Project

GSE53960: rat RNA-Seq transcriptomic Bodymap

Navigation
Downloads

Results for E2f4

Z-value: 1.55

Motif logo

Transcription factors associated with E2f4

Gene Symbol Gene ID Gene Info
ENSRNOG00000015708 E2F transcription factor 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
E2f4rn6_v1_chr19_+_37252843_372528430.792.2e-69Click!

Activity profile of E2f4 motif

Sorted Z-values of E2f4 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr13_-_108178609 75.60 ENSRNOT00000004525
centromere protein F
chr13_-_87847263 68.88 ENSRNOT00000003650
NUF2, NDC80 kinetochore complex component
chr1_+_221448661 66.48 ENSRNOT00000072493
sororin-like
chr2_+_264704769 61.39 ENSRNOT00000012667
DEP domain containing 1
chr8_+_79054237 60.73 ENSRNOT00000077613
meiosis-specific nuclear structural 1
chr5_+_152721940 58.38 ENSRNOT00000039322
aurora kinase A and ninein interacting protein
chr1_+_31967978 57.21 ENSRNOT00000081471
ENSRNOT00000021532
thyroid hormone receptor interactor 13
chr3_+_159421671 56.24 ENSRNOT00000010343
myeloblastosis oncogene-like 2
chr15_-_70399924 53.31 ENSRNOT00000087940
diaphanous-related formin 3
chr8_+_48665652 52.85 ENSRNOT00000059715
H2A histone family, member X
chr16_+_19800463 52.57 ENSRNOT00000023065
ankyrin repeat and LEM domain containing 1
chr5_-_134978125 50.57 ENSRNOT00000018004
RAD54 like (S. cerevisiae)
chr16_+_41079444 48.46 ENSRNOT00000015623
nei-like DNA glycosylase 3
chr10_-_89454681 46.42 ENSRNOT00000028109
BRCA1, DNA repair associated
chr15_-_24199341 45.10 ENSRNOT00000015553
DLG associated protein 5
chr15_-_61564695 44.53 ENSRNOT00000068216
regulator of cell cycle
chr1_-_157700064 42.49 ENSRNOT00000031974
DNA damage-induced apoptosis suppressor
chr8_+_116730641 41.33 ENSRNOT00000052289
TRAF-interacting protein
chr9_-_92963697 41.22 ENSRNOT00000023546
G protein-coupled receptor 55
chr5_-_150520884 41.01 ENSRNOT00000085482
regulator of chromosome condensation 1
chr3_+_1478525 35.90 ENSRNOT00000008161
pleckstrin and Sec7 domain containing 4
chr10_+_55626741 35.86 ENSRNOT00000008492
aurora kinase B
chrX_-_31140711 32.19 ENSRNOT00000082358
Fanconi anemia, complementation group B
chr7_-_28715224 31.23 ENSRNOT00000065899
PARP1 binding protein
chr1_-_94494980 30.80 ENSRNOT00000020014
cyclin E1
chr2_+_187447501 30.79 ENSRNOT00000038589
IQ motif containing GTPase activating protein 3
chr3_+_149131785 30.52 ENSRNOT00000090321
DNA methyltransferase 3 beta
chr6_+_129835919 30.16 ENSRNOT00000036035
vaccinia related kinase 1
chr10_-_15098791 28.47 ENSRNOT00000026139
chromosome transmission fidelity factor 18
chr15_-_60512704 27.84 ENSRNOT00000049056
tumor necrosis factor superfamily member 11
chr16_-_76110553 26.98 ENSRNOT00000043384
microcephalin 1
chr20_+_4967194 25.24 ENSRNOT00000070846
LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated
chr4_+_5841998 23.72 ENSRNOT00000010025
X-ray repair cross complementing 2
chr20_-_7930929 22.03 ENSRNOT00000000607
TEA domain transcription factor 3
chr12_-_19314016 21.93 ENSRNOT00000001825
minichromosome maintenance complex component 7
chr5_-_152198813 21.22 ENSRNOT00000082953
high mobility group nucleosomal binding domain 2
chr13_-_68858781 21.03 ENSRNOT00000065944
ENSRNOT00000092053
ring finger protein 2
chr14_-_110883784 20.63 ENSRNOT00000086299
ENSRNOT00000068190
vaccinia related kinase 2
chr6_-_26855658 20.51 ENSRNOT00000011635
ATP/GTP binding protein-like 5
chr1_-_1392329 20.19 ENSRNOT00000075346

chr13_-_90839411 19.88 ENSRNOT00000010594
SLAM family member 9
chr20_-_5037022 19.72 ENSRNOT00000091022
ENSRNOT00000060762
mutS homolog 5
chrX_-_62903530 18.94 ENSRNOT00000076652
ENSRNOT00000017370
pyruvate dehydrogenase kinase 3
chr5_-_77031120 18.72 ENSRNOT00000022987
INTS3 and NABP interacting protein
chrX_+_15171499 18.57 ENSRNOT00000008399
suppressor of variegation 3-9 homolog 1 (Drosophila)-like 1
chr7_-_2941122 17.79 ENSRNOT00000082107
extended synaptotagmin 1
chr7_-_117703094 17.44 ENSRNOT00000019754
tonsoku-like, DNA repair protein
chr1_+_48433079 17.34 ENSRNOT00000037369
solute carrier family 22 member 3
chr20_+_3156170 16.73 ENSRNOT00000082880
RT1 class Ib, locus S2
chr14_+_82356916 16.12 ENSRNOT00000040229
stem-loop binding protein
chr1_+_198214797 14.01 ENSRNOT00000068543
T-box 6
chr1_-_1116926 13.77 ENSRNOT00000062027
retinoic acid early transcript 1L
chr7_-_140951071 13.54 ENSRNOT00000082521
family with sequence similarity 186, member B
chr20_+_4966817 13.16 ENSRNOT00000081527
ENSRNOT00000081265
LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated
chr10_-_95212111 13.05 ENSRNOT00000020795
karyopherin subunit alpha 2
chr13_-_98078555 12.23 ENSRNOT00000078034
AT hook containing transcription factor 1
chr6_+_11644578 12.15 ENSRNOT00000021923
ENSRNOT00000093689
mutS homolog 6
chr14_+_17210733 11.94 ENSRNOT00000003075
C-X-C motif chemokine ligand 10
chr8_+_62482140 11.66 ENSRNOT00000026492
enhancer of mRNA decapping 3
chr18_-_27550224 11.49 ENSRNOT00000037368
cell division cycle 25C
chr18_-_56115593 11.35 ENSRNOT00000045041
treacle ribosome biogenesis factor 1
chr5_-_105212173 10.87 ENSRNOT00000010383
ribosomal protein S6
chr3_-_163477715 10.61 ENSRNOT00000009517
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
chr1_-_82546937 10.51 ENSRNOT00000028100
heterogeneous nuclear ribonucleoprotein U-like 1
chr13_+_70852023 10.48 ENSRNOT00000003661
SHC binding and spindle associated 1 like
chr6_-_55647665 10.14 ENSRNOT00000007414
basic leucine zipper and W2 domains 2
chr17_+_78735598 9.85 ENSRNOT00000020854
heat shock protein family A, member 14
chr1_+_162342051 9.72 ENSRNOT00000016478
ALG8, alpha-1,3-glucosyltransferase
chr19_+_10024947 9.47 ENSRNOT00000061392
cilia and flagella associated protein 20
chr2_+_244521699 9.36 ENSRNOT00000029382
sperm-tail PG-rich repeat containing 2
chr5_+_103024376 9.25 ENSRNOT00000058536

chr13_-_98078946 9.25 ENSRNOT00000035875
AT hook containing transcription factor 1
chr3_+_91252829 9.12 ENSRNOT00000006148
TNF receptor associated factor 6
chr6_-_7421456 9.03 ENSRNOT00000006725
zinc finger protein 36, C3H type-like 2
chrX_-_123731294 8.57 ENSRNOT00000092574
ENSRNOT00000032618
UPF3 regulator of nonsense transcripts homolog B (yeast)
chr14_+_81819799 8.51 ENSRNOT00000076840
Max dimerization protein 4
chr4_-_56438142 8.20 ENSRNOT00000077079
RNA binding motif protein 28
chr10_+_82745801 8.10 ENSRNOT00000005311
collagen type I alpha 1 chain
chr2_+_187915751 7.39 ENSRNOT00000026994
ubiquilin 4
chr8_-_12993651 6.41 ENSRNOT00000033932
lysine demethylase 4D
chr10_+_10811937 6.28 ENSRNOT00000077347
ankyrin repeat and sterile alpha motif domain containing 3
chr11_+_87522971 6.12 ENSRNOT00000043545
sphingomyelin phosphodiesterase 4
chr9_-_66845403 5.77 ENSRNOT00000041546
islet cell autoantigen 1-like
chr13_+_101790865 5.75 ENSRNOT00000087784
TATA-box binding protein associated factor, RNA polymerase I subunit A
chr6_+_55648021 5.60 ENSRNOT00000064822
ENSRNOT00000091488
ankyrin repeat and MYND domain containing 2
chr5_-_151029233 5.51 ENSRNOT00000089155
protein phosphatase 1, regulatory subunit 8
chr4_-_10329241 5.48 ENSRNOT00000017232
fibrinogen-like 2
chr13_+_110743098 5.46 ENSRNOT00000075086
retinal degeneration 3
chr1_+_36400443 5.46 ENSRNOT00000023712
poly(A) RNA polymerase D7, non-canonical
chr3_+_122114754 5.29 ENSRNOT00000006408
signal-regulatory protein alpha
chr14_+_86813082 5.20 ENSRNOT00000090360
CCM2 scaffolding protein
chr1_+_162549420 4.92 ENSRNOT00000037050
remodeling and spacing factor 1
chr9_+_16139101 4.61 ENSRNOT00000070803
uncharacterized LOC100910668
chr8_-_111850393 4.50 ENSRNOT00000044956
CDV3 homolog
chr1_-_31967915 4.30 ENSRNOT00000021000
bromodomain containing 9
chr5_+_76860515 4.28 ENSRNOT00000022866
similar to RIKEN cDNA E130308A19
chr7_+_28715300 4.12 ENSRNOT00000006760
ENSRNOT00000089161
nucleoporin 37
chr4_+_117679342 3.94 ENSRNOT00000021272
folliculogenesis specific bHLH transcription factor
chr8_-_62332115 3.53 ENSRNOT00000025783
mannose phosphate isomerase (mapped)
chr9_-_81565416 3.49 ENSRNOT00000083582
angio-associated, migratory cell protein
chr4_-_56438465 3.28 ENSRNOT00000064007
RNA binding motif protein 28
chr10_-_45851984 3.23 ENSRNOT00000058308
zinc finger protein 496
chr4_-_7281223 3.20 ENSRNOT00000019666
solute carrier family 4 member 2
chr1_-_220067123 3.19 ENSRNOT00000071020
ENSRNOT00000072373
RNA binding motif protein 14
chr10_+_39726507 3.05 ENSRNOT00000036822
meiotic kinetochore factor
chr7_-_123088819 3.02 ENSRNOT00000056077

chr10_+_55627025 2.99 ENSRNOT00000091016
aurora kinase B
chr7_-_123088279 2.91 ENSRNOT00000071998
transducer of ERBB2, 2
chr13_-_55886679 2.89 ENSRNOT00000066601
similar to novel protein
chr5_+_47186558 2.44 ENSRNOT00000007654
mitogen-activated protein kinase kinase kinase 7-like
chr20_+_27169267 2.36 ENSRNOT00000077525
heterogeneous nuclear ribonucleoprotein H3
chr10_+_15099009 2.00 ENSRNOT00000015206
RNA pseudouridylate synthase domain containing 1
chr10_+_4312863 1.62 ENSRNOT00000091610
eukaryotic peptide chain release factor GTP-binding subunit ERF3B-like
chr10_+_96663740 1.60 ENSRNOT00000037067
centrosomal protein 112
chr19_-_55967836 1.54 ENSRNOT00000051452
sulfotransferase family 5A, member 1
chr5_+_9230984 1.45 ENSRNOT00000009136
valosin containing protein interacting protein 1
chr7_+_97778260 1.24 ENSRNOT00000064264
TBC1 domain family, member 31
chr5_+_162351001 1.18 ENSRNOT00000065471
hypothetical protein LOC691162
chr1_-_221448570 1.17 ENSRNOT00000075165
zinc finger protein-like 1
chr20_-_31072469 0.92 ENSRNOT00000082448
eukaryotic translation initiation factor 4E binding protein 2
chr4_-_160803558 0.91 ENSRNOT00000049542
Sumo1/sentrin/SMT3 specific peptidase 18
chr10_+_4313100 0.85 ENSRNOT00000074487
eukaryotic peptide chain release factor GTP-binding subunit ERF3B-like
chr4_-_145329878 0.78 ENSRNOT00000011827
transcriptional adaptor 3
chr9_+_9842585 0.78 ENSRNOT00000070806
Cd70 molecule
chr11_-_36479868 0.60 ENSRNOT00000075762
non-histone chromosomal protein HMG-14-like
chr11_+_73738433 0.59 ENSRNOT00000002353
transmembrane protein 44
chr8_+_70860671 0.55 ENSRNOT00000019258
programmed cell death 7
chr9_+_93326283 0.44 ENSRNOT00000024578
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7
chr5_-_57168610 0.21 ENSRNOT00000090499
beta-1,4-galactosyltransferase 1
chr8_-_52814188 0.07 ENSRNOT00000087265
ENSRNOT00000047633
RNA exonuclease 2

Network of associatons between targets according to the STRING database.

First level regulatory network of E2f4

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
15.5 46.4 GO:2000620 positive regulation of histone H4-K16 acetylation(GO:2000620)
15.1 30.2 GO:0043987 histone H3-S10 phosphorylation(GO:0043987)
14.8 44.5 GO:0003331 regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
10.7 32.2 GO:1905168 positive regulation of double-strand break repair via homologous recombination(GO:1905168)
10.5 52.6 GO:0045950 negative regulation of mitotic recombination(GO:0045950)
10.2 30.5 GO:0060821 inactivation of X chromosome by DNA methylation(GO:0060821)
9.7 38.8 GO:0043988 histone H3-S28 phosphorylation(GO:0043988)
8.2 57.2 GO:0007144 female meiosis I(GO:0007144)
7.0 27.8 GO:0043397 corticotropin-releasing hormone secretion(GO:0043396) regulation of corticotropin-releasing hormone secretion(GO:0043397) TNFSF11-mediated signaling pathway(GO:0071847) positive regulation of osteoclast development(GO:2001206)
6.7 27.0 GO:0060623 regulation of chromosome condensation(GO:0060623)
5.3 21.0 GO:0036353 histone H2A-K119 monoubiquitination(GO:0036353)
4.7 18.9 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
4.6 50.6 GO:0000733 DNA strand renaturation(GO:0000733)
4.6 41.2 GO:0038171 cannabinoid signaling pathway(GO:0038171)
4.2 42.5 GO:2000270 negative regulation of fibroblast apoptotic process(GO:2000270)
4.0 11.9 GO:1901740 negative regulation of myoblast fusion(GO:1901740)
4.0 23.7 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
3.9 31.2 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
3.4 60.7 GO:0070986 left/right axis specification(GO:0070986)
3.2 28.5 GO:1900264 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
3.1 21.9 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
2.9 20.6 GO:2000659 regulation of interleukin-1-mediated signaling pathway(GO:2000659)
2.8 14.0 GO:0014043 negative regulation of neuron maturation(GO:0014043)
2.7 10.9 GO:0022605 oogenesis stage(GO:0022605)
2.7 16.1 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
2.6 30.8 GO:0033601 positive regulation of mammary gland epithelial cell proliferation(GO:0033601)
2.5 7.4 GO:1901097 negative regulation of autophagosome maturation(GO:1901097)
2.4 41.3 GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway(GO:0010804)
2.4 12.1 GO:0043570 maintenance of DNA repeat elements(GO:0043570)
2.4 9.5 GO:0060295 regulation of cilium movement involved in cell motility(GO:0060295) regulation of cilium beat frequency involved in ciliary motility(GO:0060296) regulation of cilium-dependent cell motility(GO:1902019)
2.3 20.5 GO:0035608 protein deglutamylation(GO:0035608)
2.2 22.0 GO:0055059 asymmetric neuroblast division(GO:0055059)
2.2 30.8 GO:0001547 antral ovarian follicle growth(GO:0001547)
2.1 6.4 GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining(GO:2001034)
2.1 75.6 GO:0021591 ventricular system development(GO:0021591)
2.0 8.1 GO:1902618 cellular response to fluoride(GO:1902618)
1.9 18.6 GO:0000183 chromatin silencing at rDNA(GO:0000183)
1.8 21.5 GO:0051292 nuclear pore complex assembly(GO:0051292)
1.7 17.3 GO:0015697 quaternary ammonium group transport(GO:0015697)
1.7 11.7 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
1.6 19.7 GO:0006298 mismatch repair(GO:0006298)
1.6 13.0 GO:0046015 regulation of transcription by glucose(GO:0046015)
1.5 9.1 GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666)
1.5 35.9 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
1.5 52.9 GO:0071480 cellular response to gamma radiation(GO:0071480)
1.3 21.2 GO:0040034 regulation of development, heterochronic(GO:0040034)
1.0 5.2 GO:0060837 blood vessel endothelial cell differentiation(GO:0060837)
1.0 48.5 GO:0006284 base-excision repair(GO:0006284)
0.9 6.1 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.8 9.0 GO:1904627 response to phorbol 13-acetate 12-myristate(GO:1904627) cellular response to phorbol 13-acetate 12-myristate(GO:1904628)
0.8 11.3 GO:0042790 transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:0042790)
0.8 135.9 GO:0007051 spindle organization(GO:0007051)
0.8 3.2 GO:0046600 negative regulation of centriole replication(GO:0046600)
0.8 3.0 GO:0051754 meiotic sister chromatid cohesion, centromeric(GO:0051754)
0.8 17.4 GO:0031297 replication fork processing(GO:0031297)
0.7 9.7 GO:0006490 oligosaccharide-lipid intermediate biosynthetic process(GO:0006490)
0.7 3.5 GO:0071554 GDP-mannose biosynthetic process(GO:0009298) cell wall macromolecule metabolic process(GO:0044036) cell wall organization or biogenesis(GO:0071554)
0.7 4.9 GO:0016584 nucleosome positioning(GO:0016584)
0.6 2.4 GO:0002184 cytoplasmic translational termination(GO:0002184)
0.4 13.8 GO:0045954 positive regulation of natural killer cell mediated cytotoxicity(GO:0045954)
0.3 1.5 GO:0090168 Golgi reassembly(GO:0090168)
0.3 10.6 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.2 8.6 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.2 5.3 GO:0006910 phagocytosis, recognition(GO:0006910)
0.2 5.5 GO:0007567 parturition(GO:0007567)
0.2 5.8 GO:0006360 transcription from RNA polymerase I promoter(GO:0006360)
0.1 16.7 GO:0019882 antigen processing and presentation(GO:0019882)
0.1 60.6 GO:0051301 cell division(GO:0051301)
0.1 2.9 GO:0045671 negative regulation of osteoclast differentiation(GO:0045671)
0.1 15.7 GO:0010212 response to ionizing radiation(GO:0010212)
0.1 40.4 GO:0006470 protein dephosphorylation(GO:0006470)
0.1 0.2 GO:0060058 apoptotic process involved in mammary gland involution(GO:0060057) positive regulation of apoptotic process involved in mammary gland involution(GO:0060058) positive regulation of apoptotic process involved in morphogenesis(GO:1902339) regulation of mammary gland involution(GO:1903519) positive regulation of mammary gland involution(GO:1903521) positive regulation of apoptotic process involved in development(GO:1904747)
0.1 3.2 GO:0015701 bicarbonate transport(GO:0015701)
0.1 2.0 GO:0001522 pseudouridine synthesis(GO:0001522)
0.1 1.6 GO:0097120 receptor localization to synapse(GO:0097120)
0.1 0.9 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.1 0.8 GO:0090043 tubulin deacetylation(GO:0090042) regulation of tubulin deacetylation(GO:0090043)
0.1 0.8 GO:0007252 I-kappaB phosphorylation(GO:0007252)
0.1 28.3 GO:0007283 spermatogenesis(GO:0007283)
0.1 17.8 GO:0006869 lipid transport(GO:0006869)
0.1 0.6 GO:0070234 positive regulation of T cell apoptotic process(GO:0070234)
0.0 10.5 GO:0009615 response to virus(GO:0009615)
0.0 11.2 GO:0000398 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
13.8 68.9 GO:0031262 Ndc80 complex(GO:0031262)
11.6 46.4 GO:0031436 BRCA1-BARD1 complex(GO:0031436)
7.7 38.4 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
6.5 38.8 GO:0032133 chromosome passenger complex(GO:0032133)
6.3 75.6 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
5.8 17.4 GO:0035101 FACT complex(GO:0035101)
4.7 23.7 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
4.7 18.7 GO:0070876 SOSS complex(GO:0070876)
4.6 110.1 GO:0001673 male germ cell nucleus(GO:0001673)
4.5 45.1 GO:0031616 spindle pole centrosome(GO:0031616)
4.0 12.1 GO:0032301 MutSalpha complex(GO:0032301)
3.7 18.6 GO:0033553 rDNA heterochromatin(GO:0033553)
3.2 28.5 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
3.0 21.0 GO:0001739 sex chromatin(GO:0001739)
2.6 25.6 GO:0031080 nuclear pore outer ring(GO:0031080)
2.4 21.9 GO:0042555 MCM complex(GO:0042555)
2.0 38.5 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
2.0 32.2 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
1.8 16.1 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
1.3 17.8 GO:0044232 organelle membrane contact site(GO:0044232)
1.2 5.8 GO:0000120 RNA polymerase I transcription factor complex(GO:0000120)
0.9 7.4 GO:0031595 nuclear proteasome complex(GO:0031595)
0.9 10.5 GO:0072687 meiotic spindle(GO:0072687)
0.8 62.2 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.8 9.1 GO:0035631 CD40 receptor complex(GO:0035631)
0.7 8.1 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.7 30.8 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.7 61.4 GO:0017053 transcriptional repressor complex(GO:0017053)
0.6 2.4 GO:0018444 translation release factor complex(GO:0018444)
0.6 12.9 GO:0019013 viral nucleocapsid(GO:0019013)
0.5 6.4 GO:0005721 pericentric heterochromatin(GO:0005721)
0.5 58.4 GO:0000922 spindle pole(GO:0000922)
0.5 60.7 GO:0036126 sperm flagellum(GO:0036126)
0.5 20.4 GO:0005720 nuclear heterochromatin(GO:0005720)
0.5 4.9 GO:0031010 ISWI-type complex(GO:0031010)
0.5 30.8 GO:0016328 lateral plasma membrane(GO:0016328)
0.4 21.3 GO:0072686 mitotic spindle(GO:0072686)
0.3 8.6 GO:0035145 exon-exon junction complex(GO:0035145)
0.2 31.8 GO:0005795 Golgi stack(GO:0005795)
0.1 7.2 GO:0005643 nuclear pore(GO:0005643)
0.1 93.1 GO:0044427 chromosomal part(GO:0044427)
0.1 6.7 GO:0005844 polysome(GO:0005844)
0.1 11.7 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 9.5 GO:0005814 centriole(GO:0005814)
0.1 7.9 GO:0043198 dendritic shaft(GO:0043198)
0.1 11.3 GO:0001650 fibrillar center(GO:0001650)
0.1 23.3 GO:0005813 centrosome(GO:0005813)
0.1 0.3 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 5.8 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 11.9 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 32.4 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 7.9 GO:0005840 ribosome(GO:0005840)
0.0 0.6 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 4.5 GO:0005667 transcription factor complex(GO:0005667)
0.0 3.3 GO:0031965 nuclear membrane(GO:0031965)
0.0 64.9 GO:0005634 nucleus(GO:0005634)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
10.3 41.2 GO:0004949 cannabinoid receptor activity(GO:0004949)
10.3 41.0 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
6.9 48.5 GO:0000405 bubble DNA binding(GO:0000405)
6.3 50.6 GO:0036310 annealing helicase activity(GO:0036310)
6.1 30.5 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
6.0 30.2 GO:0031493 nucleosomal histone binding(GO:0031493)
5.6 56.2 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
5.3 21.0 GO:0071535 RING-like zinc finger domain binding(GO:0071535)
5.1 30.8 GO:0032027 myosin light chain binding(GO:0032027)
4.7 18.9 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
4.0 12.1 GO:0032142 single guanine insertion binding(GO:0032142)
4.0 23.7 GO:0000150 recombinase activity(GO:0000150)
3.2 9.7 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
2.8 28.5 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
2.6 38.8 GO:0035174 histone serine kinase activity(GO:0035174)
2.5 71.4 GO:0070840 dynein complex binding(GO:0070840)
2.4 11.9 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
2.2 17.3 GO:0005329 dopamine transmembrane transporter activity(GO:0005329) quaternary ammonium group transmembrane transporter activity(GO:0015651)
2.1 38.4 GO:0017160 Ral GTPase binding(GO:0017160)
2.1 18.6 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
2.0 19.7 GO:0030983 mismatched DNA binding(GO:0030983)
1.7 105.7 GO:0003684 damaged DNA binding(GO:0003684)
1.4 35.9 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
1.3 41.8 GO:0070412 R-SMAD binding(GO:0070412)
1.0 21.9 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.9 30.8 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.9 37.7 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.8 20.5 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.7 5.5 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.7 3.3 GO:0001042 RNA polymerase I core binding(GO:0001042)
0.7 10.6 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.7 21.8 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.6 64.2 GO:0004519 endonuclease activity(GO:0004519)
0.6 8.1 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.5 53.3 GO:0017048 Rho GTPase binding(GO:0017048)
0.5 16.1 GO:0036002 pre-mRNA binding(GO:0036002)
0.4 11.5 GO:0050699 WW domain binding(GO:0050699)
0.4 3.5 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.4 13.0 GO:0070491 repressing transcription factor binding(GO:0070491)
0.3 14.0 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.3 3.4 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.2 22.0 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.2 41.0 GO:0005057 receptor signaling protein activity(GO:0005057)
0.2 2.4 GO:0008079 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.2 4.3 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.2 4.1 GO:0015288 porin activity(GO:0015288)
0.2 32.3 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.2 7.4 GO:0031593 polyubiquitin binding(GO:0031593)
0.1 2.0 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.1 3.2 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.1 18.6 GO:0042393 histone binding(GO:0042393)
0.1 5.3 GO:0045309 protein phosphorylated amino acid binding(GO:0045309)
0.1 3.2 GO:0043621 protein self-association(GO:0043621)
0.1 0.6 GO:0015189 L-lysine transmembrane transporter activity(GO:0015189)
0.1 0.9 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.1 17.3 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.1 4.0 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.1 0.2 GO:0003945 N-acetyllactosamine synthase activity(GO:0003945)
0.1 6.1 GO:0004620 phospholipase activity(GO:0004620)
0.1 20.6 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.1 80.5 GO:0042802 identical protein binding(GO:0042802)
0.1 5.5 GO:0016779 nucleotidyltransferase activity(GO:0016779)
0.0 17.8 GO:0008289 lipid binding(GO:0008289)
0.0 1.5 GO:0008146 sulfotransferase activity(GO:0008146)
0.0 1.5 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 0.4 GO:0008378 galactosyltransferase activity(GO:0008378)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 130.4 PID AURORA A PATHWAY Aurora A signaling
2.4 106.4 PID FOXM1 PATHWAY FOXM1 transcription factor network
1.6 83.5 PID FANCONI PATHWAY Fanconi anemia pathway
1.6 33.4 PID ATR PATHWAY ATR signaling pathway
0.9 82.9 PID CDC42 PATHWAY CDC42 signaling events
0.9 26.6 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.8 52.5 PID E2F PATHWAY E2F transcription factor network
0.7 13.0 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.6 27.8 PID IL6 7 PATHWAY IL6-mediated signaling events
0.5 8.1 PID LYMPH ANGIOGENESIS PATHWAY VEGFR3 signaling in lymphatic endothelium
0.5 41.0 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.5 10.9 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.4 11.9 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.3 10.6 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.3 5.2 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.1 5.9 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 5.5 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
4.3 99.3 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
3.3 50.1 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
3.1 87.0 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
2.0 21.9 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
1.9 17.3 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
1.6 11.5 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
1.5 32.2 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
1.5 16.1 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
1.3 133.3 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
1.3 18.9 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
1.0 9.1 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival
0.8 22.0 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.8 10.9 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.6 5.8 REACTOME RNA POL I TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.5 8.1 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.5 19.7 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.5 41.0 REACTOME LATE PHASE OF HIV LIFE CYCLE Genes involved in Late Phase of HIV Life Cycle
0.4 4.9 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.4 13.3 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.3 5.3 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.3 8.6 REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM Genes involved in Transport of Mature Transcript to Cytoplasm
0.3 53.2 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.2 9.4 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.2 6.1 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.1 10.5 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 3.2 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.6 REACTOME KERATAN SULFATE BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis