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GSE53960: rat RNA-Seq transcriptomic Bodymap
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Results for Chd1_Pml
Z-value: 2.23
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Transcription factors associated with Chd1_Pml
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Pml | rn6_v1_chr8_-_63034226_63034226 | -0.45 | 3.6e-17 | Click! |
| Chd1 | rn6_v1_chr1_+_57692836_57692983 | -0.31 | 2.3e-08 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_-_107009330 Show fit | 163.94 |
ENSRNOT00000074573
|
potassium voltage-gated channel subfamily Q member 3 |
|
| chr4_-_146016325 Show fit | 163.24 |
ENSRNOT00000067931
|
ATPase plasma membrane Ca2+ transporting 2 |
|
| chr4_-_71713063 Show fit | 153.71 |
ENSRNOT00000059447
|
family with sequence similarity 131, member B |
|
| chr14_-_82048251 Show fit | 114.88 |
ENSRNOT00000074734
|
N-acetyltransferase 8-like |
|
| chr14_-_78902063 Show fit | 114.44 |
ENSRNOT00000088469
|
protein phosphatase 2, regulatory subunit B, gamma |
|
| chr1_-_52544450 Show fit | 114.29 |
ENSRNOT00000043474
|
phosphodiesterase 10A |
|
| chr5_-_82168347 Show fit | 103.00 |
ENSRNOT00000084959
ENSRNOT00000084147 |
astrotactin 2 |
|
| chr15_+_108908607 Show fit | 102.53 |
ENSRNOT00000089455
|
Zic family member 2 |
|
| chr19_-_57192095 Show fit | 102.42 |
ENSRNOT00000058080
|
piggyBac transposable element derived 5 |
|
| chr8_-_94564525 Show fit | 99.30 |
ENSRNOT00000084437
|
synaptosomal-associated protein 91 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Chd1_Pml
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.1 | 368.9 | GO:0007269 | neurotransmitter secretion(GO:0007269) signal release from synapse(GO:0099643) |
| 8.3 | 307.6 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
| 15.1 | 302.3 | GO:0060081 | membrane hyperpolarization(GO:0060081) |
| 11.0 | 296.7 | GO:2000300 | regulation of synaptic vesicle exocytosis(GO:2000300) |
| 5.9 | 290.0 | GO:0048168 | regulation of neuronal synaptic plasticity(GO:0048168) |
| 12.8 | 282.5 | GO:0015812 | gamma-aminobutyric acid transport(GO:0015812) |
| 1.4 | 269.1 | GO:0099537 | trans-synaptic signaling(GO:0099537) |
| 7.8 | 265.6 | GO:0046928 | regulation of neurotransmitter secretion(GO:0046928) |
| 17.0 | 221.0 | GO:0019227 | neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870) |
| 16.3 | 211.4 | GO:0046069 | cGMP catabolic process(GO:0046069) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1352.0 | GO:0016021 | integral component of membrane(GO:0016021) |
| 5.8 | 986.0 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 3.9 | 718.3 | GO:0030426 | growth cone(GO:0030426) |
| 3.2 | 622.6 | GO:0098793 | presynapse(GO:0098793) |
| 13.4 | 590.9 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 7.5 | 568.3 | GO:0099501 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 9.8 | 420.6 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 14.9 | 402.0 | GO:0043194 | axon initial segment(GO:0043194) |
| 11.6 | 335.2 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 4.1 | 304.9 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.9 | 750.3 | GO:0005249 | voltage-gated potassium channel activity(GO:0005249) |
| 3.6 | 391.9 | GO:0044325 | ion channel binding(GO:0044325) |
| 1.0 | 276.4 | GO:0015631 | tubulin binding(GO:0015631) |
| 4.0 | 257.0 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
| 8.7 | 251.2 | GO:0005245 | voltage-gated calcium channel activity(GO:0005245) |
| 9.1 | 227.8 | GO:0016917 | GABA receptor activity(GO:0016917) |
| 6.0 | 202.4 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
| 3.7 | 190.8 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 24.8 | 173.8 | GO:0015185 | gamma-aminobutyric acid transmembrane transporter activity(GO:0015185) |
| 41.7 | 166.9 | GO:0060072 | large conductance calcium-activated potassium channel activity(GO:0060072) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.9 | 254.8 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 1.3 | 200.2 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 9.2 | 192.3 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 10.4 | 156.5 | PID S1P S1P4 PATHWAY | S1P4 pathway |
| 0.4 | 127.5 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 2.1 | 122.2 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 4.8 | 110.1 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 1.7 | 92.9 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 2.4 | 80.6 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 1.6 | 70.0 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 13.5 | 703.1 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 6.8 | 292.3 | REACTOME POTASSIUM CHANNELS | Genes involved in Potassium Channels |
| 17.7 | 265.3 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 17.6 | 264.7 | REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Dopamine Neurotransmitter Release Cycle |
| 10.2 | 255.5 | REACTOME PLATELET CALCIUM HOMEOSTASIS | Genes involved in Platelet calcium homeostasis |
| 9.0 | 224.4 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 11.4 | 216.0 | REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR | Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor |
| 12.6 | 214.8 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 6.5 | 207.5 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 11.5 | 207.2 | REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY | Genes involved in Adenylate cyclase inhibitory pathway |