ISMARA results: E2f2

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for E2f2_E2f5

Z-value: 2.98

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Transcription factors associated with E2f2_E2f5

Gene Symbol	Gene ID	Gene Info
E2f2 NCBI RGD Ensembl	ENSRNOG00000047741	E2F transcription factor 2
E2f5 NCBI RGD Ensembl	ENSRNOG00000010760	E2F transcription factor 5

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
E2f2	rn6_v1_chr5_+_154522119_154522119	0.83	5.4e-84	Click!
E2f5	rn6_v1_chr2_-_88366115_88366115	0.21	1.3e-04	Click!

Activity profile of E2f2_E2f5 motif

Sorted Z-values of E2f2_E2f5 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr3_+_59153280 Show fit	206.46	ENSRNOT00000002066	Cdca7 NCBI RGD Ensembl Show fit	cell division cycle associated 7
chr6_+_43884678 Show fit	205.10	ENSRNOT00000091551	Rrm2 NCBI RGD Ensembl Show fit	ribonucleotide reductase regulatory subunit M2
chr20_+_20576377 Show fit	185.05	ENSRNOT00000000783 ENSRNOT00000086806	Cdk1 NCBI RGD Ensembl Show fit	cyclin-dependent kinase 1
chr14_-_20953095 Show fit	183.40	ENSRNOT00000004440	Dck NCBI RGD Ensembl Show fit	deoxycytidine kinase
chr19_+_14523554 Show fit	170.60	ENSRNOT00000084271 ENSRNOT00000064731	Mcm5 NCBI RGD Ensembl Show fit	minichromosome maintenance complex component 5
chr13_-_45068077 Show fit	157.53	ENSRNOT00000004969	Mcm6 NCBI RGD Ensembl Show fit	minichromosome maintenance complex component 6
chr9_-_26932201 Show fit	156.83	ENSRNOT00000017081	Mcm3 NCBI RGD Ensembl Show fit	minichromosome maintenance complex component 3
chr17_+_44528125 Show fit	145.26	ENSRNOT00000084538	LOC680322 NCBI RGD Ensembl Show fit	similar to Histone H2A type 1
chr8_+_132032944 Show fit	142.64	ENSRNOT00000089278	Kif15 NCBI RGD Ensembl Show fit	kinesin family member 15
chr1_-_42467586 Show fit	141.33	ENSRNOT00000029416	Fbxo5 NCBI RGD Ensembl Show fit	F-box protein 5

Showing 1 to 10 of 198 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of E2f2_E2f5

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
6.5	508.4	GO:0006342	chromatin silencing(GO:0006342)
72.2	505.6	GO:0006268	DNA unwinding involved in DNA replication(GO:0006268)
17.4	366.1	GO:0006270	DNA replication initiation(GO:0006270)
3.7	335.6	GO:0006334	nucleosome assembly(GO:0006334)
22.1	310.0	GO:0019985	translesion synthesis(GO:0019985)
14.8	236.5	GO:0009263	deoxyribonucleotide biosynthetic process(GO:0009263)
26.4	185.1	GO:0090166	Golgi disassembly(GO:0090166)
30.6	183.4	GO:0046125	pyrimidine deoxyribonucleoside metabolic process(GO:0046125)
19.2	173.0	GO:0033314	mitotic DNA replication checkpoint(GO:0033314)
42.5	170.0	GO:0006272	leading strand elongation(GO:0006272)

Showing 1 to 10 of 115 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
11.7	1068.1	GO:0000786	nucleosome(GO:0000786)
70.1	771.3	GO:0042555	MCM complex(GO:0042555)
59.1	236.5	GO:0005971	ribonucleoside-diphosphate reductase complex(GO:0005971)
0.1	234.5	GO:0005654	nucleoplasm(GO:0005654)
45.2	225.8	GO:0008622	epsilon DNA polymerase complex(GO:0008622)
61.7	185.1	GO:0097125	cyclin B1-CDK1 complex(GO:0097125)
0.6	160.2	GO:0005819	spindle(GO:0005819)
2.1	142.6	GO:0005871	kinesin complex(GO:0005871)
15.4	122.9	GO:0001740	Barr body(GO:0001740)
39.4	118.2	GO:0000811	GINS complex(GO:0000811)

Showing 1 to 10 of 76 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.4	878.5	GO:0046982	protein heterodimerization activity(GO:0046982)
12.4	582.5	GO:0003678	DNA helicase activity(GO:0003678)
22.8	318.6	GO:0003688	DNA replication origin binding(GO:0003688)
39.4	236.5	GO:0061731	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
10.9	185.1	GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
45.8	183.4	GO:0001884	pyrimidine nucleoside binding(GO:0001884) deoxynucleoside kinase activity(GO:0019136)
1.0	152.3	GO:0042393	histone binding(GO:0042393)
1.6	142.6	GO:0003777	microtubule motor activity(GO:0003777)
27.2	135.9	GO:0010997	anaphase-promoting complex binding(GO:0010997)
26.7	133.5	GO:0008310	single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)

Showing 1 to 10 of 86 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
10.9	511.6	PID ATR PATHWAY	ATR signaling pathway
6.1	405.6	PID E2F PATHWAY	E2F transcription factor network
23.6	236.2	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
7.5	195.9	PID BARD1 PATHWAY	BARD1 signaling events
4.2	184.8	PID PLK1 PATHWAY	PLK1 signaling events
1.4	118.4	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
7.6	106.0	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
5.0	104.1	PID FANCONI PATHWAY	Fanconi anemia pathway
1.2	98.2	PID CMYB PATHWAY	C-MYB transcription factor network
1.4	61.6	PID RB 1PATHWAY	Regulation of retinoblastoma protein

Showing 1 to 10 of 25 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
80.0	880.2	REACTOME UNWINDING OF DNA	Genes involved in Unwinding of DNA
37.0	813.0	REACTOME G1 S SPECIFIC TRANSCRIPTION	Genes involved in G1/S-Specific Transcription
23.3	605.3	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
16.1	257.7	REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER	Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
11.5	183.4	REACTOME PURINE SALVAGE	Genes involved in Purine salvage
4.6	142.6	REACTOME KINESINS	Genes involved in Kinesins
0.7	114.5	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
8.2	106.1	REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX	Genes involved in Association of licensing factors with the pre-replicative complex
2.4	103.5	REACTOME MRNA SPLICING MINOR PATHWAY	Genes involved in mRNA Splicing - Minor Pathway
5.7	102.2	REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS	Genes involved in Homologous recombination repair of replication-independent double-strand breaks

Showing 1 to 10 of 36 entries

Results for E2f2_E2f5

Z-value: 2.98

Motif logo

Transcription factors associated with E2f2_E2f5

Activity-expression correlation:

Activity profile of E2f2_E2f5 motif

Sorted Z-values of E2f2_E2f5 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of E2f2_E2f5

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: