ISMARA results: Klf16

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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Klf16_Sp8

Z-value: 0.86

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Transcription factors associated with Klf16_Sp8

Gene Symbol	Gene ID	Gene Info
Klf16 NCBI RGD Ensembl	ENSRNOG00000033694	Kruppel-like factor 16
Sp8 NCBI RGD Ensembl	ENSRNOG00000005943	Sp8 transcription factor

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Klf16	rn6_v1_chr7_+_12006710_12006710	0.58	3.1e-01	Click!
Sp8	rn6_v1_chr6_+_146784915_146784915	0.39	5.1e-01	Click!

Activity profile of Klf16_Sp8 motif

Sorted Z-values of Klf16_Sp8 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr3_-_176144531 Show fit	0.70	ENSRNOT00000082266	Tcfl5 NCBI RGD Ensembl Show fit	transcription factor like 5
chr10_+_56546710 Show fit	0.52	ENSRNOT00000023003	Ybx2 NCBI RGD Ensembl Show fit	Y box binding protein 2
chr5_+_154552195 Show fit	0.46	ENSRNOT00000072864	Asap3 NCBI RGD Ensembl Show fit	ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
chr12_+_14092541 Show fit	0.45	ENSRNOT00000033998	Radil NCBI RGD Ensembl Show fit	Rap associating with DIL domain
chr12_-_19599374 Show fit	0.45	ENSRNOT00000001849	Gpc2 NCBI RGD Ensembl Show fit	glypican 2
chr20_+_5535432 Show fit	0.45	ENSRNOT00000040859	Syngap1 NCBI RGD Ensembl Show fit	synaptic Ras GTPase activating protein 1
chr7_+_142912316 Show fit	0.44	ENSRNOT00000010171	Nr4a1 NCBI RGD Ensembl Show fit	nuclear receptor subfamily 4, group A, member 1
chr8_-_64572850 Show fit	0.44	ENSRNOT00000015415	Senp8 NCBI RGD Ensembl Show fit	SUMO/sentrin peptidase family member, NEDD8 specific
chr1_-_87155118 Show fit	0.43	ENSRNOT00000072441	AABR07002854.1 NCBI RGD Ensembl Show fit
chr1_-_80544825 Show fit	0.41	ENSRNOT00000057802 ENSRNOT00000040060 ENSRNOT00000067049 ENSRNOT00000052387 ENSRNOT00000073352	Relb NCBI RGD Ensembl Show fit	RELB proto-oncogene, NF-kB subunit

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Klf16_Sp8

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.8	GO:0043966	histone H3 acetylation(GO:0043966)
0.0	0.6	GO:0097499	protein localization to nonmotile primary cilium(GO:0097499)
0.1	0.5	GO:0003415	chondrocyte hypertrophy(GO:0003415)
0.1	0.5	GO:0043435	response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.1	0.5	GO:2000969	positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000969)
0.0	0.5	GO:0016926	protein desumoylation(GO:0016926)
0.0	0.5	GO:1903861	positive regulation of dendrite extension(GO:1903861)
0.0	0.5	GO:0051489	regulation of filopodium assembly(GO:0051489)
0.1	0.4	GO:0035544	negative regulation of SNARE complex assembly(GO:0035544)
0.1	0.4	GO:0035279	mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)

Showing 1 to 10 of 569 entries

Gene overrepresentation in cellular component category:

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Total log-likelihood	Term	Description
0.8	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.8	GO:0043198	dendritic shaft(GO:0043198)
0.6	GO:0016592	mediator complex(GO:0016592)
0.5	GO:0005915	zonula adherens(GO:0005915)
0.5	GO:0030061	mitochondrial crista(GO:0030061)
0.5	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.5	GO:0001673	male germ cell nucleus(GO:0001673)
0.5	GO:0032281	AMPA glutamate receptor complex(GO:0032281)
0.4	GO:0070776	H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.4	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)

Showing 1 to 10 of 155 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.3	GO:0005096	GTPase activator activity(GO:0005096)
0.0	0.9	GO:0004843	thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0	0.8	GO:0005158	insulin receptor binding(GO:0005158)
0.1	0.6	GO:0016004	phospholipase activator activity(GO:0016004)
0.0	0.6	GO:0035064	methylated histone binding(GO:0035064)
0.2	0.5	GO:0060002	plus-end directed microfilament motor activity(GO:0060002)
0.0	0.5	GO:0016929	SUMO-specific protease activity(GO:0016929)
0.0	0.5	GO:0035497	cAMP response element binding(GO:0035497)
0.0	0.5	GO:0035198	miRNA binding(GO:0035198)
0.0	0.5	GO:0070412	R-SMAD binding(GO:0070412)

Showing 1 to 10 of 277 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Total log-likelihood	Term	Description
1.1	SIG CHEMOTAXIS	Genes related to chemotaxis
0.9	PID RAC1 PATHWAY	RAC1 signaling pathway
0.8	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.7	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.7	PID NETRIN PATHWAY	Netrin-mediated signaling events
0.7	PID BETA CATENIN NUC PATHWAY	Regulation of nuclear beta catenin signaling and target gene transcription
0.6	PID RAS PATHWAY	Regulation of Ras family activation
0.6	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.5	PID EPHB FWD PATHWAY	EPHB forward signaling
0.5	PID RET PATHWAY	Signaling events regulated by Ret tyrosine kinase

Showing 1 to 10 of 48 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.1	REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	Genes involved in Synthesis of PIPs at the plasma membrane
0.1	1.0	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.0	0.8	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.0	0.6	REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS	Genes involved in CREB phosphorylation through the activation of Ras
0.0	0.6	REACTOME IL 3 5 AND GM CSF SIGNALING	Genes involved in Interleukin-3, 5 and GM-CSF signaling
0.1	0.5	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0	0.5	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0	0.5	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.0	0.5	REACTOME NEPHRIN INTERACTIONS	Genes involved in Nephrin interactions
0.0	0.5	REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION	Genes involved in Pre-NOTCH Transcription and Translation

Showing 1 to 10 of 75 entries

Results for Klf16_Sp8

Z-value: 0.86

Motif logo

Transcription factors associated with Klf16_Sp8

Activity-expression correlation:

Activity profile of Klf16_Sp8 motif

Sorted Z-values of Klf16_Sp8 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Klf16_Sp8

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: