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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Rest
Z-value: 0.90
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Transcription factors associated with Rest
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Rest | rn6_v1_chr14_-_33150509_33150509 | 0.60 | 2.9e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_-_7498555 Show fit | 2.10 |
ENSRNOT00000017725
|
BarH-like homeobox 1 |
|
| chr10_-_40953651 Show fit | 0.84 |
ENSRNOT00000063889
|
glycine receptor, alpha 1 |
|
| chr7_-_117587103 Show fit | 0.81 |
ENSRNOT00000035423
|
scratch family transcriptional repressor 1 |
|
| chr9_+_117795132 Show fit | 0.64 |
ENSRNOT00000086943
|
A-kinase anchor inhibitor 1 |
|
| chr10_-_40953467 Show fit | 0.56 |
ENSRNOT00000092189
|
glycine receptor, alpha 1 |
|
| chr8_-_68038533 Show fit | 0.52 |
ENSRNOT00000018756
|
SKI family transcriptional corepressor 1 |
|
| chr1_+_105285419 Show fit | 0.47 |
ENSRNOT00000089693
|
solute carrier family 6 member 5 |
|
| chr1_-_215536980 Show fit | 0.47 |
ENSRNOT00000027344
|
interferon induced transmembrane protein 10 |
|
| chr1_+_106998623 Show fit | 0.46 |
ENSRNOT00000022383
|
solute carrier family 17 member 6 |
|
| chr5_+_29538380 Show fit | 0.42 |
ENSRNOT00000010845
|
calbindin 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Rest
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.1 | GO:0030901 | midbrain development(GO:0030901) |
| 0.2 | 1.4 | GO:0051970 | negative regulation of transmission of nerve impulse(GO:0051970) positive regulation of acrosome reaction(GO:2000344) |
| 0.0 | 0.8 | GO:2001222 | regulation of neuron migration(GO:2001222) |
| 0.0 | 0.6 | GO:0010738 | regulation of protein kinase A signaling(GO:0010738) |
| 0.1 | 0.5 | GO:0036233 | glycine import(GO:0036233) |
| 0.1 | 0.5 | GO:0098700 | neurotransmitter loading into synaptic vesicle(GO:0098700) |
| 0.0 | 0.5 | GO:0030514 | negative regulation of BMP signaling pathway(GO:0030514) |
| 0.1 | 0.4 | GO:0035502 | metanephric part of ureteric bud development(GO:0035502) |
| 0.0 | 0.4 | GO:0035428 | hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659) |
| 0.1 | 0.3 | GO:0060455 | gastric motility(GO:0035482) negative regulation of gastric acid secretion(GO:0060455) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | GO:0060077 | inhibitory synapse(GO:0060077) |
| 0.0 | 0.5 | GO:0098563 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 0.0 | 0.3 | GO:0043196 | varicosity(GO:0043196) |
| 0.0 | 0.3 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.0 | 0.2 | GO:0031428 | box C/D snoRNP complex(GO:0031428) |
| 0.0 | 0.2 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 0.0 | 0.2 | GO:0032426 | stereocilium tip(GO:0032426) |
| 0.0 | 0.1 | GO:0070821 | tertiary granule membrane(GO:0070821) |
| 0.0 | 0.0 | GO:0044307 | dendritic branch(GO:0044307) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 1.4 | GO:0030977 | taurine binding(GO:0030977) |
| 0.0 | 0.6 | GO:0034237 | protein kinase A regulatory subunit binding(GO:0034237) |
| 0.2 | 0.5 | GO:0005294 | neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294) |
| 0.0 | 0.5 | GO:0005313 | L-glutamate transmembrane transporter activity(GO:0005313) |
| 0.1 | 0.4 | GO:0099510 | calcium ion binding involved in regulation of cytosolic calcium ion concentration(GO:0099510) |
| 0.0 | 0.4 | GO:0005412 | glucose:sodium symporter activity(GO:0005412) |
| 0.1 | 0.3 | GO:0051431 | corticotropin-releasing hormone receptor 2 binding(GO:0051431) |
| 0.0 | 0.3 | GO:0005112 | Notch binding(GO:0005112) |
| 0.0 | 0.2 | GO:0004886 | 9-cis retinoic acid receptor activity(GO:0004886) |
| 0.0 | 0.2 | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.3 | REACTOME LIGAND GATED ION CHANNEL TRANSPORT | Genes involved in Ligand-gated ion channel transport |
| 0.0 | 0.5 | REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.0 | 0.1 | REACTOME HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS | Genes involved in Highly calcium permeable postsynaptic nicotinic acetylcholine receptors |