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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Zfx_Zfp711
Z-value: 2.02
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Transcription factors associated with Zfx_Zfp711
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Zfx | rn6_v1_chrX_-_63182385_63182385 | 0.92 | 2.7e-02 | Click! |
| Zfp711 | rn6_v1_chrX_+_84064427_84064427 | 0.62 | 2.6e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_+_130474279 Show fit | 2.31 |
ENSRNOT00000092388
|
SH3 and multiple ankyrin repeat domains 3 |
|
| chr19_-_25801526 Show fit | 1.47 |
ENSRNOT00000003884
|
nucleus accumbens associated 1 |
|
| chr3_-_164095878 Show fit | 1.42 |
ENSRNOT00000079414
|
beta-1,4-galactosyltransferase 5 |
|
| chr9_+_94980409 Show fit | 1.39 |
ENSRNOT00000035338
|
diacylglycerol kinase, delta |
|
| chr5_-_172623899 Show fit | 1.34 |
ENSRNOT00000080591
|
SKI proto-oncogene |
|
| chr4_-_145147397 Show fit | 1.31 |
ENSRNOT00000010347
|
lipoma HMGIC fusion partner-like 4 |
|
| chr3_-_92242318 Show fit | 1.19 |
ENSRNOT00000007018
|
tripartite motif-containing 44 |
|
| chr7_+_130474508 Show fit | 1.18 |
ENSRNOT00000085191
|
SH3 and multiple ankyrin repeat domains 3 |
|
| chr12_-_44279002 Show fit | 1.17 |
ENSRNOT00000064900
|
F-box protein 21 |
|
| chr11_-_65759581 Show fit | 1.16 |
ENSRNOT00000034334
|
leucine rich repeat containing 58 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Zfx_Zfp711
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 4.7 | GO:1904717 | regulation of AMPA glutamate receptor clustering(GO:1904717) |
| 0.1 | 2.0 | GO:0007205 | protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205) |
| 0.1 | 1.7 | GO:0006895 | Golgi to endosome transport(GO:0006895) |
| 0.1 | 1.7 | GO:0070208 | protein heterotrimerization(GO:0070208) |
| 0.0 | 1.7 | GO:0030866 | cortical actin cytoskeleton organization(GO:0030866) |
| 0.2 | 1.6 | GO:0043951 | negative regulation of cAMP-mediated signaling(GO:0043951) |
| 0.1 | 1.6 | GO:0072600 | establishment of protein localization to Golgi(GO:0072600) |
| 0.1 | 1.4 | GO:1901409 | positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409) |
| 0.1 | 1.4 | GO:0032957 | inositol trisphosphate metabolic process(GO:0032957) |
| 0.1 | 1.4 | GO:0032011 | ARF protein signal transduction(GO:0032011) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.3 | GO:0014069 | postsynaptic density(GO:0014069) |
| 0.0 | 6.1 | GO:0016604 | nuclear body(GO:0016604) |
| 0.1 | 5.3 | GO:0060170 | ciliary membrane(GO:0060170) |
| 0.0 | 2.8 | GO:0016605 | PML body(GO:0016605) |
| 0.1 | 1.9 | GO:0000124 | SAGA complex(GO:0000124) |
| 0.0 | 1.9 | GO:0031201 | SNARE complex(GO:0031201) |
| 0.0 | 1.9 | GO:0005778 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 0.0 | 1.8 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.0 | 1.7 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.1 | 1.6 | GO:0035861 | site of double-strand break(GO:0035861) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 5.1 | GO:0030160 | GKAP/Homer scaffold activity(GO:0030160) |
| 0.0 | 5.1 | GO:0005085 | guanyl-nucleotide exchange factor activity(GO:0005085) |
| 0.0 | 4.8 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.1 | 3.6 | GO:0004004 | RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186) |
| 0.0 | 3.3 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.1 | 2.9 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.1 | 2.8 | GO:0031435 | mitogen-activated protein kinase kinase kinase binding(GO:0031435) |
| 0.1 | 2.8 | GO:0032452 | histone demethylase activity(GO:0032452) |
| 0.0 | 2.8 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.1 | 2.5 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.4 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.1 | 2.3 | PID HIV NEF PATHWAY | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| 0.0 | 2.3 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.0 | 2.3 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.0 | 2.0 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.0 | 1.7 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.1 | 1.6 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.1 | 1.5 | PID S1P S1P1 PATHWAY | S1P1 pathway |
| 0.0 | 1.5 | PID BMP PATHWAY | BMP receptor signaling |
| 0.0 | 1.4 | PID ERBB4 PATHWAY | ErbB4 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.7 | REACTOME CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE | Genes involved in Cell death signalling via NRAGE, NRIF and NADE |
| 0.1 | 2.4 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.1 | 2.3 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.1 | 1.9 | REACTOME SIGNALING BY FGFR1 FUSION MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
| 0.1 | 1.9 | REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.1 | 1.9 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.1 | 1.7 | REACTOME N GLYCAN ANTENNAE ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.0 | 1.6 | REACTOME PI METABOLISM | Genes involved in PI Metabolism |
| 0.0 | 1.6 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.1 | 1.5 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |