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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Id4
Z-value: 0.78
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Transcription factors associated with Id4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Id4 | rn6_v1_chr17_-_16695126_16695126 | 0.09 | 8.9e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_+_142905758 Show fit | 0.75 |
ENSRNOT00000078663
|
nuclear receptor subfamily 4, group A, member 1 |
|
| chr1_-_220265772 Show fit | 0.50 |
ENSRNOT00000027119
|
neuronal PAS domain protein 4 |
|
| chr19_-_55510460 Show fit | 0.48 |
ENSRNOT00000019820
|
CBFA2/RUNX1 translocation partner 3 |
|
| chr2_-_88135410 Show fit | 0.45 |
ENSRNOT00000014180
|
carbonic anhydrase 3 |
|
| chr14_-_12387102 Show fit | 0.40 |
ENSRNOT00000038872
|
bone morphogenetic protein 3 |
|
| chr1_+_100299626 Show fit | 0.37 |
ENSRNOT00000092327
ENSRNOT00000044257 |
SH3 and multiple ankyrin repeat domains 1 |
|
| chr18_+_56193978 Show fit | 0.37 |
ENSRNOT00000041533
ENSRNOT00000080177 |
calcium/calmodulin-dependent protein kinase II alpha |
|
| chr1_+_220428481 Show fit | 0.35 |
ENSRNOT00000027335
|
ras and Rab interactor 1 |
|
| chr10_+_11912543 Show fit | 0.35 |
ENSRNOT00000045192
|
zinc finger protein 597 |
|
| chr2_-_186245163 Show fit | 0.33 |
ENSRNOT00000089339
|
doublecortin-like kinase 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Id4
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.8 | GO:0071376 | response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376) |
| 0.1 | 0.7 | GO:0098989 | NMDA selective glutamate receptor signaling pathway(GO:0098989) |
| 0.1 | 0.5 | GO:0071386 | cellular response to corticosterone stimulus(GO:0071386) |
| 0.1 | 0.5 | GO:0051388 | positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388) |
| 0.1 | 0.5 | GO:1903715 | regulation of aerobic respiration(GO:1903715) |
| 0.0 | 0.5 | GO:0021860 | pyramidal neuron development(GO:0021860) |
| 0.0 | 0.5 | GO:0070831 | basement membrane assembly(GO:0070831) |
| 0.1 | 0.4 | GO:0050893 | sensory processing(GO:0050893) |
| 0.1 | 0.4 | GO:0035106 | operant conditioning(GO:0035106) |
| 0.0 | 0.4 | GO:0001766 | membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.4 | GO:0005607 | laminin-2 complex(GO:0005607) |
| 0.1 | 0.4 | GO:0099522 | region of cytosol(GO:0099522) postsynaptic cytosol(GO:0099524) |
| 0.0 | 0.4 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
| 0.0 | 0.4 | GO:0097440 | apical dendrite(GO:0097440) |
| 0.1 | 0.3 | GO:0005588 | collagen type V trimer(GO:0005588) |
| 0.0 | 0.3 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
| 0.1 | 0.2 | GO:0033165 | interphotoreceptor matrix(GO:0033165) |
| 0.1 | 0.2 | GO:0097444 | spine apparatus(GO:0097444) |
| 0.0 | 0.2 | GO:1990716 | axonemal central apparatus(GO:1990716) |
| 0.0 | 0.2 | GO:0042567 | insulin-like growth factor ternary complex(GO:0042567) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.9 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
| 0.1 | 0.6 | GO:0030160 | GKAP/Homer scaffold activity(GO:0030160) |
| 0.0 | 0.6 | GO:0032794 | GTPase activating protein binding(GO:0032794) |
| 0.0 | 0.6 | GO:0015459 | potassium channel regulator activity(GO:0015459) |
| 0.1 | 0.5 | GO:0016151 | nickel cation binding(GO:0016151) |
| 0.0 | 0.5 | GO:0070700 | BMP receptor binding(GO:0070700) |
| 0.0 | 0.5 | GO:0035255 | ionotropic glutamate receptor binding(GO:0035255) |
| 0.0 | 0.4 | GO:0004385 | guanylate kinase activity(GO:0004385) |
| 0.0 | 0.4 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.0 | 0.4 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.9 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 0.8 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.0 | 0.7 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 0.0 | 0.7 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.0 | 0.6 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.0 | 0.6 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.0 | 0.5 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.0 | 0.4 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
| 0.0 | 0.4 | PID NEPHRIN NEPH1 PATHWAY | Nephrin/Neph1 signaling in the kidney podocyte |
| 0.0 | 0.4 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.6 | REACTOME NEPHRIN INTERACTIONS | Genes involved in Nephrin interactions |
| 0.0 | 0.5 | REACTOME PIP3 ACTIVATES AKT SIGNALING | Genes involved in PIP3 activates AKT signaling |
| 0.0 | 0.4 | REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII | Genes involved in CREB phosphorylation through the activation of CaMKII |
| 0.0 | 0.4 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.0 | 0.3 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.0 | 0.3 | REACTOME HS GAG DEGRADATION | Genes involved in HS-GAG degradation |
| 0.0 | 0.3 | REACTOME INFLAMMASOMES | Genes involved in Inflammasomes |
| 0.0 | 0.3 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.0 | 0.3 | REACTOME INTEGRIN ALPHAIIB BETA3 SIGNALING | Genes involved in Integrin alphaIIb beta3 signaling |
| 0.0 | 0.3 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |