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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for E2f2_E2f5

Z-value: 2.98

Motif logo

Transcription factors associated with E2f2_E2f5

Gene Symbol Gene ID Gene Info
ENSRNOG00000047741 E2F transcription factor 2
ENSRNOG00000010760 E2F transcription factor 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
E2f2rn6_v1_chr5_+_154522119_1545221190.835.4e-84Click!
E2f5rn6_v1_chr2_-_88366115_883661150.211.3e-04Click!

Activity profile of E2f2_E2f5 motif

Sorted Z-values of E2f2_E2f5 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr3_+_59153280 206.46 ENSRNOT00000002066
cell division cycle associated 7
chr6_+_43884678 205.10 ENSRNOT00000091551
ribonucleotide reductase regulatory subunit M2
chr20_+_20576377 185.05 ENSRNOT00000000783
ENSRNOT00000086806
cyclin-dependent kinase 1
chr14_-_20953095 183.40 ENSRNOT00000004440
deoxycytidine kinase
chr19_+_14523554 170.60 ENSRNOT00000084271
ENSRNOT00000064731
minichromosome maintenance complex component 5
chr13_-_45068077 157.53 ENSRNOT00000004969
minichromosome maintenance complex component 6
chr9_-_26932201 156.83 ENSRNOT00000017081
minichromosome maintenance complex component 3
chr17_+_44528125 145.26 ENSRNOT00000084538
similar to Histone H2A type 1
chr8_+_132032944 142.64 ENSRNOT00000089278
kinesin family member 15
chr1_-_42467586 141.33 ENSRNOT00000029416
F-box protein 5
chr5_+_144581427 135.88 ENSRNOT00000015227
claspin
chr12_-_52452040 133.49 ENSRNOT00000067453
DNA polymerase epsilon, catalytic subunit
chr12_-_19314016 132.92 ENSRNOT00000001825
minichromosome maintenance complex component 7
chr3_-_105298108 131.04 ENSRNOT00000010994
Rho GTPase activating protein 11A
chr17_-_44738330 130.23 ENSRNOT00000072195
histone cluster 1, H2bd-like
chr17_+_42302540 123.85 ENSRNOT00000025389
geminin, DNA replication inhibitor
chr17_+_44520537 122.11 ENSRNOT00000077985
histone cluster 1, H2ai-like2
chr3_+_146695344 118.22 ENSRNOT00000010955
GINS complex subunit 1
chr17_-_44527801 116.84 ENSRNOT00000089643
histone cluster 1 H2B family member k
chr3_-_150073721 105.97 ENSRNOT00000022428
E2F transcription factor 1
chr17_-_44520240 105.90 ENSRNOT00000086538
histone cluster 1 H2B family member h
chr13_-_110257367 104.98 ENSRNOT00000005576
denticleless E3 ubiquitin protein ligase homolog
chr8_+_48665652 104.13 ENSRNOT00000059715
H2A histone family, member X
chr3_-_124884570 103.85 ENSRNOT00000028887
proliferating cell nuclear antigen
chr4_-_120840111 103.53 ENSRNOT00000022231
minichromosome maintenance complex component 2
chr3_+_110918243 102.20 ENSRNOT00000056432
RAD51 recombinase
chr6_-_91518996 101.15 ENSRNOT00000005835
DNA polymerase epsilon 2, accessory subunit
chr7_+_97984862 97.06 ENSRNOT00000008508
ATPase family, AAA domain containing 2
chr10_+_67427066 96.38 ENSRNOT00000035642
ATPase family, AAA domain containing 5
chr17_+_44738643 92.72 ENSRNOT00000087643
histone H2A type 1-like
chr2_+_243105674 91.53 ENSRNOT00000013919
H2A histone family, member Z
chr6_+_144291974 81.32 ENSRNOT00000035255
non-SMC condensin II complex, subunit G2
chr4_-_77347011 80.03 ENSRNOT00000008149
enhancer of zeste 2 polycomb repressive complex 2 subunit
chr17_+_44763598 79.81 ENSRNOT00000079880
histone cluster 1, H3b
chr17_+_44748482 72.66 ENSRNOT00000083765
histone cluster 1 H2B family member l
chr5_+_152681101 72.20 ENSRNOT00000076052
ENSRNOT00000022574
stathmin 1
chr6_-_36940868 71.96 ENSRNOT00000006470
GEN1 Holliday junction 5' flap endonuclease
chr17_-_44748188 68.03 ENSRNOT00000081970
histone H2A type 1-E
chr8_+_71514281 67.68 ENSRNOT00000022256
NS5A (hepatitis C virus) transactivated protein 9
chr17_-_1672021 65.25 ENSRNOT00000036287
zinc finger protein 367
chr8_-_21968415 61.59 ENSRNOT00000067325
ENSRNOT00000064932
DNA methyltransferase 1
chr2_+_200187179 56.37 ENSRNOT00000093564
ENSRNOT00000025718
notch 2
chr2_+_198390166 54.54 ENSRNOT00000081042
histone cluster 2, H3c2
chr12_+_23151180 51.77 ENSRNOT00000059486
cut-like homeobox 1
chr5_-_58455819 49.46 ENSRNOT00000078082
Fanconi anemia, complementation group G
chr1_+_221448661 45.19 ENSRNOT00000072493
sororin-like
chr5_+_152721940 45.13 ENSRNOT00000039322
aurora kinase A and ninein interacting protein
chr9_+_93545396 45.07 ENSRNOT00000025093
hypothetical protein LOC100359583
chr15_+_83442144 43.47 ENSRNOT00000039344
bora, aurora kinase A activator
chr9_-_78369031 43.23 ENSRNOT00000087870
BRCA1 associated RING domain 1
chr10_+_45289741 40.92 ENSRNOT00000066190
histone cluster 3, H2ba
chr17_+_77224112 38.71 ENSRNOT00000024178
minichromosome maintenance 10 replication initiation factor
chr4_+_81244469 38.64 ENSRNOT00000044407
ENSRNOT00000015828
chromobox 3
chr8_+_117953444 37.99 ENSRNOT00000028141
cell division cycle 25A
chr8_+_111790678 37.08 ENSRNOT00000013265
topoisomerase (DNA) II binding protein 1
chr2_+_219628695 37.04 ENSRNOT00000067324
SAS-6 centriolar assembly protein
chr1_+_198214797 36.62 ENSRNOT00000068543
T-box 6
chr10_+_13061170 36.53 ENSRNOT00000004936
protein kinase, membrane associated tyrosine/threonine 1
chrX_-_62698830 36.52 ENSRNOT00000076359
DNA polymerase alpha 1, catalytic subunit
chr4_-_183426439 36.26 ENSRNOT00000083310
family with sequence similarity 60, member A
chr1_+_274310153 35.45 ENSRNOT00000054686
structural maintenance of chromosomes 3
chr4_-_170145262 34.39 ENSRNOT00000074526
histone cluster 1, H4b
chr6_-_2886465 33.41 ENSRNOT00000038448
serine and arginine rich splicing factor 7
chr7_-_94774569 31.78 ENSRNOT00000036399
DNA replication and sister chromatid cohesion 1
chr17_+_43734461 31.55 ENSRNOT00000072564
histone cluster 1, H1d
chr8_-_33661049 31.45 ENSRNOT00000068037
Fli-1 proto-oncogene, ETS transcription factor
chr9_-_119818310 31.42 ENSRNOT00000019359
structural maintenance of chromosomes flexible hinge domain containing 1
chr15_+_4356261 30.99 ENSRNOT00000009009
DnaJ heat shock protein family (Hsp40) member C9
chr6_+_11644578 28.60 ENSRNOT00000021923
ENSRNOT00000093689
mutS homolog 6
chr16_+_41079444 27.89 ENSRNOT00000015623
nei-like DNA glycosylase 3
chr4_+_49017311 27.41 ENSRNOT00000007476
inhibitor of growth family, member 3
chr18_+_1866080 26.47 ENSRNOT00000018646
small nuclear ribonucleoprotein D1
chr1_+_274309758 25.10 ENSRNOT00000019560
structural maintenance of chromosomes 3
chr4_+_34282625 24.18 ENSRNOT00000011138
ENSRNOT00000086735
glucocorticoid induced 1
chr19_-_9843673 23.91 ENSRNOT00000015795
GINS complex subunit 3
chr6_+_93462852 23.73 ENSRNOT00000089473
AT-rich interaction domain 4A
chr4_-_34282351 23.09 ENSRNOT00000011123
replication protein A3
chr10_-_65424802 23.06 ENSRNOT00000018468
Tnf receptor associated factor 4
chr8_+_117347029 22.14 ENSRNOT00000047717
inosine monophosphate dehydrogenase 2
chr15_+_45422010 21.16 ENSRNOT00000012231
ribonuclease H2, subunit B
chr1_-_198706852 19.45 ENSRNOT00000024074
dCTP pyrophosphatase 1
chr2_+_211176556 19.43 ENSRNOT00000055880
proline and serine rich coiled-coil 1
chr1_+_142034423 19.38 ENSRNOT00000090006
tubulin tyrosine ligase-like family, member 13
chrX_+_15171499 19.23 ENSRNOT00000008399
suppressor of variegation 3-9 homolog 1 (Drosophila)-like 1
chr15_-_58068892 18.44 ENSRNOT00000044254
general transcription factor IIF subunit 2
chr1_+_273563441 18.07 ENSRNOT00000048691
similar to 60S ribosomal protein L8
chr1_+_167538263 17.90 ENSRNOT00000074058
ribonucleotide reductase catalytic subunit M1
chr3_+_125470551 17.74 ENSRNOT00000028898
minichromosome maintenance 8 homologous recombination repair factor
chr7_-_34485034 17.25 ENSRNOT00000007351
small nuclear ribonucleoprotein polypeptide F
chr5_+_47853818 17.18 ENSRNOT00000009228
ENSRNOT00000079656
caspase 8 associated protein 2
chr11_+_89511191 17.04 ENSRNOT00000002510
minichromosome maintenance complex component 4
chr19_+_37600148 16.86 ENSRNOT00000023853
CCCTC-binding factor
chr8_-_22111863 16.60 ENSRNOT00000046983
ribonucleoprotein, PTB-binding 1
chr14_+_81488008 16.23 ENSRNOT00000018477
TNFAIP3 interacting protein 2
chr9_-_93377643 15.27 ENSRNOT00000024712
nucleolin
chr7_-_117703094 14.99 ENSRNOT00000019754
tonsoku-like, DNA repair protein
chr17_+_17965881 14.88 ENSRNOT00000021751
DEK proto-oncogene
chr7_+_27438351 14.85 ENSRNOT00000077976

chr1_-_71399751 14.76 ENSRNOT00000020787
zinc finger protein 444
chr6_+_126636662 14.55 ENSRNOT00000010739
ubiquitin protein ligase E3 component n-recognin 7 (putative)
chr17_-_82060123 14.44 ENSRNOT00000025046
NOP2/Sun RNA methyltransferase family member 6
chr20_+_46429222 13.98 ENSRNOT00000076818
forkhead box O3
chr8_+_12355767 13.88 ENSRNOT00000068445
family with sequence similarity 76, member B
chr1_+_167538744 13.48 ENSRNOT00000093070
ribonucleotide reductase catalytic subunit M1
chr14_-_60594844 13.23 ENSRNOT00000005349
phosphatidylinositol 4-kinase type 2 beta
chr1_+_174767960 13.14 ENSRNOT00000013362
WEE1 G2 checkpoint kinase
chr6_+_126636491 12.58 ENSRNOT00000089601
ubiquitin protein ligase E3 component n-recognin 7 (putative)
chr20_+_6049286 12.44 ENSRNOT00000042143
ENSRNOT00000092566
bromodomain and PHD finger containing, 3
chr10_+_67325347 12.06 ENSRNOT00000079002
ENSRNOT00000085914
suppressor of zeste 12 homolog (Drosophila)
chr4_+_170820594 11.99 ENSRNOT00000032568
similar to C030030A07Rik protein
chr16_+_7103998 11.18 ENSRNOT00000016581
polybromo 1
chr6_+_36941596 10.96 ENSRNOT00000083383
structural maintenance of chromosomes 6
chr16_-_7103604 10.94 ENSRNOT00000033677
G protein nucleolar 3
chrX_+_157353577 10.74 ENSRNOT00000090596
HAUS augmin-like complex, subunit 7
chr14_-_44375804 10.69 ENSRNOT00000042825
ribosomal protein P2-like
chr12_+_8085525 10.56 ENSRNOT00000089804
ENSRNOT00000001234
solute carrier family 7 member 1
chr10_+_11206226 10.54 ENSRNOT00000006979
transcription factor AP-4
chr12_+_660011 10.06 ENSRNOT00000040830
PDS5 cohesin associated factor B
chr9_+_81783349 10.02 ENSRNOT00000021548
CCR4-NOT transcription complex subunit 9
chr1_+_243477493 9.67 ENSRNOT00000021779
ENSRNOT00000085356
doublesex and mab-3 related transcription factor 1
chr10_-_14324170 9.55 ENSRNOT00000035513
ENSRNOT00000090587
hematological and neurological expressed 1-like
chr3_-_176791960 9.46 ENSRNOT00000018237
glucocorticoid modulatory element binding protein 2
chr2_+_207108552 9.44 ENSRNOT00000027234
solute carrier family 16 member 1
chr15_-_44627765 9.18 ENSRNOT00000058887
dedicator of cytokinesis 5
chr10_+_36098051 9.07 ENSRNOT00000083971
ADAM metallopeptidase with thrombospondin type 1 motif, 2
chr1_-_128341240 9.06 ENSRNOT00000070864
ENSRNOT00000072915
myocyte enhancer factor 2a
chr2_-_4195810 8.72 ENSRNOT00000018457
SMC5-SMC6 complex localization factor 1
chr18_-_48720472 8.68 ENSRNOT00000023236
centrosomal protein 120
chr6_+_132805794 7.74 ENSRNOT00000006281
WD repeat domain 25
chr1_-_265420503 7.65 ENSRNOT00000072223
F-box and WD repeat domain containing 4
chr3_+_38742072 7.49 ENSRNOT00000006774
ADP ribosylation factor like GTPase 6 interacting protein 6
chr3_-_117766120 7.40 ENSRNOT00000056022
fibrillin 1
chr5_+_154668179 7.36 ENSRNOT00000015971
heterogeneous nuclear ribonucleoprotein R
chr10_-_105795958 7.24 ENSRNOT00000067739
serine and arginine rich splicing factor 2
chr5_-_16706909 7.17 ENSRNOT00000011314
ribosomal protein S20
chr7_+_12006710 7.15 ENSRNOT00000045421
Kruppel-like factor 16
chrX_+_113510621 6.58 ENSRNOT00000025912
nuclear transport factor 2-like export factor 2
chr2_+_104854572 6.42 ENSRNOT00000064828
ENSRNOT00000090912
helicase-like transcription factor
chr3_-_59688692 6.21 ENSRNOT00000078752
Sp3 transcription factor
chr19_-_52206310 5.88 ENSRNOT00000087886
membrane-bound transcription factor peptidase, site 1
chr5_-_128186532 5.86 ENSRNOT00000012635
pre-mRNA processing factor 38A
chr4_+_62299044 5.83 ENSRNOT00000032077
ATP/GTP binding protein-like 3
chr11_+_86329012 5.81 ENSRNOT00000072027
cell division cycle 45
chr10_-_109757550 5.76 ENSRNOT00000054957
Rho GDP dissociation inhibitor alpha
chr5_-_173659675 5.72 ENSRNOT00000027547
kelch-like family member 17
chr1_-_82546937 5.52 ENSRNOT00000028100
heterogeneous nuclear ribonucleoprotein U-like 1
chr14_-_86706626 5.52 ENSRNOT00000082893
H2A histone family, member V
chr13_+_48679774 5.38 ENSRNOT00000075674
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr11_-_86276430 5.24 ENSRNOT00000075164
histone cell cycle regulator
chr6_-_103935122 5.17 ENSRNOT00000058354
hypothetical protein LOC500684
chr1_-_80630038 5.10 ENSRNOT00000025281
translocase of outer mitochondrial membrane 40
chr3_-_160608308 4.89 ENSRNOT00000047560
WAP four-disulfide core domain 15B
chr15_-_83442008 4.84 ENSRNOT00000039400
mitotic spindle organizing protein 1
chr6_+_135610743 4.60 ENSRNOT00000010906
Tnf receptor-associated factor 3
chrX_+_71540895 4.55 ENSRNOT00000004692
ENSRNOT00000082967
O-linked N-acetylglucosamine (GlcNAc) transferase
chr3_-_125470413 4.39 ENSRNOT00000028893
tRNA methyltransferase 6
chrX_+_156812064 4.33 ENSRNOT00000077142
host cell factor C1
chrY_+_380382 4.31 ENSRNOT00000092110
RNA binding motif protein, Y-linked, family 1, member J
chr8_-_123371257 4.29 ENSRNOT00000017243
STT3B, catalytic subunit of the oligosaccharyltransferase complex
chr9_+_78862013 4.25 ENSRNOT00000021105
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr3_-_113091770 4.11 ENSRNOT00000068132
leucine carboxyl methyltransferase 2
chr5_-_62001196 3.98 ENSRNOT00000012602
tRNA methyltransferase O
chrX_+_157353730 3.87 ENSRNOT00000080691
HAUS augmin-like complex, subunit 7
chr3_-_164964702 3.84 ENSRNOT00000014595
activity-dependent neuroprotector homeobox
chrX_-_155862363 3.79 ENSRNOT00000089847
dyskerin pseudouridine synthase 1
chr13_+_101698096 3.75 ENSRNOT00000089309
axin interactor, dorsalization associated
chr10_+_4312863 3.70 ENSRNOT00000091610
eukaryotic peptide chain release factor GTP-binding subunit ERF3B-like
chr6_+_10912383 3.39 ENSRNOT00000061747
ENSRNOT00000086247
tetratricopeptide repeat domain 7A
chr10_+_4313100 3.33 ENSRNOT00000074487
eukaryotic peptide chain release factor GTP-binding subunit ERF3B-like
chr19_-_25261911 3.27 ENSRNOT00000045180
ENSRNOT00000009806
coiled-coil and C2 domain containing 1A
chr1_+_203509731 3.19 ENSRNOT00000028007
H6 family homeobox 3
chr7_+_123308041 3.04 ENSRNOT00000009428
meiotic double-stranded break formation protein 1
chr18_-_30775401 2.93 ENSRNOT00000027128
solute carrier family 25 member 2
chr10_+_10530365 2.93 ENSRNOT00000003843
eukaryotic elongation factor 2 lysine methyltransferase
chr4_-_85174931 2.77 ENSRNOT00000014324
ENSRNOT00000088085
nucleotide-binding oligomerization domain containing 1
chr5_+_103024376 2.75 ENSRNOT00000058536

chr1_+_278557792 2.61 ENSRNOT00000023414
attractin like 1
chr17_-_30714410 2.50 ENSRNOT00000022902
ENSRNOT00000081993
pre-mRNA processing factor 4B
chr13_+_49933155 2.48 ENSRNOT00000037039
protein phosphatase 1, regulatory subunit 15B
chr3_-_176431423 2.28 ENSRNOT00000037271
YTH N(6)-methyladenosine RNA binding protein 1
chr10_+_4411766 2.00 ENSRNOT00000003213
eukaryotic peptide chain release factor GTP-binding subunit ERF3B-like
chr20_-_5037022 1.95 ENSRNOT00000091022
ENSRNOT00000060762
mutS homolog 5
chr7_-_36499784 1.92 ENSRNOT00000011948
suppressor of cytokine signaling 2
chr1_+_1771710 1.55 ENSRNOT00000080138
ENSRNOT00000073528
nucleoporin 43
chr4_+_10631073 1.39 ENSRNOT00000081939
ENSRNOT00000017907
protein tyrosine phosphatase, non-receptor type 12
chrX_-_128268285 1.38 ENSRNOT00000009755
ENSRNOT00000081880
THO complex 2
chr10_+_59743544 1.35 ENSRNOT00000093497
ENSRNOT00000056460
Tax1 binding protein 3
chr7_+_13039781 1.25 ENSRNOT00000067771
ENSRNOT00000090048
mesoderm induction early response 1, family member 2
chr14_+_4125380 1.15 ENSRNOT00000002882
zinc finger protein 644
chr2_+_128461224 1.04 ENSRNOT00000018872
jade family PHD finger 1
chr7_-_123101851 0.98 ENSRNOT00000090984
ENSRNOT00000005837
PHD finger protein 5A
chr7_-_11783849 0.82 ENSRNOT00000026202
splicing factor 3a, subunit 2
chr10_+_75335146 0.73 ENSRNOT00000073005
serine and arginine rich splicing factor 1
chr1_-_201110928 0.69 ENSRNOT00000027721
NSE4 homolog A, SMC5-SMC6 complex component
chrX_+_54734385 0.68 ENSRNOT00000005023
nuclear receptor subfamily 0, group B, member 1
chr10_-_108150511 0.55 ENSRNOT00000073337
chromobox 8
chr6_+_36941233 0.51 ENSRNOT00000007073
structural maintenance of chromosomes 6
chr1_-_200163106 0.12 ENSRNOT00000027644
minichromosome maintenance complex binding protein

Network of associatons between targets according to the STRING database.

First level regulatory network of E2f2_E2f5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
72.2 505.6 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
47.1 141.3 GO:0007056 spindle assembly involved in female meiosis(GO:0007056)
43.2 129.7 GO:0071163 DNA replication preinitiation complex assembly(GO:0071163)
42.5 170.0 GO:0006272 leading strand elongation(GO:0006272)
30.6 183.4 GO:0046125 pyrimidine deoxyribonucleoside metabolic process(GO:0046125)
26.4 185.1 GO:0090166 Golgi disassembly(GO:0090166)
22.1 310.0 GO:0019985 translesion synthesis(GO:0019985)
21.2 106.0 GO:0071930 negative regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071930)
19.5 19.5 GO:0046075 pyrimidine deoxyribonucleoside triphosphate metabolic process(GO:0009211) dTTP metabolic process(GO:0046075)
19.2 173.0 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
18.8 56.4 GO:0035622 intrahepatic bile duct development(GO:0035622)
18.1 72.2 GO:0070495 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
17.4 366.1 GO:0006270 DNA replication initiation(GO:0006270)
15.4 61.6 GO:0010424 DNA methylation on cytosine within a CG sequence(GO:0010424) positive regulation of methylation-dependent chromatin silencing(GO:0090309)
14.8 236.5 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
14.8 118.2 GO:1902969 mitotic DNA replication(GO:1902969)
13.3 80.0 GO:0014834 skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration(GO:0014834) response to trichostatin A(GO:0035983) cellular response to trichostatin A(GO:0035984)
10.5 31.4 GO:0060821 inactivation of X chromosome by DNA methylation(GO:0060821)
9.0 72.0 GO:0090267 positive regulation of spindle checkpoint(GO:0090232) positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267)
8.8 97.1 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
8.4 16.9 GO:0010216 maintenance of DNA methylation(GO:0010216)
7.9 31.8 GO:0034421 post-translational protein acetylation(GO:0034421)
7.4 96.4 GO:0048304 positive regulation of isotype switching to IgG isotypes(GO:0048304)
7.3 36.6 GO:0014043 negative regulation of neuron maturation(GO:0014043)
6.9 116.8 GO:0002227 innate immune response in mucosa(GO:0002227)
6.7 60.6 GO:0044789 modulation by host of viral release from host cell(GO:0044789) positive regulation by host of viral release from host cell(GO:0044791)
6.5 508.4 GO:0006342 chromatin silencing(GO:0006342)
5.7 22.9 GO:0043570 maintenance of DNA repeat elements(GO:0043570)
5.5 43.6 GO:0098532 histone H3-K27 trimethylation(GO:0098532)
5.1 81.3 GO:0001833 inner cell mass cell proliferation(GO:0001833)
4.4 22.1 GO:0006177 GMP biosynthetic process(GO:0006177)
4.0 23.7 GO:0034773 histone H4-K20 trimethylation(GO:0034773)
3.9 43.2 GO:0085020 protein K6-linked ubiquitination(GO:0085020)
3.7 335.6 GO:0006334 nucleosome assembly(GO:0006334)
3.4 17.2 GO:0036337 Fas signaling pathway(GO:0036337)
3.1 9.2 GO:1904694 negative regulation of vascular smooth muscle contraction(GO:1904694)
2.7 62.9 GO:0060236 regulation of mitotic spindle organization(GO:0060236)
2.7 8.2 GO:1990166 protein localization to site of double-strand break(GO:1990166)
2.5 7.4 GO:2001205 negative regulation of osteoclast development(GO:2001205)
2.4 9.7 GO:0019042 viral latency(GO:0019042) release from viral latency(GO:0019046)
2.4 51.8 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
2.3 14.0 GO:0071386 cellular response to corticosterone stimulus(GO:0071386)
2.3 23.1 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
2.3 9.1 GO:0055005 ventricular cardiac myofibril assembly(GO:0055005)
2.3 9.0 GO:0002184 cytoplasmic translational termination(GO:0002184)
2.2 15.3 GO:1901838 positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901838)
2.2 8.7 GO:0010825 positive regulation of centrosome duplication(GO:0010825)
2.1 14.9 GO:2001032 regulation of double-strand break repair via nonhomologous end joining(GO:2001032)
2.0 16.2 GO:0023035 CD40 signaling pathway(GO:0023035)
2.0 10.0 GO:2000325 regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
1.9 9.7 GO:0060903 positive regulation of meiosis I(GO:0060903)
1.9 5.8 GO:0071461 cellular response to redox state(GO:0071461)
1.8 25.5 GO:0043968 histone H2A acetylation(GO:0043968)
1.6 4.8 GO:0033566 gamma-tubulin complex localization(GO:0033566)
1.5 10.6 GO:1990822 arginine transmembrane transport(GO:1903826) basic amino acid transmembrane transport(GO:1990822)
1.3 14.7 GO:1904816 positive regulation of protein localization to chromosome, telomeric region(GO:1904816)
1.3 21.2 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
1.3 10.5 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
1.3 25.0 GO:0006298 mismatch repair(GO:0006298)
1.3 43.7 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
1.3 37.0 GO:0007099 centriole replication(GO:0007099)
1.3 11.5 GO:0000722 telomere maintenance via recombination(GO:0000722)
1.2 27.5 GO:0035855 megakaryocyte development(GO:0035855)
1.1 4.6 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
1.0 9.4 GO:0035879 plasma membrane lactate transport(GO:0035879)
1.0 2.9 GO:1903352 L-ornithine transmembrane transport(GO:1903352)
0.9 18.4 GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968)
0.9 6.2 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
0.8 5.8 GO:0035610 protein side chain deglutamylation(GO:0035610)
0.7 15.0 GO:0031297 replication fork processing(GO:0031297)
0.7 6.4 GO:0006301 postreplication repair(GO:0006301)
0.7 4.3 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.7 25.9 GO:0006284 base-excision repair(GO:0006284)
0.6 4.3 GO:0043686 co-translational protein modification(GO:0043686)
0.6 31.0 GO:0032781 positive regulation of ATPase activity(GO:0032781)
0.5 3.8 GO:0010835 regulation of protein ADP-ribosylation(GO:0010835)
0.5 38.6 GO:0071549 cellular response to dexamethasone stimulus(GO:0071549)
0.5 4.6 GO:0008063 Toll signaling pathway(GO:0008063)
0.5 44.5 GO:0001541 ovarian follicle development(GO:0001541)
0.5 12.7 GO:0030488 tRNA methylation(GO:0030488)
0.5 56.1 GO:0007051 spindle organization(GO:0007051)
0.5 2.8 GO:1904415 regulation of xenophagy(GO:1904415) positive regulation of xenophagy(GO:1904417)
0.4 3.7 GO:0043496 regulation of protein homodimerization activity(GO:0043496)
0.4 45.1 GO:0051092 positive regulation of NF-kappaB transcription factor activity(GO:0051092)
0.4 2.5 GO:1903912 negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:1903912)
0.4 91.5 GO:0007018 microtubule-based movement(GO:0007018)
0.3 7.4 GO:0061157 mRNA destabilization(GO:0061157)
0.3 7.2 GO:0033197 response to vitamin E(GO:0033197)
0.3 25.1 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.3 13.2 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.3 1.4 GO:0010793 regulation of mRNA export from nucleus(GO:0010793)
0.3 3.0 GO:0090220 meiotic telomere clustering(GO:0045141) chromosome localization to nuclear envelope involved in homologous chromosome segregation(GO:0090220)
0.3 7.7 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.3 17.7 GO:0000724 double-strand break repair via homologous recombination(GO:0000724)
0.2 9.1 GO:0030199 collagen fibril organization(GO:0030199)
0.2 12.3 GO:0034644 cellular response to UV(GO:0034644)
0.2 2.3 GO:0045948 positive regulation of translational initiation(GO:0045948)
0.2 7.1 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.1 6.7 GO:0002181 cytoplasmic translation(GO:0002181)
0.1 2.9 GO:0018023 peptidyl-lysine trimethylation(GO:0018023)
0.1 1.0 GO:0043983 histone H4-K12 acetylation(GO:0043983)
0.1 29.7 GO:0030336 negative regulation of cell migration(GO:0030336)
0.1 3.2 GO:0060135 maternal process involved in female pregnancy(GO:0060135)
0.1 1.4 GO:2000009 negative regulation of protein localization to cell surface(GO:2000009)
0.1 0.7 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.1 5.9 GO:0042990 regulation of transcription factor import into nucleus(GO:0042990)
0.1 3.4 GO:0006879 cellular iron ion homeostasis(GO:0006879)
0.1 3.6 GO:0043966 histone H3 acetylation(GO:0043966)
0.1 11.2 GO:0001890 placenta development(GO:0001890)
0.1 3.8 GO:0051028 mRNA transport(GO:0051028)
0.0 0.7 GO:0033144 negative regulation of intracellular steroid hormone receptor signaling pathway(GO:0033144)
0.0 3.3 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123)
0.0 1.4 GO:0042058 regulation of epidermal growth factor receptor signaling pathway(GO:0042058)
0.0 0.6 GO:0016574 histone ubiquitination(GO:0016574)
0.0 0.7 GO:2001022 positive regulation of response to DNA damage stimulus(GO:2001022)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
70.1 771.3 GO:0042555 MCM complex(GO:0042555)
61.7 185.1 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
59.1 236.5 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
45.2 225.8 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
39.4 118.2 GO:0000811 GINS complex(GO:0000811)
34.6 103.8 GO:0070557 PCNA-p21 complex(GO:0070557)
20.1 100.6 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
17.7 106.0 GO:0035189 Rb-E2F complex(GO:0035189)
15.4 122.9 GO:0001740 Barr body(GO:0001740)
11.7 1068.1 GO:0000786 nucleosome(GO:0000786)
10.8 43.2 GO:0031436 BRCA1-BARD1 complex(GO:0031436)
10.2 81.3 GO:0000796 condensin complex(GO:0000796)
9.5 28.6 GO:0032301 MutSalpha complex(GO:0032301)
8.7 60.6 GO:0034991 nuclear meiotic cohesin complex(GO:0034991)
7.9 102.2 GO:0000800 lateral element(GO:0000800)
7.7 38.6 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
7.4 37.0 GO:0098536 deuterosome(GO:0098536)
7.3 43.7 GO:0034715 pICln-Sm protein complex(GO:0034715)
6.9 27.4 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
5.6 44.5 GO:0031298 replication fork protection complex(GO:0031298)
5.4 92.1 GO:0035098 ESC/E(Z) complex(GO:0035098)
5.3 21.2 GO:0032299 ribonuclease H2 complex(GO:0032299)
4.8 19.2 GO:0033553 rDNA heterochromatin(GO:0033553)
4.6 36.5 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
3.7 18.7 GO:0035061 interchromatin granule(GO:0035061)
3.5 31.8 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
3.1 43.5 GO:0072687 meiotic spindle(GO:0072687)
3.1 49.5 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
3.1 37.1 GO:0001673 male germ cell nucleus(GO:0001673)
3.1 15.3 GO:0001651 dense fibrillar component(GO:0001651)
2.6 36.1 GO:0016580 Sin3 complex(GO:0016580)
2.5 61.6 GO:0005721 pericentric heterochromatin(GO:0005721)
2.3 9.0 GO:0018444 translation release factor complex(GO:0018444)
2.1 142.6 GO:0005871 kinesin complex(GO:0005871)
1.8 18.4 GO:0097550 transcriptional preinitiation complex(GO:0097550)
1.6 4.8 GO:0008275 gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274) gamma-tubulin small complex(GO:0008275)
1.5 4.4 GO:0031515 tRNA (m1A) methyltransferase complex(GO:0031515)
1.5 14.6 GO:0070652 HAUS complex(GO:0070652)
1.3 10.5 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.8 9.6 GO:0005662 DNA replication factor A complex(GO:0005662)
0.8 3.8 GO:0090661 box H/ACA telomerase RNP complex(GO:0090661)
0.7 35.7 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.7 7.4 GO:0001527 microfibril(GO:0001527) fibril(GO:0043205)
0.6 160.2 GO:0005819 spindle(GO:0005819)
0.6 5.1 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.5 68.0 GO:0005874 microtubule(GO:0005874)
0.5 2.4 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.5 11.2 GO:0090544 BAF-type complex(GO:0090544)
0.4 4.6 GO:0035631 CD40 receptor complex(GO:0035631)
0.4 6.8 GO:0071011 precatalytic spliceosome(GO:0071011)
0.3 24.5 GO:0017053 transcriptional repressor complex(GO:0017053)
0.3 4.3 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.3 4.3 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.2 4.8 GO:0019013 viral nucleocapsid(GO:0019013)
0.2 5.7 GO:0032839 dendrite cytoplasm(GO:0032839)
0.2 2.5 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.2 0.7 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.2 7.7 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.2 1.6 GO:0031080 nuclear pore outer ring(GO:0031080)
0.1 4.6 GO:0042588 zymogen granule(GO:0042588)
0.1 12.1 GO:0016605 PML body(GO:0016605)
0.1 5.8 GO:0001772 immunological synapse(GO:0001772)
0.1 1.4 GO:0000445 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.1 44.5 GO:0043235 receptor complex(GO:0043235)
0.1 51.7 GO:0005813 centrosome(GO:0005813)
0.1 10.7 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 7.2 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 234.5 GO:0005654 nucleoplasm(GO:0005654)
0.1 1.9 GO:0000795 synaptonemal complex(GO:0000795)
0.1 14.9 GO:0043292 contractile fiber(GO:0043292)
0.1 5.6 GO:0000790 nuclear chromatin(GO:0000790)
0.1 5.9 GO:0005795 Golgi stack(GO:0005795)
0.1 4.6 GO:0001650 fibrillar center(GO:0001650)
0.0 1.4 GO:0002102 podosome(GO:0002102)
0.0 16.5 GO:0005730 nucleolus(GO:0005730)
0.0 45.7 GO:0005634 nucleus(GO:0005634)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
45.8 183.4 GO:0001884 pyrimidine nucleoside binding(GO:0001884) deoxynucleoside kinase activity(GO:0019136)
39.4 236.5 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
34.6 103.8 GO:0030337 DNA polymerase processivity factor activity(GO:0030337)
27.2 135.9 GO:0010997 anaphase-promoting complex binding(GO:0010997)
26.7 133.5 GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
22.8 318.6 GO:0003688 DNA replication origin binding(GO:0003688)
17.0 102.2 GO:0000150 recombinase activity(GO:0000150)
12.4 582.5 GO:0003678 DNA helicase activity(GO:0003678)
12.3 61.6 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
10.9 185.1 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
10.3 20.6 GO:0032564 dATP binding(GO:0032564)
10.3 72.0 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
8.0 80.0 GO:0070878 primary miRNA binding(GO:0070878)
7.6 22.9 GO:0032142 single guanine insertion binding(GO:0032142)
7.0 56.0 GO:0019103 pyrimidine nucleotide binding(GO:0019103)
7.0 27.9 GO:0000405 bubble DNA binding(GO:0000405)
6.4 38.6 GO:1990226 histone methyltransferase binding(GO:1990226)
6.1 18.4 GO:0000991 transcription factor activity, core RNA polymerase II binding(GO:0000991)
4.9 24.3 GO:0036033 mediator complex binding(GO:0036033)
4.2 21.2 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
3.9 101.1 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
3.8 15.3 GO:0042134 rRNA primary transcript binding(GO:0042134)
3.6 14.4 GO:0016428 tRNA (cytosine-5-)-methyltransferase activity(GO:0016428)
3.5 31.8 GO:0043142 single-stranded DNA-dependent ATPase activity(GO:0043142)
2.9 26.5 GO:1990446 U1 snRNP binding(GO:1990446)
2.6 13.2 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
2.6 91.5 GO:0031492 nucleosomal DNA binding(GO:0031492)
2.3 122.8 GO:0003684 damaged DNA binding(GO:0003684)
2.3 81.3 GO:0043425 bHLH transcription factor binding(GO:0043425)
2.1 17.2 GO:0032184 SUMO polymer binding(GO:0032184)
2.1 19.2 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
2.0 42.3 GO:0031996 thioesterase binding(GO:0031996)
1.9 5.7 GO:0031208 POZ domain binding(GO:0031208)
1.9 123.8 GO:0070491 repressing transcription factor binding(GO:0070491)
1.6 142.6 GO:0003777 microtubule motor activity(GO:0003777)
1.6 56.4 GO:0051059 NF-kappaB binding(GO:0051059)
1.5 4.6 GO:0097363 protein O-GlcNAc transferase activity(GO:0097363)
1.5 36.6 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
1.4 878.5 GO:0046982 protein heterodimerization activity(GO:0046982)
1.4 51.1 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
1.3 10.6 GO:0015181 arginine transmembrane transporter activity(GO:0015181)
1.3 31.5 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
1.2 9.4 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
1.0 4.0 GO:0016426 tRNA (adenine) methyltransferase activity(GO:0016426)
1.0 152.3 GO:0042393 histone binding(GO:0042393)
0.8 108.4 GO:0001047 core promoter binding(GO:0001047)
0.8 9.0 GO:0008079 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.6 4.3 GO:0019238 cyclohydrolase activity(GO:0019238)
0.6 2.9 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.6 5.1 GO:0015266 protein channel activity(GO:0015266)
0.5 3.8 GO:0034061 DNA polymerase activity(GO:0034061)
0.5 31.0 GO:0031072 heat shock protein binding(GO:0031072)
0.5 16.9 GO:0031490 chromatin DNA binding(GO:0031490)
0.5 10.9 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.4 5.2 GO:0031491 nucleosome binding(GO:0031491)
0.4 2.8 GO:0050700 CARD domain binding(GO:0050700)
0.4 2.3 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.4 16.2 GO:0031593 polyubiquitin binding(GO:0031593)
0.3 4.3 GO:0004579 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.2 19.8 GO:0051087 chaperone binding(GO:0051087)
0.2 1.9 GO:0030983 mismatched DNA binding(GO:0030983)
0.2 5.8 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.2 13.1 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.2 0.7 GO:0044547 DNA topoisomerase binding(GO:0044547)
0.2 22.1 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor(GO:0016616)
0.2 0.7 GO:0050682 AF-2 domain binding(GO:0050682)
0.1 27.1 GO:0016874 ligase activity(GO:0016874)
0.1 2.1 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.1 7.4 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.1 2.5 GO:0097472 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.1 67.2 GO:0019901 protein kinase binding(GO:0019901)
0.1 10.4 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 7.4 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 49.7 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.1 7.4 GO:0004386 helicase activity(GO:0004386)
0.1 9.1 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 10.5 GO:0003713 transcription coactivator activity(GO:0003713)
0.1 3.8 GO:0005507 copper ion binding(GO:0005507)
0.1 63.9 GO:0005524 ATP binding(GO:0005524)
0.1 2.9 GO:0016279 lysine N-methyltransferase activity(GO:0016278) protein-lysine N-methyltransferase activity(GO:0016279)
0.1 4.1 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity(GO:0008757)
0.0 4.9 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 2.5 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 1.4 GO:0008013 beta-catenin binding(GO:0008013)
0.0 5.4 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 5.9 GO:0004252 serine-type endopeptidase activity(GO:0004252)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
23.6 236.2 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
10.9 511.6 PID ATR PATHWAY ATR signaling pathway
7.6 106.0 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
7.5 195.9 PID BARD1 PATHWAY BARD1 signaling events
6.1 405.6 PID E2F PATHWAY E2F transcription factor network
5.0 104.1 PID FANCONI PATHWAY Fanconi anemia pathway
4.2 184.8 PID PLK1 PATHWAY PLK1 signaling events
2.9 34.8 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
1.4 118.4 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
1.4 61.6 PID RB 1PATHWAY Regulation of retinoblastoma protein
1.3 24.3 PID ATM PATHWAY ATM pathway
1.2 98.2 PID CMYB PATHWAY C-MYB transcription factor network
1.2 17.2 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
1.0 56.4 PID NOTCH PATHWAY Notch signaling pathway
0.7 14.0 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.5 19.6 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.5 23.1 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.4 7.4 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.3 16.2 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.3 9.1 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.2 10.0 PID TELOMERASE PATHWAY Regulation of Telomerase
0.2 5.8 PID THROMBIN PAR1 PATHWAY PAR1-mediated thrombin signaling events
0.1 7.7 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 0.7 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 9.1 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
80.0 880.2 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
37.0 813.0 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
23.3 605.3 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
16.1 257.7 REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
11.5 183.4 REACTOME PURINE SALVAGE Genes involved in Purine salvage
8.2 106.1 REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
6.3 56.4 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
5.7 102.2 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
4.6 142.6 REACTOME KINESINS Genes involved in Kinesins
4.3 38.7 REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX Genes involved in Activation of the pre-replicative complex
4.1 49.7 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
2.9 31.6 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
2.6 49.5 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
2.4 103.5 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
2.2 26.4 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
1.9 51.8 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
1.7 31.4 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
1.6 38.6 REACTOME RNA POL I TRANSCRIPTION Genes involved in RNA Polymerase I Transcription
0.9 13.2 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.7 114.5 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.7 9.4 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.6 14.0 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.5 3.8 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
0.4 4.6 REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.4 19.0 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.4 5.9 REACTOME ACTIVATION OF CHAPERONES BY ATF6 ALPHA Genes involved in Activation of Chaperones by ATF6-alpha
0.4 9.1 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.3 10.6 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.2 9.1 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.1 7.2 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 9.2 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 1.9 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.1 7.4 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 2.9 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 6.7 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.1 1.6 REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus