-leader removal(GO:0001682)
1.1 69.8 GO:0090307 mitotic spindle assembly(GO:0090307)
1.0 21.7 GO:0045948 positive regulation of translational initiation(GO:0045948)
0.9 2.6 GO:1905076 regulation of interleukin-17 secretion(GO:1905076) negative regulation of interleukin-17 secretion(GO:1905077)
0.8 8.3 GO:0044821 telomere tethering at nuclear periphery(GO:0034398) meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic attachment of telomere to nuclear envelope(GO:0070197) chromosome attachment to the nuclear envelope(GO:0097240)
0.6 1.8 GO:0043932 ossification involved in bone remodeling(GO:0043932)
0.5 47.3 GO:0007093 mitotic cell cycle checkpoint(GO:0007093)
0.5 31.4 GO:0033045 regulation of sister chromatid segregation(GO:0033045)
0.5 3.7 GO:0021979 hypothalamus cell differentiation(GO:0021979)
0.5 13.9 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.5 3.2 GO:0007144 female meiosis I(GO:0007144)
0.4 4.4 GO:0043983 histone H4-K12 acetylation(GO:0043983)
0.4 1.2 GO:0046060 dATP metabolic process(GO:0046060)
0.2 8.2 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.1 7.4 GO:0006513 protein monoubiquitination(GO:0006513)
0.1 58.9 GO:0007017 microtubule-based process(GO:0007017)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
17.1 51.2 GO:1990423 RZZ complex(GO:1990423)
12.4 49.5 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
12.3 135.6 GO:0042555 MCM complex(GO:0042555)
10.9 32.7 GO:0033186 CAF-1 complex(GO:0033186)
6.4 19.2 GO:0044611 nuclear pore inner ring(GO:0044611)
3.5 159.2 GO:0000791 euchromatin(GO:0000791)
3.0 17.8 GO:0035189 Rb-E2F complex(GO:0035189)
2.6 15.7 GO:0001739 sex chromatin(GO:0001739)
2.3 71.7 GO:0005721 pericentric heterochromatin(GO:0005721)
1.9 32.6 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
1.6 4.8 GO:0000172 ribonuclease MRP complex(GO:0000172)
1.3 12.7 GO:0008290 F-actin capping protein complex(GO:0008290) pinosome(GO:0044352) macropinosome(GO:0044354)
1.1 9.9 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.7 4.3 GO:0005663 DNA replication factor C complex(GO:0005663)
0.7 11.0 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.6 8.2 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.5 11.6 GO:0001673 male germ cell nucleus(GO:0001673)
0.4 59.9 GO:0036064 ciliary basal body(GO:0036064)
0.4 8.3 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.4 6.3 GO:0001741 XY body(GO:0001741)
0.4 16.0 GO:0000795 synaptonemal complex(GO:0000795)
0.2 4.5 GO:0044447 axoneme part(GO:0044447)
0.1 15.3 GO:0000922 spindle pole(GO:0000922)
0.1 5.2 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 33.8 GO:0016607 nuclear speck(GO:0016607)
0.1 9.4 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.1 11.3 GO:0001669 acrosomal vesicle(GO:0001669)
0.1 4.4 GO:0000123 histone acetyltransferase complex(GO:0000123)
0.1 21.4 GO:0005667 transcription factor complex(GO:0005667)
0.0 15.1 GO:0005874 microtubule(GO:0005874)
0.0 12.1 GO:0044427 chromosomal part(GO:0044427)
0.0 1.2 GO:0005758 mitochondrial intermembrane space(GO:0005758)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
31.1 124.2 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
8.2 49.5 GO:0016728 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
7.0 69.8 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
5.5 77.5 GO:0003688 DNA replication origin binding(GO:0003688)
4.7 28.0 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
4.1 32.7 GO:0070087 chromo shadow domain binding(GO:0070087)
3.8 11.3 GO:0008413 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity(GO:0008413) 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity(GO:0035539)
2.4 21.7 GO:0008494 translation activator activity(GO:0008494)
2.3 32.6 GO:0004579 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
1.8 55.7 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
1.6 4.8 GO:0000171 ribonuclease MRP activity(GO:0000171)
1.3 5.2 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
1.0 19.2 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.7 35.0 GO:0070888 E-box binding(GO:0070888)
0.6 6.3 GO:0008432 JUN kinase binding(GO:0008432)
0.5 59.9 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.5 15.7 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.4 2.6 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.4 4.3 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.4 13.4 GO:0017025 TBP-class protein binding(GO:0017025)
0.3 16.6 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.3 9.9 GO:0036002 pre-mRNA binding(GO:0036002)
0.2 43.0 GO:0001047 core promoter binding(GO:0001047)
0.2 14.2 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.2 1.8 GO:0036122 BMP binding(GO:0036122)
0.2 8.2 GO:0016876 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.1 4.4 GO:0035064 methylated histone binding(GO:0035064)
0.1 1.2 GO:0004017 adenylate kinase activity(GO:0004017)
0.1 58.0 GO:0003682 chromatin binding(GO:0003682)
0.1 54.7 GO:0008270 zinc ion binding(GO:0008270)
0.0 15.1 GO:0015631 tubulin binding(GO:0015631)
0.0 57.9 GO:0005524 ATP binding(GO:0005524)
0.0 12.7 GO:0005543 phospholipid binding(GO:0005543)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 223.2 PID E2F PATHWAY E2F transcription factor network
1.2 28.0 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
1.2 15.1 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
1.1 71.7 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.6 22.4 PID ATR PATHWAY ATR signaling pathway
0.4 11.0 PID FANCONI PATHWAY Fanconi anemia pathway
0.4 16.6 PID ARF6 PATHWAY Arf6 signaling events
0.2 6.3 PID HIV NEF PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.2 15.3 PID CMYB PATHWAY C-MYB transcription factor network
0.2 4.3 PID FAS PATHWAY FAS (CD95) signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
12.1 133.2 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
3.8 82.6 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
3.1 50.0 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
2.5 25.3 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
1.4 35.0 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.9 9.9 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.7 19.2 REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.5 11.0 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.3 32.6 REACTOME ASPARAGINE N LINKED GLYCOSYLATION Genes involved in Asparagine N-linked glycosylation
0.3 8.2 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.3 24.2 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 2.6 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.1 9.4 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.1 1.2 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 1.8 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases