ISMARA results: Dbp

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Dbp

Z-value: 1.06

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Transcription factors associated with Dbp

Gene Symbol	Gene ID	Gene Info
Dbp NCBI RGD Ensembl	ENSRNOG00000021027	D-box binding PAR bZIP transcription factor

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Dbp	rn6_v1_chr1_+_101688297_101688297	-0.04	4.3e-01	Click!

Activity profile of Dbp motif

Sorted Z-values of Dbp motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr16_-_39476384 Show fit	53.85	ENSRNOT00000092968	Gpm6a NCBI RGD Ensembl Show fit	glycoprotein m6a
chr9_-_28732919 Show fit	51.21	ENSRNOT00000083915	Rims1 NCBI RGD Ensembl Show fit	regulating synaptic membrane exocytosis 1
chr16_-_39476025 Show fit	48.88	ENSRNOT00000014312	Gpm6a NCBI RGD Ensembl Show fit	glycoprotein m6a
chr6_+_48452369 Show fit	43.02	ENSRNOT00000044310	Myt1l NCBI RGD Ensembl Show fit	myelin transcription factor 1-like
chr11_+_42259761 Show fit	42.47	ENSRNOT00000047310	Epha6 NCBI RGD Ensembl Show fit	Eph receptor A6
chr15_-_77736892 Show fit	37.91	ENSRNOT00000057924	Pcdh9 NCBI RGD Ensembl Show fit	protocadherin 9
chr2_+_66940057 Show fit	33.17	ENSRNOT00000043050	Cdh9 NCBI RGD Ensembl Show fit	cadherin 9
chr2_-_89310946 Show fit	32.70	ENSRNOT00000015195	Ralyl NCBI RGD Ensembl Show fit	RALY RNA binding protein-like
chr2_+_54191538 Show fit	31.79	ENSRNOT00000019524	Plcxd3 NCBI RGD Ensembl Show fit	phosphatidylinositol-specific phospholipase C, X domain containing 3
chr16_-_28716885 Show fit	31.73	ENSRNOT00000059750	Spock3 NCBI RGD Ensembl Show fit	SPARC/osteonectin, cwcv and kazal like domains proteoglycan 3

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Dbp

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.4	102.7	GO:0051491	positive regulation of filopodium assembly(GO:0051491)
1.3	59.9	GO:0048013	ephrin receptor signaling pathway(GO:0048013)
0.4	53.0	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
17.1	51.2	GO:0031632	positive regulation of synaptic vesicle fusion to presynaptic membrane(GO:0031632)
1.3	34.2	GO:0048266	behavioral response to pain(GO:0048266)
4.0	31.7	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
6.1	30.6	GO:0098989	NMDA selective glutamate receptor signaling pathway(GO:0098989)
5.1	30.4	GO:0051964	negative regulation of synapse assembly(GO:0051964)
0.2	30.1	GO:1990138	neuron projection extension(GO:1990138)
1.5	28.2	GO:0050884	neuromuscular process controlling posture(GO:0050884)

Showing 1 to 10 of 114 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.9	129.9	GO:0044295	axonal growth cone(GO:0044295)
0.2	120.3	GO:0045202	synapse(GO:0045202)
0.3	81.1	GO:0045211	postsynaptic membrane(GO:0045211)
0.1	56.2	GO:0005887	integral component of plasma membrane(GO:0005887)
6.4	51.2	GO:0098831	presynaptic active zone cytoplasmic component(GO:0098831)
1.0	45.2	GO:0046658	anchored component of plasma membrane(GO:0046658)
0.2	34.2	GO:0043679	axon terminus(GO:0043679)
0.1	27.5	GO:0043235	receptor complex(GO:0043235)
1.1	25.5	GO:1902711	GABA-A receptor complex(GO:1902711)
0.3	24.0	GO:0044291	cell-cell contact zone(GO:0044291)

Showing 1 to 10 of 59 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	90.5	GO:0005262	calcium channel activity(GO:0005262)
3.6	71.5	GO:0005003	ephrin receptor activity(GO:0005003)
0.4	52.8	GO:0017124	SH3 domain binding(GO:0017124)
4.3	34.3	GO:0044323	retinoic acid-responsive element binding(GO:0044323)
0.4	34.2	GO:0048306	calcium-dependent protein binding(GO:0048306)
0.3	31.8	GO:0008081	phosphoric diester hydrolase activity(GO:0008081)
2.6	31.7	GO:0008191	metalloendopeptidase inhibitor activity(GO:0008191)
2.4	30.8	GO:0070097	alpha-catenin binding(GO:0045294) delta-catenin binding(GO:0070097)
1.4	30.6	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0	27.4	GO:0042802	identical protein binding(GO:0042802)

Showing 1 to 10 of 90 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.1	88.9	PID EPHA FWDPATHWAY	EPHA forward signaling
1.6	30.6	PID ARF6 DOWNSTREAM PATHWAY	Arf6 downstream pathway
0.5	26.2	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.3	25.2	PID CDC42 PATHWAY	CDC42 signaling events
1.2	20.4	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.5	19.9	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.3	16.9	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.0	14.6	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.3	13.4	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.3	11.0	ST WNT BETA CATENIN PATHWAY	Wnt/beta-catenin Pathway

Showing 1 to 10 of 23 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.5	67.4	REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Dopamine Neurotransmitter Release Cycle
1.6	44.5	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
2.4	38.8	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.5	30.6	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
1.1	27.2	REACTOME SYNTHESIS OF PC	Genes involved in Synthesis of PC
1.5	25.5	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
1.6	23.7	REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP	Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
1.3	22.5	REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1	Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.5	15.2	REACTOME NEPHRIN INTERACTIONS	Genes involved in Nephrin interactions
1.1	13.8	REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS	Genes involved in Tandem pore domain potassium channels

Showing 1 to 10 of 31 entries

Results for Dbp

Z-value: 1.06

Motif logo

Transcription factors associated with Dbp

Activity-expression correlation:

Activity profile of Dbp motif

Sorted Z-values of Dbp motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Dbp

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: