ISMARA results: Dlx1

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Dlx1

Z-value: 1.48

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Transcription factors associated with Dlx1

Gene Symbol	Gene ID	Gene Info
Dlx1 NCBI RGD Ensembl	ENSRNOG00000001520	distal-less homeobox 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Dlx1	rn6_v1_chr3_+_58164931_58164931	-0.57	2.2e-28	Click!

Activity profile of Dlx1 motif

Sorted Z-values of Dlx1 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr2_-_216348194 Show fit	83.83	ENSRNOT00000087839	LOC103689940 NCBI RGD Ensembl Show fit	pancreatic alpha-amylase-like
chr2_-_216382244 Show fit	71.50	ENSRNOT00000086695 ENSRNOT00000087259	LOC103689940 NCBI RGD Ensembl Show fit	pancreatic alpha-amylase-like
chr11_+_85532526 Show fit	66.86	ENSRNOT00000036565	AABR07034730.2 NCBI RGD Ensembl Show fit
chr3_-_16999720 Show fit	58.80	ENSRNOT00000074382	RGD1563231 NCBI RGD Ensembl Show fit	similar to immunoglobulin kappa-chain VK-1
chr4_-_163049084 Show fit	58.30	ENSRNOT00000091644	Cd69 NCBI RGD Ensembl Show fit	Cd69 molecule
chr6_-_142903440 Show fit	57.57	ENSRNOT00000075707	AABR07065823.2 NCBI RGD Ensembl Show fit
chr3_+_19045214 Show fit	55.75	ENSRNOT00000070878	AABR07051670.1 NCBI RGD Ensembl Show fit
chr18_+_55666027 Show fit	55.36	ENSRNOT00000045950	RGD1305184 NCBI RGD Ensembl Show fit	similar to CDNA sequence BC023105
chr10_-_34242985 Show fit	50.99	ENSRNOT00000046438	RGD1559575 NCBI RGD Ensembl Show fit	similar to novel protein
chr10_-_56506446 Show fit	50.98	ENSRNOT00000021357	Acap1 NCBI RGD Ensembl Show fit	ArfGAP with coiled-coil, ankyrin repeat and PH domains 1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Dlx1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.2	153.9	GO:0035458	cellular response to interferon-beta(GO:0035458)
5.2	78.1	GO:0016540	protein autoprocessing(GO:0016540)
7.3	66.0	GO:0070543	response to linoleic acid(GO:0070543)
4.1	56.8	GO:0001867	complement activation, lectin pathway(GO:0001867)
6.6	46.0	GO:0015670	carbon dioxide transport(GO:0015670)
1.1	40.5	GO:0002474	antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
13.5	40.4	GO:0045575	basophil activation(GO:0045575)
3.7	37.1	GO:0048251	elastic fiber assembly(GO:0048251)
1.1	37.1	GO:0019731	antibacterial humoral response(GO:0019731)
0.8	36.8	GO:0050830	defense response to Gram-positive bacterium(GO:0050830)

Showing 1 to 10 of 312 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	181.5	GO:0009897	external side of plasma membrane(GO:0009897)
0.8	62.3	GO:0045095	keratin filament(GO:0045095)
0.6	57.7	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
3.2	47.7	GO:1990023	mitotic spindle midzone(GO:1990023)
0.6	45.9	GO:0000118	histone deacetylase complex(GO:0000118)
2.7	43.2	GO:0042613	MHC class II protein complex(GO:0042613)
0.2	40.9	GO:0009898	cytoplasmic side of plasma membrane(GO:0009898)
0.0	33.6	GO:0005773	vacuole(GO:0005773)
6.2	30.8	GO:0071953	elastic fiber(GO:0071953)
1.2	25.7	GO:0019013	viral nucleocapsid(GO:0019013)

Showing 1 to 10 of 141 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	218.2	GO:0030246	carbohydrate binding(GO:0030246)
0.5	208.8	GO:0005525	GTP binding(GO:0005525)
51.8	155.3	GO:0004556	alpha-amylase activity(GO:0004556)
0.9	128.1	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
1.3	96.6	GO:0003823	antigen binding(GO:0003823)
0.3	78.8	GO:0003735	structural constituent of ribosome(GO:0003735)
2.6	67.2	GO:0004190	aspartic-type endopeptidase activity(GO:0004190)
0.5	48.7	GO:0005178	integrin binding(GO:0005178)
2.0	46.9	GO:0051861	glycolipid binding(GO:0051861)
5.7	46.0	GO:0022840	leak channel activity(GO:0022840) narrow pore channel activity(GO:0022842)

Showing 1 to 10 of 194 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	84.2	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
1.4	63.5	PID ARF6 PATHWAY	Arf6 signaling events
0.3	59.2	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
3.2	58.0	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.6	46.7	PID RB 1PATHWAY	Regulation of retinoblastoma protein
0.4	42.7	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
0.9	34.5	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.4	24.8	PID TELOMERASE PATHWAY	Regulation of Telomerase
1.1	21.7	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.4	21.1	PID REG GR PATHWAY	Glucocorticoid receptor regulatory network

Showing 1 to 10 of 64 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.9	97.4	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.5	55.8	REACTOME MRNA SPLICING	Genes involved in mRNA Splicing
0.4	40.4	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.5	36.1	REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1	Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.3	31.2	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.8	28.8	REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX	Genes involved in Activation of the pre-replicative complex
1.3	27.6	REACTOME REGULATION OF SIGNALING BY CBL	Genes involved in Regulation of signaling by CBL
1.9	26.7	REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the early endosome membrane
0.7	25.6	REACTOME AMINE COMPOUND SLC TRANSPORTERS	Genes involved in Amine compound SLC transporters
2.1	25.4	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome

Showing 1 to 10 of 75 entries

Results for Dlx1

Z-value: 1.48

Motif logo

Transcription factors associated with Dlx1

Activity-expression correlation:

Activity profile of Dlx1 motif

Sorted Z-values of Dlx1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Dlx1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: