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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Hoxb7
Z-value: 1.84
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Transcription factors associated with Hoxb7
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Hoxb7 | rn6_v1_chr10_+_84135116_84135116 | -0.19 | 7.6e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr16_+_46731403 Show fit | 1.81 |
ENSRNOT00000017624
|
teneurin transmembrane protein 3 |
|
| chr10_-_16046033 Show fit | 1.23 |
ENSRNOT00000089460
|
cytoplasmic polyadenylation element binding protein 4 |
|
| chr9_+_2190915 Show fit | 1.19 |
ENSRNOT00000077417
|
SATB homeobox 1 |
|
| chr18_+_27558089 Show fit | 1.18 |
ENSRNOT00000027499
|
family with sequence similarity 53, member C |
|
| chr4_-_168517177 Show fit | 1.12 |
ENSRNOT00000009151
|
dual specificity phosphatase 16 |
|
| chr3_+_47677720 Show fit | 1.06 |
ENSRNOT00000065340
|
T-box, brain, 1 |
|
| chr11_-_62451149 Show fit | 1.01 |
ENSRNOT00000093686
ENSRNOT00000081443 |
zinc finger and BTB domain containing 20 |
|
| chr17_+_63635086 Show fit | 0.97 |
ENSRNOT00000020634
|
disco-interacting protein 2 homolog C |
|
| chr1_-_43638161 Show fit | 0.96 |
ENSRNOT00000024460
|
interaction protein for cytohesin exchange factors 1 |
|
| chr2_-_31753528 Show fit | 0.90 |
ENSRNOT00000075057
|
phosphoinositide-3-kinase regulatory subunit 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Hoxb7
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.9 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.2 | 2.3 | GO:2000766 | negative regulation of cytoplasmic translation(GO:2000766) |
| 0.0 | 2.1 | GO:0090630 | activation of GTPase activity(GO:0090630) |
| 0.1 | 2.0 | GO:0021860 | pyramidal neuron development(GO:0021860) |
| 0.2 | 1.8 | GO:0097264 | self proteolysis(GO:0097264) |
| 0.1 | 1.5 | GO:0043374 | CD8-positive, alpha-beta T cell differentiation(GO:0043374) |
| 0.2 | 1.3 | GO:0010606 | positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606) |
| 0.0 | 1.2 | GO:0000188 | inactivation of MAPK activity(GO:0000188) |
| 0.1 | 1.0 | GO:0021902 | commitment of neuronal cell to specific neuron type in forebrain(GO:0021902) |
| 0.1 | 1.0 | GO:0010459 | negative regulation of heart rate(GO:0010459) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.3 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.0 | 2.3 | GO:0042641 | actomyosin(GO:0042641) |
| 0.3 | 2.0 | GO:0097441 | basilar dendrite(GO:0097441) |
| 0.1 | 2.0 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.0 | 1.2 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
| 0.0 | 1.0 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.3 | 0.9 | GO:0005943 | phosphatidylinositol 3-kinase complex, class IA(GO:0005943) |
| 0.0 | 0.9 | GO:0030673 | axolemma(GO:0030673) |
| 0.0 | 0.9 | GO:0016592 | mediator complex(GO:0016592) |
| 0.2 | 0.8 | GO:0030015 | CCR4-NOT core complex(GO:0030015) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.1 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.0 | 2.7 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.1 | 2.0 | GO:0000900 | translation repressor activity, nucleic acid binding(GO:0000900) |
| 0.1 | 2.0 | GO:0005452 | inorganic anion exchanger activity(GO:0005452) |
| 0.1 | 1.3 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.0 | 1.3 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.0 | 1.2 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 0.1 | 1.0 | GO:0008046 | axon guidance receptor activity(GO:0008046) |
| 0.2 | 0.9 | GO:0046935 | 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935) |
| 0.1 | 0.9 | GO:0045499 | chemorepellent activity(GO:0045499) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.7 | PID TNF PATHWAY | TNF receptor signaling pathway |
| 0.0 | 1.6 | PID CDC42 PATHWAY | CDC42 signaling events |
| 0.0 | 1.5 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.0 | 1.4 | PID P38 ALPHA BETA PATHWAY | Regulation of p38-alpha and p38-beta |
| 0.1 | 1.3 | PID PDGFRA PATHWAY | PDGFR-alpha signaling pathway |
| 0.1 | 1.2 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.0 | 0.9 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 0.9 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.0 | 0.8 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 0.7 | PID EPHA2 FWD PATHWAY | EPHA2 forward signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.9 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.1 | 1.6 | REACTOME REGULATION OF SIGNALING BY CBL | Genes involved in Regulation of signaling by CBL |
| 0.1 | 1.5 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.1 | 1.3 | REACTOME DCC MEDIATED ATTRACTIVE SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.0 | 1.3 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.1 | 1.1 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.0 | 1.1 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.0 | 1.0 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.0 | 0.9 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.0 | 0.9 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |