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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Hsf1
Z-value: 0.65
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Transcription factors associated with Hsf1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Hsf1 | rn6_v1_chr7_+_117538523_117538523 | 0.15 | 8.1e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_-_23841049 Show fit | 0.28 |
ENSRNOT00000031555
|
heat shock protein family B (small) member 1 |
|
| chr1_+_80135391 Show fit | 0.22 |
ENSRNOT00000021893
|
G protein-coupled receptor 4 |
|
| chr7_+_11737293 Show fit | 0.18 |
ENSRNOT00000046059
|
leucine rich repeat and Ig domain containing 3 |
|
| chr3_+_154043873 Show fit | 0.15 |
ENSRNOT00000072502
ENSRNOT00000034166 |
neuronatin |
|
| chr7_-_59763219 Show fit | 0.15 |
ENSRNOT00000041210
|
similar to 60S ribosomal protein L12 |
|
| chr1_-_164308317 Show fit | 0.15 |
ENSRNOT00000022983
|
serpin family H member 1 |
|
| chr20_+_295250 Show fit | 0.15 |
ENSRNOT00000000955
|
chloride intracellular channel 2 |
|
| chr7_-_125497691 Show fit | 0.15 |
ENSRNOT00000049445
|
|
|
| chr20_+_3149114 Show fit | 0.14 |
ENSRNOT00000084770
|
RT1 class Ib, locus N2 |
|
| chr1_-_154170409 Show fit | 0.13 |
ENSRNOT00000089014
|
Hikeshi, heat shock protein nuclear import factor |
Network of associatons between targets according to the STRING database.
First level regulatory network of Hsf1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.3 | GO:0071348 | cellular response to interleukin-11(GO:0071348) response to butyrate(GO:1903544) |
| 0.0 | 0.2 | GO:0072144 | glomerular mesangial cell development(GO:0072144) |
| 0.0 | 0.2 | GO:1904871 | protein localization to nuclear body(GO:1903405) protein localization to Cajal body(GO:1904867) regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871) protein localization to nucleoplasm(GO:1990173) |
| 0.0 | 0.1 | GO:0017185 | peptidyl-lysine hydroxylation(GO:0017185) |
| 0.0 | 0.1 | GO:0042769 | DNA damage response, detection of DNA damage(GO:0042769) |
| 0.0 | 0.1 | GO:0036112 | medium-chain fatty-acyl-CoA metabolic process(GO:0036112) fatty-acyl-CoA catabolic process(GO:0036115) |
| 0.0 | 0.1 | GO:0042985 | negative regulation of amyloid precursor protein biosynthetic process(GO:0042985) |
| 0.0 | 0.1 | GO:0070682 | proteasome regulatory particle assembly(GO:0070682) |
| 0.0 | 0.1 | GO:0033364 | mast cell secretory granule organization(GO:0033364) |
| 0.0 | 0.1 | GO:1903753 | negative regulation of p38MAPK cascade(GO:1903753) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.3 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.0 | 0.2 | GO:0002199 | zona pellucida receptor complex(GO:0002199) |
| 0.0 | 0.1 | GO:0016222 | procollagen-proline 4-dioxygenase complex(GO:0016222) |
| 0.0 | 0.0 | GO:1990826 | nucleoplasmic periphery of the nuclear pore complex(GO:1990826) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.5 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
| 0.0 | 0.1 | GO:0070815 | peptidyl-lysine 5-dioxygenase activity(GO:0070815) |
| 0.0 | 0.1 | GO:0004656 | procollagen-proline 4-dioxygenase activity(GO:0004656) |
| 0.0 | 0.1 | GO:0032767 | copper-dependent protein binding(GO:0032767) |
| 0.0 | 0.1 | GO:0036042 | long-chain fatty acyl-CoA binding(GO:0036042) |
| 0.0 | 0.1 | GO:0055131 | C3HC4-type RING finger domain binding(GO:0055131) |
| 0.0 | 0.1 | GO:0000774 | adenyl-nucleotide exchange factor activity(GO:0000774) |
| 0.0 | 0.1 | GO:0031694 | alpha-2A adrenergic receptor binding(GO:0031694) |
| 0.0 | 0.1 | GO:0032564 | dATP binding(GO:0032564) |
| 0.0 | 0.0 | GO:0008502 | melatonin receptor activity(GO:0008502) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.3 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.2 | REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |