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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Tfap2c
Z-value: 0.67
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Transcription factors associated with Tfap2c
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Tfap2c | rn6_v1_chr3_+_170550314_170550314 | 0.08 | 9.0e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_+_9483594 Show fit | 0.68 |
ENSRNOT00000089272
|
|
|
| chr1_+_226435979 Show fit | 0.67 |
ENSRNOT00000048704
ENSRNOT00000036232 ENSRNOT00000035576 ENSRNOT00000036180 ENSRNOT00000036168 ENSRNOT00000047964 ENSRNOT00000036283 ENSRNOT00000007429 |
synaptotagmin 7 |
|
| chr7_+_130532435 Show fit | 0.50 |
ENSRNOT00000092672
ENSRNOT00000092535 |
SH3 and multiple ankyrin repeat domains 3 |
|
| chr12_-_30304036 Show fit | 0.39 |
ENSRNOT00000001218
|
nuclear protein 2, transcriptional regulator |
|
| chr6_-_99783047 Show fit | 0.38 |
ENSRNOT00000009028
|
spectrin, beta, erythrocytic |
|
| chr4_+_100209951 Show fit | 0.31 |
ENSRNOT00000015807
|
hypothetical protein LOC691113 |
|
| chr16_-_71319449 Show fit | 0.27 |
ENSRNOT00000029284
|
Fibroblast growth factor receptor 1 |
|
| chr10_+_61685645 Show fit | 0.26 |
ENSRNOT00000003933
|
MAX network transcriptional repressor |
|
| chr12_-_41671437 Show fit | 0.23 |
ENSRNOT00000001883
|
LIM homeobox 5 |
|
| chr15_+_61692116 Show fit | 0.23 |
ENSRNOT00000071455
|
kelch repeat and BTB domain containing 6 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Tfap2c
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 0.7 | GO:1990926 | short-term synaptic potentiation(GO:1990926) |
| 0.1 | 0.5 | GO:1904717 | regulation of AMPA glutamate receptor clustering(GO:1904717) |
| 0.1 | 0.4 | GO:0048372 | ventricular zone neuroblast division(GO:0021847) fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development(GO:0035607) lateral mesodermal cell fate commitment(GO:0048372) lateral mesodermal cell fate specification(GO:0048377) regulation of lateral mesodermal cell fate specification(GO:0048378) |
| 0.0 | 0.4 | GO:0006779 | porphyrin-containing compound biosynthetic process(GO:0006779) |
| 0.0 | 0.3 | GO:0071157 | negative regulation of cell cycle arrest(GO:0071157) |
| 0.0 | 0.2 | GO:0072086 | specification of loop of Henle identity(GO:0072086) |
| 0.0 | 0.2 | GO:0050893 | sensory processing(GO:0050893) |
| 0.0 | 0.2 | GO:0010045 | response to nickel cation(GO:0010045) |
| 0.0 | 0.2 | GO:0021937 | cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation(GO:0021937) |
| 0.0 | 0.2 | GO:0046725 | negative regulation by virus of viral protein levels in host cell(GO:0046725) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.7 | GO:0032009 | early phagosome(GO:0032009) |
| 0.0 | 0.4 | GO:0008091 | spectrin(GO:0008091) spectrin-associated cytoskeleton(GO:0014731) |
| 0.0 | 0.3 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
| 0.0 | 0.2 | GO:0030877 | beta-catenin destruction complex(GO:0030877) |
| 0.0 | 0.1 | GO:0035363 | histone locus body(GO:0035363) |
| 0.0 | 0.1 | GO:0016533 | cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533) |
| 0.0 | 0.1 | GO:0005583 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.0 | 0.1 | GO:0044194 | cytolytic granule(GO:0044194) tertiary granule(GO:0070820) |
| 0.0 | 0.1 | GO:0031045 | dense core granule(GO:0031045) |
| 0.0 | 0.0 | GO:0005760 | gamma DNA polymerase complex(GO:0005760) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | GO:0001786 | phosphatidylserine binding(GO:0001786) |
| 0.1 | 0.7 | GO:0030160 | GKAP/Homer scaffold activity(GO:0030160) |
| 0.0 | 0.4 | GO:0005007 | fibroblast growth factor-activated receptor activity(GO:0005007) |
| 0.0 | 0.4 | GO:0030506 | ankyrin binding(GO:0030506) |
| 0.0 | 0.2 | GO:0008332 | low voltage-gated calcium channel activity(GO:0008332) |
| 0.0 | 0.2 | GO:0044729 | hemi-methylated DNA-binding(GO:0044729) |
| 0.0 | 0.2 | GO:0033149 | FFAT motif binding(GO:0033149) |
| 0.0 | 0.1 | GO:0033906 | hyaluronoglucuronidase activity(GO:0033906) |
| 0.0 | 0.1 | GO:0031749 | D2 dopamine receptor binding(GO:0031749) |
| 0.0 | 0.1 | GO:0070697 | activin receptor binding(GO:0070697) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.0 | 0.3 | REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 | Genes involved in Signaling by activated point mutants of FGFR1 |
| 0.0 | 0.2 | REACTOME ACYL CHAIN REMODELLING OF PG | Genes involved in Acyl chain remodelling of PG |
| 0.0 | 0.2 | REACTOME CTNNB1 PHOSPHORYLATION CASCADE | Genes involved in Beta-catenin phosphorylation cascade |
| 0.0 | 0.1 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |