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GSE53960: rat RNA-Seq transcriptomic Bodymap
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Results for E2f4
Z-value: 1.55
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Transcription factors associated with E2f4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E2f4 | rn6_v1_chr19_+_37252843_37252843 | 0.79 | 2.2e-69 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr13_-_108178609 Show fit | 75.60 |
ENSRNOT00000004525
|
centromere protein F |
|
| chr13_-_87847263 Show fit | 68.88 |
ENSRNOT00000003650
|
NUF2, NDC80 kinetochore complex component |
|
| chr1_+_221448661 Show fit | 66.48 |
ENSRNOT00000072493
|
sororin-like |
|
| chr2_+_264704769 Show fit | 61.39 |
ENSRNOT00000012667
|
DEP domain containing 1 |
|
| chr8_+_79054237 Show fit | 60.73 |
ENSRNOT00000077613
|
meiosis-specific nuclear structural 1 |
|
| chr5_+_152721940 Show fit | 58.38 |
ENSRNOT00000039322
|
aurora kinase A and ninein interacting protein |
|
| chr1_+_31967978 Show fit | 57.21 |
ENSRNOT00000081471
ENSRNOT00000021532 |
thyroid hormone receptor interactor 13 |
|
| chr3_+_159421671 Show fit | 56.24 |
ENSRNOT00000010343
|
myeloblastosis oncogene-like 2 |
|
| chr15_-_70399924 Show fit | 53.31 |
ENSRNOT00000087940
|
diaphanous-related formin 3 |
|
| chr8_+_48665652 Show fit | 52.85 |
ENSRNOT00000059715
|
H2A histone family, member X |
Network of associatons between targets according to the STRING database.
First level regulatory network of E2f4
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 135.9 | GO:0007051 | spindle organization(GO:0007051) |
| 2.1 | 75.6 | GO:0021591 | ventricular system development(GO:0021591) |
| 3.4 | 60.7 | GO:0070986 | left/right axis specification(GO:0070986) |
| 0.1 | 60.6 | GO:0051301 | cell division(GO:0051301) |
| 8.2 | 57.2 | GO:0007144 | female meiosis I(GO:0007144) |
| 1.5 | 52.9 | GO:0071480 | cellular response to gamma radiation(GO:0071480) |
| 10.5 | 52.6 | GO:0045950 | negative regulation of mitotic recombination(GO:0045950) |
| 4.6 | 50.6 | GO:0000733 | DNA strand renaturation(GO:0000733) |
| 1.0 | 48.5 | GO:0006284 | base-excision repair(GO:0006284) |
| 15.5 | 46.4 | GO:2000620 | positive regulation of histone H4-K16 acetylation(GO:2000620) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.6 | 110.1 | GO:0001673 | male germ cell nucleus(GO:0001673) |
| 0.1 | 93.1 | GO:0044427 | chromosomal part(GO:0044427) |
| 6.3 | 75.6 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 13.8 | 68.9 | GO:0031262 | Ndc80 complex(GO:0031262) |
| 0.0 | 64.9 | GO:0005634 | nucleus(GO:0005634) |
| 0.8 | 62.2 | GO:0000794 | condensed nuclear chromosome(GO:0000794) |
| 0.7 | 61.4 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.5 | 60.7 | GO:0036126 | sperm flagellum(GO:0036126) |
| 0.5 | 58.4 | GO:0000922 | spindle pole(GO:0000922) |
| 11.6 | 46.4 | GO:0031436 | BRCA1-BARD1 complex(GO:0031436) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 105.7 | GO:0003684 | damaged DNA binding(GO:0003684) |
| 0.1 | 80.5 | GO:0042802 | identical protein binding(GO:0042802) |
| 2.5 | 71.4 | GO:0070840 | dynein complex binding(GO:0070840) |
| 0.6 | 64.2 | GO:0004519 | endonuclease activity(GO:0004519) |
| 5.6 | 56.2 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
| 0.5 | 53.3 | GO:0017048 | Rho GTPase binding(GO:0017048) |
| 6.3 | 50.6 | GO:0036310 | annealing helicase activity(GO:0036310) |
| 6.9 | 48.5 | GO:0000405 | bubble DNA binding(GO:0000405) |
| 1.3 | 41.8 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 10.3 | 41.2 | GO:0004949 | cannabinoid receptor activity(GO:0004949) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.2 | 130.4 | PID AURORA A PATHWAY | Aurora A signaling |
| 2.4 | 106.4 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 1.6 | 83.5 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.9 | 82.9 | PID CDC42 PATHWAY | CDC42 signaling events |
| 0.8 | 52.5 | PID E2F PATHWAY | E2F transcription factor network |
| 0.5 | 41.0 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 1.6 | 33.4 | PID ATR PATHWAY | ATR signaling pathway |
| 0.6 | 27.8 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.9 | 26.6 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.7 | 13.0 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 133.3 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 4.3 | 99.3 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 3.1 | 87.0 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 0.3 | 53.2 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 3.3 | 50.1 | REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 0.5 | 41.0 | REACTOME LATE PHASE OF HIV LIFE CYCLE | Genes involved in Late Phase of HIV Life Cycle |
| 1.5 | 32.2 | REACTOME FANCONI ANEMIA PATHWAY | Genes involved in Fanconi Anemia pathway |
| 0.8 | 22.0 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 2.0 | 21.9 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.5 | 19.7 | REACTOME MEIOTIC RECOMBINATION | Genes involved in Meiotic Recombination |