Project

GSE49485: Hypoxia transcriptome sequencing of rat brain.

Navigation
Downloads

Results for Rest

Z-value: 0.90

Motif logo

logo of

Transcription factors associated with Rest

Gene Symbol Gene ID Gene Info
Rest
ENSRNOG00000002074 RE1-silencing transcription factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Restrn6_v1_chr14_-_33150509_331505090.602.9e-01Click!

Activity profile of Rest motif

Sorted Z-values of Rest motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_7498555 2.10 ENSRNOT00000017725
Barhl1
BarH-like homeobox 1
chr10_-_40953651 0.84 ENSRNOT00000063889
Glra1
glycine receptor, alpha 1
chr7_-_117587103 0.81 ENSRNOT00000035423
Scrt1
scratch family transcriptional repressor 1
chr9_+_117795132 0.64 ENSRNOT00000086943
Akain1
A-kinase anchor inhibitor 1
chr10_-_40953467 0.56 ENSRNOT00000092189
Glra1
glycine receptor, alpha 1
chr8_-_68038533 0.52 ENSRNOT00000018756
Skor1
SKI family transcriptional corepressor 1
chr1_+_105285419 0.47 ENSRNOT00000089693
Slc6a5
solute carrier family 6 member 5
chr1_-_215536980 0.47 ENSRNOT00000027344
Ifitm10
interferon induced transmembrane protein 10
chr1_+_106998623 0.46 ENSRNOT00000022383
Slc17a6
solute carrier family 17 member 6
chr5_+_29538380 0.42 ENSRNOT00000010845
Calb1
calbindin 1
chr1_+_193187972 0.35 ENSRNOT00000090172
ENSRNOT00000065342
Slc5a11
solute carrier family 5 member 11
chr1_-_215536770 0.32 ENSRNOT00000078030
Ifitm10
interferon induced transmembrane protein 10
chr8_+_130749838 0.29 ENSRNOT00000079273
Snrk
SNF related kinase
chr12_-_45801842 0.28 ENSRNOT00000078837
AABR07036513.1

chr6_+_26602144 0.27 ENSRNOT00000008037
Ucn
urocortin
chr9_-_92291220 0.25 ENSRNOT00000093357
Dner
delta/notch-like EGF repeat containing
chr7_+_120067379 0.23 ENSRNOT00000011270
Cdc42ep1
CDC42 effector protein 1
chr10_+_61403130 0.22 ENSRNOT00000092490
ENSRNOT00000077649
Ccdc92b
coiled-coil domain containing 92B
chr4_+_145238947 0.21 ENSRNOT00000067396
ENSRNOT00000091934
Cpne9
copine family member 9
chr5_-_172809353 0.20 ENSRNOT00000022246
Gabrd
gamma-aminobutyric acid type A receptor delta subunit
chr10_+_14598014 0.17 ENSRNOT00000068336
Tsr3
TSR3, 20S rRNA accumulation
chr20_+_3827367 0.16 ENSRNOT00000079967
Rxrb
retinoid X receptor beta
chr20_+_5815837 0.16 ENSRNOT00000036999
Lhfpl5
lipoma HMGIC fusion partner-like 5
chr16_-_75855745 0.16 ENSRNOT00000031291
Agpat5
1-acylglycerol-3-phosphate O-acyltransferase 5
chr10_-_20622600 0.15 ENSRNOT00000020554
Fbll1
fibrillarin-like 1
chr1_+_86938138 0.14 ENSRNOT00000075601
Ccer2
coiled-coil glutamate-rich protein 2
chr5_+_154294806 0.14 ENSRNOT00000012853
Hmgcl
3-hydroxymethyl-3-methylglutaryl-CoA lyase
chr18_-_24182012 0.13 ENSRNOT00000023594
Syt4
synaptotagmin 4
chr2_-_189096785 0.12 ENSRNOT00000028200
Chrnb2
cholinergic receptor nicotinic beta 2 subunit
chr3_+_151310598 0.12 ENSRNOT00000092194
Mmp24
matrix metallopeptidase 24
chr13_-_111765944 0.12 ENSRNOT00000073041
Syt14
synaptotagmin 14
chr6_+_137997335 0.12 ENSRNOT00000006872
Tmem121
transmembrane protein 121
chr3_+_147643250 0.12 ENSRNOT00000000013
Tcf15
transcription factor 15
chr8_-_62248013 0.12 ENSRNOT00000080012
ENSRNOT00000089602
Scamp5
secretory carrier membrane protein 5
chr6_+_126434226 0.11 ENSRNOT00000090857
Chga
chromogranin A
chr3_+_125428260 0.10 ENSRNOT00000028892
Chgb
chromogranin B
chr10_-_13075864 0.10 ENSRNOT00000005220
Paqr4
progestin and adipoQ receptor family member 4
chr3_-_3661810 0.10 ENSRNOT00000025047
Lhx3
LIM homeobox 3
chr9_+_17216495 0.09 ENSRNOT00000026331
Mad2l1bp
MAD2L1 binding protein
chr9_+_86874685 0.09 ENSRNOT00000041337
NEWGENE_1305560
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2
chr3_-_176816114 0.09 ENSRNOT00000079262
ENSRNOT00000018697
Stmn3
stathmin 3
chr7_-_58587787 0.09 ENSRNOT00000005814
Lgr5
leucine rich repeat containing G protein coupled receptor 5
chr17_-_23923792 0.08 ENSRNOT00000018739
Gfod1
glucose-fructose oxidoreductase domain containing 1
chr1_+_220322940 0.08 ENSRNOT00000074972
LOC108348085
beta-1,4-glucuronyltransferase 1
chr1_-_225128740 0.07 ENSRNOT00000026897
Rom1
retinal outer segment membrane protein 1
chr9_+_81656116 0.06 ENSRNOT00000083421
Slc11a1
solute carrier family 11 member 1
chr12_+_41073824 0.06 ENSRNOT00000001844
Rph3a
rabphilin 3A
chr9_+_45605552 0.05 ENSRNOT00000059587
NMS
neuromedin S
chr3_-_80000091 0.05 ENSRNOT00000079394
Madd
MAP-kinase activating death domain
chr3_+_3310954 0.05 ENSRNOT00000061773
Kcnt1
potassium sodium-activated channel subfamily T member 1
chr3_-_2534663 0.04 ENSRNOT00000049297
ENSRNOT00000044246
Grin1
glutamate ionotropic receptor NMDA type subunit 1
chr10_+_90342051 0.03 ENSRNOT00000028487
Rundc3a
RUN domain containing 3A
chrX_+_156911345 0.03 ENSRNOT00000080945
L1cam
L1 cell adhesion molecule
chr6_+_147876237 0.03 ENSRNOT00000056649
Tmem196
transmembrane protein 196
chr9_+_77834091 0.03 ENSRNOT00000033459
Vwc2l
von Willebrand factor C domain-containing protein 2-like
chr10_+_67862054 0.02 ENSRNOT00000031746
Cdk5r1
cyclin-dependent kinase 5 regulatory subunit 1
chr6_+_147876557 0.02 ENSRNOT00000080090
Tmem196
transmembrane protein 196
chr11_-_74315248 0.02 ENSRNOT00000002346
Hes1
hes family bHLH transcription factor 1
chr3_-_2534375 0.01 ENSRNOT00000037725
Grin1
glutamate ionotropic receptor NMDA type subunit 1
chr3_+_161433410 0.01 ENSRNOT00000024657
Slc12a5
solute carrier family 12 member 5
chr5_+_145257714 0.01 ENSRNOT00000019214
Dlgap3
DLG associated protein 3
chr6_-_137084739 0.01 ENSRNOT00000060943
Tmem179
transmembrane protein 179
chr17_-_10766253 0.00 ENSRNOT00000000117
Cplx2
complexin 2
chr1_+_84470829 0.00 ENSRNOT00000025472
Ttc9b
tetratricopeptide repeat domain 9B

Network of associatons between targets according to the STRING database.

First level regulatory network of Rest

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.4 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970) positive regulation of acrosome reaction(GO:2000344)
0.1 0.4 GO:0035502 metanephric part of ureteric bud development(GO:0035502)
0.1 0.5 GO:0036233 glycine import(GO:0036233)
0.1 0.3 GO:0060455 gastric motility(GO:0035482) negative regulation of gastric acid secretion(GO:0060455)
0.1 0.5 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)
0.1 0.2 GO:0018364 peptidyl-glutamine methylation(GO:0018364)
0.0 0.1 GO:0060084 synaptic transmission involved in micturition(GO:0060084)
0.0 0.1 GO:1900738 positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738)
0.0 0.1 GO:0046951 ketone body biosynthetic process(GO:0046951)
0.0 0.1 GO:0021526 medial motor column neuron differentiation(GO:0021526)
0.0 0.3 GO:0007220 Notch receptor processing(GO:0007220)
0.0 0.1 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.0 0.1 GO:2001013 epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.0 0.2 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
0.0 0.1 GO:0055073 cadmium ion homeostasis(GO:0055073)
0.0 0.6 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.0 2.1 GO:0030901 midbrain development(GO:0030901)
0.0 0.1 GO:0021586 pons maturation(GO:0021586)
0.0 0.0 GO:0036395 amylase secretion(GO:0036394) pancreatic amylase secretion(GO:0036395) regulation of pancreatic amylase secretion(GO:1902276)
0.0 0.8 GO:2001222 regulation of neuron migration(GO:2001222)
0.0 0.5 GO:0030514 negative regulation of BMP signaling pathway(GO:0030514)
0.0 0.4 GO:0035428 hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.0 0.2 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
0.0 0.1 GO:0044331 cell-cell adhesion mediated by cadherin(GO:0044331)
0.0 0.1 GO:0045198 establishment of epithelial cell apical/basal polarity(GO:0045198)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.1 GO:0060077 inhibitory synapse(GO:0060077)
0.0 0.5 GO:0098563 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.1 GO:0070821 tertiary granule membrane(GO:0070821)
0.0 0.2 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.0 0.3 GO:0043196 varicosity(GO:0043196)
0.0 0.3 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.2 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 0.0 GO:0044307 dendritic branch(GO:0044307)
0.0 0.2 GO:0032426 stereocilium tip(GO:0032426)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0030977 taurine binding(GO:0030977)
0.2 0.5 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.1 0.4 GO:0099510 calcium ion binding involved in regulation of cytosolic calcium ion concentration(GO:0099510)
0.1 0.3 GO:0051431 corticotropin-releasing hormone receptor 2 binding(GO:0051431)
0.0 0.4 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.0 0.1 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.0 0.5 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)
0.0 0.2 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.0 0.6 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.0 0.1 GO:0030348 syntaxin-3 binding(GO:0030348)
0.0 0.2 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 0.2 GO:0008649 rRNA methyltransferase activity(GO:0008649)
0.0 0.2 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 0.3 GO:0005112 Notch binding(GO:0005112)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.3 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.0 0.5 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.1 REACTOME HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Highly calcium permeable postsynaptic nicotinic acetylcholine receptors